Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 22344-22352

  Kumasaka, Takashi ^a,c   Aritake, Kosuke ^b   Ago, Hideo ^a   Irikura, Daisuke ^a,b,d   Tsurumura, Toshiharu ^b   Yamamoto, Masaki ^a   Miyano, Masashi ^a   Urade, Yoshihiro ^b   Hayaishi, Osamu ^b  

^a Harima Institute ^*  (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^d Nippon Bio test Laboratories Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ABILITIES; CATALYTIC MECHANISMS; CLOSED CAVITY; CONFORMATIONAL CHANGE; EXTRACELLULAR; HUMAN CEREBROSPINAL FLUID; HYDROPHOBIC AMINO ACIDS; LIPOCALIN; MULTIFUNCTIONAL PROTEIN; OPEN CAVITY; POLAR RESIDUES; PROSTAGLANDIN D SYNTHASE; SITE DIRECTED MUTAGENESIS; STRUCTURAL BASIS; TITRATION ANALYSIS;

AMINES; AMINO ACIDS; ENZYME ACTIVITY; ENZYMES; HYDROGEN; ORGANIC ACIDS; TITRATION; WIRELESS NETWORKS;

HYDROGEN BONDS;

CYSTEINE; LIPOCALIN PROSTAGLANDIN D SYNTHASE; PROSTAGLANDIN D SYNTHASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROGEN BOND; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMYLOID BETA-PROTEIN; ANIMALS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ESCHERICHIA COLI; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

EID: 69249089709     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.018341     Document Type: Article

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