Isolation of two new prenylflavonols from Epimedium brevicornum and their effects on cytokine production in vitro

Planta Medica

Volumn 75, Issue 8, 2009, Pages 843-847

  Luo, Guo Jun ^a   Ci, Xin Xin ^b   Ren, Rong ^a   Wu, Zhao Yuan ^a   Li, Hong Mei ^a   Li, Hai Zhou ^a   Li, Rong Tao ^a   Deng, Xu Ming ^a,b  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

Anti inflammatory; Berberidaceae; Biogenetic relationship; Epimedium brevicornum; Prenylflavonol

Indexed keywords

2'' HYDROXY 3'' EN ANHYDROICARITIN; 2'' HYDROXY BETA EN ANHYDROICARITIN; ANTIINFLAMMATORY AGENT; EPIMEDIUM EXTRACT; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG ACTIVITY; DRUG STRUCTURE; EPIMEDIUM; EPIMEDIUM BREVICORNUM; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DOWN-REGULATION; EPIMEDIUM; FLAVONOLS; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; PLANT EXTRACTS; PRENYLATION; TUMOR NECROSIS FACTOR-ALPHA;

BERBERIDACEAE; EPIMEDIUM BREVICORNUM;

EID: 69049110933     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185376     Document Type: Article

References (20)

1. Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae. Flora reipublicae popularis sinicae. Beijing: Science Press; 2001: 262
2. Zhang YF, Yu QH. The anti-inflammatory effects of total flavonoids of epimedium. J Shengyang Pharm Univ 1999; 16: 122-124
3. Yap SP, Shen P, Butler MS, Gong Y, Loy CJ, Yong EL. New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Med 2005; 71: 114-119 (Pubitemid 40363552)
4. Pan Y, Zhang WY, Xia X, Kong LD. Effects of icariin on hypothalamic-pituitary-adrenal axis and cytokine levels in stressed Sprague-Dawley rats. Biol Pharm Bull 2006; 29: 2399-2403 (Pubitemid 44885858)
5. Wu B, Yan S, Lin Y,Wang Q, Yang Y, Yang GJ, Shen ZY, Zhang WD. Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium. Mol Biosyst 2008; 4: 855-861 (Pubitemid 352009215)
6. Cai WJ, Zhang XM, Huang JH. Effects of epimedium flavonoids in retarding aging of C. elegans. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008; 28: 522-525
7. Meng FH, Li YB, Xiong ZL, Jiang ZM, Li FM. Osteoblastic proliferative activity of Epimdium brevicornum Maxim. Phytomedicine 2005; 12: 189-193
8. Chung BH, Kim JD, Kim CK. Icariin stimulates angiogenenesis by activating the MEK/ERK- and P13K/AKt/eNOS-dependent signal pathways in human endothelial cells. Biochem Biophys Res Commun 2008; 376: 404
9. Mizuno M, Iinuma M, Tanaka T. Flavonol glycosides in the roots of Epimedium diphyllum. Phytochemistry 1988; 27: 3645
10. Ding PL, Chen DF, Bastow KF, Nyarko AK, Wang X, Lee KH. Cytotoxic isoprenylated flavonoids from the roots of Sophora flavescens. Helv Chim Acta 2004; 87: 2574-2580 (Pubitemid 39506771)
11. Guo BL, Li WK, Yu JG, Xiao PG. Brevicornin, a flavonol from Epimedium brevicornum. Phytochemistry 1996; 41: 991-992
12. Tian XM, Chen SZ, Li T, Tu PF. Three new isoflavonoids from the aerial parts of Ammopiptanthus mongolicus. Helv Chim Acta 2008; 91: 1015-1022
13. Tahara S, Ingham IL, Miztani J. Identification of an epoxy-intermediate resulting from the fungal metabolism of a prenylated isoflavone. Phytochemistry 1989; 28: 2079-2084
14. Tanaka M, Tahara S. Fad-dependent epoxidase as a key enzyme in fungal metabolism of prenylated flavonoids. Phytochemistry 1997; 46: 433-439 (Pubitemid 27414920)
15. Wang H, Liao H, Ochani M, Justiniani M, Lin XC, Yang LH,Wang HC, Metz C. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004; 10: 1216-1221 (Pubitemid 39540438)
16. Reimold AM. TNF-alpha as therapeutic target: new drugs, more applications. Curr Drug Targets Inflamm Allergy 2002; 1: 377-392
17. Dinarello CA. Anti-cytokine therapeutics and infections. Vaccine 2003; 21: 24-34
18. Gérard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A, Fiers W, Goldman M, Velu T. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993; 177: 547-550 (Pubitemid 23117107)
19. Ertel W, Keel M, Steckholzer U, Trentz O. Interleukin-10 attenuates the release of proinflammatory cytokines but depresses splenocyte functions in murine endotoxemia. Arch Surg 1996; 131: 51-56 (Pubitemid 26015407)
20. Grutz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol 2005; 77: 3-15 (Pubitemid 40310687)