Merkel cells as putative regulatory cells in skin disorders: An in vitro study

PLoS ONE

Volumn 4, Issue 8, 2009, Pages

  Boulais, Nicholas ^a,c   Pereira, Ulysse ^a   Lebonvallet, Nicolas ^a   Gobin, Eric ^b   Dorange, Germaine ^a   Rougier, Nathalie ^c   Chesne, Christophe ^c   Misery, Laurent ^a,b  

^a UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^b BREST UNIVERSITY HOSPITAL   (France)

^c Biopredic International   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; HISTAMINE; KERATINOCYTE GROWTH FACTOR; KI 67 ANTIGEN; NEUROPEPTIDE; NEUROTROPHIN; VANILLOID RECEPTOR 4; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACIDIFICATION; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL SPREADING; CELL SURVIVAL; CELL SWELLING; CONTROLLED STUDY; EXOCYTOSIS; IMMUNOREACTIVITY; IN VITRO STUDY; MECHANOTRANSDUCTION; MERKEL CELL; NEUROSECRETORY CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; OSMORECEPTOR; SKIN DISEASE; ANIMAL; BIOSYNTHESIS; CALCIUM SIGNALING; CELL CULTURE; METABOLISM; PATHOLOGY; SKIN; SWINE;

SUIDAE;

ANIMALS; CALCIUM SIGNALING; CELL PROLIFERATION; CELLS, CULTURED; SKIN; SKIN DISEASES; SWINE; VASOACTIVE INTESTINAL PEPTIDE;

EID: 68949126784     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006528     Document Type: Article

References (59)

1. Moll I, Roessler M, Brandner JM, Eispert AC, Houdek P, et al. (2005) Human Merkel cells-aspects of cell biology, distribution and functions. Eur J Cell Biol 84: 259-271.
2. Halata Z, Grim M, Bauman KI (2003) Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol 271: 225-239.
3. Boulais N, Misery L (2007) Merkel cells. J Am Acad Dermatol 57: 147-165.
4. Ogawa H (1996) The Merkel cell as a possible mechanoreceptor cell. Prog Neurobiol 49: 317-334.
5. Yamashita Y, Akaike N, Wakamori M, Ikeda I, Ogawa H (1992) Voltage-dependent currents in isolated single Merkel cells of rats. J Physiol 450: 143-162.
6. Haeberle H, Fujiwara M, Chuang J, Medina MM, Panditrao MV, et al. (2004) Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A 101: 14503-14508.
7. Shimohira-Yamasaki M, Toda S, Narisawa Y, Sugihara H (2006) Merkel cell-nerve cell interaction undergoes formation of a synapse-like structure in a primary culture. Cell Struct Funct 31: 39-45.
8. Chateau Y, Dorange G, Clement JF, Pennec JP, Gobin E, et al. (2007) In vitro reconstruction of neuro-epidermal connections. J Invest Dermatol 127: 979-981.
9. Senok SS, Baumann KI (1997) Functional evidence for calcium-induced calcium release in isolated rat vibrissal Merkel cell mechanoreceptors. J Physiol 500 (Pt 1): 29-37.
10. Piskorowski R, Haeberle H, Panditrao MV, Lumpkin EA (2008) Voltage-activated ion channels and Ca(2+)-induced Ca (2+) release shape Ca (2+) signaling in Merkel cells. Pflugers Arch.
11. Haeberle H, Bryan LA, Vadakkan TJ, Dickinson ME, Lumpkin EA (2008) Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. PLoS ONE 3: e1750.
12. Hartschuh W, Weihe E, Yanaihara N (1989) Immunohistochemical analysis of chromogranin A and multiple peptides in the mammalian Merkel cell: further evidence for its paraneuronal function? Arch Histol Cytol 52 Suppl: 423-431.
13. Gaudillere A, Misery L (1994) Merkel cell. Ann Dermatol Venereol 121: 909-917.
14. Narisawa Y, Hashimoto K, Kohda H (1994) Merkel cells of the terminal hair follicle of the adult human scalp. J Invest Dermatol 102: 506-510.
15. Tachibana T, Yamamoto H, Takahashi N, Kamegai T, Shibanai S, et al. (1997) Polymorphism of Merkel cells in the rodent palatine mucosa: immunohistochemical and ultrastructural studies. Arch Histol Cytol 60: 379-389.
16. Tachibana T (1995) The Merkel cell: recent findings and unresolved problems. Arch Histol Cytol 58: 379-396.
17. Moll I, Paus R, Moll R (1996) Merkel cells in mouse skin: intermediate filament pattern, localization, and hair cycle-dependent density. J Invest Dermatol 106: 281-286.
18. Fradette J, Larouche D, Fugere C, Guignard R, Beauparlant A, et al. (2003) Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites. J Invest Dermatol 120: 313-317.
19. Kim DK, Holbrook KA (2001) The nerve-dependency of Merkel cell proliferation in cultured human fetal glabrous skin. Yonsei Med J 42: 311-315.
20. Vaigot P, Pisani A, Darmon YM, Ortonne JP (1987) The majority of epidermal Merkel cells are non-proliferative: a quantitative immunofluorescence analysis. Acta Derm Venereol 67: 517-520.
21. Merot Y, Saurat JH (1988) Proliferation of Merkel cells in the skin. Acta Derm Venereol 68: 366-367.
22. Moll I, Zieger W, Schmelz M (1996) Proliferative Merkel cells were not detected in human skin. Arch Dermatol Res 288: 184-187.
23. Tachibana T, Fujiwara N, Nawa T (2000) Postnatal differentiation of Merkel cells in the rat palatine mucosa, with special reference to the timing of peripheral nerve development and the potency of cell mitosis. Anat Embryol (Berl) 202: 359-367.
24. Tachibana T, Kamegai T, Takahashi N, Nawa T (1998) Evidence for polymorphism of Merkel cells in the adult human oral mucosa. Arch Histol Cytol 61: 115-124.
25. Merot Y, Mooy A (1989) Merkel cell hyperplasia in hypertrophic varieties of actinic keratoses. Dermatologica 178: 189-193.
26. Regazzini R, De Filippi C (1995) Merkel cell hyperplasia in circumscribed neurodermatitis: a quantitative study. Eur J Dermatol 5: 326-329.
27. Kanitakis J, Bourchany D, Faure M, Claudy A (1998) Merkel Cells in Hyperplastic and Neoplastic Lesions of the Skin. Dermatology 196: 208-212.
28. Hartschuh W, Reinecke M, Weihe E, Yanaihara N (1984) VIP-immunoreactivity in the skin of various mammals: immunohistochemical, radioimmunological and experimental evidence for a dual localization in cutaneous nerves and merkel cells. Peptides 5: 239-245.
29. Boulais N, Misery L (2008) The epidermis: a sensory tissue. Eur J Dermatol 18: 119-127.
30. Granoth R, Fridkin M, Gozes I (2000) VIP and the potent analog, stearyl-Nle(17)-VIP, induce proliferation of keratinocytes. FEBS Lett 475: 78-83.
31. Kulka M, Sheen CH, Tancowny BP, Grammer LC, Schleimer RP (2008) Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 123: 398-410.
32. Dallos A, Kiss M, Polyanka H, Dobozy A, Kemeny L, et al. (2006) Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides.
33. Kakurai M, Fujita N, Murata S, Furukawa Y, Demitsu T, et al. (2001) Vasoactive intestinal peptide regulates its receptor expression and functions of human keratinocytes via type I vasoactive intestinal peptide receptors. J Invest Dermatol 116: 743-749.
34. Fernandez-Martin A, Gonzalez-Rey E, Chorny A, Martin J, Pozo D, et al. (2006) VIP prevents experimental multiple sclerosis by downregulating both inflammatory and autoimmune components of the disease. Ann N Y Acad Sci 1070: 276-281.
35. Delgado M, Munoz-Elias EJ, Gomariz RP, Ganea D (1999) Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kappa B and IFN regulatory factor 1 activation. J Immunol 162: 4685-4696.
36. Reich A, Szepietowski JC (2008) Vasoactive peptides in the pathogenesis of psoriasis. G Ital Dermatol Venereol 143: 289-298.
37. Fantini F, Pincelli C, Romualdi P, Donatini A, Giannetti A (1992) Substance P levels are decreased in lesional skin of atopic dermatitis. Exp Dermatol 1: 127-128.
38. Misery L, Meyronet D, Pichon M, Brutin JL, Pestre P, et al. (2003) [Aquadynia: a role for VIP?]. Ann Dermatol Venereol 130: 195-198.
39. Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, et al. (2003) Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns 3: 389-395.
40. Gallego R, Garcia-Caballero T, Fraga M, Beiras A, Forteza J (1995) Neural cell adhesion molecule immunoreactivity in Merkel cells and Merkel cell tumours. Virchows Arch 426: 317-321.
41. McNiff JM, Cowper SE, Lazova R, Subtil A, Glusac EJ (2005) CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both? J Cutan Pathol 32: 541-545.
42. Eispert AC, Fuchs F, Brandner JM, Houdek P, Wladykowski E, et al. (2009) Evidence for distinct populations of human Merkel cells. Histochem Cell Biol.
43. Cheng Chew SB, Leung PY (1994) Ultrastructural study of the Merkel cell and its expression of met-enkephalin immunoreactivity during fetal and postnatal development in mice. J Anat 185 (Pt 3): 511-520.
44. Szeder V, Grim M, Halata Z, Sieber-Blum M (2003) Neural crest origin of mammalian Merkel cells. Dev Biol 253: 258-263.
45. Hartschuh W, Weihe E, Yanaihara N, Reinecke M (1983) Immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in Merkel cells of various mammals: evidence for a neuromodulator function of the Merkel cell. J Invest Dermatol 81: 361-364.
46. Cannon KE, Chazot PL, Hann V, Shenton F, Hough LB, et al. (2007) Immunohistochemical localization of histamine H(3) receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: Potential antinociceptive targets. Pain 129: 76-92.
47. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, et al. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-535.
48. Brosius DC, Hackett JT, Tuttle JB (1992) Ca(2+)-independent and Ca(2+)-dependent stimulation of quantal neurosecretion in avian ciliary ganglion neurons. J Neurophysiol 68: 1229-1234.
49. Seino S, Shibasaki T (2005) PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev 85: 1303-1342.
50. Bartfai T, Iverfeldt K, Fisone G, Serfozo P (1988) Regulation of the release of coexisting neurotransmitters. Annu Rev Pharmacol Toxicol 28: 285-310.
51. Vos P, Stark F, Pittman RN (1991) Merkel cells in vitro: production of nerve growth factor and selective interactions with sensory neurons. Dev Biol 144: 281-300.
52. Ichikawa H, Matsuo S, Silos-Santiago I, Jacquin MF, Sugimoto T (2001) Developmental dependency of Merkel endings on trks in the palate. Brain Res Mol Brain Res 88: 171-175.
53. Fundin BT, Silos-Santiago I, Ernfors P, Fagan AM, Aldskogius H, et al. (1997) Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Dev Biol 190: 94-116.
54. Szeder V, Grim M, Kucera J, Sieber-Blum M (2003) Neurotrophin-3 signaling in mammalian Merkel cell development. Dev Dyn 228: 623-629.
55. Krimm RF, Davis BM, Woodbury CJ, Albers KM (2004) NT3 expressed in skin causes enhancement of SA1 sensory neurons that leads to postnatal enhancement of Merkel cells. J Comp Neurol 471: 352-360.
56. Botchkarev VA, Kief S, Paus R, Moll I (1999) Overexpression of brain-derived neurotrophic factor increases Merkel cell number in murine skin. J Invest Dermatol 113: 691-692.
57. Feng H, Shuda M, Chang Y, Moore PS (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319: 1096-1100.
58. Gottschaldt KM, Vahle-Hinz C (1982) Evidence against transmitter function of met-enkephalin and chemosynaptic impulse generation in "Merkel cell" mechanoreceptors. Exp Brain Res 45: 459-463.
59. Cahusac PM, Senok SS (2006) Metabotropic glutamate receptor antagonists selectively enhance responses of slowly adapting type I mechanoreceptors. Synapse 59: 235-242.