Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 521-529

  Bunik, Victoria I ^a   Kabysheva, Maria S ^a   Klimuk, Eugeny I ^a   Storozhevykh, Tatiana P ^b   Pinelis, Vsevolod G ^b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

2 oxoglutarate dehydrogenase; Delayed calcium deregulation; Glutamate; Neuronal mitochondrial metabolism; Neurotoxicity; Phosphono analogue; Tricarboxylic acid cycle

Indexed keywords

ENZYME INHIBITOR; GLUTARIC ACID DERIVATIVE; OXOGLUTARATE DEHYDROGENASE; OXOGLUTARATE DEHYDROGENASE INHIBITOR; PHOSPHONIC ACID DERIVATIVE; RHODAMINE 123; SUCCINYL PHOSPHONATE; UNCLASSIFIED DRUG;

ANIMAL CELL; BRAIN NERVE CELL; CONFERENCE PAPER; CONTROLLED STUDY; DEPOLARIZATION; EXCITOTOXICITY; FLUORESCENCE; GRANULE CELL; IN VITRO STUDY; MITOCHONDRION; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; RAT;

EID: 69149103056     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04709.x     Document Type: Conference Paper

References (27)

1. Hertz, L. H.R. Zielke. 2004. Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci. 27 : 735 743
2. Huang, Y.H. D.E. Bergles. 2004. Glutamate transporters bring competition to the synapse. Curr. Opin. Neurobiol. 14 : 346 352.
3. Genoud, C. et al. 2006. Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex. PLoS Biol. 4 : 2057 2064.
4. Strumilo, S. 2005. Short-term regulation of the alpha-ketoglutarate dehydrogenase complex by energy-linked and some other effectors. Biochemistry (Mosc). 70 : 726 729.
5. 2+ signals to neuronal mitochondria. J. Biol. Chem. 281 : 1039 1047.
6. Lambeth, D.O. et al. 2000. Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues. J. Biol. Chem. 279 : 36621 36624.
7. Gibson, G. E. et al. 2005. The α-ketoglutarate dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol. Neurobiol. 31 : 43 63.
8. Bunik, V.I. et al. 2007. Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases. Neurochem. Res. 32 : 871 891.
9. Bunik, V. 2003. 2-Oxo acid dehydrogenase complexes in redox regulation. Role of the lipoate residues and thioredoxin. Eur. J. Biochem. 270 : 1036 1042.
10. Bunik, V. C. Sievers. 2002. Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. Eur. J. Biochem. 269 : 5004 5015.
11. Bunik, V. et al. 2005. Phosphonate analogs of α-ketoglutarate inhibit the activity of the α-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry 44 : 10552 10561.
12. 13C]glutamate metabolism in cerebellar granule neurons. J. Neurosci. Res. 83 : 450 458.
13. Khodorov, B.I. et al. 2001. The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disorder in Ca(2+)-homeostasis. Ross. Fiziol. Zh. Im. I M Sechenova 87 : 459 467.
14. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260 : 3440 3450.
15. Golovina, V.A. M.P. Blaustein. 1997. Spatially and functionally distinct Ca2+ stores in sarcoplasmic and endoplasmic reticulum. Science 275 : 1643 1648.
16. de Souza Durão, M., Jr. et al. 2003. The role of growth factors on renal tubular cells submitted to hypoxia and deprived of glucose. Ren. Fail. 25 : 341 353.
17. Thévenod, F. et al. 2000. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J. Biol. Chem. 275 : 1887 1896.
18. Bunik, V.I. et al. 2006. Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ether of the Refsum disease marker phytanic acid. FEBS Lett. 580 : 3551 3557.
19. Khodorov, B.I. 2004. Glutamate-induced deregulation of calcium homeostasis and mitochondrial dysfunction in mammalian central neurones. Prog. Biophys. Mol. Biol. 86 : 279 351.
20. Nicholls, D.G. S.L. Budd. 2000. Mitochondrial and neuronal survival. Physiol. Rev. 80 : 315 360.
21. Bunik, V.I. et al. 1992. Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate. FEBS Lett. 303 : 197 201.
22. Mayer, M.L. 2006. Glutamate receptors at atomic resolution. Nature 440 : 456 462
23. Bunik, V.I. O.G. Pavlova. 1997. Inactivation of alpha-ketoglutarate dehydrogenase during its enzymatic reaction. Biochemistry (Mosc). 62 : 973 982.
24. Chinopoulos, C. V. Adam-Vizi. 2006. Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J. 273 : 433 450.
25. Coyle, J.T. P. Puttfarcken. 1993. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262 : 689 695.
26. 2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes. J. Neurosci. Res. 79 : 262 271.
27. Ruiz, F. et al. 2000. Cyclosporin A targets involved in protection against glutamate excitotoxicity. Eur. J. Pharmacol. 404 : 29 39.