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Effects of torcetrapib in patients at high risk for coronary events
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Recent large randomised study with effects on lipid values but failed effect on outcome, ▶
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Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007;357:2109-22. ▶ Recent large randomised study with effects on lipid values but failed effect on outcome.
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Barter, P.J.1
Caulfield, M.2
Eriksson, M.3
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2
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0030956673
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Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
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Recent statin trial targeting elevated CRP concentrations and found effective, but mechanism for the effect was not clarified, ▶
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Ridker PM, Cushman M, Stampfer MJ, et al. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997;336:973-9. ▶ Recent statin trial targeting elevated CRP concentrations and found effective, but mechanism for the effect was not clarified.
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N Engl J Med
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Ridker, P.M.1
Cushman, M.2
Stampfer, M.J.3
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3
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0035901619
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Effect of hydroxymethyl glutaryl coenzyme A reductase inhibitor therapy on high sensitive Creactive protein levels
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Jialal I, Stein D, Balis D, et al. Effect of hydroxymethyl glutaryl coenzyme A reductase inhibitor therapy on high sensitive Creactive protein levels. Circulation 2001;103:1933-5.
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Jialal, I.1
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4
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11344279659
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C-reactive protein levels and outcomes after statin therapy
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Ridker PM, Cannon CP, Morrow D, et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005;352:20-8.
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N Engl J Med
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Ridker, P.M.1
Cannon, C.P.2
Morrow, D.3
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5
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Rosuvastatin to prevent vascular events in men and women with elevated Creactive protein
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Ridker PM, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent vascular events in men and women with elevated Creactive protein. N Engl J Med 2008;359:2195-207.
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N Engl J Med
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Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.H.3
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6
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43549099569
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Biomarkers in heart failure
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Braunwald E. Biomarkers in heart failure. N Engl J Med 2008;358:2148-59.
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N Engl J Med
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Braunwald, E.1
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Kjekshus J, Apetrei E, Barrios V, et al. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 2007;357:2248-61. ▶ Large neutral study where a statin failed to show an effect on outcomes in patients with heart failure.
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Kjekshus J, Apetrei E, Barrios V, et al. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 2007;357:2248-61. ▶ Large neutral study where a statin failed to show an effect on outcomes in patients with heart failure.
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8
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53049095795
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Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): A randomised, doubleblind, placebo-controlled trial
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Gissi-HF Investigators
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Gissi-HF Investigators. Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, doubleblind, placebo-controlled trial. Lancet 2008;372:1231-9.
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Lancet
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9
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The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction
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Important trial demonstrating the relationship between ventricular arrhythmias, ejection fraction and prognosis, ▶
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Bigger JT, Fleiss JL, Kleiger R, et al. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation 1984;69:250- 8. ▶ Important trial demonstrating the relationship between ventricular arrhythmias, ejection fraction and prognosis.
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Bigger, J.T.1
Fleiss, J.L.2
Kleiger, R.3
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10
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CAST Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N Engl J Med 1989;321:406-12. ▶ Landmark study where class I antiarrhythmic agents in responders increased mortality.
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CAST Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N Engl J Med 1989;321:406-12. ▶ Landmark study where class I antiarrhythmic agents in responders increased mortality.
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11
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Cohn JN, Goldstein SO, Greenberg BH, et al. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. N Engl J Med 1998;339:1810-16. ▶ Large randomised study with two doses of an inotropic agent increased mortality in a dose dependent manner.
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Cohn JN, Goldstein SO, Greenberg BH, et al. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. N Engl J Med 1998;339:1810-16. ▶ Large randomised study with two doses of an inotropic agent increased mortality in a dose dependent manner.
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12
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0025347391
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Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context
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▶ Randomised trial where blood pressure reduction did not translate into reduction of strokes
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Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990;335:827-38. ▶ Randomised trial where blood pressure reduction did not translate into reduction of strokes.
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Lancet
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Collins, R.1
Peto, R.2
MacMahon, S.3
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13
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Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan Heart Failure Survival Study ELITE II. Lancet 2000;355:1582-7. ▶ Large, randomised trial with active control which could not confirm initial positive results in pilot trial.
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Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan Heart Failure Survival Study ELITE II. Lancet 2000;355:1582-7. ▶ Large, randomised trial with active control which could not confirm initial positive results in pilot trial.
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14
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Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian enalapril survival study (CONSENSUS)
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CONSENSUS Trial Study Group
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CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian enalapril survival study (CONSENSUS). N Engl J Med 1987;316:1429- 35.
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Long-term survival in severe heart failure in patients treated with enalapril. Ten year follow-up of CONSENSUS I
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Swedberg K, Kjekshus J, Snapinn S. Long-term survival in severe heart failure in patients treated with enalapril. Ten year follow-up of CONSENSUS I. Eur Heart J 1999;20:136-9.
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Swedberg, K.1
Kjekshus, J.2
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Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: A follow-up study
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Jong P, Yusuf S, Rousseau MF, et al. Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study. Lancet 2003;361:1843-8.
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Lancet
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Jong, P.1
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Perceptions of benefit and risk of patients undergoing first-time elective percutaneous coronary revascularization
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Holmboe ES, Fiellin DA, Cusanelli E, et al. Perceptions of benefit and risk of patients undergoing first-time elective percutaneous coronary revascularization. J Gen Intern Med 2000;15:632-7.
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Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: A meta-analysis
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Katritsis DG, Ioannidis JP. Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis. Circulation 2005;111:2906-12.
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Katritsis, D.G.1
Ioannidis, J.P.2
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19
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Coronary intervention for persistent occlusion after myocardial infarction
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Important randomised trial which showed that the open artery concept was not completely clear, ▶
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Hochman JS, Lamas GA, Buller CE, et al. Coronary intervention for persistent occlusion after myocardial infarction. N Engl J Med 2006;355:2395-407. ▶ Important randomised trial which showed that the open artery concept was not completely clear.
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N Engl J Med
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Hochman, J.S.1
Lamas, G.A.2
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Late thrombosis of drug-eluting stents: A meta-analysis of randomized clinical trials
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Meta-analysis which indicated problems with metal stents, ▶
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Bavry AA, Kumbhani DJ, Helton TJ, et al. Late thrombosis of drug-eluting stents: a meta-analysis of randomized clinical trials. Am J Med 2006;119:1056-61. ▶ Meta-analysis which indicated problems with metal stents.
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Am J Med
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Bavry, A.A.1
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Lancet
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Long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden
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