Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H 2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 564-569

  Lee, Yun Kyoung ^a   Lee, Mee Sook ^a   Kim, Young Min ^a   Park, Ock Jin ^a  

^a Hannam University   (South Korea)

Author keywords

AMPK; Apoptosis; COX 2; High level H2O2; Low level H2O2; TPA

Indexed keywords

CYCLOOXYGENASE 2; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHORBOL 13 ACETATE 12 MYRISTATE;

APOPTOSIS; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; COLON CANCER; CONFERENCE PAPER; ENZYME REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 69149105020     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04695.x     Document Type: Conference Paper

References (17)

1. Boonstra, J. J.A. Post. 2004. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337 : 1 13.
2. McCarty, M.F., J. Barroso-Aranda F. Contreras. 2007. A two-phase strategy for treatment of oxidant-dependent cancers. Med. Hypotheses 69 : 489 496.
3. Fruehauf, J.P. F.L. Meyskens, Jr. 2007. Reactive oxygen species: a breath of life or death? Clin. Cancer Res. 13 : 789 794.
4. Park, I.J. et al. 2006. Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. Ann. N.Y. Acad. Sci. 1091 : 102 109.
5. Fang, J., H. Nakamura A.K. Iyer. 2007. Tumor-targeted induction of oxystress for cancer therapy. J. Drug Target. 15 : 475 486.
6. Chun, K.S. et al. 2003. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis 24 : 1515 1524.
7. Wu, W.S. 2006. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev. 25 : 695 705.
8. Zheng, X. et al. 2006. Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice. Clin. Cancer Res. 12 : 3444 3451.
9. Arber, N. R.N. Dubois. 1999. Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer. Curr. Gastroenterol. Rep. 1 : 441 448.
10. Gupta, R.A. R.N. Dubois. 2001. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat. Rev. Cancer 1 : 11 21.
11. Pelicano, H., D. Carney P. Huang. 2004. ROS stress in cancer cells and therapeutic implications. Drug Resist. Updat. 7 : 97 110.
12. Salabat, M.R. et al. 2006. On the mechanisms of 12-O- tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells. Pancreas 33 : 148 155.
13. Wen-Sheng, W. 2006. Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. Cancer Lett. 239 : 27 35.
14. Hwang, J.T. et al. 2006. Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. Cancer Res. 66 : 10057 10063.
15. Hwang, J.T. et al. 2007. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett. 247 : 115 121.
16. Hwang, J.T., J. Ha O.J. Park. 2005. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem. Biophys. Res. Commun. 332 : 433 440.
17. Hwang, J.T. et al. 2007. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Ann. N.Y. Acad. Sci. 1095 : 441 448.