메뉴 건너뛰기




Volumn 26, Issue 8, 2009, Pages 647-664

Tumour necrosis factor-α antagonists in the management of rheumatoid arthritis in the elderly: A review of their efficacy and safety

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; INFLIXIMAB; METHOTREXATE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

EID: 69049115215     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11316460-000000000-00000     Document Type: Review
Times cited : (21)

References (88)
  • 1
    • 0029657780 scopus 로고    scopus 로고
    • Shift in the incidence of rheumatoid arthritis toward elderly patients in Finland during 1975-1990
    • Kaipiainen-Seppanen O, Aho K, Isomaki H, et al. Shift in the incidence of rheumatoid arthritis toward elderly patients in Finland during 1975-1990. Clin Exp Rheumatol 1996; 14 (5): 537-542
    • (1996) Clin Exp Rheumatol , vol.14 , Issue.5 , pp. 537-542
    • Kaipiainen-Seppanen, O.1    Aho, K.2    Isomaki, H.3
  • 2
    • 0036449213 scopus 로고    scopus 로고
    • Epidemiology of rheumatoid arthritis: Determinants of onset, persistence and outcome
    • DOI 10.1053/berh.2002.0257
    • Symmons DPM. Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome. Best Pract Res Clin Rheumatol 2002; 16 (5): 707-722 (Pubitemid 35460345)
    • (2002) Best Practice and Research in Clinical Rheumatology , vol.16 , Issue.5 , pp. 707-722
    • Symmons, D.P.M.1
  • 3
    • 0035089721 scopus 로고    scopus 로고
    • Prevalence of rheumatoid arthritis and musculoskeletal diseases in the elderly population
    • DOI 10.1007/s002960000087
    • Laiho K, Tuomilehto J, Tilvis R. Prevalence of rheumatoid arthritis and musculoskeletal diseases in the elderly population. Rheumatol Int 2001; 20 (3): 85-87 (Pubitemid 32250117)
    • (2001) Rheumatology International , vol.20 , Issue.3 , pp. 85-87
    • Laiho, K.1    Tuomilehto, J.2    Tilvis, R.3
  • 4
    • 0022910863 scopus 로고
    • Joint disorders at ages 70, 75 and 79 years: Cross-sectional comparison
    • Bergstrom G, Bjelle A, Sundh V, et al. Joint disorders at ages 70, 75 and 79 years: cross-sectional comparison. Br J Rheumatol 1986; 25 (4): 333-341
    • (1986) Br J Rheumatol , vol.25 , Issue.4 , pp. 333-341
    • Bergstrom, G.1    Bjelle, A.2    Sundh, V.3
  • 5
    • 0037388276 scopus 로고    scopus 로고
    • Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: Effect of different methods of case classification
    • DOI 10.1002/art.10897
    • Rasch EK, Hirsch R, Paulose-Ram R, et al. Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification. Arthritis Rheum 2003; 48 (4): 917-926 (Pubitemid 36418233)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.4 , pp. 917-926
    • Rasch, E.K.1    Hirsch, R.2    Paulose-Ram, R.3    Hochberg, M.C.4
  • 7
    • 0018920615 scopus 로고
    • The epidemiology of rheumatoid arthritis in Rochester, Minnesota: A study of incidence, prevalence, and mortality
    • Linos A, Worthington JW, Ofallon WM, et al. Epidemiology of rheumatoid arthritis in Rochester, Minnesota: study of incidence, prevalence, and mortality. Am J Epidemiol 1980; 111 (1): 87-98 (Pubitemid 10207608)
    • (1980) American Journal of Epidemiology , vol.111 , Issue.1 , pp. 87-98
    • Linos, A.1    Worthington, J.W.2    O'Fallon, W.M.3    Kurland, L.T.4
  • 8
    • 0043125779 scopus 로고    scopus 로고
    • Immunosenescence epidemiology and rheumatoid arthritis
    • Weyand CM, Fulbright JW, Goronzy JJ. Immunosenescence epidemiology and rheumatoid arthritis. Exp Gerontol 2003; 38 (8): 833-841
    • (2003) Exp Gerontol , vol.38 , Issue.8 , pp. 833-841
    • Weyand, C.M.1    Fulbright, J.W.2    Goronzy, J.J.3
  • 9
    • 0018881864 scopus 로고
    • Age influence on the immune system
    • Makinodan T, Kay MMB. Age influence on the immune system. Adv Immunol 1980; 29: 287-330
    • (1980) Adv Immunol , vol.29 , pp. 287-330
    • Makinodan, T.1    Kay, M.M.B.2
  • 10
    • 33947396395 scopus 로고    scopus 로고
    • Risk: Benefit profile of etanercept in elderly patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis
    • DOI 10.2165/00002512-200724030-00005
    • Fleischmann R, Iqbal I. Risk : benefit profile of etanercept in elderly patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis. Drugs Aging 2007; 24 (3): 239-254 (Pubitemid 46457026)
    • (2007) Drugs and Aging , vol.24 , Issue.3 , pp. 239-254
    • Fleischmann, R.1    Iqbal, I.2
  • 11
    • 7044227565 scopus 로고    scopus 로고
    • Why results of clinical trials and observational studies of antitumour necrosis factor (anti-TNF) therapy differ: Methodological and interpretive issues
    • Wolfe F, Michaud K, Dewitt EM. Why results of clinical trials and observational studies of antitumour necrosis factor (anti-TNF) therapy differ: methodological and interpretive issues. Ann Rheum Dis 2004; 63 Suppl. 2: ii13-7
    • (2004) Ann Rheum Dis , vol.63 , Issue.SUPPL. 2
    • Wolfe, F.1    Michaud, K.2    Dewitt, E.M.3
  • 12
    • 0008348082 scopus 로고    scopus 로고
    • Available from URL: Accessed 2009 May 21
    • European Medicines Agency. European public assessment report [online]. Available from URL: http://www.emea. europa.eu/htms/human/epar/eparintro.htm [Accessed 2009 May 21]
    • European Public Assessment Report [Online]
  • 13
    • 0348109372 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: Results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis)
    • Furst DE, Schiff MH, Fleischmann RM, et al. Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis). J Rheumatol 2003; 30 (12): 2563-2571
    • (2003) J Rheumatol , vol.30 , Issue.12 , pp. 2563-2571
    • Furst, D.E.1    Schiff, M.H.2    Fleischmann, R.M.3
  • 14
    • 11144354315 scopus 로고    scopus 로고
    • Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate
    • Maini RN, Breedveld FC, Kalden JR, et al. Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate. Arthritis Rheum 2004; 50 (4): 1051-1065
    • (2004) Arthritis Rheum , vol.50 , Issue.4 , pp. 1051-1065
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3
  • 18
    • 0036274944 scopus 로고    scopus 로고
    • Etanercept versus methotrexate in patients with early rheumatoid arthritis: Two-year radiographic and clinical outcomes
    • Genovese MC, Bathon JM, Martin RW, et al. Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes. Arthritis Rheum 2002; 46 (6): 1443-1450
    • (2002) Arthritis Rheum , vol.46 , Issue.6 , pp. 1443-1450
    • Genovese, M.C.1    Bathon, J.M.2    Martin, R.W.3
  • 21
    • 2342658406 scopus 로고    scopus 로고
    • Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo-controlled, 52-week trial
    • Keystone EC, Kavanaugh AF, Sharp JT, et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum 2004; 50 (5): 1400-1411
    • (2004) Arthritis Rheum , vol.50 , Issue.5 , pp. 1400-1411
    • Keystone, E.C.1    Kavanaugh, A.F.2    Sharp, J.T.3
  • 22
    • 47949103818 scopus 로고    scopus 로고
    • Patientreported health outcomes in a trial of etanercept monotherapy versus combination therapy with etanercept and methotrexate for rheumatoid arthritis: The ADORE trial
    • van Riel PL, Freundlich B, MacPeek D, et al. Patientreported health outcomes in a trial of etanercept monotherapy versus combination therapy with etanercept and methotrexate for rheumatoid arthritis: the ADORE trial. Ann Rheum Dis 2008; 67 (8): 1104-1110
    • (2008) Ann Rheum Dis , vol.67 , Issue.8 , pp. 1104-1110
    • Van Riel, P.L.1    Freundlich, B.2    MacPeek, D.3
  • 24
    • 33750938687 scopus 로고    scopus 로고
    • Effectiveness of tumor necrosis factor inhibitors in rheumatoid arthritis in an observational cohort study: Comparison of patients according to their eligibility for major randomized clinical trials
    • DOI 10.1002/art.22193
    • Zink A, Strangfeld A, Schneider M, et al. Effectiveness of tumor necrosis factor inhibitors in rheumatoid arthritis in an observational cohort study: comparison of patients according to their eligibility for major randomized clinical trials. Arthritis Rheum 2006; 54 (11): 3399-3407 (Pubitemid 44737150)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.11 , pp. 3399-3407
    • Zink, A.1    Strangfeld, A.2    Schneider, M.3    Herzer, P.4    Hierse, F.5    Stoyanova-Scholz, M.6    Wassenberg, S.7    Kapelle, A.8    Listing, J.9
  • 25
    • 17044432625 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibitors: Clinical implications of their different immunogenicity profiles
    • DOI 10.1016/j.semarthrit.2005.01.005
    • Anderson PJ. Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles. Semin Arthritis Rheum 2005; 34 (5 Suppl. 1): 19-22 (Pubitemid 40502156)
    • (2005) Seminars in Arthritis and Rheumatism , vol.34 , Issue.5 SUPPL. , pp. 19-22
    • Anderson, P.J.1
  • 26
    • 14944347610 scopus 로고    scopus 로고
    • Anti-TNF-alpha therapies: They are all the same (aren't they?)
    • DOI 10.1093/rheumatology/keh483
    • Mpofu S, Fatima F, Moots RJ. Anti-TNF-alpha therapies: they are all the same (aren't they?). Rheumatology (Oxford) 2005; 44 (3): 271-273 (Pubitemid 40361279)
    • (2005) Rheumatology , vol.44 , Issue.3 , pp. 271-273
    • Mpofu, S.1    Fatima, F.2    Moots, R.J.3
  • 27
    • 10944261085 scopus 로고    scopus 로고
    • Do anti- TNF agents have equal efficacy in patients with rheumatoid arthritis?
    • Schwartzman S, Fleischmann R, Morgan Jr GJ. Do anti- TNF agents have equal efficacy in patients with rheumatoid arthritis? Arthritis Res Ther 2004; 6 Suppl. 2: S3-11
    • (2004) Arthritis Res Ther , vol.6 , Issue.SUPPL. 2
    • Schwartzman, S.1    Fleischmann, R.2    Morgan Jr., G.J.3
  • 29
    • 34247218183 scopus 로고    scopus 로고
    • Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor alpha antagonists
    • DOI 10.1002/art.22504
    • Curtis JR, Patkar N, Xie AY, et al. Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor alpha antagonists. Arthritis Rheum 2007; 56 (4): 1125-1133 (Pubitemid 46608637)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.4 , pp. 1125-1133
    • Curtis, J.R.1    Patkar, N.2    Xie, A.3    Martin, C.4    Allison, J.J.5    Saag, M.6    Shatin, D.7    Saag, K.G.8
  • 30
    • 33747008410 scopus 로고    scopus 로고
    • Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register
    • DOI 10.1002/art.21978
    • Dixon WG, Watson K, Lunt M, et al. Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving antitumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register. Arthritis Rheum 2006; 54 (8): 2368-2376 (Pubitemid 44204996)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.8 , pp. 2368-2376
    • Dixon, W.G.1    Watson, K.2    Lunt, M.3    Hyrich, K.L.4    Silman, A.J.5    Symmons, D.P.M.6
  • 31
    • 67549117204 scopus 로고    scopus 로고
    • The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: Meta and exposure-adjusted pooled analyses of serious adverse events
    • Jul
    • Leombruno JP, Einarson TR, Keystone EC. The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events. Ann Rheum Dis 2009 Jul; 68 (7): 1136-1145
    • (2009) Ann Rheum Dis , vol.68 , Issue.7 , pp. 1136-1145
    • Leombruno, J.P.1    Einarson, T.R.2    Keystone, E.C.3
  • 34
    • 24944529247 scopus 로고    scopus 로고
    • TNF-blocking agents and tuberculosis: New drugs illuminate an old topic
    • DOI 10.1093/rheumatology/keh567
    • Keane J. TNF-blocking agents and tuberculosis: new drugs illuminate an old topic. Rheumatology 2005; 44 (6): 714-720 (Pubitemid 41487198)
    • (2005) Rheumatology , vol.44 , Issue.6 , pp. 714-720
    • Keane, J.1
  • 36
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • DOI 10.1001/jama.295.19.2275
    • Bongartz T, Sutton AJ, Sweeting MJ, et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and metaanalysis of rare harmful effects in randomized controlled trials. JAMA 2006; 295 (19): 2275-2285 (Pubitemid 43736578)
    • (2006) Journal of the American Medical Association , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 37
    • 27444437191 scopus 로고    scopus 로고
    • Biologics Register
    • The British Society for Rheumatology
    • Watson K, Symmons D, Griffiths I, et al. The British Society for Rheumatology. Biologics Register. Ann Rheum Dis 2005; 64 Suppl. 4: iv42-3
    • (2005) Ann Rheum Dis , vol.64 , Issue.SUPPL. 4
    • Watson, K.1    Symmons, D.2    Griffiths, I.3
  • 39
    • 66149084485 scopus 로고    scopus 로고
    • Anti-TNF therapy in RA and risk of malignant lymphomas: Relative risks and time-trend in the Swedish Biologics Register
    • Askling J, Baecklund E, Granath F, et al. Anti-TNF therapy in RA and risk of malignant lymphomas: relative risks and time-trend in the Swedish Biologics Register. Ann Rheum Dis 2009; 68 (5): 648-653
    • (2009) Ann Rheum Dis , vol.68 , Issue.5 , pp. 648-653
    • Askling, J.1    Baecklund, E.2    Granath, F.3
  • 40
    • 34248547187 scopus 로고    scopus 로고
    • The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation
    • DOI 10.1002/art.22579
    • Wolfe F, Michaud K. The effect of methotrexate and antitumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation. Arthritis Rheum 2007; 56 (5): 1433-1439 (Pubitemid 46764070)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.5 , pp. 1433-1439
    • Wolfe, F.1    Michaud, K.2
  • 41
    • 2642554059 scopus 로고    scopus 로고
    • Lymphoma in rheumatoid arthritis: The effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients
    • DOI 10.1002/art.20311
    • Wolfe F, Michaud K. Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 2004; 50 (6): 1740-1751 (Pubitemid 38725085)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.6 , pp. 1740-1751
    • Wolfe, F.1    Michaud, K.2
  • 42
    • 47849128962 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha antagonist use and heart failure in elderly patients with rheumatoid arthritis
    • Setoguchi S, Schneeweiss S, Avorn J, et al. Tumor necrosis factor-alpha antagonist use and heart failure in elderly patients with rheumatoid arthritis. Am Heart J 2008; 156 (2): 336-341
    • (2008) Am Heart J , vol.156 , Issue.2 , pp. 336-341
    • Setoguchi, S.1    Schneeweiss, S.2    Avorn, J.3
  • 43
    • 0038755661 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: Results of the anti-TNF therapy against congestive heart failure (ATTACH) trial
    • DOI 10.1161/01.CIR.0000077913.60364.D2
    • Chung ES, Packer M, Lo KH, et al. Randomized, doubleblind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factoralpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation 2003; 107 (25): 3133-3140 (Pubitemid 36793081)
    • (2003) Circulation , vol.107 , Issue.25 , pp. 3133-3140
    • Chung, E.S.1    Packer, M.2    Lo, K.H.3    Fasanmade, A.A.4    Willerson, J.T.5
  • 44
    • 40549134937 scopus 로고    scopus 로고
    • Does tumor necrosis factor inhibition promote or prevent heart failure in patients with rheumatoid arthritis?
    • Listing J, Strangfeld A, Kekow J, et al. Does tumor necrosis factor inhibition promote or prevent heart failure in patients with rheumatoid arthritis? Arthritis Rheum 2008; 58 (3): 667-677
    • (2008) Arthritis Rheum , vol.58 , Issue.3 , pp. 667-677
    • Listing, J.1    Strangfeld, A.2    Kekow, J.3
  • 45
    • 1242315583 scopus 로고    scopus 로고
    • Heart failure in rheumatoid arthritis: Rates, predictors, and the effect of anti-tumor necrosis factor therapy
    • DOI 10.1016/j.amjmed.2003.09.039
    • Wolfe F, Michaud K. Heart failure in rheumatoid arthritis: rates, predictors, and the effect of anti-tumor necrosis factor therapy. Am J Med 2004; 116 (5): 305-311 (Pubitemid 38230289)
    • (2004) American Journal of Medicine , vol.116 , Issue.5 , pp. 305-311
    • Wolfe, F.1    Michaud, K.2
  • 46
    • 16844372053 scopus 로고    scopus 로고
    • TNF-alpha, rheumatoid arthritis, and heart failure: A rheumatological dilemma
    • DOI 10.1016/j.autrev.2004.09.004
    • Sarzi-Puttini P, Atzeni F, Shoenfeld Y, et al. TNF-alpha, rheumatoid arthritis, and heart failure: a rheumatological dilemma. Autoimmun Rev 2005; 4 (3): 153-161 (Pubitemid 40488744)
    • (2005) Autoimmunity Reviews , vol.4 , Issue.3 , pp. 153-161
    • Sarzi-Puttini, P.1    Atzeni, F.2    Shoenfeld, Y.3    Ferraccioli, G.4
  • 48
    • 0242624574 scopus 로고    scopus 로고
    • Perturbations of TCR signal transduction pathways with ageing - A biochemical paradigm for the ageing immune system
    • Fulop T, Larbi A, Dupuis G, et al. Ageing, autoimmunity and arthritis: perturbations of TCRsignal transduction pathways with ageing a biochemical paradigm for the ageing immune system. Arthritis Res Ther 2003; 5 (6): 290-302 (Pubitemid 37407979)
    • (2003) Arthritis Research and Therapy , vol.5 , Issue.6 , pp. 290-302
    • Fulop Jr., T.1    Larbi, A.2    Dupuis, G.3    Pawelec, G.4
  • 49
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: How much can the adaptive immune system adapt?
    • Weng NP. Aging of the immune system: how much can the adaptive immune system adapt? Immunity 2006; 24 (5): 495-499
    • (2006) Immunity , vol.24 , Issue.5 , pp. 495-499
    • Weng, N.P.1
  • 50
    • 0035884911 scopus 로고    scopus 로고
    • Down-regulation of CD28 expression by TNF-alpha
    • Bryl E, Vallejo AN, Weyand CM, et al. Down-regulation of CD28 expression by TNF-alpha. J Immunol 2001; 167 (6): 3231-3238
    • (2001) J Immunol , vol.167 , Issue.6 , pp. 3231-3238
    • Bryl, E.1    Vallejo, A.N.2    Weyand, C.M.3
  • 51
    • 3242669036 scopus 로고    scopus 로고
    • CD28 (null) CD4 (+) T cells: Characterization of an effector memory T-cell population in patients with rheumatoid arthritis
    • Fasth AER, Cao D, van Vollenhoven R, et al. CD28 (null) CD4 (+) T cells: characterization of an effector memory T-cell population in patients with rheumatoid arthritis. Scand J Rheumatol 2004; 60 (1-2): 199-208
    • (2004) Scand J Rheumatol , vol.60 , Issue.1-2 , pp. 199-208
    • Fasth, A.E.R.1    Cao, D.2    Van Vollenhoven, R.3
  • 52
    • 0033845475 scopus 로고    scopus 로고
    • Changes in immune function with age
    • Yung RL. Changes in immune function with age. Rheum Dis Clin North Am 2000; 26 (3): 455-469
    • (2000) Rheum Dis Clin North Am , vol.26 , Issue.3 , pp. 455-469
    • Yung, R.L.1
  • 53
    • 0027162602 scopus 로고
    • Altered regulation of Il-6 production with normal aging: Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulphated derivative
    • Daynes RA, Araneo BA, Ershler WB, et al. Altered regulation of Il-6 production with normal aging: possible linkage to the age-associated decline in dehydroepiandrosterone and its sulphated derivative. J Immunol 1993; 150 (12): 5219-5230
    • (1993) J Immunol , vol.150 , Issue.12 , pp. 5219-5230
    • Daynes, R.A.1    Araneo, B.A.2    Ershler, W.B.3
  • 54
    • 0026550820 scopus 로고
    • Fever, tumor-necrosisfactor, and interleukin-6 in young, mature, and aged Fischer 344 rats
    • Foster KD, Conn CA, Kluger MJ. Fever, tumor-necrosisfactor, and interleukin-6 in young, mature, and aged Fischer 344 rats. Am J Physiol 1992; 262 (2): R211-5
    • (1992) Am J Physiol , vol.262 , Issue.2
    • Foster, K.D.1    Conn, C.A.2    Kluger, M.J.3
  • 55
    • 0032524973 scopus 로고    scopus 로고
    • Altered cytokine production in the elderly
    • Rink L, Cakman I, Kirchner H. Altered cytokine production in the elderly. Mech Ageing Dev 1998; 102 (2-3): 199-209
    • (1998) Mech Ageing Dev , vol.102 , Issue.2-3 , pp. 199-209
    • Rink, L.1    Cakman, I.2    Kirchner, H.3
  • 56
    • 57949087452 scopus 로고    scopus 로고
    • Molecular inflammation: Underpinnings of aging and age-related diseases
    • Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2008; 8 (1): 18-30
    • (2008) Ageing Res Rev , vol.8 , Issue.1 , pp. 18-30
    • Chung, H.Y.1    Cesari, M.2    Anton, S.3
  • 57
    • 56849125235 scopus 로고    scopus 로고
    • Aging is associated with greater nuclear NFkappaB, reduced I-kappa-B-alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
    • Donato AJ, Black AD, Jablonski KL, et al. Aging is associated with greater nuclear NFkappaB, reduced I-kappa- B-alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell 2008; 7: 805-812
    • (2008) Aging Cell , vol.7 , pp. 805-812
    • Donato, A.J.1    Black, A.D.2    Jablonski, K.L.3
  • 58
    • 0040790480 scopus 로고    scopus 로고
    • The upregulation of TNFalpha production is not a generalised phenomenon in the elderly between their sixth and seventh decades of life
    • DOI 10.1016/S0047-6374(98)00111-0, PII S0047637498001110
    • Mysliwska J, Bryl E, Foerster J, et al. The upregulation of TNF alpha production is not a generalised phenomenon in the elderly between their sixth and seventh decades of life. Mech Ageing Dev 1999; 107 (1): 1-14 (Pubitemid 29113069)
    • (1999) Mechanisms of Ageing and Development , vol.107 , Issue.1 , pp. 1-14
    • Mysliwska, J.1    Bryl, E.2    Foerster, J.3    Mysliwski, A.4
  • 60
    • 0032708885 scopus 로고    scopus 로고
    • The increase of parathyroid hormone-related peptide and cytokine levels in synovial fluid of elderly rheumatoid arthritis and osteoarthritis
    • Horiuchi T, Yoshida T, Koshihara Y, et al. The increase of parathyroid hormone-related peptide and cytokine levels in synovial fluid of elderly rheumatoid arthritis and osteoarthritis. Endocr J 1999; 46 (5): 643-649
    • (1999) Endocr J , vol.46 , Issue.5 , pp. 643-649
    • Horiuchi, T.1    Yoshida, T.2    Koshihara, Y.3
  • 61
    • 0029835252 scopus 로고    scopus 로고
    • Synovial fluid levels of proinflammatory interleukins and their inter-relationships in elderly vs younger onset rheumatoid arthritis
    • Punzi L, Bertazzolo N, Pianon M, et al. Synovial fluid levels of proinflammatory interleukins and their interrelationships in elderly vs younger onset rheumatoid arthritis. Aging Clin Exp Res 1996; 8 (4): 277-281 (Pubitemid 126790748)
    • (1996) Aging , vol.8 , Issue.4 , pp. 277-281
    • Punzi, L.1    Bertazzolo, N.2    Pianon, M.3    Rizzi, E.4    Rossini, P.5    Todesco, S.6
  • 62
    • 67249147791 scopus 로고    scopus 로고
    • Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: A comparison with younger-onset disease
    • Chen DY, Hsieh TY, Chen YM, et al. Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease. Gerontology 2008; 55 (3): 250-258
    • (2008) Gerontology , vol.55 , Issue.3 , pp. 250-258
    • Chen, D.Y.1    Hsieh, T.Y.2    Chen, Y.M.3
  • 63
    • 0037385625 scopus 로고    scopus 로고
    • Response to etanercept (Enbrel®) in elderly patients with rheumatoid arthritis: A retrospective analysis of clinical trial results
    • Fleischmann RM, Baumgartner SW, Tindall EA, et al. Response to etanercept (Enbrel®) in elderly patients with rheumatoid arthritis: a retrospective analysis of clinical trial results. J Rheumatol 2003; 30 (4): 691-696
    • (2003) J Rheumatol , vol.30 , Issue.4 , pp. 691-696
    • Fleischmann, R.M.1    Baumgartner, S.W.2    Tindall, E.A.3
  • 65
    • 32144441476 scopus 로고    scopus 로고
    • Long-term experience with etanercept in the treatment of rheumatoid arthritis in elderly and younger patients: Patient-reported outcomes from multiple controlled and open-label extension studies
    • Schiff MH, Yu EB, Weinblatt ME, et al. Long-term experience with etanercept in the treatment of rheumatoid arthritis in elderly and younger patients: patient-reported outcomes from multiple controlled and open-label extension studies. Drugs Aging 2006; 23 (2): 167-178
    • (2006) Drugs Aging , vol.23 , Issue.2 , pp. 167-178
    • Schiff, M.H.1    Yu, E.B.2    Weinblatt, M.E.3
  • 66
    • 34248561928 scopus 로고    scopus 로고
    • Tolerance and effectiveness of anti-tumor necrosis factor alpha therapies in elderly patients with rheumatoid arthritis: A population-based cohort study
    • DOI 10.1002/art.22688
    • Genevay S, Finckh A, Ciurea A, et al. Tolerance and effectiveness of anti-tumor necrosis factor alpha therapies in elderly patients with rheumatoid arthritis: a populationbased cohort study. Arthritis Rheum 2007; 57 (4): 679-685 (Pubitemid 46764060)
    • (2007) Arthritis Care and Research , vol.57 , Issue.4 , pp. 679-685
    • Genevay, S.1    Finckh, A.2    Ciurea, A.3    Chamot, A.-M.4    Kyburz, D.5    Gabay, C.6
  • 67
    • 70350654815 scopus 로고    scopus 로고
    • Influence of age on the outcome of anti-TNFa therapy in rheumatoid arthritis
    • Epub 2008 Nov 19
    • Radovits BJ, Kievit W, Fransen J, et al. Influence of age on the outcome of anti-TNFa therapy in rheumatoid arthritis. Ann Rheum Dis. Epub 2008 Nov 19
    • Ann Rheum Dis
    • Radovits, B.J.1    Kievit, W.2    Fransen, J.3
  • 68
    • 57149127008 scopus 로고    scopus 로고
    • Anti-TNFalpha agents in elderly patients with rheumatoid arthritis: A study of a group of 105 over sixty five years old patients
    • in Italian
    • Filippini M, Bazzani C, Zingarelli S, et al. Anti-TNFalpha agents in elderly patients with rheumatoid arthritis: a study of a group of 105 over sixty five years old patients [in Italian]. Reumatismo 2008; 60 (1): 41-49
    • (2008) Reumatismo , vol.60 , Issue.1 , pp. 41-49
    • Filippini, M.1    Bazzani, C.2    Zingarelli, S.3
  • 72
    • 0034035114 scopus 로고    scopus 로고
    • Feasibility and validity of the RADAI, a self-administered rheumatoid arthritis disease activity index
    • Fransen J, Langenegger T, Michel BA, et al. Feasibility and validity of the RADAI, a self-administered rheumatoid arthritis disease activity index. Rheumatology (Oxford) 2000; 39 (3): 321-327 (Pubitemid 30204219)
    • (2000) Rheumatology , vol.39 , Issue.3 , pp. 321-327
    • Fransen, J.1    Langenegger, T.2    Michel, B.A.3    Stucki, G.4
  • 75
    • 34447521875 scopus 로고    scopus 로고
    • Antitumor necrosis factor alpha therapy and the risk of severe bacterial infections in elderly patients with rheumatoid arthritis
    • Schneeweiss S, Setoguchi S, Weinblatt ME, et al. Antitumor necrosis factor alpha therapy and the risk of severe bacterial infections in elderly patients with rheumatoid arthritis. Arthritis Rheum 2007; 6: 1754-1764
    • (2007) Arthritis Rheum , vol.6 , pp. 1754-1764
    • Schneeweiss, S.1    Setoguchi, S.2    Weinblatt, M.E.3
  • 76
    • 33747768640 scopus 로고    scopus 로고
    • Do patients with older onset rheumatoid arthritis receive less aggressive treatment than younger patients?
    • Tutuncu Z, Reed G, Kremer J, et al. Do patients with older onset rheumatoid arthritis receive less aggressive treatment than younger patients? Ann Rheum Dis 2006; 65 (9): 1226-1229
    • (2006) Ann Rheum Dis , vol.65 , Issue.9 , pp. 1226-1229
    • Tutuncu, Z.1    Reed, G.2    Kremer, J.3
  • 77
    • 34447304631 scopus 로고    scopus 로고
    • Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis
    • DOI 10.1093/rheumatology/kem076
    • Bernatsky S, Hudson M, Suissa S. Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis. Rheumatology 2007; 46 (7): 1157-1160 (Pubitemid 47050621)
    • (2007) Rheumatology , vol.46 , Issue.7 , pp. 1157-1160
    • Bernatsky, S.1    Hudson, M.2    Suissa, S.3
  • 78
    • 33751413086 scopus 로고    scopus 로고
    • Are rheumatologists' treatment decisions influenced by patients' age?
    • Fraenkel L, Rabidou N, Dhar R. Are rheumatologists' treatment decisions influenced by patients' age? Rheumatology 2006; 45 (12): 1555-1557
    • (2006) Rheumatology , vol.45 , Issue.12 , pp. 1555-1557
    • Fraenkel, L.1    Rabidou, N.2    Dhar, R.3
  • 79
    • 0036745010 scopus 로고    scopus 로고
    • Predictors of infection in rheumatoid arthritis
    • Doran MF, Crowson CS, Pond GR, et al. Predictors of infection in rheumatoid arthritis. Arthritis Rheum 2002; 46 (9): 2294-2300
    • (2002) Arthritis Rheum , vol.46 , Issue.9 , pp. 2294-2300
    • Doran, M.F.1    Crowson, C.S.2    Pond, G.R.3
  • 80
    • 58749090375 scopus 로고    scopus 로고
    • Serious infections during anti-TNF treatment in RA patients: Clinical practice experience
    • Favalli EG, Desiati F, Atzeni F, et al. Serious infections during anti-TNF treatment in RA patients: clinical practice experience. Autoimmun Rev 2009; 8 (3): 266-273
    • (2009) Autoimmun Rev , vol.8 , Issue.3 , pp. 266-273
    • Favalli, E.G.1    Desiati, F.2    Atzeni, F.3
  • 81
    • 0030249449 scopus 로고    scopus 로고
    • Assessing the impact of comorbidity in the older population
    • Guralnik JM. Assessing the impact of comorbidity in the older population. Ann Epidemiol 1996; 6 (5): 376-380
    • (1996) Ann Epidemiol , vol.6 , Issue.5 , pp. 376-380
    • Guralnik, J.M.1
  • 82
    • 22244443784 scopus 로고    scopus 로고
    • Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis
    • Jacobsson LTH, Turesson C, Gulfe A, et al. Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis. J Rheumatol 2005; 32 (7): 1213-1218 (Pubitemid 40995372)
    • (2005) Journal of Rheumatology , vol.32 , Issue.7 , pp. 1213-1218
    • Jacobsson, L.T.H.1    Turesson, C.2    Gulfe, A.3    Kapetanovic, M.C.4    Petersson, I.F.5    Saxne, T.6    Geborek, P.7
  • 84
    • 28544447762 scopus 로고    scopus 로고
    • Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: A prospective open-label pilot study
    • DOI 10.1093/rheumatology/kei082
    • Lange U, Teichmann J, Muller-Ladner U, et al. Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: a prospective openlabel pilot study. Rheumatology (Oxford) 2005; 44 (12): 1546-1548 (Pubitemid 41742473)
    • (2005) Rheumatology , vol.44 , Issue.12 , pp. 1546-1548
    • Lange, U.1    Teichmann, J.2    Muller-Ladner, U.3    Strunk, J.4
  • 87
    • 0037333368 scopus 로고    scopus 로고
    • Risk communication in rheumatoid arthritis
    • Fraenkel L, Bogardus S, Concato J, et al. Risk communication in rheumatoid arthritis. J Rheumatol 2003; 30 (3): 443-448
    • (2003) J Rheumatol , vol.30 , Issue.3 , pp. 443-448
    • Fraenkel, L.1    Bogardus, S.2    Concato, J.3
  • 88
    • 0031823278 scopus 로고    scopus 로고
    • The risk of treatment. a study of rheumatoid arthritis patients' attitudes
    • Ho M, Lavery B, Pullar T. The risk of treatment: a study of rheumatoid arthritis patients' attitudes. Br J Rheumatol 1998; 37 (4): 459-460 (Pubitemid 28372205)
    • (1998) British Journal of Rheumatology , vol.37 , Issue.4 , pp. 459-460
    • Ho, M.1    Lavery, B.2    Pullar, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.