In silico prediction and ex vivo evaluation of potential T-cell epitopes in glycoproteins 4 and 5 and nucleocapsid protein of genotype-I (European) of porcine reproductive and respiratory syndrome virus

Vaccine

Volumn 27, Issue 41, 2009, Pages 5603-5611

  Díaz, Ivan ^a   Pujols, Joan ^a,b   Ganges, Llilianne ^a,d   Gimeno, Mariona ^a,c   Darwich, Laila ^a,c   Domingo, Mariano ^a,c   Mateu, Enric ^a,c  

^a CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^b IRTA   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d INIA   (Spain)

Author keywords

Bioinformatics; Porcine reproductive and respiratory syndrome virus; T cell epitopes

Indexed keywords

BETA N ACETYLGLUCOSAMINYLGLYCOPEPTIDE BETA 1,4 GALACTOSYLTRANSFERASE; DNA VACCINE; EPITOPE; GAMMA INTERFERON; GLYCOPROTEIN; GLYCOPROTEIN V; LIVE VACCINE; NUCLEOCAPSID PROTEIN; PORCILIS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERIVIRUS; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSPOT ASSAY; EVALUATION; EX VIVO STUDY; GENOTYPE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PREDICTION; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; UNINDEXED SEQUENCE;

ANIMALS; COMPUTATIONAL BIOLOGY; EPITOPES, T-LYMPHOCYTE; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; NUCLEOCAPSID PROTEINS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SWINE; VACCINES, ATTENUATED; VACCINES, DNA; VIRAL ENVELOPE PROTEINS;

EID: 68949166049     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.07.029     Document Type: Article

References (42)

1. Wensvoort G., Terpstra C., Pol J.M., ter Laak E.A., Bloemraad M., de Kluyver E.P., et al. Mystery swine disease in the Netherlands: the isolation of Lelystad virus. Vet Q 13 3 (1991) 121-130
2. Meulenberg J.J., Hulst M.M., de Meijer E.J., Moonen P.L., den Besten A., de Kluyver E.P., et al. Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus. Arch Virol Suppl 9 (1994) 441-448
3. Forsberg R., Storgaard T., Nielsen H.S., Oleksiewicz M.B., Cordioli P., Sala G., et al. The genetic diversity of European type PRRSV is similar to that of the North American type but is geographically skewed within Europe. Virology 299 1 (2002) 38-47
4. Stadejek T., Stankevicius A., Storgaard T., Oleksiewicz M.B., Belák S., Drew T.W., et al. Identification of radically different variants of porcine reproductive and respiratory syndrome virus in Eastern Europe: towards a common ancestor for European and American viruses. Gen Virol 83 Pt 8 (2002) 1861-1873
5. Larochelle R., D'Allaire S., and Magar R. Molecular epidemiology of porcine reproductive and respiratory syndrome virus (PRRSV) in Québec. Virus Res 96 1-2 (2003) 3-14
6. Mateu E., Martin M., and Vidal D. Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-type porcine reproductive and respiratory virus strains in Spain. J Gen Virol 84 Pt 3 (2003) 529-534
7. Stadejek T., Oleksiewicz M.B., Potapchuk D., and Podgórska K. Porcine reproductive and respiratory syndrome virus strains of exceptional diversity in Eastern Europe support the definition of new genetic subtypes. J Gen Virol 87 Pt 7 (2006) 1835-1841
8. Stadejek T., Oleksiewicz M.B., Scherbakov A.V., Timina A.M., Krabbe J.S., Chabros K., et al. Definition of subtypes in the European genotype of porcine reproductive and respiratory syndrome virus: nucleocapsid characteristics and geographical distribution in Europe. Arch Virol 153 8 (2008) 1479-1488
9. Meulenberg J.J., Petersen-den Besten A., de Kluyver E.P., Moormann R.J., Schaaper W.M., and Wensvoort G. Characterization of proteins encoded by ORFs 2 to 7 of Lelystad virus. Virology 206 (1995) 155-163
10. Meulenberg J.J., Petersen den Besten A., de Kluyver E., van Nieuwstadt A., Wensvoort G., and Moormann R.J. Molecular characterization of Lelystad virus. Vet Microbiol 55 1-4 (1997) 197-202
11. Snijder E.J., and Meulenberg J.J. The molecular biology of arteriviruses. J Gen Virol 79 Pt 5 (1998) 961-979
12. Wu W.H., Fang Y., Farwell R., Steffen-Bien M., Rowland R.R., Christopher-Hennings J., et al. A 10-kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF 2b. Virology 287 (2001) 183-191
13. López O.J., and Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Vet Immunol Immunopathol 102 3 (2004) 155-163
14. Vashisht K., Goldberg T.L., Husmann R.J., Schnitzlein W., and Zuckermann F.A. Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus. Vaccine 26 36 (2008) 4747-4753
15. De Groot A.S. Immunomics: discovering new targets for vaccine and therapeutics. Drug Discov Today 11 5-6 (2006) 203-209
16. Brusic V., Rudy G., Honeyman G., Hammer J., and Harrison L. Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network. Bioinformatics 14 2 (1998) 121-130
17. Mateu E., Díaz I., Darwich L., Casal J., Martín M., and Pujols J. Evolution of ORF5 of Spanish porcine reproductive and respiratory syndrome virus strains from 1991 to 2005. Virus Res 115 2 (2006) 198-206
18. Díaz I., Darwich L., Pappaterra G., Pujols J., and Mateu E. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. J Gen Virol 86 Pt 7 (2005) 1943-1951
19. Díaz I., Darwich L., Pappaterra G., Pujols J., and Mateu E. Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Virology 351 2 (2006) 249-259
20. van Nieuwstadt A.P., Meulenberg J.J., van Essen-Zanbergen A., Petersen-den Besten A., Bende R.J., Moormann R.J., et al. Proteins encoded by open reading frames 3 and 4 of the genome of Lelystad virus (Arteriviridae) are structural proteins of the virion. J Virol 70 7 (1996) 4767-4772
21. Ganges L., Barrera M., Núñez J.I., Blanco I., Frias M.T., Rodríguez F., et al. A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge. Vaccine 23 28 (2005) 3741-3752
22. Anthony D.D., and Lehmann P.V. T-cell epitope mapping using the ELISPOT approach. Methods 29 3 (2003) 260-269
23. Dean G.A., LaVoy A., and Burkhard M.J. Peptide mapping of feline immunodeficiency virus by IFN-gamma ELISPOT. Vet Immunol Immunopathol 1-2 (2004) 49-59
24. Lowe J.E., Husmann R., Firkins L.D., Zuckermann F.A., and Goldberg T.L. Correlation of cell-mediated immunity against porcine reproductive and respiratory syndrome virus with protection against reproductive failure in sows during outbreaks of porcine reproductive and respiratory syndrome in commercial herds. J Am Vet Med Assoc 226 10 (2005) 1707-1711
25. Zuckermann F.A., Garcia E.A., Luque I.D., Christopher-Hennings J., Doster A., Brito M., et al. Assessment of the efficacy of commercial porcine reproductive and respiratory syndrome virus (PRRSV) vaccines based on measurement of serologic response, frequency of gamma-IFN-producing cells and virological parameters of protection upon challenge. Vet Microbiol 123 1-3 (2007) 69-85
26. Zuckermann F.A., Martin S., Husmann R.J., and Brandt J. Use of interleukin 12 to enhance the cellular immune response of swine to an inactivated herpesvirus vaccine. Adv Vet Med 41 (1999) 447-461
27. Osorio F.A., Galeota J.A., Nelson E., Brodersen B., Doster A., Wills R., et al. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology 302 1 (2002) 9-20
28. Lopez O.J., Oliveira M.F., Garcia E.A., Kwon B.J., Doster A., and Osorio F.A. Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSV-neutralizing antibodies is dose dependent. Clin Vaccine Immunol 14 3 (2007) 269-275
29. Plagemann P.G. The primary GP5 neutralization epitope of North American isolates of porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 102 3 (2004) 263-275
30. Plagemann P.G. GP5 ectodomain epitope of porcine reproductive and respiratory syndrome virus, strain Lelystad virus. Virus Res 102 2 (2004) 225-230
31. Gonin P., Pirzadeh B., Gagnon C.A., and Dea S. Seroneutralization of porcine reproductive and respiratory syndrome virus correlates with antibody response to the GP5 major envelope glycoprotein. J Vet Diagn Invest 11 1 (1999) 20-26
32. Weiland E., Wieczorek-Krohmer M., Kohl D., Conzelmann K.K., and Weiland F. Monoclonal antibodies to the GP5 of porcine reproductive and respiratory syndrome virus are more effective in virus neutralization than monoclonal antibodies to the GP4. Vet Microbiol 66 3 (1999) 171-186
33. Yang L., Frey M.L., Yoon K.J., Zimmerman J.J., and Platt K.B. Categorization of North American porcine reproductive and respiratory syndrome viruses: epitopic profiles of the N, M, GP5 and GP3 proteins and susceptibility to neutralization. Arch Virol 145 8 (2000) 1599-1619
34. Cancel-Tirado S.M., Evans R.B., and Yoon K.J. Monoclonal antibody analysis of porcine reproductive and respiratory syndrome virus epitopes associated with antibody-dependent enhancement and neutralization of virus infection. Vet Immunol Immunopathol 102 3 (2004) 249-262
35. De Groot A.S., Bosma A., Chinai N., Frost J., Jesdale B.M., Gonzalez M.A., et al. From genome to vaccine: in silico predictions, ex vivo verification. Vaccine 19 31 (2001) 4385-4395
36. Martin W., Sbai H., and De Groot A.S. Bioinformatics tools for identifying class I-restricted epitopes. Methods 29 3 (2003) 289-298
37. Xue Q., Zhao Y.G., Zhou Y.J., Qiu H.J., Wang Y.F., Wu D.L., et al. Immune responses of swine following DNA immunization with plasmids encoding porcine reproductive and respiratory syndrome virus ORFs 5 and 7, and porcine IL-2 and IFNgamma. Vet Immunol Immunopathol 102 3 (2004) 291-298
38. Rompato G., Ling E., Chen Z., Van Kruiningen H., and Garmendia A.E. Positive inductive effect of IL-2 on virus-specific cellular responses elicited by a PRRSV-ORF7 DNA vaccine in swine. Vet Immunol Immunopathol 109 1-2 (2006) 151-160
39. Rammensee H.G. Chemistry of peptides associated with MHC class I and II molecules. Curr Opin Immunol 7 1 (1995) 85-86
40. Elliott M.B., Irwin D.M., and Diamandis E.P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88 5 (2006) 591-599
41. Oldfield N.J., Donovan E.A., Worrall K.E., Wooldridge K.G., Langford P.R., Rycroft A.N., et al. Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Vaccine 26 16 (2008) 1942-1954
42. Song Y., La T., Phillips N.D., Bellgard M.I., and Hampson D.J. A reverse vaccinology approach to swine dysentery vaccine development. Vet Microbiol (2008) [Epub ahead of print]