Synthesis and anticonvulsant evaluation of some N-substituted phthalimides

Acta Poloniae Pharmaceutica - Drug Research

Volumn 66, Issue 3, 2009, Pages 249-257

  Wiȩcek, Małgorzata ^a   Kieć Kononowicz, Katarzyna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Anticonvulsant activity; Lipophilicity; Phthalimides; Structure activity relationships

Indexed keywords

ALKYL GROUP; ANTICONVULSIVE AGENT; NITROGEN; PENTETRAZOLE; PHTHALIMIDE DERIVATIVE; THALIDOMIDE;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; LIPOPHILICITY; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; SEIZURE; ANIMAL; CHEMISTRY; DISEASE MODEL; HYDROPHOBICITY; METHODOLOGY; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; HYDROPHOBICITY; MICE; PHTHALIMIDES; SEIZURES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 68949211764     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Greenwood R.S.: Epilepsia, 41, 42 (2000).
2. Saxsena A.K., Saxsena M.: In Progress in Drug Research vol. 44, p. 185 Jucker E. Ed.; Birkhauser Verlag, Basel 1995.
3. Vamecq J., Lambert D., Paupaert J.H., Masereel B., Stables J.P.: J. Med. Chem. 41, 3307 (1998).
4. Marona H., Kieć-Kononowicz K.: Pharmazie 53, 603 (1998).
5. Vamecq J., Bac P., Herrenknecht Ch., Maurois P., Delcourt P., Stables J.P.: J. Med. Chem. 43, 1311 (2000).
6. Kieć-Kononowicz K., Zejc A.: Pol. J. Chem. 58, 761 (1984)
7. Mitsunobu O.: Synthesis 1981, 1.
8. Porter R., Cereghino J., Gladding G., Hessie B., Kupferberg H., Scoville B., White B.: Cleveland Clin. Q. 51, 293, (1984).
9. CS Chem3D Ultra, version 7.0.0, CambridgeSoft (2001).
10. Pallas, version 3.1.1.2 (demo), CompuDrug Chemistry Ltd. (1995)
11. Copp F. Ch., Hodson H.F.: Patent; Burroughs Wellcome and Co. (USA); US3474134 (1969).
12. Boissier J.R., Ratouis R.: Patent; S.J.F.A.; DE 1933158 (1970).
13. Bremner J.B., Browne E.J., Gunawardana I.W.K.: Aust. J. Chem. 37, 129 (1984).
14. Tiecco M., Testaferri L., Temperini A., Bagnoli L., Marini F., Santi C., Terlizzi R.: Eur. J. Org. Chem. 16, 3447 (2004).
15. Ettlinger M.G., Hodgkins J.E.: J. Am. Chem. Soc. 77, 1831 (1955).
16. Bunton C.A., Hachey D.L., LerescheJ.P.: J. Org. Chem. 59, 4036 (1972).