An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: Taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1β-mediated NFκB activation

European Journal of Pharmacology

Volumn 618, Issue 1-3, 2009, Pages 91-97

  Joo, Kanghyun ^a   Lee, Youna ^a   Choi, Deakyu ^a   Han, Jeongoh ^a   Hong, Sungchae ^a   Kim, Young Mi ^a   Jung, Yunjin ^a  

^a Pusan National University   (South Korea)

Author keywords

5 aminosalicylic acid; Colon specific prodrug; Inflammatory bowel disease; Nuclear factor kappa B; Taurine chloramine

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESALAZINE; SALICYLIC ACID DERIVATIVE; SYNAPTOTAGMIN I; TAURINE CHLORAMINE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENTIATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; COLITIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-1BETA; MESALAMINE; NF-KAPPA B; PRODRUGS; TAURINE;

EID: 68949183220     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.07.009     Document Type: Article

References (26)

1. Andrews N.C., and Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19 (1991) 2499
2. Atreya I., Atreya R., and Neurath M.F. NF-kappaB in inflammatory bowel disease. J. Intern. Med. 263 (2008) 591-596
3. Auphan N., DiDonato J.A., Rosette C., Helmberg A., and Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270 (1995) 286-290
4. Baeuerle P.A., and Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242 (1988) 540-546
5. Barua M., Liu Y., and Quinn M.R. Taurine chloramine inhibits inducible nitric oxide synthase and TNF-alpha gene expression in activated alveolar macrophages: decreased NF-kappaB activation and IkappaB kinase activity. J. Immunol. 167 (2001) 2275-2281
6. Crotty B., and Jewell D.P. Drug therapy of ulcerative colitis. Br. J. Clin. Pharmacol. 34 (1992) 189-198
7. Egan L.J., Mays D.C., Huntoon C.J., Bell M.P., Pike M.G., Sandborn W.J., Lipsky J.J., and McKean D.J. Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J. Biol. Chem. 274 (1999) 26448-26453
8. Hanauer S.B., Krawitt E.L., Robinson M., Rick G.G., and Safdi M.A. Long-term management of Crohn's disease with mesalamine capsules (Pentasa). Pentasa Crohn's Disease Compassionate Use Study Group. Am. J. Gastroenterol. 88 (1993) 1343-1351
9. Henkel T., Machleidt T., Alkalay I., Kronke M., Ben-Neriah Y., and Baeuerle P.A. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature 365 (1993) 182-185
10. Jung Y.J., Kim H.H., Kong H.S., and Kim Y.M. Synthesis and properties of 5-aminosalicyl-taurine as a colon-specific prodrug of 5-aminosalicylic acid. Arch. Pharm. Res. 26 (2003) 264-269
11. Jung Y., Kim H.H., Kim H., Kong H., Choi B., Yang Y., and Kim Y. Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis. Eur. J. Pharm. Sci. 28 (2006) 26-33
12. Kaiser G.C., Yan F., and Polk D.B. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology 116 (1999) 602-609
13. Kanayama A., Inoue J., Sugita-Konishi Y., Shimizu M., and Miyamoto Y. Oxidation of Ikappa Balpha at methionine 45 is one cause of taurine chloramine-induced inhibition of NF-kappa B activation. J. Biol. Chem. 277 (2002) 24049-24056
14. Karin M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J. Biol. Chem. 274 (1999) 27339-27342
15. Kim H., Jeon H., Kong H., Yang Y., Choi B., Kim Y.M., Neckers L., and Jung Y. A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon. Mol. Pharmacol. 69 (2006) 1405-1412
16. Li Q., and Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
17. Nemetz A., Nosti-Escanilla M.P., Molnar T., Kope A., Kovacs A., Feher J., Tulassay Z., Nagy F., Garcia-Gonzalez M.A., and Pena A.S. IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease. Immunogenetics 49 (1999) 527-531
18. Neurath M.F., and Pettersson S. Predominant role of NF-kappa B p65 in the pathogenesis of chronic intestinal inflammation. Immunobiology 198 (1997) 91-98
19. Neurath M.F., Becker C., and Barbulescu K. Role of NF-kappaB in immune and inflammatory responses in the gut. Gut 43 (1998) 856-860
20. Ruemmele F.M., Beaulieu J.F., Dionne S., Levy E., Seidman E.G., Cerf-Bensussan N., and Lentze M.J. Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha. Gut 51 (2002) 842-848
21. Sanchez-Munoz F., Dominguez-Lopez A., and Yamamoto-Furusho J.K. Role of cytokines in inflammatory bowel disease. World J. Gastroenterol. 14 (2008) 4280-4288
22. Shibata W., Maeda S., Hikiba Y., Yanai A., Ohmae T., Sakamoto K., Nakagawa H., Ogura K., and Omata M. Cutting edge: the IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. J. Immunol. 179 (2007) 2681-2685
23. Tang E.D., Wang C.Y., Xiong Y., and Guan K.L. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J. Biol. Chem. 278 (2003) 37297-37305
24. Yamamoto Y., and Gaynor R.B. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 107 (2001) 135-142
25. Yan F., and Polk D.B. Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. J. Biol. Chem. 274 (1999) 36631-36636
26. Yang L., Chu J.S., and Fix J.A. Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation. Int. J. Pharm. 235 (2002) 1-15