Tumor size is an unreliable predictor of prognosis in basal-like breast cancers and does not correlate closely with lymph node status

Breast Cancer Research and Treatment

Volumn 117, Issue 1, 2009, Pages 199-204

  Foulkes, William D ^a   Grainge, Matthew J ^b   Rakha, Emad A ^b,c   Green, Andrew R ^b   Ellis, Ian O ^b,c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

Basal like breast cancer; Breast cancer; HER2; Luminal A; Luminal B; Lymph node status; Poisson distribution; Survival; Tumor size

Indexed keywords

BRCA1 PROTEIN;

ARTICLE; AXILLARY LYMPH NODE; BASAL LIKE BREAST CANCER; BREAST CANCER; CANCER SIZE; CANCER SURVIVAL; CONTROLLED STUDY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; UNITED KINGDOM;

BREAST NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN;

EID: 69049088222     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0102-6     Document Type: Article

References (23)

1. SE Singletary C Allred P Ashley LW Bassett D Berry KI Bland et al. 2002 Revision of the American Joint Committee on cancer staging system for breast cancer J Clin Oncol 20 17 3628 3636 10.1200/JCO.2002.02.026
2. CL Carter C Allen DE Henson 1989 Relation of tumor size, lymph node status, and survival in 24, 740 breast cancer cases Cancer 63 181 187 10.1002/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H
3. WD Foulkes K Metcalfe W Hanna HT Lynch P Ghadirian N Tung et al. 2003 Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma Cancer 98 8 1569 1577 10.1002/cncr.11688
4. R Dent M Trudeau KI Pritchard WM Hanna HK Kahn CA Sawka et al. 2007 Triple-negative breast cancer: clinical features and patterns of recurrence Clin Cancer Res 13 15 Pt 1 4429 4434 10.1158/1078-0432.CCR-06-3045
5. MC Cheang D Voduc C Bajdik S Leung S McKinney SK Chia et al. 2008 Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype Clin Cancer Res 14 5 1368 1376 10.1158/1078-0432.CCR-07-1658
6. NC Turner JS Reis-Filho 2006 Basal-like breast cancer and the BRCA1 phenotype Oncogene 25 43 5846 5853 10.1038/sj.onc.1209876
7. CM Perou T Sorlie MB Eisen M van de Rijn SS Jeffrey CA Rees et al. 2000 Molecular portraits of human breast tumours Nature 406 6797 747 752 10.1038/35021093
8. C Sotiriou SY Neo LM McShane EL Korn PM Long A Jazaeri et al. 2003 Breast cancer classification and prognosis based on gene expression profiles from a population-based study Proc Natl Acad Sci USA 100 18 10393 10398 10.1073/pnas.1732912100
9. T Sorlie CM Perou R Tibshirani T Aas S Geisler H Johnsen et al. 2001 Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc Natl Acad Sci USA 98 19 10869 10874 10.1073/pnas.191367098
10. M Tischkowitz JS Brunet LR Begin DG Huntsman MC Cheang LA Akslen et al. 2007 Use of immunohistochemical markers can refine prognosis in triple negative breast cancer BMC Cancer 7 134 10.1186/1471-2407-7-134
11. DM Abd El-Rehim SE Pinder CE Paish J Bell RW Blamey JF Robertson et al. 2004 Expression of luminal and basal cytokeratins in human breast carcinoma J Pathol 203 2 661 671 10.1002/path.1559
12. LA Carey CM Perou CA Livasy LG Dressler D Cowan K Conway et al. 2006 Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study JAMA 295 21 2492 2502 10.1001/jama.295.21.2492
13. BG Haffty Q Yang M Reiss T Kearney SA Higgins J Weidhaas et al. 2006 Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer J Clin Oncol 24 36 5652 5657 10.1200/JCO.2006.06.5664
14. TO Nielsen FD Hsu K Jensen M Cheang G Karaca Z Hu et al. 2004 Immunohistochemical and clinical characterization of the Basal-like subtype of invasive breast carcinoma Clin Cancer Res 10 16 5367 5374 10.1158/1078-0432.CCR- 04-0220
15. JB Arnes JS Brunet I Stefansson LR Begin N Wong PO Chappuis et al. 2005 Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer Clin Cancer Res 11 11 4003 4011 10.1158/1078-0432.CCR-04-2064
16. AJ Evans EA Rakha SE Pinder AR Green C Paish IO Ellis 2007 Basal phenotype: a powerful prognostic factor in small screen-detected invasive breast cancer with long-term follow-up J Med Screen 14 4 210 214 10.1258/ 096914107782912004
17. MJ van de Vijver YD He LJ Van't Veer H Dai AA Hart DW Voskuil et al. 2002 A gene-expression signature as a predictor of survival in breast cancer N Engl J Med 347 25 1999 2009 10.1056/NEJMoa021967
18. EA Rakha DA El-Rehim C Paish AR Green AH Lee JF Robertson et al. 2006 Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance Eur J Cancer 42 18 3149 3156 10.1016/j.ejca.2006.08.015
19. EA Rakha ME El-Sayed AR Green AH Lee JF Robertson IO Ellis 2007 Prognostic markers in triple-negative breast cancer Cancer 109 1 25 32 10.1002/cncr.22381
20. SM Rodriguez-Pinilla D Sarrio E Honrado D Hardisson F Calero J Benitez et al. 2006 Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas Clin Cancer Res 12 5 1533 1539 10.1158/1078-0432.CCR-05-2281
21. AA Luck AJ Evans AR Green EA Rakha C Paish IO Ellis 2008 The influence of basal phenotype on the metastatic pattern of breast cancer Clin Oncol (R Coll Radiol) 20 1 40 45 10.1016/j.clon.2007.10.002
22. WY Chen GA Colditz 2007 Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer Nat Clin Pract Oncol 4 7 415 423 10.1038/ncponc0851
23. RC Millikan B Newman CK Tse PG Moorman K Conway LV Smith et al. 2008 Epidemiology of basal-like breast cancer Breast Cancer Res Treat 109 1 123 139 10.1007/s10549-007-9632-6