A selective monotropic elevation of FSH, but not that of LH, amplifies the proliferation and differentiation of spermatogonia in the adult rhesus monkey (Macaca mulatta)

Human Reproduction

Volumn 24, Issue 7, 2009, Pages 1584-1595

  Simorangkir, D R ^a   Ramaswamy, S ^a   Marshall, G R ^b   Pohl, C R ^c   Plant, T M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHATHAM UNIVERSITY   (United States)

^c DUQUESNE UNIVERSITY   (United States)

Author keywords

FSH; Primate; Spermatogenesis; Testicular clamp; Testis

Indexed keywords

BROXURIDINE; FOLLITROPIN; GONADORELIN ANTAGONIST; INHIBIN B; LUTEINIZING HORMONE; TESTOSTERONE; GONADOTROPIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL DEGENERATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FOLLITROPIN RELEASE; HISTOLOGY; HORMONAL REGULATION; LUTEINIZING HORMONE RELEASE; MACACA; MALE; NONHUMAN; SPERMATOGONIUM; SPERMATOZOON MATURATION; TESTIS SIZE; ANIMAL; BIOSYNTHESIS; METABOLISM; SPERMATOGENESIS; TESTIS; TIME; TREATMENT OUTCOME;

MACACA MULATTA; PRIMATES;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; FOLLICLE STIMULATING HORMONE; GONADOTROPINS; LUTEINIZING HORMONE; MACACA MULATTA; MALE; RECOMBINANT PROTEINS; SPERMATOGENESIS; SPERMATOGONIA; TESTIS; TESTOSTERONE; TIME FACTORS; TREATMENT OUTCOME;

EID: 69149091351     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dep052     Document Type: Article

References (28)

1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946;94:239-247.
2. Clermont Y. Kinetics of spermatogenesis in mammals. Seminiferous epithelium cycle and spermatogonial renewal. Physiol Rev 1972; 52:198-236.
3. de Rooij DG, van Beek MEB. Possibilities to improve primate spermatogenesis by way of hormonal treatment. In: Hamamah S, Mieusset R (eds). Research in Male Gametes: Production and Quality. Paris: INSERM, 1996, 257-268.
4. Griswold MD, McLean D. The sertoli cell. In: Neill JD (ed). Knobil and Neill's Physiology of Reproduction. Chapter 19, Vol.1, 3rd edn. San Diego, CA: Elsevier, 2006, 949-975.
5. Jacobsen KD, Theodorsen L, Fossa SD. Spermatogenesis after unilateral orchiectomy for testicular cancer in patients following surveillance policy. J Urol 2001;165:93-96.
6. Lee PA, Coughlin MT. The single testis: paternity after presentation as unilateral cryptorchidism. J Urol 2002;168:1680-1683.
7. Majumdar SS, Winters SJ, Plant TM. A study of the relative roles of follicle-stimulating hormone and luteinizing hormone in the regulation of testicular inhibin secretion in the rhesus monkey (Macaca mulatta). Endocrinology 1997;138:1363-1373.
8. Marshall GR, Plant TM. Puberty occurring either spontaneously or induced precociously in rhesus monkey (Macaca mulatta) is associated with a marked proliferation of Sertoli cells. Biol Reprod 1996;54:1192-1199.
9. Marshall GR, Wickings EJ, Lüdecke DK, Nieschlag E. Stimulation of spermatogenesis in stalk-sectioned rhesus monkeys by testosterone alone. J Clin Endocrinol Metab 1983;57:152-159.
10. Marshall GR, Zorub DS, Plant TM. Follicle-stimulating hormone amplifies the population of differentiated spermatogonia in the hypophysectomized testosterone-replaced adult rhesus monkey (Macaca mulatta). Endocrinology 1995;136:3504-3511.
11. Marshall GR, Ramaswamy S, Plant TM. Gonadotropin independent proliferation of the pale type A spermatogonia in the adult rhesus monkey (Macaca mulatta). Biol Reprod 2005;73:222-229.
12. McLachlan RI, O'Donnell L, Meachem SJ, Stanton PG, de Kretser DM, Pratis K, Robertson DM. Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man. Rec Prog Horm Res 2002;57:149-179.
13. Medhamurthy R, Aravindan GR, Moudgal NR. Hemiorchidectomy leads to dramatic and immediate alterations in pituitary follicle-stimulating hormone secretion and the functional activity of the remaining testis in the adult male bonnet monkey (Macaca radiata). Biol Reprod 1993; 49:743-749.
14. Narula A, Gu YQ, O'Donnell L, Stanton PG, Robertson DM, McLachlan RI, Bremner WJ. Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens. J Clin Endocrinol Metab 2002;87:3399-3406.
15. Odell WD, Swerdloff RS, Jacobs HS, Hescox MA. FSH induction of sensitivity to LH: one cause of sexual maturation in the male rat. Endocrinology 1973;92:160-165.
16. Plant TM. Time courses of concentrations of circulating gonadotropin, prolactin, testosterone, and cortisol in adult male rhesus monkeys (Macaca mulatta) throughout the 24 h light-dark cycle. Biol Reprod 1981;25:244-252.
17. Plant TM, Marshall GR. The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocr Rev 2001;22:764-786.
18. Ramaswamy S, Marshall GR, McNeilly AS, Plant TM. Dynamics of the follicle-stimulating hormone (FSH)-inhibin B feedback loop and its role in regulating spermatogenesis in the adult male rhesus monkey (Macaca mulatta) as revealed by unilateral orchidectomy. Endocrinology 2000a;141:18-27.
19. Ramaswamy S, Plant TM, Marshall GR. Pulsatile stimulation with recombinant single chain human luteinizing hormone elicits precocious Sertoli cell proliferation in the juvenile male rhesus monkey (Macaca mulatta). Biol Reprod 2000b;63:82-88.
20. Ramaswamy S, Marshall GR, Pohl CR, Friedman RI, Plant TM. Inhibitory and stimulatory regulation of testicular inhibin B secretion by luteinizing hormone and follicle-stimulating hormone, respectively, in the rhesus monkey (Macaca mulatta). Endocrinology 2003; 144:1175-1185.
21. Ruwanpura SM, McLachlan RI, Matthiesson KL, Meachem SJ. Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men. Hum Reprod 2008;23:403-411.
22. Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev 1997;18:739-773.
23. Simorangkir DR, Ramaswamy S, Marshall GR, Plant TM. In the adult male rhesus monkey (Macaca mulatta), unilateral orchidectomy in the face of unchanging gonadotropin stimulation results in partial compensation of testosterone secretion by the remaining testis. Endocrinology 2004; 145:5115-5120.
24. Simorangkir DR, Marshall GR, Plant TM. A re-examination of proliferation and differentiation of type A spermatogonia in the adult rhesus monkey (Macaca mulatta). Hum Reprod 2009;doi: 10.1093/humrep/dep051.
25. van Alphen MMA, van de Kant HJG, de Rooij DG. Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. Endocrinology 1988; 123:1449-1455.
26. Vihko KK, La Polt PS, Nishimori K, Hsueh AJW. Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats. Endocrinology 1991;129:1926-1932.
27. Weinbauer GF, Behre HM, Fingscheidt U, Nieschlag E. Human follicle-stimulating hormone exerts a stimulatory effect on spermatogenesis, testicular size, and serum inhibin levels in the gonadotropin-releasing hormone antagonist-treated nonhuman primate (Macaca fascicularis). Endocrinology 1991;129:1831-1839.
28. Young J, Couzinet B, Chanson P, Brailly S, Loumaye E, Schaison G. Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Leydig cell secretions and interactions. J Clin Endocrinol Metab 2000;85: 3239-3244.