Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine

Clinical Toxicology

Volumn 47, Issue 7, 2009, Pages 683-685

  Cheung, Wing I ^a   Tse, Man Li ^a   Ngan, Teresa ^b   Lin, Jieru ^b   Lee, Ws Ken ^b   Poon, Wing Tat ^c   Mak, Tony Wl ^c   Leung, Vincent King Sun ^a   Chau, Tai Nin ^a  

^a UNITED CHRISTIAN HOSPITAL   (Hong Kong)

^b HOSPITAL AUTHORITY   (Hong Kong)

^c PRINCESS MARGARET HOSPITAL   (Hong Kong)

Author keywords

Bol gol zhee; Bu gu zhi; Fructus Psoraleae; Herbs; Liver injury

Indexed keywords

FRUCTUS PSORALEAE EXTRACT; LIVER ENZYME; PLANT EXTRACT; UNCLASSIFIED DRUG; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILIRUBIN; HERBACEOUS AGENT; PLANT TOXIN;

ACUTE HEPATITIS; ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; FEMALE; FRUCTUS PSORALEAE; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; JAUNDICE; LIVER INJURY; LIVER TOXICITY; MALE; POSTMENOPAUSE OSTEOPOROSIS; PSORIASIS; TREATMENT DURATION; VITILIGO; BLOOD; CLINICAL CHEMISTRY; DRUG EFFECT; LIVER; METABOLISM; PLANT SEED; PSORALEA; TOXIC HEPATITIS;

ADULT; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; BILIRUBIN; CLINICAL CHEMISTRY TESTS; DRUGS, CHINESE HERBAL; FEMALE; HEPATITIS, TOXIC; HUMANS; LIVER; MALE; PLANT POISONING; PSORALEA; SEEDS; VITILIGO; YOUNG ADULT;

EID: 69149086208     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650903059136     Document Type: Article

References (12)

1. Ji L, Xu Z. Review of constituents in fruits of Psoralea corylifolia L. Chung Kuo Chung Yao Tsa Chih 1995; 20:120-128.
2. Pariser DM, Wyles RJ. Toxic hepatitis from oral methoxsalen phototherapy (PUVA). J Am Acad Dermatol 1980; 3(3):248-250.
3. Stephens RB, Cooper A. Hepatitis from 5-mehtoxypsoralen occurring in a patient with previous flucloxacillin hepatitis. Australas J Dermatol 1999; 40(4): 217-219.
4. Chitturi S, Farrell GC. Hepatotoxic slimming aids and other herbal hepatotoxins. J Gastroenterol Hepatol 2008; 23:366-373.
5. Nam SW, Baek JT, Lee DS, Kang SB, Ahn BM, Chung KW. A case of acute cholestatic hepatitis associated with the seeds of Psoralae corylifolia (Boh-Gol-Zhee). Clin Toxicol (Phila) 2005; 43(6):589-591.
6. Danan G, Benichou C. Causality assessment of adverse reactions to drugs. I. A novel method based on the conclusions of international consensus meetings: application to drug induced liver injuries. J Clin Epidemiol 1993; 46:1323-1330.
7. Chinese Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China. Vol 1. Beijing: People's Medical Publishing House; 2005:107-108.
8. Adverse Drug Reaction Notice No. 9. State Food and Drug Administration website. http://www.sda.gov.cn/WS01/CL0078/11281.html. Accessed 1 November 2008.
9. Xu F, Zhong J, Yan M, Huang Y, Yan H, Wang XT. Determination of psoralen and isopsoralen in Qubai Babuqi Tablets by HPLC. Northwest Pharm J 2006; 21(2):51-53.
10. Deng PX, Xu M. Comparision on hepatotoxicity in rats by using Fructus Psoralea alone and in combination with other herbs. Guang Xi Chung Yi Yao 2005; 28(2):49-50.
11. Herold M, Berbey B, Angignard D, Le Duc R. Toxicological study of the compound 5-methoxypsoralen (5 MOP). Psoralens in cosmetics and dermatology. Proceedings of the International Symposium, Paris, April 1981.
12. Choi HJ, Kim S, Hann SK, et al. The effect on liver transaminases of 5-methoxypsoralen used in systemic photochemotherapy. Anna Dermatol 1995; 7(1):51-53.