Mitosis-specific marker phospho-histone h3 in the assessment of mitotic index in uterine smooth muscle tumors: A pilot study

International Journal of Gynecological Pathology

Volumn 28, Issue 4, 2009, Pages 316-321

  Veras, Emanuela ^a   Malpica, Anais ^b   Deavers, Michael T ^b   Silva, Elvio G ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Assessment; Leiomyosarcoma; Mitotic index; Phospho histone H3; Smooth muscle tumor of uncertain malignant potential; Uterine smooth muscle tumor

Indexed keywords

EOSIN; HEMATOXYLIN; HISTONE H3; MONOCLONAL ANTIBODY;

ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MITOSIS INDEX; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RELIABILITY; STAINING; UTERINE SMOOTH MUSCLE TUMOR OF UNCERTAIN MALIGNANT POTENTIAL; UTERUS LEIOMYOSARCOMA; UTERUS TUMOR;

ADULT; ANTIBODIES, MONOCLONAL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HISTONES; HUMANS; LEIOMYOSARCOMA; MIDDLE AGED; MITOSIS; MITOTIC INDEX; PILOT PROJECTS; SMOOTH MUSCLE TUMOR; TUMOR MARKERS, BIOLOGICAL; UTERINE NEOPLASMS;

EID: 69049085568     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/PGP.0b013e318193df97     Document Type: Article

References (19)

1. Silverberg SG. Reproducibility of the mitosis count in the histologic diagnosis of the smooth muscle tumors of the uterus. Hum Pathol 1976;7:451-454
2. Kempson RL, Hendrickson MR. Pure mesenchymal neoplasms of the uterus. In: Fox H, ed. Haines and Taylor Obstetrical and Gynecological Pathology. 3rd ed. Edinburgh: Churchill Livingstone; 1987:411-456
3. Kempson RL, Hendrickson MR. Pure mesenchymal neoplasms of the uterus: selected problems. Semin Diagn Pathol 1988;5:172-198
4. Evans HL, Chawla SP, Simpson C, et al. Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988;62:2239-2247 (Pubitemid 18261867)
5. Silverberg SG, Kurman RJ. Smooth muscle and other mesenchymal tumors. Tumors of the uterine corpus and gestational trophoblastic disease. In: Rosai J, ed. Atlas of Tumor Pathology, 3rd Series (fascicle 3). Bethesda: Armed Forces Institutes of Pathology; 1992:113-151
6. Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 1994;18:535-558 (Pubitemid 24150803)
7. Hendzel MJ, Wei Y, Mancini MA, et al. Mitosis-specific phosphorilation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997;106:348-360 (Pubitemid 27510848)
8. Van Hooser A, Goodrich DW, Allis CD, et al. Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation. J Cell Sci 1998;111:3497-3506 (Pubitemid 29015387)
9. Goto H, Tomono Y, Ajiro K, et al. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem 1999;274:25543-25549 (Pubitemid 129530724)
10. Tapia C, Kutzner H, Mentzel T, et al. Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 (Ser28), allow rapid and precise determination of mitotic activity. Am J Surg Pathol 2006;30:83-89 (Pubitemid 43740213)
11. Kapur P, Rakheja D, Balani JP, et al. Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and Cleaved Caspase-3 expression in benign and atypical granular cell tumors. Arch Pathol Lab Med 2007;131:57-64. (Pubitemid 46174136)
12. Bossard C, Jarry A, Colombeix C, et al. Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index. J Clin Pathol 2006;59:706-710 (Pubitemid 44048778)
13. Brenner RM, Slayden OD, Rodgers WH, et al. Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium. Hum Reprod 2003;18:1185-1193
14. Ribalta T, McCutcheon IE, Aldape KD, et al. The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria. Am J Surg Pathol 2004;28:1532-1536 (Pubitemid 39425522)
15. Kim YJ, Ketter R, Steudel WI, et al. Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas. Am J Clin Pathol 2007;128:118-125 (Pubitemid 47121724)
16. Scott IS, Morris LS, Bird K, et al. A novel immunohistochemical method to estimate cell-cycle phase distribution in archival tissue: implications for the prediction of outcome in colorectal cancer. J Pathol 2003;201:187-197 (Pubitemid 37258929)
17. Colman H, Giannini C, Huang L, et al. Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas. Am J Surg Pathol 2006;30:657-664 (Pubitemid 44265019)
18. O'Neill CJ, McBride HA, Connolly LE, et al. Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology 2007;50:851-858
19. Scott IS, Heath TM, Morris LS, et al. A novel immunohistochemical method for estimating cell cycle phase distribution in ovarian serous neoplasms: implications for the histopathological assessment of paraffin-embedded specimens. Br J Cancer 2004;90:1583-1590