Biomonitoring of genotoxic risk in agricultural workers from five Colombian regions: Association to occupational exposure to glyphosate

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 15-16, 2009, Pages 986-997

  Bolognesi, C ^a   Carrasquilla, G ^b   Volpi, S ^a   Solomon, K R ^c   Marshall, E J P ^d  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSIDAD DEL VALLE   (Colombia)

^c UNIVERSITY OF GUELPH   (Canada)

^d Marshall Agroecology Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYPHOSATE; PESTICIDE; DRUG DERIVATIVE; GLYCINE; HERBICIDE; MUTAGENIC AGENT;

ADULT; AEROSOL; AGRICULTURAL WORKER; AIR POLLUTION; ARTICLE; BIOLOGICAL MONITORING; BLOOD SAMPLING; CELL CULTURE; CHROMOSOME DAMAGE; COCA; COFFEE; COLOMBIA; CONTROLLED STUDY; CROP; CYTOGENETICS; CYTOKINESIS; CYTOTOXICITY; CYTOTOXICITY TEST; FEMALE; GENOTOXICITY; HEALTH STATUS; HUMAN; INTERVIEW; LIFESTYLE; LYMPHOCYTE; MAJOR CLINICAL STUDY; MATURATION; MICRONUCLEUS; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SELF CONCEPT; SPOUSE; SUGARCANE; ADOLESCENT; BLOOD; CHEMICALLY INDUCED DISORDER; CHROMOSOME ABERRATION; CLASSIFICATION; DRUG EFFECT; ENVIRONMENTAL MONITORING; MALE; MICRONUCLEUS TEST; MIDDLE AGED; OCCUPATIONAL DISEASE; POLLUTANT; RISK ASSESSMENT;

PAPAVER; SACCHARUM;

ADOLESCENT; ADULT; AGRICULTURAL WORKERS' DISEASES; CHROMOSOME ABERRATIONS; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; GLYCINE; HERBICIDES; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; MUTAGENS; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; YOUNG ADULT;

EID: 69149090155     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390902929741     Document Type: Article

References (57)

1. Acquavella, J. F., Alexander, B. H., Mandel, J. S., Gustin, C., Baker, B., Chapman, P., and Bleeke, M. 2004. Glyphosate biomonitoring for farmers and their families: Results from the farm family exposure study. Environ. Health Perpect. 112:321-326.
2. Arbuckle, T. E., Cole, D. C., Ritter, L., and Ripley, B. D. 2004. Farm children's exposure to herbicides: Comparison of biomonitoring and questionnaire data. Epidemiology 15:187-194.
3. Baylis, A. D. 2000. Why glyphosate is a global herbicide: Strengths, weaknesses and prospects. Pestic. Manage. Sci. 56:299-308.
4. Bolognesi, C. 2003. Genotoxicity of pesticides: A review of human biomonitoring studies. Mutat. Res. 543:251-272.
5. Bolognesi, C., Abbondandolo, A., Barale, R., Casalone, R., Dalpraà, L., De Ferrari, M., Degrassi, F., Forni, A., Lamberti, L., Lando, C., Migliore, L., Padovani, D., Pasquini, P., Puntoni, R., Sbrana, I., Stella, M., and Bonass, S. 1997a. Agerelated increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes. Cancer Epidemiol. Biomarkers. Prev. 6:249-256.
6. Bolognesi, C., Bonatti, S., Degan, P., Gallerani, E., Peluso, M., Rabboni, R., Roggieri, P., and Abbondandolo, A. 1997b. Genotoxic activity of glypho-sate and its technical formulation, Roundup. J. Agric. Food. Chem. 45:1957-1962.
7. Bonassi, S., Bolognesi, C., Abbondandobo, A., Barale, R., Bigatti, P., Camurri, L., Dalpra, L., De Ferrari, M., Forni, A., Lando, C., Padovani, P., Pasquini, R., Stella, M., and Puntoni, R. 1995. Influence of sex on cytogenetic endpoints: Evidence from a large human sample and review of the literature. Cancer Epidemiol. Biomarkers. Prev. 4:671-679.
8. Bonassi, S., Fenech, M., Lando, C., Lin, Y. P., Ceppi, M., Chang, W. P., Holland, N., Kirsch-Volders, M., Zeiger, E., Ban, S., Barale, R., Bigatti, M., Bolognesi, C., Jia, C., Di Giorgio, M., Ferguson, L. R., Fucic, A., Lima, O. G., Hrelia, P., Krishnaja, A. P., Lee, T. K., Migliore, L., Mikhalevich, L., Mirkova, E., Mosesso, P., Müller, W. U., Odagiri, Y., Scarffi, M. R., Szabova, E., Vorobtsova, I., Vral, A., and Zijno, A. 2001. HUman MicroNucleus project: International database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ. Mol. Mutagen. 37:31-45.
9. Bonassi, S., Neri, M., Lando, C., Ceppi, M., Lin, Y.-P., Chang, W. P., Holland, N., Kirsch-Volders, M., Zeiger, E., Fenech, M., and The HUMN collaborative group. 2003. Effect of smoking habit on the frequency of micronuclei in human lymphocytes: Results from the Human MicroNucleus project. Mutat. Res. 543:155-166.
10. Bull, S., Fletcher, K., Boobis, A. R., and Battershill, J. M. 2006. Evidence for genotoxicity of pesticides in pesticide applicators: A review. Mutagenesis 2:93-103.
11. Costa, C., Teixeira, J. P., Silva, S., Roma-Torres, J., Coelho, P., Gaspar, J., Alves, M., Laffon, B., Rueff, J., and Mayan, O. 2006. Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides. Mutagenesis 21:343-350.
12. De Roos, A. J., Blair, A., Rusiecki, J. A., Hoppin, J. A., Svec, M., Dosemeci, M., Sandler, D. P., and Alavanja, M. C. 2005. Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ. Health Perspect. 113:49-54.
13. De Roos, A. J., Zahm, S. H., Cantor, K. P., Weisenburger, D. D., Holmes, F. F., Burmeister, L. F., and Blair, A. 2003. Integrative assessment of multiple pesticides as risk factors for non-Hodgkin's lymphoma among men. Occup. Environ. Med. 60:E11.
14. Dimitrov, B. D., Gadeva, P. G., Benova, D. K., and Bineva, M. V. 2006. Comparative genotoxicity of the herbicides Roundup, Stomp and Reglone in plant and mammalian test systems. Mutagenesis 21:375-382.
15. Duke, S. O., and Powles, S. B. 2008. Glyphosate: A once-in-a-century herbicide. Pestic. Manage. Sci. 64:319-325.
16. Eriksson, M., Hardell, L., Carlberg, M., and Akerman, M. 2008. Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopatho-logical subgroup analysis. Int. J. Cancer 123:1657-1663.
17. Fenech, M. 2007. Cytokinesis-block micronucleus cytome assay. Nat. Prot. 2:1084-1104.
18. Fenech, M., and Morley, A. A. 1985. Measurement of micronuclei in lymphocytes. Mutat. Res., 147:29-36.
19. Fenech, M., and Rinaldi, J. 1994. The relationship between micronuclei in human lymphocytes and plasma levels of vitamin C, vitamin E, vitamin B12 and folic acid. Carcinogenesis 15:1405-1411.
20. Firth, H. M., Rothstein, D. S., Herbison, G. P., and McBride, D. I. 2007. Chemical exposure among NZ farmers. Int. J. Environ. Health. Res. 17:33-44.
21. Gebel, T., Kevekordes, S., Pav, K., Edenharder, R., and Dunkelberg, H. 1997. In vivo genotoxicity of selected herbicides in the mouse bone marrow micronucleus test. Arch. Toxicol. 71:193-197.
22. Giesy, J. P., Dobson, S., and Solomon, K. R. 2000. Ecotoxicological risk assessment for Roundup® herbicide. Rev. Environ. Contam. Toxicol. 167:35-120.
23. Gopalan, H. N. B., and Njagi, G. D. E. 1981. Mutagenicity testing of pesticides: III. Drosophila: Recessive sex-linked lethals. Genetics 97(Suppl.):S44.
24. Grisolia, C. K. 2002. A comparison between mouse and fish micronucleus test using cyclophosphamide, mitomycin C and various pesticides. Mutat. Res. 518:145-150.
25. Hardell, L., and Eriksson, M. 1999. A case-control study of non-Hodgkin lymphoma and exposure to pesticides. Cancer 85:1353-1360.
26. Hardell, L., Eriksson, M., and Nordstrom, M. 2002. Exposure to pesticides as risk factor for non-Hodgkin's lymphoma and hairy cell leukemia: Pooled analysis of two Swedish case-control studies. Leuk. Lymphoma 43:1043-1049.
27. Herbert, V. 1987. Recommended dietary intakes (RDI) of folate in humans. Am. J. Clin. Nutr. 45:661-670. (Pubitemid 17077909)
28. Heydens, W. F., Healy, C. E., Hotz, K. J., Kier, L. D., Martens, M. A., Wilson, A. G. E., and Farmer, D. R. 2008. Genotoxic potential of glyphosate formulations: Mode-of-action investigations. J. Agric. Food. Chem. 56:1517-1523.
29. Hill, A. B. 1965. The environment and disease: association or causation? Proc. R. Soc. Med. 58:295-300.
30. Kier, L. D., Stegeman, S. D., Dudek, S., McAdams, J. G., Flowers, F. J., Huffman, M. B., and Heydens, W. F. 1997. Genotoxicity studies of glyphosate, alachlor and butachlor formulations. Fundam. Appl. Toxicol. 36:305.
31. Li, A. P., and Long, T. J. 1988. .An evaluation of genotoxic potential of glyphosate. Fundam. Appl. Toxicol. 10:537-546.
32. Manteuca, R., Lombaert, N., V, A. P., Decordier, I., and Kirsch-Volders, M. 2006. Chromosomal changes: induction, detection methods and applicability in human biomonitoring. Biochimie 88:1515-1531.
33. Marc, J., Bellé, R., Morales, J., Cormier, P., and Mulner-Lorillon, O. 2004a. Formulated glyphosate activates the DNA-response checkpoint of the cell cycle leading to the prevention of G2/M transition. Toxicol. Sci. 82:436-442.
34. Marc, J., Mulner-Lorillon, O., and Bellé, R. 2004b. Glyphosate-based pesticides affect cell cycle regulation. Biol. Cell. 96:245-247.
35. Martinez, A., Reyes, I., and Reyes, N. 2007. Cytotoxicity of the herbicide glypho-sate in human peripheral blood mononuclear cells. Biomédica 27:594-604.
36. McDuffie, H. H., Pahwa, P., McLaughlin, J. R., Spinelli, J. J., Fincham, S., Dosman, J. A., Robson, D., Skinnider, L., and Choi, N. W. 2001. Non-Hodgkin's lymphoma and specific pesticide exposures in men: Cross-Canada study of pesticides and health. Cancer Epidemiol. Biomarkers. Prev. 10:1155-1163.
37. Monroy, C. M., Cortes, A. C., Sicard, D. M., and Groot, H. 2005. Citotoxicidad y genotoxicidad de células humanas espuestas in vitro a glifosato. Biomédica 25:335-345.
38. Montero, R., Serrano, L., Araujo, A., Davila, V., Ponce, J., Camacho, R., Morales, E., and Mendez, A. 2006. Increased cytogenetic damage in a zone in transition from agricultural to industrial use: Comprehensive analysis of the micronucleus test in peripheral blood lymphocytes. Mutagenesis 21:335-342.
39. Moriya, M., Ohta, T., Watanabe, K., Miyasawa, T., Kato, K., and Shirasu, Y. 1983. Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutat. Res., 116:185-216.
40. Paz-y-Miño, C., Sánchez, M. E., Arévalo, M., Muñoz, M. J., Witte, T., De-la-Carrera, G. O., and Paola, L. E. 2007. Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate. Genet. Mol. Biol. 30:456-460.
41. Peixoto, F. 2005. Comparative effects of the Roundup and glyphosate on mito-chondrial oxidative phosphorylation. Chemosphere 61:1115-1122.
42. Peluso, M., Munnia, A., Bolognesi, C., and Parodi, S. 1998. 32P-postlabeling detection of DNA adducts in mice treated with the herbicide Roundup.Environ. Mol. Mutagen. 31:55-59.
43. Rank, J., Jensen, A. G., Skov, B., Pedersen, L. H., and Jensen, K. 1993. Genotoxicity testing of Roundup and its active ingredient glyphosate isopropylamine using the mouse bone marrow micronucleus test, Salmonella mutagenicity test and Allium anaphase-telophase test. Mutat. Res. 300:29-36.
44. Richard, S., Moslemi, S., Sipahutar, H., Benachour, N., and Seralini, G.-E. 2005. Differential effects of glyphosate and Roundup on human placental cells and aromatase. Environ. Health Perpect. 113:716-720.
45. Ritter, L., Goushleff, N. C. I., Arbuckle, T., Cole, D., and Raizenne, M. 2006. Addressing the linkage between exposure to pesticides and human health effects-Research trends and priorities for research 1. J. Toxicol. Environ. Health B 9:441-456.
46. Rull, R. P., Ritz, B., and Shaw, G. M. 2006. Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am. J. Epidemiol. 163:743-753.
47. Sanin, L.-H., Carrasquilla, G., Solomon, K. R., Cole, D. C., and Marshall, E. J. P. 2009. Regional differences in time to pregnancy among fertile women from five Colombian regions with different uses of glyphosate. J. Toxicol. Environ. Health A 72:949-960.
48. Sirisattha, S., Momse, Y., Kitagawa, E., and Iwahashi, H. 2004. Genomic profile of roundup treatment of yeast using DNA microarray analysis. Environ. Sci. 11:313-323.
49. Solomon, K. R., Anadón, A., Brain, R. A., Cerdeira, A. L., Crossan, A. N., Marshall, A. J., Sanin, L. H., and Smith, L. 2007a. Comparative hazard assessment of the substances used for production and control of coca and poppy in Colombia. In Rational environmental management of agro-chemicals: Risk assessment, monitoring, and remedial action. ACS Symposium Series no. 966 (vol. 966), eds. Kennedy, I. R., Solomon, K. R., Gee, S., Crossan, A. N., Wang, S., and Sanchez-Bayo, F. pp. 87-99. Washington, DC: American Chemical Society.
50. Solomon, K. R., Anadón, A., Carrasquilla, G., Cerdeira, A., Marshall, J., and Sanin, L.-H. 2007b. Coca and poppy eradication in Colombia: Environmental and human health assessment of aerially applied glyphosate. Rev. Environ. Contam. Toxicol. 190:43-125.
51. UNODC. 2007. World drug report 2007. United Nations Office on Drugs and Crime. Accessed January 29, 2008. http://www.unodc.org U.S.
52. Environmental Protection Agency. 1993. R.E.D. Facts Glyphosate. Technical report EPA 738-R-93-1014 Washington, DC: U.S. Environmental Protection Agency.
53. Wigle, D. T., Arbuckle, T. E., Turner, M. C., Berube, A., Yang, Q., Lui, S., and Krewski, D. 2008. Epidemiologic evidence of relationships between Reproductive and child health outcomes and environmental chemical contaminants. J. Toxicol. Environ. Health B 11:373-517.
54. Wildeman, A. G., and Nazar, R. N. 1982. Significance of plant metabolism in the mutagenicity and toxicity of pesticides. Can. J. Genet. Cytol. 24:437-449.
55. Williams, G. M., Kroes, R., and Munro, I. C. 2000. Safety evaluation and risk assessment of the herbicide Roundup® and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 31:117-165.
56. Woodburn, A. T. 2000. Glyphosate: production, pricing and use worldwide. Pestic. Manage. Sci. 56:309-312.
57. World Health Organization International Program on Chemical Safety. 1994. Glyphosate (vol. 159). Geneva: WHO IPCS.