Dexamethasone and mifepristone increase retroviral infectivity through different mechanisms

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 297, Issue 3, 2009, Pages

  Solodushko, Victor ^a   Bitko, Vira ^a   Fouty, Brian ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Gene delivery; Pulmonary artery endothelium; Retroviruses

Indexed keywords

DEXAMETHASONE; GREEN FLUORESCENT PROTEIN; MIFEPRISTONE; RETROVIRUS VECTOR; STEROID HORMONE; VIRUS RNA;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL VIABILITY; CHEMOSENSITIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; EXPRESSION VECTOR; LUNG BLOOD VESSEL; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTIVITY; VIRUS PARTICLE; VIRUS TITRATION;

ANIMALS; CULTURE MEDIA, CONDITIONED; DEXAMETHASONE; ENDOTHELIAL CELLS; GENE TRANSFER TECHNIQUES; HORMONES; MIFEPRISTONE; PROMOTER REGIONS, GENETIC; RATS; RECEPTORS, GLUCOCORTICOID; RETROVIRIDAE; SERUM; SUBCELLULAR FRACTIONS; TERMINAL REPEAT SEQUENCES; VIRAL PROTEINS;

EID: 68949101949     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00162.2009     Document Type: Article

References (27)

1. Akahane M, Kuriyama S, Ohgushi H, Akahane T, Kawamura K, Watanabe S, Funakoshi F, Yoshiji H, Ikenaka K, Takakura Y. Enhancing and suppressing effects of dexamethasone on transgene expression in vitro. Int J Mol Med 10: 107-112, 2002.
2. Barquinero J, Eixarch H, Perez-Melgosa M. Retroviral vectors: new applications for an old tool. Gene Ther 11, Suppl 1: S3-S9, 2004.
3. Beato M, Chalepakis G, Schauer M, Slater EP. DNA regulatory elements for steroid hormones. J Steroid Biochem 32: 737-747, 1989.
4. Bourgeois S, Pfahl M, Baulieu EE. DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486. EMBO J 3: 751-755, 1984.
5. Bruland T, Lavik LA, Dai HY, Dalen A. A glucocorticoid response element in the LTR U3 region of Friend murine leukaemia virus variant FIS-2 enhances virus production in vitro and is a major determinant for sex differences in susceptibility to FIS-2 infection in vivo. J Gen Virol 84: 907-916, 2003.
6. Cato AC, Miksicek R, Schutz G, Arnemann J, Beato M. The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J 5: 2237-2240, 1986.
7. Celander D, Hsu BL, Haseltine WA. Regulatory elements within the murine leukemia virus enhancer regions mediate glucocorticoid responsiveness. J Virol 62: 1314-1322, 1988.
8. Coezy E, Bouhnik J, Clauser E, Pinet F, Philippe M, Menard J, Corvol P. Effects of glucocorticoids and antiglucocorticoid on angiotensinogen production by hepatoma cells in culture. In Vitro 20: 528-534, 1984.
9. Darbre P, Page M, King RJ. Androgen regulation by the long terminal repeat of mouse mammary tumor virus. Mol Cell Biol 6: 2847-2854, 1986.
10. DeFranco D, Yamamoto KR. Two different factors act separately or together to specify functionally distinct activities at a single transcriptional enhancer. Mol Cell Biol 6: 993-1001, 1986.
11. Duch M, Paludan K, Lovmand J, Pedersen L, Jorgensen P, Pedersen FS. A correlation between dexamethasone inducibility and basal expression levels of retroviral vector proviruses. Nucleic Acids Res 21: 4777-4782, 1993.
12. Golemis EA, Speck NA, Hopkins N. Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design. J Virol 64: 534-542, 1990.
13. Hu WS, Pathak VK. Design of retroviral vectors and helper cells for gene therapy. Pharmacol Rev 52: 493-511, 2000.
14. Jaalouk DE, Eliopoulos N, Couture C, Mader S, Galipeau J. Glucocorticoid-inducible retrovector for regulated transgene expression in genetically engineered bone marrow stromal cells. Hum Gene Ther 11: 1837-1849, 2000.
15. Kolesnitchenko V, Snart RS. Regulatory elements in the human immunodeficiency virus type 1 long terminal repeat LTR (HIV-1) responsive to steroid hormone stimulation. AIDS Res Hum Retroviruses 8: 1977-1980, 1992.
16. Lundstrom K. Gene therapy applications of viral vectors. Technol Cancer Res Treat 3: 467-477, 2004.
17. Miksicek R, Heber A, Schmid W, Danesch U, Posseckert G, Beato M, Schutz G. Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus. Cell 46: 283-290, 1986.
18. Mitra D, Sikder SK, Laurence J. Role of glucocorticoid receptor binding sites in the human immunodeficiency virus type 1 long terminal repeat in steroid-mediated suppression of HIV gene expression. Virology 214: 512-521, 1995.
19. Niermann GL, Buehring GC. Hormone regulation of bovine leukemia virus via the long terminal repeat. Virology 239: 249-258, 1997.
20. Otten AD, Sanders MM, McKnight GS. The MMTV LTR promoter is induced by progesterone and dihydrotestosterone but not by estrogen. Mol Endocrinol 2: 143-147, 1988.
21. Roe T, Reynolds TC, Yu G, Brown PO. Integration of murine leukemia virus DNA depends on mitosis. EMBO J 12: 2099-2108, 1993.
22. Russo FO, Patel PC, Ventura AM, Pereira CA. HIV-1 long terminal repeat modulation by glucocorticoids in monocytic and lymphocytic cell lines. Virus Res 64: 87-94, 1999.
23. Schafer EA, Venkatachari NJ, Ayyavoo V. Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR). Antiviral Res 72: 224-232, 2006.
24. Schule R, Muller M, Kaltschmidt C, Renkawitz R. Many transcription factors interact synergistically with steroid receptors. Science 242: 1418-1420, 1988.
25. Soudeyns H, Geleziunas R, Shyamala G, Hiscott J, Wainberg MA. Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1. Virology 194: 758-768, 1993.
26. Soudeyns H, Wainberg MA. Effects of RU486 on HIV-1 replication. Nat Med 3: 1302-1303, 1997.
27. Warnock JN, Merten OW, Al-Rubeai M. Cell culture processes for the production of viral vectors for gene therapy purposes. Cytotechnology 50: 141-162, 2006.