Stimulation of spermatogenesis with recombinant human follicle-stimulating hormone (follitropin alfa; GONAL-f®): long-term treatment in azoospermic men with hypogonadotropic hypogonadism

Fertility and Sterility

Volumn 92, Issue 3, 2009, Pages 979-990

  Matsumoto, Alvin M ^a,b   Snyder, Peter J ^c   Bhasin, Shalender ^d   Martin, Kathryn ^e   Weber, Thomas ^f   Winters, Stephen ^g   Spratt, Daniel ^h   Brentzel, Jim ⁱ   O'Dea, Louis ^j  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^h MAINE MEDICAL CENTER   (United States)

ⁱ EMD SERONO INC   (United States)

^j Radius Health Inc   (United States)

more..

Author keywords

chorionic gonadotropin; follicle stimulating hormone; follitropin alfa; gonadotropin deficiency; Hypogonadotropic hypogonadism; Kallmann's syndrome; spermatogenesis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHORIONIC GONADOTROPIN; GLUCOSE; HYDROCORTISONE; LUTEINIZING HORMONE; PROLACTIN; RECOMBINANT FOLLITROPIN; TESTOSTERONE; THYROTROPIN; URIC ACID;

ACNE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ALLERGY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AZOOSPERMIA; BACKACHE; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; DRUG DOSE ESCALATION; DRUG WITHDRAWAL; DYSPEPSIA; FATIGUE; FLU LIKE SYNDROME; GLUCOSE BLOOD LEVEL; GYNECOMASTIA; HEART MURMUR; HEMORRHOID; HORMONE SUBSTITUTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOGONADOTROPIC HYPOGONADISM; INJECTION SITE PAIN; INJECTION SITE PRURITUS; INJECTION SITE REACTION; INJECTION SITE SWELLING; KALLMANN SYNDROME; LIBIDO DISORDER; LONG TERM CARE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MULTICENTER STUDY; MYALGIA; OPEN STUDY; OUTCOME ASSESSMENT; PAIN; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; SCROTAL PAIN; SEBORRHEA; SIDE EFFECT; SINUSITIS; SOMNOLENCE; SPERMATOGENESIS; SPERMATOZOON MOTILITY; SWEATING; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; UPPER RESPIRATORY TRACT INFECTION; URIC ACID BLOOD LEVEL; VARICOCELE;

ADOLESCENT; ADULT; AZOOSPERMIA; CHORIONIC GONADOTROPIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FOLLICLE STIMULATING HORMONE, HUMAN; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HUMANS; HYPOGONADISM; MALE; MIDDLE AGED; ORGAN SIZE; SPERM MOTILITY; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TESTOSTERONE; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

EID: 69049105594     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.07.1742     Document Type: Article

References (34)

1. Jones J.R., and Kemmann E. Olfacto-genital dysplasia in the female. Obstet Gynecol 5 (1976) 443-446
2. Silveira L.F.G., MacColl G.S., and Bouloux P.M.G. Hypogonadotropic hypogonadism. Semin Reprod Med 20 (2002) 327-338
3. Spratt D.I., Carr D.B., Merriam G.R., Scully R.E., Rao P.N., and Crowley W.F. The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopathic hypogonadotropic hypogonadism: clinical and laboratory correlations. J Clin Endocrinol Metab 64 (1987) 283-291
4. Bardin C.W., Ross G.T., Rifkin A.B., Cargille C.M., and Lipsett M.B. Studies of the pituitary-Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepubertal boys and hypopituitary patients. J Clin Invest 48 (1969) 2046-2056
5. McClure R.D. Endocrine investigation and therapy. Urol Clin North Am 14 (1987) 471-488
6. Finkelstein J.S., Klibanski A., Neer R.M., Greenspan S.L., Rosenthal D.I., and Crowley Jr. W.F. Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Ann Intern Med 106 (1987) 354-361
7. Finkel D.M., Phillips J.L., and Snyder P.J. Stimulation of spermatogenesis by gonadotropins in men with hypogonadotropic hypogonadism. N Engl J Med 313 (1985) 651-655
8. Saal W., Happ J., Cordes U., Baum R.P., and Schmidt M. Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. Fertil Steril 56 (1991) 319-324
9. Schopohl J., Mehltretter G., Von Zumbusch R., Eversmann T., and Von Werder K. Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism. Fertil Steril 56 (1991) 1143-1150
10. Okada Y., Kondo T., Okamoto S., and Ogawa M. Induction of ovulation and spermatogenesis by rMG/hCG in hypogonadotropic GH-deficient patients. Endocr J 39 (1992) 31-43
11. Kirk J.M., Savage M.O., Grant D.B., Bouloux P.M.G., and Besser G.M. Gonadal function and response to human chorionic and menopausal gonadotrophin therapy in male patients with idiopathic hypogonadotropic hypogonadism. Clin Endocrinol 41 (1994) 57-63
12. Kung A.W.C., Zhong Y.Y., Lam K.S.L., and Wang C. Induction of spermatogenesis with gonadotrophins in Chinese men with hypogonadotrophic hypogonadism. Int J Androl 17 (1994) 241-247
13. Mastrogiacomo I., Motta R.G., Botteon G., and Schiesaro M. Achievement of spermatogenesis and genital tract maturation in hypogonadotropic hypogonadic subjects during long-term treatment with gonadotropins or LHRH. Andrologia 23 (1991) 285-289
14. Burgues S., and Calderon M.D. Subcutaneous self-administration of highly purified stimulating hormone and human chorionic gonadotrophin for the treatment of male hypogonadotrophic hypogonadism. Hum Reprod 12 (1997) 980-986
15. European Metrodin HP Study Group. Efficacy and safety of highly purified urinary follicle-stimulating hormone with human chorionic gonadotropin for treating men with isolated hypogonadotropic hypogonadism. Fertil Steril 70 (1998) 256-262
16. Liu L., Chaudhari N., Corle D., and Sherins R.J. Comparison of pulsatile subcutaneous gonadotropins in the treatment of men with isolated hypogonadotropic hypogonadism. Fertil Steril 49 (1988) 302-308
17. Burris A.S., Rodbard H.W., Winters S.J., and Sherins R.J. Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size. J Clin Endocrinol Metab 66 (1988) 1144-1151
18. Pitteloud N., Hayes F.J., Dwyer A., Boepple P.A., Lee H., and Crowley Jr. W.F. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 87 (2002) 4128-4136
19. Barkan A.L., Reame N.E., Kelch R.P., and Marshall J.C. Idiopathic hypogonadotrophic hypogonadism in men: dependence of the hormone responses to gonadotropin-releasing hormone (GnRH) on the magnitude of the endogenous GnRH secretory defect. J Clin Endocrinol Metab 61 (1985) 1118-1125
20. Warne D.W., Decosterd G., Okada H., Yano Y., Koide N., and Howles C.M. A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin. Submitted to Fertil Steril (2008)
21. Burris A.S., Clark R.V., Vantman D.J., and Sherins R.J. A low sperm concentration does not preclude fertility in men with isolated hypogonadotropic hypogonadism after gonadotropin therapy. Fertil Steril 50 (1988) 343-347
22. Büchter D., Behre H.M., Kliesch S., and Nieschlag E. Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol 139 (1998) 298-303
23. Kliesch S., Behre H.M., and Nieschlag E. Recombinant human follicle-stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadotropic male. Fertil Steril 63 (1995) 1326-1328
24. ®) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone. J Androl 24 (2003) 604-611
25. Bouloux P., Warne D.W., and Loumaye E. Efficacy and safety of recombinant human follicle-stimulating hormone in men with isolated hypogonadotropic hypogonadism. Fertil Steril 77 (2002) 270-273
26. ®) with urinary human chorionic gonadotropin for induction of spermatogenesis and fertility in gonadotropin-deficient men. Hum Reprod 14 (1999) 1540-1545
27. World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 3rd ed. (1992), Cambridge University Press, Cambridge
28. Zachmann M., Prader A., and Kind H.P. Testicular volume during adolescence: cross sectional and longitudinal studies. Helv Paediatr Acta 29 (1974) 61-72
29. ®) and human chorionic gonadotropin is effective and well tolerated in azoospemic Japanese men with hypogonadotropic hypogonadism. Clin Endocrinol Jpn 54 (2006) 87-94
30. Ley S.B., and Leonard J.M. Male hypogonadotropic hypogonadism: factors influencing response to human chorionic gonadotropin and human menopausal gonadotropin, including prior exogenous androgens. J Clin Endocrinol Metab 61 (1985) 746-752
31. Lunenfeld B., Mor A., and Mani M. Treatment of male infertility. I. Human gonadotropins. Fertil Steril 18 (1967) 581-592
32. Young J., Couzinet B., Chanson P., Brailly S., Loumaye E., and Schaison G. Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of sertoli and leydig cell secretions and interactions. J Clin Endocrin Metab 85 (2000) 3239-3244
33. Winters S.J., and Troen P. Testosterone and estradiol are co-secreted episodically by the human testis. J Clin Invest 78 (1986) 870-873
34. Santen R.J. The testis: function and dysfunction. In: Yen S.S.C., Jaffe R.B., and Barbieri R.L. (Eds). Reproductive endocrinology: physiology, pathophysiology and clinical management (1999), W.B. Saunders Company, Philadelphia, PA 632-668