Phenotypic differences between two Gnmt-/- mouse models for hepatocellular carcinoma

Hepatology

Volumn 49, Issue 6, 2009, Pages 2130-2131

  Chen, Yi Ming Arthur ^a   Liao, Yi Jen ^a   Liu, Shih Ping ^b   Tsai, Ting Fen ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DINUCLEOTIDE; GLYCINE METHYLTRANSFERASE; GUANOSINE;

ANIMAL MODEL; CANCER SUSCEPTIBILITY; CAPILLARY ELECTROPHORESIS; CARCINOGENESIS; CHRONIC HEPATITIS; DNA METHYLATION; ENZYME IMMUNOASSAY; EXPERIMENTAL MODEL; GLYCOGEN STORAGE DISEASE; KNOCKOUT MOUSE; LETTER; LIVER CANCER; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DISEASE MODELS, ANIMAL; GLYCINE N-METHYLTRANSFERASE; LIVER NEOPLASMS; MICE; PHENOTYPE;

EID: 68949144726     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22984     Document Type: Letter

References (10)

1. Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martinez N, Varela M, Luka Z, et al. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. HEPATOLOGY 2008;47:1191-1199.
2. Chen YM, Shiu JY, Tzeng SJ, Shih LS, Chen YJ, Lui WY, et al. Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. Int J Cancer 1998;75:787-793.
3. Tseng TL, Shih YP, Huang YC, Wang CK, Chen PH, Chang JG, et al. Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. Cancer Res 2003;63:647-654.
4. Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, et al. Glycine Nmethyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology 2007;46:1413-1425.
5. Chen YM, Liu SP. Glycine-N-methyltransferase (GNMT) animal model and use thereof. Patent application number: 11/832,304. Filing date: 08-01-2007. Link:hTtp://portal.uspto.gov/external/portal/pair
6. Liao YJ, Liu SP, Lee CM, Yen CH, Chuang PC, Chen CY, et al. Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. Int J Cancer 2009;124:816-826.
7. Calvisi DF, Ladu S, Gorden A, Farina M, Lee JS, Conner EA, et al. Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest 2007;117:2713-2722.
8. Luka Z, Capdevila A, Mato JM, Wagner C. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res 2006;15:393-397.
9. Fu Z, Hu Y, Konishi K, Takata Y, Ogawa H, Gomi T, et al. Crystal structure of glycine N-methyltransferase from rat liver. Biochemistry 1996;35:11985-11993.
10. Luka Z, Ham AJ, Norris JL, Yeo EJ, Yermalitsky V, Glenn B, et al. Identification of phosphorylation sites in glycine N-methyltransferase from rat liver. Protein Sci 2006;15:785-794.