Immunoglobulin gm genes as functional risk and protective factors for the development of alzheimers disease

Journal of Alzheimer's Disease

Volumn 17, Issue 4, 2009, Pages 753-756

  Pandey, Janardan P ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antibody dependent cellular cytotoxicity; Fc receptor; GM allotypes; Herpes simplex virus type 1; Immune evasion

Indexed keywords

ALZHEIMER DISEASE VACCINE; FC RECEPTOR; HERPES SIMPLEX VIRUS 1 ANTIBODY; IMMUNOGLOBULIN ALLOTYPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ALZHEIMER DISEASE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; CHROMOSOME 14; COMPLEMENT DEPENDENT CYTOTOXICITY; GENE LOCATION; GENE LOCUS; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; GENETIC RISK; GENOME; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; VACCINATION; VIRUS PATHOGENESIS; AGED; GENETIC ASSOCIATION; GENETICS; IMMUNOLOGY; RISK FACTOR; VERY ELDERLY; VIROLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CHROMOSOMES, HUMAN, PAIR 14; GENETIC LINKAGE; GENOME-WIDE ASSOCIATION STUDY; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOGLOBULIN GM ALLOTYPES; IMMUNOGLOBULIN HEAVY CHAINS; RISK FACTORS;

EID: 68949100346     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2009-1094     Document Type: Review

References (27)

1. Bertram L, Tanzi RE (2008) Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 9, 768-778.
2. Virus clue to cause of Alzheimer's, The Times (London), http: //www.timesonline.co.uk/tol/news/uk/health/article5295794. ece. Posted 6 December 2008, Accessed January 16, 2009.
3. Itzhaki RF, Wozniak MA (2008) Herpes simplex virus type 1 in Alzheimer's disease: the enemy within. J Alzheimers Dis 13, 393-405.
4. Wozniak M, Mee A, Itzhaki R (2009) Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques. J Pathol 217, 131-138.
5. Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB (2007) Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci Lett 429, 95-100.
6. Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL (2000) Viral subversion of the immune system. Annu Rev Immunol 18, 861-926.
7. Chu CF, Meador MG, Young CG, Strasser JE, Bourne N, Milligan GN (2008) Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms. J Reprod Immunol 78, 58-67.
8. Hessell AJ, Hangartner L, Hunter M, Havenith CE, Beurskens FJ, Bakker JM, Lanigan CM, Landucci G, Forthal DN, Parren PW, Marx PA, Burton DR (2007) Fc receptor but not complement binding is important in antibody protection against HIV. Nature 449, 101-104.
9. Frank I, Friedman HM (1989) A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G. J Virol 63, 4479-4488.
10. Dubin G, Socolof E, Frank I, Friedman HM (1991) Herpes simplex virus type 1 Fc receptor protects infected cells from antibody-dependent cellular cytotoxicity. J Virol 65, 7046-7050.
11. Sprague ER, Wang C, Baker D, Bjorkman PJ (2006) Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging. PLoS Biol 4, e148.
12. Grubb R (1995) Advances in human immunoglobulin allotypes. Exp Clin Immunogenet 12, 191-197.
13. Dard P, Lefranc MP, Osipova L, Sanchez-Mazas A (2001) DNA sequence variability of IGHG3 alleles associated to the main G3m haplotypes in human populations. EurJ Hum Genet 9, 765-772.
14. Pandey JP (2007) Genetics of immunoglobulins. In Medical Immunology, Virella G, editor. Marcel Dekker Inc., New York, Sixth Edition, pp. 73-81.
15. Lederberg J(1999) J.B.S. Haldane (1949) on infectious disease and evolution. Genetics 153, 1-3.
16. Atherton A,Armour KL, Bell S,Minson AC, Clark MR (2000) The herpes simplex virus type 1 Fc receptor discriminates between IgG1 allotypes. Eur J Immunol 30, 2540-2547.
17. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE (2008) Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet 83, 623-632.
18. Weitkamp LR, Nee L, Keats B, Polinsky RJ, Guttormsen S (1983) Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14. Am J Hum Genet 35, 443-453.
19. Mikloska Z, Sanna PP, Cunningham AL (1999) Neutralizing antibodies inhibit axonal spread of herpes simplex virus type 1 to epidermal cells in vitro. J Virol 73, 5934-5944.
20. Lin WR, Jennings R, Smith TL, Wozniak MA, Itzhaki RF (2001) Vaccination prevents latent HSV1 infection of mouse brain. Neurobiol Aging 22, 699-703.
21. Biggar RJ, Pandey JP, Henle W, Nkrumah FK, Levine PH (1984) Humoral immune response to Epstein-Barr virus antigens and immunoglobulin allotypes in African Burkitt lymphoma patients. Int J Cancer 33, 577-580.
22. Hyöty H, Pandey JP, Lehtinen M, Kulomaa P, Leinikki P (1988) Immunoglobulin allotypes and virus antibodies in Finnish type 1 diabetic patients. Exp Clin Immunogenet 5, 52-59.
23. Pandey JP (2004) Immunoglobulin GM genes and IgG antibodies to cytomegalovirus in patients with systemic sclerosis. Clin Exp Rheumatol 22, S35-S37.
24. Pandey JP, Luo Y, Elston RC, Wu Y, Hite Philp F,Astemborski J, Thomas DL, Netski DM (2008) Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2. Hum Immunol 69, 158-164.
25. Lenoir AA, Pandey JP, Granoff DM (1988) Antibody responses of black children to Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine in relation to the Km(1) allotype. J Infect Dis 157, 1242-1245.
26. Sarvas H, Rautonen N, Käyhty H, Kallio M, Mäkelä O (1990) Effect of Gm allotypes on IgG2 antibody responses and IgG2 concentrations in children and adults. Int Immunol 2, 317-322.
27. Granoff DM, Holmes SJ (1992) G2m(23) immunoglobulin allotype and immunity to Haemophilus influenzae type b. J Infect Dis 165, S66-S69.