New insights into the activation of Escherichia coli tyrosine kinase revealed by molecular dynamics simulation and biochemical analysis

Biochemistry

Volumn 48, Issue 33, 2009, Pages 7986-7995

  Lu, Tian ^a   Tan, Hongwei ^a   Lee, Daniel ^b   Chen, Guangju ^a   Jia, Zongchao ^b  

^a BEIJING NORMAL UNIVERSITY   (China)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ACTIVE SITE; BIOCHEMICAL ANALYSIS; CAPSULAR POLYSACCHARIDES; COFACTORS; ELECTROSTATIC INTERACTIONS; ENZYMATIC ASSAY; KINASE ACTIVITY; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR SWITCHES; POSITIVELY CHARGED; PROTEIN KINASE; SHORT PERIODS; SIDE CHAINS; SIMULATION RESULT; STRUCTURAL EVIDENCE; SUBSTRATE PEPTIDES; TYROSINE KINASE; TYROSINE RESIDUES;

AMINES; AMINO ACIDS; ESCHERICHIA COLI; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PHOSPHORYLATION; POLYSACCHARIDES;

ACTIVATION ANALYSIS;

ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; PROTEIN TYROSINE KINASE;

ARTICLE; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; ELECTRICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STABILITY; ESCHERICHIA COLI; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; SIMULATION;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME STABILITY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; QUANTUM THEORY; STATIC ELECTRICITY; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 69049106642     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900811p     Document Type: Article

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