Coordinating the timing of cardiac precursor development during gastrulation: A new role for Notch signaling

Developmental Biology

Volumn 333, Issue 2, 2009, Pages 285-296

  Miazga, Carolyn M ^a   McLaughlin, Kelly A ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Cardiogenesis; Esr10; Esr9; Gastrulation; GATA4; Heart; Heart field specification; Notch signaling; Organogenesis; Xenopus laevis

Indexed keywords

NOTCH RECEPTOR; PROTEIN; PROTEIN ESR9; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FATE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GASTRULATION; HEART DEVELOPMENT; HEART MUSCLE CELL; MESODERM; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL;

XENOPUS LAEVIS;

EID: 69049114961     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2009.06.040     Document Type: Article

References (109)

1. Abe T., Furue M., Myoishi Y., Okamoto T., Kondow A., and Asashima M. Activin-like signaling activates Notch signaling during mesodermal induction. Int. J. Dev. Biol. 48 (2004) 327-332
2. Appel B., Fritz A., Westerfield M., Grunwald D.J., Eisen J.S., and Riley B.B. Delta-mediated specification of midline cell fates in zebrafish embryos. Curr. Biol. 9 (1999) 247-256
3. Artavanis-Tsakonas S., Rand M.D., and Lake R.J. Notch signaling: cell fate control and signal transduction in development. Science 284 (1999) 770-776
4. Austin C.P., Feldman D.E., Ida J.A., and Cepko C.L. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development 121 (1995) 3637-3650
5. Beis D., Bartman T., Jin S.W., Scott I.C., D'Amico L.A., Ober E.A., Verkade H., Frantsve J., Field H.A., Wehman A., Baier H., Tallafuss A., Bally-Cuif L., Chen J.N., Stainier D.Y., and Jungblut B. Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development 132 (2005) 4193-4204
6. Boni A., Urbanek K., Nascimbene A., Hosoda T., Zheng H., Delucchi F., Amano K., Gonzalez A., Vitale S., Ojaimi C., Rizzi R., Bolli R., Yutzey K.E., Rota M., Kajstura J., Anversa P., and Leri A. Notch1 regulates the fate of cardiac progenitor cells. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 15529-15534
7. Brennan K., and Gardner P. Notching up another pathway. BioEssays 24 (2002) 405-410
8. Brewer A.C., Alexandrovich A., Mjaatvedt C.H., Shah A.M., Patient R.K., and Pizzey J.A. GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev. 14 (2005) 425-439
9. Brown III C.O., Chi X., Garcia-Gras E., Shirai M., Feng X.H., and Schwartz R.J. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J. Biol. Chem. 279 (2004) 10659-10669
10. Campa V.M., Gutierrez-Lanza R., Cerignoli F., Diaz-Trelles R., Nelson B., Tsuji T., Barcova M., Jiang W., and Mercola M. Notch activates cell cycle reentry and progression in quiescent cardiomyocytes. J. Cell Biol. 183 (2008) 129-141
11. Carroll T., Wallingford J., Seufert D., and Vize P.D. Molecular regulation of pronephric development. Curr. Top. Dev. Biol. 44 (1999) 67-100
12. Chang C., Holtzman D.A., Chau S., Chickering T., Woolf E.A., Holmgren L.M., Bodorova J., Gearing D.P., Holmes W.E., and Brivanlou A.H. Twisted gastrulation can function as a BMP antagonist. Nature 410 (2001) 483-487
13. Chen J.-N., Haffter P., Odenthal J., Vogelsang E., Brand M., van Eeden F.J.M., Furutani-Seiki M., Granato M., Hammerschmidt M., Heisenberg C.P., Jiang Y.-J., Kane D.A., Kelsh R.N., Mullins M.C., and Nusslein-Volhard C. Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123 (1996) 293-302
14. Chitnis A., Henrique D., Lewis J., Ish-Horowicz D., and Kintner C. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature 375 (1995) 761-766
15. Coffman C., Harris W., and Kintner C. Xotch, the Xenopus homolog of Drosophila Notch. Science 249 (1990) 1438-1441
16. Collesi C., Zentilin L., Sinagra G., and Giacca M. Notch1 signaling stimulates proliferation of immature cardiomyocytes. J. Cell Biol. 183 (2008) 117-128
17. Contakos S.P., Gaydos C.M., Pfeil E.C., and McLaughlin K.A. Subdividing the embryo: a role for Notch signaling during germ layer patterning in Xenopus laevis. Dev. Biol. 288 (2005) 294-307
18. Cui Y. Hairy is a cell context signal controlling Notch activity. Dev. Growth Differ. 47 (2005) 609-625
19. Davis L.A., and Turner D. Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20 (2001) 8342-8357
20. Del Amo F.F., Smith D.E., Swiatek P.J., Gendron-Maguire M., Greenspan R.J., McMahon A.P., and Gridley T. Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115 (1992) 737-744
21. Dorsky R.I., Rapaport D.H., and Harris W.A. Xotch inhibits cell differentiation in the Xenopus retina. Neuron 14 (1995) 487-496
22. Drysdale T.A., Tonissen K.F., Patterson K.D., Crawford M.J., and Krieg P.A. Cardiac troponin I is a heart-specific marker in the Xenopus embryo: expression during abnormal heart morphogenesis. Dev. Biol. 165 (1994) 432-441
23. Evans S.M., Yan W., Murillo M.P., Ponce J., and Papalopulu N. tin man a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Development 121 (1995) 3889-3899
24. Fischer A., Klattig J., Kneitz B., Diez H., Maier M., Holtmann B., Englert C., and Gessler M. Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol. Cell. Biol. 25 (2005) 8960-8970
25. Fletcher G., Jones G.E., Patient R., and Snape A. A role for GATA factors in Xenopus gastrulation movements. Mech. Dev. 123 (2006) 730-745
26. Garg V., Muth A.N., Ransom J.F., Schluterman M.K., Barnes R., King I.N., Grossfeld P.D., and Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature 437 (2005) 270-274
27. Grepin C., Nemer G., and Nemer M. Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 124 (1997) 2387-2395
28. Han Z., and Bodmer R. Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130 (2003) 3039-3051
29. Harland R.M. In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol. 36 (1991) 685-695
30. Harper J.A., Yuan J.S., Tan J.B., Visan I., and Guidos C.J. Notch signaling in development and disease. Clin. Genet. 64 (2003) 461-472
31. Haworth K.E., Kotecha S., Mohun T.J., and Latinkic B.V. GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos. BMC Dev. Biol. 8 (2008) 74
32. Heicklen-Klein A., McReynolds L.J., and Evans T. Using the zebrafish model to study GATA transcription factors. Semin. Cell Dev. Biol. 16 (2005) 95-106
33. Horb M.E., and Thomsen G.H. Tbx5 is essential for heart development. Development 126 (1999) 1739-1751
34. Ishiko E., Matsumura I., Ezoe S., Gale K., Ishiko J., Satoh Y., Tanaka H., Shibayama H., Mizuki M., Era T., Enver T., and Kanakura Y. Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1. J. Biol. Chem. 280 (2005) 4929-4939
35. Iso T., Kedes L., and Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194 (2003) 237-255
36. Jen W.C., Wettstein D., Turner D., Chitnis A., and Kintner C. The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos. Development 124 (1997) 1169-1178
37. Jen W.C., Gawantka V., Pollet N., Niehrs C., and Kintner C. Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. Genes Dev. 13 (1999) 1486-1499
38. Jiang Y., and Evans T. The Xenopus GATA 4,5,6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol. 174 (1996) 258-270
39. Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., and Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J. Biol. Chem. 279 (2004) 54937-54943
40. Kelley C., Blumberg H., Zon L.I., and Evans T. GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development (1993) 817-827
41. Kikuchi Y., Verkade H., Reiter J.F., Kim C.H., Chitnis A.B., Kuroiwa A., and Stainier D.Y. Notch signaling can regulate endoderm formation in zebrafish. Dev. Dyn. 229 (2004) 756-762
42. Kiyota T., Jono H., Kuriyama S., Hasegawa K., Miyatani S., and Kinoshita T. X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1. Dev. Genes Evol. 211 (2001) 367-376
43. Kiyota T., Kato A., Altmann C.R., and Kato Y. The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling. Dev. Biol. 315 (2008) 579-592
44. Klinedinst S.L., and Bodmer R. Gata factor Pannier is required to establish competence for heart progenitor formation. Development 130 (2003) 3027-3038
45. Lai E.C. Notch signaling: control of cell communication and cell fate. Development 131 (2004) 965-973
46. Lamar E., and Kintner C. The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors. Development 132 (2005) 3619-3630
47. Latimer A.J., Dong X., Markov Y., and Appel B. Delta-Notch signaling induces hypochord development in zebrafish. Development 129 (2002) 2555-2563
48. Latinkic B.V., Kotecha S., and Mohun T.J. Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants. Development 130 (2003) 3865-3876
49. Lawson N.D., Scheer N., Pham V.N., Kim C.H., Chitnis A.B., Campos-Ortega J.A., and Weinstein B.M. Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development 128 (2001) 3675-3683
50. le Roux I., Lewis J., and Ish-Horowicz D. Notch activity is required to maintain floorplate identity and to control neurogenesis in the chick hindbrain and spinal cord. Int. J. Dev. Biol. 47 (2003) 263-272
51. Li L., Krantz I.D., Deng Y., Genin A., Banta A.B., Collins C.C., Qi M., Trask B.J., Kuo W.L., Cochran J., Costa T., Pierpont M., Rand E.B., Piccoli D.A., Hood L., and Spinner N.B. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat. Genet. 16 (1997) 243-251
52. Li Y., Fenger U., Niehrs C., and Pollet N. Cyclic expression of esr9 gene in Xenopus presomitic mesoderm. Differentiation 71 (2003) 83-89
53. Lien C.-L., Wu C., Mercer B., Webb R., Richardson J.A., and Olson E.N. Control of early cardiac-specific transcription of Nkx2.5 by a GATA-dependent enhancer. Development 126 (1999) 75-84
54. Logan M., and Mohun T. Induction of cardiac muscle differentiation in isolated animal pole explants of Xenopus laevis embryos. Development 118 (1993) 865-875
55. Loomes K.M., Underkoffler L.A., Morabito J., Gottlieb S., Piccoli D.A., Spinner N.B., Baldwin H.S., and Oakey R.J. The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome. Hum. Mol. Genet. 8 (1999) 2443-2449
56. Loomes K.M., Taichman D.B., Glover C.L., Williams P.T., Markowitz J.E., Piccoli D.A., Baldwin H.S., and Oakey R.J. Characterization of Notch receptor expression in the developing mammalian heart and liver. Am. J. Med. Genet. 112 (2002) 181-189
57. Lopez S.L., Paganelli A.R., Siri M.V., Ocana O.H., Franco P.G., and Carrasco A.E. Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus. Development 130 (2003) 2225-2238
58. Lopez S.L., Rosato-Siri M.V., Franco P.G., Paganelli A.R., and Carrasco A.E. The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos. Development 132 (2005) 1035-1046
59. Lorent K., Yeo S.Y., Oda T., Chandrasekharappa S., Chitnis A., Matthews R.P., and Pack M. Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development 131 (2004) 5753-5766
60. Lough J., and Sugi Y. Endoderm and heart development. Dev. Dyn. 217 (2000) 327-342
61. Ma Q., Kintner C., and Anderson D.J. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87 (1996) 43-52
62. McCright B., Lozier J., and Gridley T. A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development 129 (2002) 1075-1082
63. McLaughlin K.A., Rones M.S., and Mercola M. Notch regulates cell fate in the developing pronephros. Dev. Biol. 227 (2000) 567-580
64. Mead P.E., Parganas E., Ohtsuka S., Morishita K., Gamer L., Kuliyev E., Wright C.V., and Ihle J.N. Evi-1 expression in Xenopus. Gene Expr. Patterns 5 (2005) 601-608
65. Mohun T.J., Brennan S., Dathan N., Fairman S., and Gurdon J.B. Cell type-specific activation of actin genes in the early amphibian embryo. Nature 311 (1984) 716-721
66. Mohun T., Orford R., and Shang C. The origins of cardiac tissue in the amphibian, Xenopus laevis. Trends Cardiovasc. Med. 13 (2003) 244-248
67. Molkentin J.D., Kalvakolanu D.V., and Markham B.E. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol. Cell. Biol. 14 (1994) 4947-4957
68. Myat A., Henrique D., Ish-Horowicz D., and Lewis J. A chick homologue of serrate and its relationship with notch and delta homologues during central neurogenesis. Dev. Biol. 174 (1996) 233-247
69. Nagao K., Taniyama Y., Kietzmann T., Doi T., Komuro I., and Morishita R. HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus. J. Biol. Chem. 283 (2008) 11841-11849
70. Nascone N., and Mercola M. An inductive role for the endoderm in Xenopus cardiogenesis. Development 121 (1995) 515-523
71. Nemir M., Croquelois A., Pedrazzini T., and Radtke F. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ. Res. 98 (2006) 1471-1478
72. Nieuwkoop P.D., and Faber J. Normal Table of Xenopus laevis (1994), North-Holland Publishing Company, Amsterdam
73. Oda T., Elkaloun A.G., Pike B.L., Okajima K., Krantz I.D., Genin A., Piccoli D.A., Meltzer P.S., Spinner N.B., Collins F.S., and Chandrasekharappa S.C. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat. Genet. 16 (1997) 235-242
74. Ogino H., Fisher M., and Grainger R.M. Convergence of a head-field selector Otx2 and Notch signaling: a mechanism for lens specification. Development 135 (2008) 249-258
75. Pasini A., Jiang Y.J., and Wilkinson D.G. Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm. Development 131 (2004) 1529-1541
76. Peng H.B., and Kay B.K. Xenopus laevis: practical uses in cell and molecular biology. Pictorial collage of embryonic stages. Methods Cell Biol. 36 (1991) 679-681
77. Perrino C., and Rockman H.A. GATA4 and the two sides of gene expression reprogramming. Circ. Res. 98 (2006) 715-716
78. Pichon B., Taelman V., Kricha S., Christophe D., and Bellefroid E.J. XHRT-1, a hairy and Enhancer of split related gene with expression in floor plate and hypochord during early Xenopus embryogenesis. Dev. Genes Evol. 212 (2002) 491-495
79. Pirot P., van Grunsven L.A., Marine J.C., Huylebroeck D., and Bellefroid E.J. Direct regulation of the Nrarp gene promoter by the Notch signaling pathway. Biochem. Biophys. Res. Commun. 322 (2004) 526-534
80. Reaume A.G., Conlon R.A., Zirngibl R., Yamaguchi T.P., and Rossant J. Expression analysis of a Notch homologue in the mouse embryo. Dev. Biol. 154 (1992) 377-387
81. Reecy J.M., Li X., Yamada M., DeMayo F.J., Newman C.S., Harvey R.P., and Schwartz R.J. Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5. Development 126 (1999) 839-849
82. Rones M.S., McLaughlin K.A., Raffin M., and Mercola M. Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127 (2000) 3865-3876
83. Rones M.S., Woda J., Mercola M., and McLaughlin K.A. Isolation and characterization of Xenopus Hey-1: a downstream mediator of Notch signaling. Dev. Dyn. 225 (2002) 554-560
84. Sater A.K., and Jacobson A.G. The specification of heart mesoderm occurs during gastrulation in Xenopus laevis. Development 105 (1989) 821-830
85. Sater A.K., and Jacobson A.G. The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis. Development 108 (1990) 461-470
86. Schneider C., Wicht H., Enderich J., Wegner M., and Rohrer H. Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons. Neuron 24 (1999) 861-870
87. Schroeder T., Kohlhof H., Rieber N., and Just U. Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression. J. Immunol. 170 (2003) 5538-5548
88. Schroeder T., Meier-Stiegen F., Schwanbeck R., Eilken H., Nishikawa S., Hasler R., Schreiber S., Bornkamm G.W., Nishikawa S., and Just U. Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development. Mech. Dev. 123 (2006) 570-579
89. Schultheiss T.M., Xydas S., and Lassar A.B. Induction of avian cardiac myogenesis by anterior endoderm. Development 121 (1995) 4203-4214
90. Schweisguth F. Regulation of notch signaling activity. Curr. Biol. 14 (2004) R129-R138
91. Searcy R.D., Vincent E.B., Liberatore C.M., and Yutzey K.E. A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 125 (1998) 4461-4470
92. Sepulveda J.L., Belaguli N., Nigam V., Chen C.Y., Nemer M., and Schwartz R.J. GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol. Cell. Biol. 18 (1998) 3405-3415
93. Small E.M., Warkman A.S., Wang D.Z., Sutherland L.B., Olson E.N., and Krieg P.A. Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. Development 132 (2005) 987-997
94. Taelman V., Van Wayenbergh R., Solter M., Pichon B., Pieler T., Christophe D., and Bellefroid E.J. Sequences downstream of the bHLH domain of the Xenopus hairy-related transcription factor-1 act as an extended dimerization domain that contributes to the selection of the partners. Dev. Biol. 276 (2004) 47-63
95. Taira M., Otani H., Jamrich M., and Dawid I.B. Expression of the LIM class homeobox gene Xlim-1 in pronephros and CNS cell lineages of Xenopus embryos is affected by retinoic acid and exogastrulation. Development 120 (1994) 1525-1536
96. Takke C., Dornseifer P., Weizsacker E., and Campos-Ortega J.A. her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of Notch signaling. Development 126 (1999) 1811-1821
97. Tonissen K.F., Drysdale T.A., Lints T.J., Harvey R.P., and Krieg P.A. XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. Dev. Biol. 162 (1994) 325-328
98. Tsuji S., Cho K.W., and Hashimoto C. Expression pattern of a basic helix-loop-helix transcription factor Xhairy2b during Xenopus laevis development. Dev. Genes Evol. 213 (2003) 407-411
99. Umbhauer M., Boucaut J.C., and Shi D.L. Repression of XMyoD expression and myogenesis by Xhairy-1 in Xenopus early embryo. Mech. Dev. 109 (2001) 61-68
100. Wang H.U., Chen Z.-F., and Anderson D.J. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93 (1998) 741-753
101. Weinmaster G. The ins and outs of notch signaling. Mol. Cell. Neurosci. 9 (1997) 91-102
102. Weinmaster G. Notch signaling: direct or what?. Curr. Opin. genet. Dev. 8 (1998) 436-442
103. Westin J., and Lardelli M. Three novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function. Dev. Genes Evol. 207 (1997) 51-63
104. Wettstein D.A., Turner D.L., and Kintner C. The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development 124 (1997) 693-702
105. Williams R., Lendahl U., and Lardelli M. Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mech. Dev. 53 (1995) 357-368
106. Wittenberger T., Steinbach O.C., Authaler A., Kopan R., and Rupp R.A. MyoD stimulates delta-1 transcription and triggers notch signaling in the Xenopus gastrula. EMBO J. 18 (1999) 1915-1922
107. Xiang F., Sakata Y., Cui L., Youngblood J.M., Nakagami H., Liao J.K., Liao R., and Chin M.T. Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) 1997-2006
108. Ye Q., Shieh J.H., Morrone G., and Moore M.A. Expression of constitutively active Notch4 (Int-3) modulates myeloid proliferation and differentiation and promotes expansion of hematopoietic progenitors. Leukemia 18 (2004) 777-787
109. Zhao R., Watt A.J., Battle M.A., Li J., Bondow B.J., and Duncan S.A. Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev. Biol. 317 (2008) 614-619