A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal

Journal of Studies on Alcohol and Drugs

Volumn 70, Issue 3, 2009, Pages 467-474

  Kumar, Channaveerachari Naveen ^a   Andrade, Chittaranjan ^a   Murthy, Pratima ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORDIAZEPOXIDE; CYANOCOBALAMIN; LORAZEPAM; PANTOTHENIC ACID; PYRIDOXINE; THIAMINE;

ADULT; ALCOHOL WITHDRAWAL; AMINOTRANSFERASE BLOOD LEVEL; AMNESIA; ANOREXIA; ARTHRALGIA; ARTICLE; ATAXIA; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COPPER DEFICIENCY; DELIRIUM; DELIRIUM TREMENS; DEPRESSION; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG FEVER; DRUG WITHDRAWAL; EVENING DOSAGE; FATTY LIVER; GASTRITIS; HALLUCINOSIS; HEAD INJURY; HEART PALPITATION; HEMATEMESIS; HEPATITIS; HOSPITAL PATIENT; HUMAN; INSOMNIA; IRRITABILITY; LASSITUDE; MAJOR CLINICAL STUDY; MALE; MENTAL CONCENTRATION; MORNING DOSAGE; MYELONEUROPATHY; MYOPATHY; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; PSYCHOEDUCATION; PSYCHOSOCIAL CARE; RANDOMIZED CONTROLLED TRIAL; SCREENING TEST; SIDE EFFECT; WITHDRAWAL SEIZURE;

ADOLESCENT; ADULT; ALCOHOL-INDUCED DISORDERS; ALCOHOLISM; CHLORDIAZEPOXIDE; DRUG ADMINISTRATION SCHEDULE; ETHANOL; HUMANS; HYPNOTICS AND SEDATIVES; LORAZEPAM; MALE; MIDDLE AGED; PATIENT DROPOUTS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 68949203696     PISSN: 19371888     EISSN: 19384114     Source Type: Journal    
DOI: 10.15288/jsad.2009.70.467     Document Type: Article

References (22)

1. AMERICAN PSYCHIATRIC ASSOCIATION. Practice Guideline for the Treatment of Patients With Substance Use Disorders, 2nd Edition, Arlington, VA: American Psychiatric Publishing, 2006 (available at: www.psychiatry-online.com).
2. ANDRADE, C. Psychopharmacology. In: BHUGRA, D., RANJITH, G., AND PATEL, V. (Eds.) Handbook of Psychiatry: A South Asian Perspective, New Delhi, India: Byword, 2005, pp. 517-552.
3. CHARNEY, D.S., MIHIC, S.J., AND HARRIS, R.A. Hypnotics and sedatives. In: HARDMAN, J.G., LIMBIRD, L.E., AND GILMAN, A.G. (Eds.) Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th Edition, New York: McGraw Hill, 2001, pp. 399-427.
4. D'ONOFRIO, G., RATHLEV, N.K., ULRICH, A.S., FISH, S.S., AND FREEDLAND, E.S. Lorazepam for the prevention of recurrent seizures related to alcohol. New Eng. J. Med. 340: 915-919, 1999.
5. FULLER, R.K. AND HILLER-STURMHÖFEL, S. Alcoholism treatment in the United States. An overview. Alcohol Res. Hlth 23: 69-77, 1999.
6. KIRKWOOD, C.K. AND MELTON, S.T. Anxiety disorders. In: DIPIRO, J.T., TALBERT, R.L., YEE, G.C., MATZKE, G.R., WELLS, B.G., AND POSEY, L.M. (Eds.) Pharmacotherapy: A Pathophysiologic Approach, 5th Edition, New York: McGraw Hill, 2002, pp. 1289-1310.
7. KOSTEN, T.R. AND O'CONNOR, P.G. Management of drug and alcohol withdrawal. New Eng. J. Med. 348: 1786-1995, 2003.
8. MAYO-SMITH, M.F. Pharmacological management of alcohol withdrawal: A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA 278: 144-151, 1997.
9. MILLER, W.C., JR., AND MCCURDY, L. A double-blind comparison of the efficacy and safety of lorazepam and diazepam in the treatment of the acute alcohol withdrawal syndrome. Clin. Ther. 6: 364-371, 1984.
10. NTAIS, C., PAKOS, E., KYZAS, P., AND IOANNIDIS, J.P. Benzodiazepines for alcohol withdrawal. Cochrane Database Syst. Rev. 3: CD005063, 2005.
11. O'BRIEN, J.E., MEYER, R.E., AND THOMS, D.C. Double-blind comparison of lorazepam and diazepam in the treatment of the acute alcohol abstinence syndrome. Curr. Ther. Res. Clin. Exp. 34: 825-831, 1983.
12. PETRAKIS, I.L. A rational approach to the pharmacotherapy of alcohol dependence. J. Clin. Psychopharmacol. 26 (Suppl. No. 1): S3-S12, 2006.
13. REUS, V.I. Mental disorders. In: BRAUNWALD, E., FAUCI, A.S., KASPER, D.L., HAUSER, S.L., LONGO, D.L., AND JAMESON, J.L. (Eds.) Harrison's Principles of Internal Medicine, 15th Edition, Vol. 2, New York: McGraw Hill, 2001, pp. 2542-2556.
14. RITSON, B. AND CHICK, J. Comparison of two benzodiazepines in the treatment of alcohol withdrawal: Effects on symptoms and cognitive recovery. Drug Alcohol Depend. 18: 329-334, 1986.
15. ROBINSON, M.J. AND OWEN, J.A. Psychopharmacology. In: LEVENSON, J.L. (Ed.) The American Psychiatric Publishing Textbook of Psychosomatic Medicine, Arlington, VA: American Psychiatric Publishing, 2005, pp. 871-922.
16. SCHATZBERG, A.F., COLE, J.O., AND DEBATTISTA, C. Manual of Clinical Psychopharmacology, 4th Edition, Arlington, VA: American Psychiatric Publishing, 2002.
17. SCHUCKIT, M.A. Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment, 5th Edition, New York: Kluwer Academic/Plenum Publishers, 2000.
18. SOLOMON, J., ROUCK, L.A., AND KOEPKE, H.H. Double-blind comparison of lorazepam and chlordiazepoxide in the treatment of the acute alcohol abstinence syndrome. Clin. Ther. 6: 52-58, 1983.
19. STAHL, S.M. Essential Psychopharmacology: The Prescriber's Guide, Revised and Updated Edition, New York: Cambridge Univ. Press, 2006.
20. STOCKWELL, T., SITHARTHAN, T., MCGRATH, D., AND LANG, E. The measurement of alcohol dependence and impaired control in community samples. Addiction 89: 167-174, 1994.
21. SULLIVAN, J.T., SYKORA, K., SCHNEIDERMAN, J., NARANJO, C.A., AND SELLERS, E.M. Assessment of alcohol withdrawal: The revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). Brit. J. Addict. 84: 1353-1357, 1989.
22. TREIMAN, D.M. The role of benzodiazepines in the management of status epilepticus. Neurology 40 (Suppl. No. 2): 32-42, 1990.