Role of lactate in lipid metabolism, just always inhibiting lipolysis?

Journal of Biological Chemistry

Volumn 284, Issue 31, 2009, Pages

  Xu, Hai Jun ^a  

^a WEST ANHUI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 81; GLUCOSE; GLYCEROL; LACTIC ACID; LIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANAEROBIC GLYCOLYSIS; BIOACCUMULATION; ENERGY METABOLISM; FATTY ACID OXIDATION; HYPOGLYCEMIA; LETTER; LIPID HYDROLYSIS; LIPID METABOLISM; LIPOLYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; HUMANS; LACTIC ACID; LIPOLYSIS; MICE; MUSCLE, SKELETAL; OXIDATION-REDUCTION; RATS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 68949125412     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.L806409200     Document Type: Letter

References (4)

1. Liu, C., Wu, J., Zhu, J., Kuei, C., Yu, J., Shelton, J., Sutton, S.W., Li, X., Yun, S. J., Mirzadegan, T., Mazur, C., Kamme, F., and Lovenberg, T. W (2009) Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. J. Biol. Chem. 284, 2811-2822
2. Prentki, M, and Madiraju, S. R. M. (2008) Glycerolipid metabolism and signaling in health and disease. Endocr. Rev. 29, 647-676
3. Dulloo, A. G., Gubler, M., Montani, J. P., Seydoux, J., and Solinas, G. (2004) Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity. Int. J. Obes. 28, 529-537
4. Hagström-Toft, E., Enoksson, S., Moberg. E., Bolinder, J., and Arner, P. (1997) Absolute concentrations of glycerol and lactate in human skeletal muscle, adipose tissue, and blood. Am. J. Physiol. 273, E584-E592