Analysis of EGFR gene amplification, protein over-expression and tyrosine kinase domain mutation in recurrent glioblastoma

Pathology and Oncology Research

Volumn 15, Issue 2, 2009, Pages 225-229

  Toth, Judit ^a   Egervari, Kristof ^a   Klekner, Almos ^a   Bognar, Laszlo ^a   Szanto, Janos ^a   Nemes, Zoltan ^a   Szollosi, Zoltan ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

EGFR; Glioblastoma multiforme; Kinase inhibitor treatment

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN TYROSINE KINASE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR VIII; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, HUMAN;

ARTICLE; CLINICAL ARTICLE; GENE AMPLIFICATION; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECURRENT CANCER; BRAIN TUMOR; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; METABOLISM; MUTATION; PROGNOSIS; TUMOR RECURRENCE;

BRAIN NEOPLASMS; GENE AMPLIFICATION; GLIOBLASTOMA; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MUTATION; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 68949110285     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9082-4     Document Type: Article

References (16)

1. JM Bruner 1994 Neuropathology of malignant gliomas Semin Oncol 21 2 126 138 8153659 1:STN:280:DyaK2c3gsVKktQ%3D%3D
2. MR Gilbert M Loghin 2005 The treatment of malignant gliomas Curr Treat Options Neurol 7 4 293 303 15967092 10.1007/s11940-005-0039-6
3. JN Rich C Hans B Jones, et al. 2005 Gene expression profiling and genetic markers in glioblastoma survival Cancer Res. 65 10 4051 4058 15899794 10.1158/0008-5472.CAN-04-3936 1:CAS:528:DC%2BD2MXktlSmsLY%3D (Pubitemid 40775641)
4. RI Nicholson JM Gee ME Harper 2001 EGFR and cancer prognosis Eur J Cancer 37 suppl 4 S9 S15 11597399 10.1016/S0959-8049(01)00231-3 1:CAS:528: DC%2BD3MXntlOku7w%3D
5. TJ Lynch DW Bell R Sordella, et al. 2004 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2129 2139 15118073 10.1056/NEJMoa040938 1:CAS:528:DC%2BD2cXktF2js7c%3D (Pubitemid 38637993)
6. JG Paez PA Janne JC Lee, et al. 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500 15118125 10.1126/science.1099314 1:CAS:528:DC%2BD2cXksVGmsbs%3D (Pubitemid 38720929)
7. N Nathoo S Goldlust MA Vogelbaum 2004 Epidermal growth factor receptor antagonists: novel therapy for the treatment of high-grade gliomas Neurosurgery 54 1480 1488 15157306 10.1227/01.NEU.0000125006.88478.F6
8. TD Barber B Vogelstein KW Kinzler, et al. 2004 Somatic mutations of EGFR in colorectal cancers and glioblastomas N Engl J Med 351 2883 2883 15625347 10.1056/NEJM200412303512724 1:CAS:528:DC%2BD2MXhsl2isg%3D%3D (Pubitemid 40051921)
9. MG Kris RB Natale RS Herbst, et al. 2003 Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial JAMA 290 2149 2158 14570950 10.1001/jama.290.16.2149 1:CAS:528:DC%2BD3sXosVOnsbo%3D (Pubitemid 37432975)
10. M Fukuoka S Yano G Giaccone, et al. 2003 Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) J Clin Oncol 21 2237 2246 12748244 10.1200/JCO.2003.10.038 1:CAS:528:DC%2BD2cXpsVGqu7w%3D (Pubitemid 46621858)
11. IK Mellinghoff MY Wang I Vivanco, et al. 2005 Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors N Engl J Med 353 2012 2024 16282176 10.1056/NEJMoa051918 1:CAS:528:DC%2BD2MXht1SrtrrE (Pubitemid 41609094)
12. JN Rich DA Reardon T Peery, et al. 2004 Phase II trial of gefitinib in recurrent glioblastoma J Clin Oncol 22 133 142 14638850 10.1200/JCO.2004.08.110 1:CAS:528:DC%2BD2cXpsVKhsr8%3D (Pubitemid 41095125)
13. B Li CM Chang M Yuan, et al. 2003 Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas Cancer Res 63 7443 7450 14612544 1:CAS:528:DC%2BD3sXovVGltb8%3D
14. JN Rich BK Rasheed H Yan 2004 EGFR mutations and sensitivity to gefitinib N Engl J Med 351 1260 1261 15376352 10.1056/NEJM200409163511221 1:CAS:528:DC%2BD2cXnslSjtrw%3D (Pubitemid 39296317)
15. KD Aldape K Ballman A Furth, et al. 2004 Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance J Neuropathol Exp Neurol 63 700 707 15290895 1:CAS:528: DC%2BD2cXmtFGhu7g%3D
16. T De Pas P Pelosi F de Braud, et al. 2004 Modulation of epidermal growth factor receptor status by chemotherapy in patients with locally advanced non-small-cell lung cancer is rare J Clin Oncol 22 4966 4970 15611511 10.1200/JCO.2004.01.195 (Pubitemid 46638622)