Study of the MR relaxation of microglia cells labeled with Gd-DTPA-bearing nanoparticles

Contrast Media and Molecular Imaging

Volumn 4, Issue 3, 2009, Pages 109-117

  Ribot, Emeline Julie ^a   Miraux, Sylvain ^a   Delville, Marie Hélène ^b   Bouchaud, Vŕonique ^a   Lacomme, Sabrina ^c   Gontier, Etienne ^c   Bouzier Sore, Anne Karine ^a   Franconi, Jean Michel ^a   Thiaudiere, Eric ^a   Voisin, Pierre ^a  

^a CNRS University Bordeaux Segalen   (France)

^b INST CHIM MATIERE COND BORDEAUX   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Cellular MR imaging; Compartmentalization effect; Gd based nanoparticles; Kinetics; Microglia; Relaxation rate

Indexed keywords

GADOLINIUM PENTETATE; GLYCINE; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL CELL; ARTICLE; CELL BASED GENE THERAPY; CELL COMPARTMENTALIZATION; CELL GROWTH; CELL LABELING; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELL SPREADING; CELLULAR DISTRIBUTION; CHEMICAL BINDING; CONTROLLED STUDY; EXTRACELLULAR SPACE; FLUORESCENCE MICROSCOPY; GLIOMA CELL; INCUBATION TIME; INTERNALIZATION; MEMBRANE DAMAGE; MICROGLIA; MOLECULAR IMAGING; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOCHEMICAL INTERNALIZATION; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; RELAXATION RATE; SIGNAL PROCESSING; SUICIDE GENE THERAPY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 68949202400     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.268     Document Type: Article

References (25)

1. Brekke C, Williams SC, Price J, Thorsen F, Modo M. Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model. Neuroimage 2007; 37(3): 769-782.
2. Smirnov P, Lavergne E, Gazeau F, Lewin M, Boissonnas A, Doan BT, Gillet B, Combadière C, Combadière B, Clément O. In vivo cellular imaging of lymphocyte trafficking by MRI: a tumor model approach to cell-based anticancer therapy. Magn. Reson. Med. 2006; 56(3): 498-508.
3. Zelivyanskaya ML, Nelson JA, Poluektova L, Uberti M, Mellon M, Gendelman HE, Boska MD. Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging. J. Neurosci. Res. 2003; 73(3): 284-295.
4. Hoehn M, Küstermann E, Blunk J, Wiedermann D, Trapp T, Wecker S, Föcking M, Arnold H, Hescheler J, Fleischmann BK, Schwindt W, Bührle C. Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc. Natl Acad. Sci. USA 2002; 99(25): 16267-16272.
5. Anderson SA, Glod J, Arbab AS, Noel M, Ashari P, Fine HA, Frank JA. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood 2005; 105(1): 420-425.
6. Gao F, Kar S, Zhang J, Qiu B, Walczak P, Larabi M, Xue R, Frost E, Qian Z, Bulte JW, Yang X. MRI of intravenously injected bone marrow cells homing to the site of injured arteries. NMR Biomed. 2007; 20(7): 673-681.
7. Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003; 63(23): 8122-8125.
8. Rejman J, Oberle V, Zuhorn IS, Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 2004; 377: 159-169.
9. Terreno E, Geninatti Crich S, Belfiore S, Biancone L, Cabella C, Esposito G, Manazza AD, Aime S. Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons. Magn. Reson. Med. 2006; 55(3): 491-497.
10. 2 relaxivity of intracellular and extracellular USPIO at 1. 5T and 3T clinical MR scanning. Eur. Radiol. 2006; 16(3): 738-745.
11. Billotey C, Wilhelm C, Devaud M, Bacri JC, Bittoun J, Gazeau F. Cell internalization of anionic maghemite nanoparticles: quantitative effect on magnetic resonance imaging. Magn. Reson. Med. 2003; 49(4): 646-654.
12. Miraux S, Massot P, Ribot EJ, Franconi JM, Thiaudiere E. 3D TrueFISP imaging of mouse brain at 4.7 T and 9.4 T. J Magn. Reson. Imag. 2008; DOI: 10.1002/jmri.21449
13. Klasson A, Ahrén M, Hellqvist E, Söderlind F, Rosén A, Käll PO, Uvdal K, Engström M. Positive MRI contrast enhancement in THP-1 cells with Gd(2)O(3) nanoparticles. Contrast Media Mol. Imag. 2008(3): (3): 106-111.
14. Gilad AA, Walczak P, McMahon MT, Na HB, Lee JH, An K, Hyeon T, van Zijl PC, Bulte JW. MR tracking of transplanted cells with 'positive contrast' using manganese oxide nanoparticles. Magn. Reson. Med. 2008; 60(1): 1-7.
15. Voisin P, Ribot EJ, Miraux S, Bouzier-Sore AK, Lahitte JF, Bouchaud V, Mornet S, Thiaudière E, Franconi JM, Raison L, Labrugère C, Delville MH. Use of lanthanide-grafted inorganic nanoparticles as effective contrast agents for cellular uptake imaging. Bioconjug. Chem. 2007; 18(4): 1053-1063.
16. Ribot E, Bouzier-Sore AK, Bouchaud V, Miraux S, Delville MH, Franconi JM, Voisin P. Microglia used as vehicles for both inducible thymidine kinase gene therapy and MRI contrast agents for glioma therapy. Cancer Gene Ther. 2007; 14(8): 724-737.
17. Di Pasqua AJ, Sharma KK, Shi YL, Toms BB, Ouellette W, Dabrowiak JC, Asefa T. Cytotoxicity of mesoporous silica nanomaterials. J. Inorg. Biochem. 2008; 102(7): 1416-1423.
18. Vekris A, Maurange C, Moonen C, Mazurier F, De Verneuil H, Canioni P, Voisin P. Control of transgene expression using local hyperthermia in combination with a heat-sensitive promoter. J. Gene Med. 2000; 2(2): 89-96.
19. Song Y, Morikawa S, Morita M, Inubushi T, Takada T, Torii R, Tooyama I. Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain. Neurosci. Lett. 2006; 395(1): 42-45.
20. Badie B, Schartner JM. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery 2000; 46(4): 957-961.
21. Briner VA, Williams B, Tsai P, Schrier RW. Demonstration of processing and recycling of biologically active V1 vasopressin receptors in vascular smooth muscle. Proc. Natl Acad. Sci. USA 1992; 89(7): 2854-2858.
22. Valable S, Barbier EL, Bernaudin M, Roussel S, Segebarth C, Petit E, Rémy C. In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma. Neuroimage 2007; 37 (suppl. 1): S47-58.
23. Hamm J, Pulito R, Benedetto S, Barberis L, Hirsch E, Poli V, Silengo L. Magnetically enriched bone marrow-derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice. NMR Biomed. 2008; 21(2): 120-128.
24. 3+ ions. Contrast Media Mol. Imag. 2006; 1(1): 23-29.
25. Steinman RM, Mellman IS, Muller WA, Cohn ZA. Endocytosis and the recycling of plasma membrane. J. Cell Biol. 1983; 96(1): 1-27.