Oral Protein Supplementation Alone Improves Anabolism in a Dose-Dependent Manner in Chronic Hemodialysis Patients

Journal of Renal Nutrition

Volumn 19, Issue 5, 2009, Pages 412-421

  Sundell, Mary B ^a   Cavanaugh, Kerri L ^a   Wu, Pingsheng ^a   Shintani, Ayumi ^a   Hakim, Raymond M ^a,b   Ikizler, T Alp ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b FRESENIUS MEDICAL CARE NORTH AMERICA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBON; DIAGNOSTIC AGENT; LEUCINE; MUSCLE PROTEIN; PROTEIN;

ADULT; ARTICLE; BLOOD; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PROSPECTIVE STUDY; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; SKELETAL MUSCLE;

ADULT; AMINO ACIDS; CARBON ISOTOPES; CROSS-OVER STUDIES; DIETARY PROTEINS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; LEUCINE; MALE; METABOLISM; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROSPECTIVE STUDIES; PROTEINS; RENAL DIALYSIS;

EID: 68949167788     PISSN: 10512276     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jrn.2009.01.019     Document Type: Article

References (13)

1. Ikizler T.A., and Hakim R.M. Nutrition in end-stage renal disease. Kidney Int 50 (1996) 343-357
2. Kopple J.D. Effect of nutrition on morbidity and mortality in maintenance dialysis patients. Am J Kidney Dis 24 (1994) 1002-1009
3. Pupim L.B., Flakoll P.J., Brouillette J.R., et al. Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 110 (2002) 483-492
4. Pupim L.B., Majchrzak K.M., Flakoll P.J., and Ikizler T.A. Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patients with deranged nutritional status. J Am Soc Nephrol 17 (2006) 3149-3157
5. Cano N.J., Fouque D., Roth H., et al. Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomized study. J Am Soc Nephrol 18 (2007) 2583-2591
6. Wolfe R.R. Protein supplements and exercise. Am J Clin Nutr 72 Suppl (2000) 551S-557S
7. Ikizler T.A., Pupim L.B., Brouillette J.R., et al. Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab 282 (2002) E107-E116
8. Pupim L.B., Flakoll P.J., Brouillette J.R., et al. Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 110 (2002) 483-492
9. Wolfe R. Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis (1992), Wiley-Liss, New York pp 283-316
10. Ikizler T.A., Pupim R.B., Brouillette J.R., et al. Hemodialysis stimulates muscle and whole-body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab 282 (2002) E107-E116
11. Kobayashi H., Borsheim E., Anthony T.G., et al. Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab 284 (2003) E488-E498
12. Flakoll P.J., Carlson M., and Cherrington A.C. Physiological action of insulin. In: Leroith D.T.S., and Olefsky J. (Eds). Diabetes mellitus: a fundamental and clinical text. 2nd ed (2000), Williams & Wilkins, Philadelpia 148-161
13. Stratton R.J., Bircher G., Fouque D., et al. Multinutrient oral supplements and tube feeding in maintenance dialysis: a systematic review and meta-analysis. Am J Kidney Dis 46 (2005) 387-405