Calculating excess risk with age-dependent adjustment factors and cumulative doses: Ethylene oxide case study

Regulatory Toxicology and Pharmacology

Volumn 55, Issue 1, 2009, Pages 76-81

  Sielken, Robert L ^a   Flores, Ciriaco Valdez ^a  

^a Sielken & Associates Inc   (United States)

Author keywords

Age dependent adjustment factors; Cumulative exposure; EPA guidelines; Epidemiology data; Ethylene oxide; Excess risk calculation; Flaws; Regulatory risk assessment

Indexed keywords

ETHYLENE OXIDE;

AGE; ARTICLE; CALCULATION; DOCUMENTATION; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; LIFESPAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT;

AGE FACTORS; CARCINOGENS, ENVIRONMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; ETHYLENE OXIDE; GUIDELINES AS TOPIC; HUMANS; MODELS, BIOLOGICAL; RISK ASSESSMENT; TIME FACTORS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 69049094841     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.06.004     Document Type: Article

References (3)

1. Biological Effects of Ionizing Radiation (BEIR) IV, 1988. Health Risks of Radon and Other Internally Deposited Alpha-Emitters. Committee on the Biological Effects of Ionizing Radiations. Board on Radiation Effects Research. Commission of Life Sciences. National Research Council. National Academy Press, Washington, DC.
2. US EPA, 2005. Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. EPA/360/R-03/003F. US Environmental Protection Agency, Risk Assessment Forum, March, 2005.
3. US EPA, 2006. Evaluation of the Carcinogenicity of Ethylene Oxide. EPA/635/R-061/003. External Review Draft. US Environmental Protection Agency, National Center for Environmental Assessment, Office of Research and Development, Washington, DC.