Wortmannin inhibits K562 lukemic cells by regulating PI3k/Akt channel in vitro

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 29, Issue 4, 2009, Pages 451-456

  Wu, Qing ^a   Chen, Yan ^a   Cui, Guohui ^a   Cheng, Yiquan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

IKK B; K562 cell; NF B; P AKT; Wortmannin

Indexed keywords

ANDROSTANE DERIVATIVE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RELA PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL STRAIN K 562; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; SIGNAL TRANSDUCTION;

ANDROSTADIENES; APOPTOSIS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; K562 CELLS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 68949132404     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-009-0412-x     Document Type: Article

References (25)

1. B.B. Olsen M. Bjørling-Poulsen B. Guerra 2007 Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action Int J Biochem Cell Biol 39 1 227 237
2. M. Rudelius S. Pittaluga S. Nishizuka 2006 Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma Blood 108 5 1668 1676
3. G.C. Fillmore Q. Wang M.J. Carey 2005 Expression of Akt (protein kinase B) and its isoforms in malignant lymphomas Leuk Lymphoma 46 12 1765 1773
4. M. Priulla A. Calastretti P. Bruno 2007 Preferential chemosensitization of PTEN-mutated prostate cells by silencing the Akt kinase Prostate 67 7 782 789
5. A.M. Martelli M. Nyåkern G. Tabellini 2006 Phosphoinositide 3-kinase/Akt signaling pathway and its theraeutical implications for human acute myeloid leukemia Leukemia 20 6 91 98
6. J.M. Tang Q.Y. He R.X. Guo 2006 Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis Lung Cancer 51 2 181 191
7. P. George P. Bali S. Annavarapu 2005 Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3 Blood 105 4 1768 1776
8. Y. Liao R. Grobholz U. Abel 2003 Increase of Akt/PKB expression correlates with gleason pattern in human prostate cancer Int J Cancer 107 4 676 680
9. J. Hsu Y. Shi S. Krajewski 2001 The Akt kinase is activated in multiple myeloma tumor cells Blood 98 9 2853 2855
10. K. Nakanishi M. Sakamoto S. Yamasaki 2005 Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma Cancer 103 2 307 312
11. P. Wipf R.J. Halter 2005 Chemistry and biology of wortmannin Org Biomol Chem 3 11 2053 2061
12. C. Wu J. Huang 2007 Phosphatidylinositol 3-kinase/AKT mammalian target of rapamycin pathway is essential for neuroendocrine diferentiation of prostate cancer J Biol Chem 282 6 3571 3583
13. X.L. Huang G.H. Cui K.Y. Zhou 2008 Correlation of PI3K-Akt signal pathway to apoptosis of tumor cells Chin J Cancer (Chinese) 27 3 331 336
14. V.L. Grandage R.E. Gale D.C. Linch 2005 PI3-kinase/Akt is constitutively active in primary acute myeloid leukemia cells and regulates survival and chemoresistance via NF-κB, MAP kinase and p53 pathways Leukemia 19 4 586 594
15. C. Zhang N. Yang X.W. Zhang 2006 Advances in kinase inhibitors targeting PI3K/Akt-mTOR signal transduction pathway Chin Oncol (Chinese) 16 12 1064 1070
16. Q. Xu S.E. Simpson T.J. Scialla 2003 Survival of acute myeloid leukemia cells requires PI3 kinase activation Blood 102 3 972 980
17. S.D. Westfll M.K. Skinner 2005 Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment Mol Cancer Ther 4 11 1764 1771
18. A. Panwalkar S. Verstovsek F.J. Giles 2004 Mammalian target of rapamyein inhibition as therapy for hematologic malignancies Cancer 100 4 657 666
19. X. Xie Q. Gao Y.L. Wang 2008 Inhibition of PI3 K/PKB signal pathway improves chemotherapeutic effect on gastric carcinoma cell lines Chin Pharmacol Bull (Chinese) 24 12 1666 1670
20. M. Karin Y. Cao F. R. Greten 2002 NF-kappaB in cancer: from innocent bystander to major culprit Nat Rev Cancer 2 4 301 310
21. A.S. Baldwin 2001 Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB J Clin Invest 107 3 241 246
22. B. Kaltschmidt C. Kaltschmidt T.G. Hofmann 2000 The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus Eur J Biochem 267 12 3828 3835
23. A.C. Bharti B.B. Aggarwal 2002 Nuclear factor-kappa B and cancer: its role in prevention and therapy Biochem Pharmacol 64 5-6 883 888
24. T.W. Poh S. Pervaiz 2005 LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway Cancer Res 65 14 6264 6274
25. T. Ohta M. Ohnfiehi T. Hayasaka 2006 Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in vivo ovarian cancer models Endocrinology 147 4 1761 1769