Node-positive adenocarcinoma of the endometrium: Outcome and patterns of recurrence with and without external beam irradiation

Gynecologic Oncology

Volumn 115, Issue 1, 2009, Pages 6-11

  Klopp, Ann H ^a   Jhingran, Anuja ^a   Ramondetta, Lois ^a   Lu, Karen ^a   Gershenson, David M ^a   Eifel, Patricia J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Endometrial cancer; Endometrioid histology; Node positive; Paraortic nodes; Radiation

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; MEGESTROL ACETATE; PACLITAXEL;

ADULT; AGE; AGED; ARTICLE; BODY MASS; BRACHYTHERAPY; CANCER RADIOTHERAPY; ENDOMETRIUM CARCINOMA; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; RADICAL HYSTERECTOMY; RECURRENCE RISK; RECURRENT CANCER; SALPINGOOOPHORECTOMY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRACHYTHERAPY; CARBOPLATIN; CHEMOTHERAPY, ADJUVANT; CISPLATIN; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; HYSTERECTOMY; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; OVARIECTOMY; PACLITAXEL; RADIOTHERAPY, ADJUVANT; TREATMENT OUTCOME;

EID: 69149098489     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.06.035     Document Type: Article

References (27)

1. Carcangiu M.L., and Chambers J.T. Early pathologic stage clear cell carcinoma and uterine papillary serous carcinoma of the endometrium: comparison of clinicopathologic features and survival. Int. J. Gynecol. Pathol. 14 1 (1995 Jan) 30-38
2. Kosary C.L. FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. Semin. Surg. Oncol. 10 1 (1994 Jan-Feb) 31-46
3. Hendrickson M., Ross J., Eifel P., Martinez A., and Kempson R. Uterine papillary serous carcinoma: a highly malignant form of endometrial adenocarcinoma. Am. J. Surg. Pathol. 6 2 (1982 Mar) 93-108
4. Randall M.E., Filiaci V.L., Muss H., Spirtos N.M., Mannel R.S., Fowler J., et al. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J. Clin. Oncol. 1 24(1) (2006 Jan) 36-44
5. Susumu N., Sagae S., Udagawa Y., Niwa K., Kuramoto H., Satoh S., et al. Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: a Japanese Gynecologic Oncology Group study. Gynecol. Oncol. 108 1 (2008 Jan) 226-233
6. Burke T.W., Gershenson D.M., Morris M., Stringer C.A., Levenback C., Tortolero-Luna G., et al. Postoperative adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy in women with high-risk endometrial carcinoma. Gynecol. Oncol. 55 1 (1994 Oct) 47-50
7. Ajani J.A., Winter K.A., Gunderson L.L., Pedersen J., Benson III A.B., Thomas Jr. C.R., et al. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA 299 16 (2008 Apr 23) 1914-1921
8. Bonner J.A., Harari P.M., Giralt J., Azarnia N., Shin D.M., Cohen R.B., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 354 6 (2006 Feb 9) 567-578
9. Eifel P.J., Winter K., Morris M., Levenback C., Grigsby P.W., Cooper J., et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J. Clin. Oncol. 22 5 (2004 Mar 1) 872-880
10. Creutzberg C.L. GOG-99: ending the controversy regarding pelvic radiotherapy for endometrial carcinoma?. Gynecol. Oncol. 92 3 (2004 Mar) 740-743
11. Creutzberg C.L., van Putten W.L., Koper P.C., Lybeert M.L., Jobsen J.J., Warlam-Rodenhuis C.C., et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post operative radiation therapy in endometrial carcinoma. Lancet 355 9213 (2000 Apr 22) 1404-1411
12. Kitchener H., Swart A.M., Qian Q., Amos C., and Parmar M.K. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 373 9658 (2009 Jan 10) 125-136
13. Blake P., Swart A.M., Orton J., Kitchener H., Whelan T., Lukka H., et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis. Lancet 373 9658 (2009 Jan 10) 137-146
14. Rossi P.J., Jani A.B., Horowitz I.R., and Johnstone P.A. Adjuvant brachytherapy removes survival disadvantage of local disease extension in stage IIIC endometrial cancer: a SEER registry analysis. Int. J. Radiat. Oncol. Biol. Phys. 70 1 (2008 Jan 1) 134-138
15. Mundt A.J., Murphy K.T., Rotmensch J., Waggoner S.E., Yamada S.D., and Connell P.P. Surgery and postoperative radiation therapy in FIGO Stage IIIC endometrial carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 50 5 (2001 Aug 1) 1154-1160
16. Touboul E., Belkacemi Y., Buffat L., Deniaud-Alexandre E., Lefranc J.P., Lhuillier P., et al. Adenocarcinoma of the endometrium treated with combined irradiation and surgery: study of 437 patients. Int. J. Radiat. Oncol. Biol. Phys. 50 1 (2001 May 1) 81-97
17. Nelson G., Randall M., Sutton G., Moore D., Hurteau J., and Look K. FIGO stage IIIC endometrial carcinoma with metastases confined to pelvic lymph nodes: analysis of treatment outcomes, prognostic variables, and failure patterns following adjuvant radiation therapy. Gynecol. Oncol. 75 2 (1999 Nov) 211-214
18. Abu-Rustum N.R., Iasonos A., Zhou Q., Oke E., Soslow R.A., Alektiar K.M., et al. Is there a therapeutic impact to regional lymphadenectomy in the surgical treatment of endometrial carcinoma?. Am. J. Obstet. Gynecol. 198(4) 457 (2008 Apr) e1-5 discussion e5-6.
19. Chan J.K., Cheung M.K., Huh W.K., Osann K., Husain A., Teng N.N., et al. Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients. Cancer 107 8 (2006 Oct 15) 1823-1830
20. Havrilesky L.J., Cragun J.M., Calingaert B., Synan I., Secord A.A., Soper J.T., et al. Resection of lymph node metastases influences survival in stage IIIC endometrial cancer. Gynecol. Oncol. 99 3 (2005 Dec) 689-695
21. Lo K.W., Cheung T.H., Yu M.Y., Yim S.F., and Chung T.K. The value of pelvic and para-aortic lymphadenectomy in endometrial cancer to avoid unnecessary radiotherapy. Int. J. Gynecol. Cancer 13 6 (2003 Nov-Dec) 863-869
22. Mariani A., Dowdy S.C., Cliby W.A., Haddock M.G., Keeney G.L., Lesnick T.G., et al. Efficacy of systematic lymphadenectomy and adjuvant radiotherapy in node-positive endometrial cancer patients. Gynecol. Oncol. 101 2 (2006 May) 200-208
23. Onda T., Yoshikawa H., Mizutani K., Mishima M., Yokota H., Nagano H., et al. Treatment of node-positive endometrial cancer with complete node dissection, chemotherapy and radiation therapy. Br. J. Cancer 75 12 (1997) 1836-1841
24. Kilgore L.C., Partridge E.E., Alvarez R.D., Austin J.M., Shingleton H.M., Noojin III F., et al. Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol. Oncol. 56 1 (1995 Jan) 29-33
25. Benedetti Panici P., Basile S., Maneschi F., Alberto Lissoni A., Signorelli M., Scambia G., et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J. Natl. Cancer Inst. 100 23 (2008 Dec 3) 1707-1716
26. Smith D.C., Macdonald O.K., Lee C.M., and Gaffney D.K. Survival impact of lymph node dissection in endometrial adenocarcinoma: a surveillance, epidemiology, and end results analysis. Int. J. Gynecol. Cancer 18 2 (2008 Mar-Apr) 255-261
27. Greven K., Winter K., Underhill K., Fontenesci J., Cooper J., and Burke T. Final analysis of RTOG 9708: adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer. Gynecol. Oncol. 103 1 (2006 Oct) 155-159