Altered Resting and Exercise Respiratory Physiology in Obesity

Clinics in Chest Medicine

Volumn 30, Issue 3, 2009, Pages 445-454

  Sood, Akshay ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Exercise; Expiratory reserve volume; Obesity; Obstructive ventilatory abnormality; Oxygen consumption; Respiratory physiology; Restrictive ventilatory abnormality

Indexed keywords

METHACHOLINE;

AIRWAY RESISTANCE; BREATHING MUSCLE; CARDIOVASCULAR RESPONSE; EXERCISE; HUMAN; LUNG COMPLIANCE; LUNG DIFFUSION CAPACITY; LUNG FUNCTION TEST; LUNG GAS EXCHANGE; LUNG VENTILATION; LUNG VOLUME; MUSCLE STRENGTH; OBESITY; OBESITY HYPOVENTILATION SYNDROME; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY FUNCTION; RESPIRATORY TRACT DISEASE; REST; REVIEW; SPIROMETRY;

EXERCISE; HUMANS; OBESITY; OXYGEN CONSUMPTION; PULMONARY VENTILATION; RESPIRATORY MECHANICS; RESPIRATORY MUSCLES; REST;

EID: 68849129342     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2009.05.003     Document Type: Review

References (73)

1. National Center for Health Statistics. Chartbook on trends in the health of Americans, Health, United States, 2006 (2006), Public Health Service, Hyattsville (MD)
2. Ray C.S., Sue D.Y., Bray G., et al. Effects of obesity on respiratory function. Am Rev Respir Dis 128 3 (1983) 501-506
3. Naimark A., and Cherniack R.M. Compliance of the respiratory system and its components in health and obesity. J Appl Phys 15 (1960) 377-382
4. Rochester D.F., and Enson Y. Current concepts in the pathogenesis of the obesity-hypoventilation syndrome. Mechanical and circulatory factors. Am J Med 57 3 (1974) 402-420
5. Koenig S.M. Pulmonary complications of obesity. Am J Med Sci 321 4 (2001) 249-279
6. Chlif M., Keochkerian D., Feki Y., et al. Inspiratory muscle activity during incremental exercise in obese men. Int J Obes (Lond) 31 9 (2007) 1456-1463
7. Chlif M., Keochkerian D., Mourlhon C., et al. Noninvasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects. Int J Obes (Lond) 29 12 (2005) 1478-1483
8. Weiner P., Waizman J., Weiner M., et al. Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance. Thorax 53 1 (1998) 39-42
9. Sharp J.T., Druz W.S., and Kondragunta V.R. Diaphragmatic responses to body position changes in obese patients with obstructive sleep apnea. Am Rev Respir Dis 133 1 (1986) 32-37
10. Krotkiewski M., Grimby G., Holm G., et al. Increased muscle dynamic endurance associated with weight reduction on a very-low-calorie diet. Am J Clin Nutr 51 3 (1990) 321-330
11. Damsbo P., Vaag A., Hother-Nielsen O., et al. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34 4 (1991) 239-245
12. Lennmarken C., Sandstedt S., von Schenck H., et al. Skeletal muscle function and metabolism in obese women. JPEN J Parenter Enteral Nutr 10 6 (1986) 583-587
13. Newham D.J., Harrison R.A., Tomkins A.M., et al. The strength, contractile properties and radiological density of skeletal muscle before and 1 year after gastroplasty. Clin Sci (Lond) 74 1 (1988) 79-83
14. Fadell E.J., Richman A.D., Ward W.W., et al. Fatty infiltration of respiratory muscles in the Pickwickian syndrome. N Engl J Med 266 (1962) 861-863
15. Rochester D. Obesity and pulmonary function. In: Alpert M., and Alexander J. (Eds). The heart and lung in obesity (1998), Futura Publishing Company, Armonk (NY) 108-132
16. Perrin C., Unterborn J.N., Ambrosio C.D., et al. Pulmonary complications of chronic neuromuscular diseases and their management. Muscle Nerve 29 1 (2004) 5-27
17. Kress J.P., Pohlman A.S., Alverdy J., et al. The impact of morbid obesity on oxygen cost of breathing (VO(2RESP)) at rest. Am J Respir Crit Care Med 160 3 (1999) 883-886
18. Bedell G.N., Wilson W.R., and Seebohm P.M. Pulmonary function in obese persons. J Clin Invest 37 7 (1958) 1049-1060
19. Sutherland T.J., Goulding A., Grant A.M., et al. The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function. Eur Respir J 32 1 (2008) 85-91
20. Jenkins S.C., and Moxham J. The effects of mild obesity on lung function. Respir Med 85 4 (1991) 309-311
21. Jones R.L., and Nzekwu M.M. The effects of body mass index on lung volumes. Chest 130 3 (2006) 827-833
22. Gibson G.J. Obesity, respiratory function and breathlessness. Thorax 55 Suppl 1 (2000) S41-S44
23. Rubinstein I., Zamel N., DuBarry L., et al. Airflow limitation in morbidly obese, nonsmoking men. Ann Intern Med 112 11 (1990) 828-832
24. Douglas F.G., and Chong P.Y. Influence of obesity on peripheral airways patency. J Appl Phys 33 5 (1972) 559-563
25. Biring M.S., Lewis M.I., Liu J.T., et al. Pulmonary physiologic changes of morbid obesity. Am J Med Sci 318 5 (1999) 293-297
26. Lazarus R., Sparrow D., and Weiss S.T. Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest 111 4 (1997) 891-898
27. Thomas P.S., Cowen E.R., Hulands G., et al. Respiratory function in the morbidly obese before and after weight loss. Thorax 44 5 (1989) 382-386
28. Refsum H.E., Holter P.H., Lovig T., et al. Pulmonary function and energy expenditure after marked weight loss in obese women: observations before and one year after gastric banding. Int J Obes 14 2 (1990) 175-183
29. Sugerman H.J. Pulmonary function in morbid obesity. Gastroenterol Clin North Am 16 2 (1987) 225-237
30. Leone N., Courbon D., Thomas F., et al. Lung function impairment and metabolic syndrome: the critical role of abdominal obesity. Am J Respir Crit Care Med 179 6 (2009) 509-516
31. Enright P. Overindulgence → overweight → reduced vital capacity → reduced longevity. Am J Respir Crit Care Med 179 6 (2009) 432-433
32. Cancello R., Tounian A., Poitou C., et al. Adiposity signals, genetic and body weight regulation in humans. Diabete Metab 30 3 (2004) 215-227
33. Steffes M.W., Gross M.D., Schreiner P.J., et al. Serum adiponectin in young adults-interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study. Ann Epidemiol 14 7 (2004) 492-498
34. Franssen F.M., O'Donnell D.E., Goossens G.H., et al. Obesity and the lung: 5. Obesity and COPD. Thorax 63 12 (2008) 1110-1117
35. Fogarty A.W., Jones S., Britton J.R., et al. Systemic inflammation and decline in lung function in a general population: a prospective study. Thorax 62 6 (2007) 515-520
36. Thyagarajan B., Jacobs D.R., Apostol G.G., et al. Plasma fibrinogen and lung function: the CARDIA Study. Int J Epidemiol 35 4 (2006) 1001-1008
37. Thyagarajan B., Smith L.J., Barr R.G., et al. Association of circulating adhesion molecules with lung function: the CARDIA study. Chest 135 6 (2009) 1481-1487
38. Carey I.M., Cook D.G., and Strachan D.P. The effects of adiposity and weight change on forced expiratory volume decline in a longitudinal study of adults. Int J Obes Relat Metab Disord 23 9 (1999) 979-985
39. Chen Y., Rennie D., Cormier Y.F., et al. Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects. Am J Clin Nutr 85 1 (2007) 35-39
40. Rochester D.F. Respiratory muscles and ventilatory failure: 1993 perspective. Am J Med Sci 305 6 (1993) 394-402
41. Parameswaran K., Todd D.C., and Soth M. Altered respiratory physiology in obesity. Can Respir J 13 4 (2006) 203-210
42. Wannamethee S.G., Shaper A.G., and Whincup P.H. Body fat distribution, body composition, and respiratory function in elderly men. Am J Clin Nutr 82 5 (2005) 996-1003
43. Thyagarajan B., Jacobs Jr. D.R., Apostol G.G., et al. Longitudinal association of body mass index with lung function: the CARDIA study. Respir Res 9 (2008) 31
44. Wise R.A., Enright P.L., Connett J.E., et al. Effect of weight gain on pulmonary function after smoking cessation in the Lung Health Study. Am J Respir Crit Care Med 157 3 Pt 1 (1998) 866-872
45. Wang M.L., McCabe L., Petsonk E.L., et al. Weight gain and longitudinal changes in lung function in steel workers. Chest 111 6 (1997) 1526-1532
46. Chen Y., Horne S.L., and Dosman J.A. Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study. Thorax 48 4 (1993) 375-380
47. Bottai M., Pistelli F., Di Pede F., et al. Longitudinal changes of body mass index, spirometry and diffusion in a general population. Eur Respir J 20 3 (2002) 665-673
48. Womack C.J., Harris D.L., Katzel L.I., et al. Weight loss, not aerobic exercise, improves pulmonary function in older obese men. J Gerontol A Biol Sci Med Sci 55 8 (2000) M453-M457
49. Soterakis J., Glennon J.A., Ishihara A.M., et al. Pulmonary function studies before and after jejunoileal bypass surgery. Am J Dig Dis 21 7 (1976) 553-556
50. Zerah F., Harf A., Perlemuter L., et al. Effects of obesity on respiratory resistance. Chest 103 5 (1993) 1470-1476
51. Watson R.A., and Pride N.B. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J Appl Phys 98 2 (2005) 512-517
52. King G.G., Brown N.J., Diba C., et al. The effects of body weight on airway calibre. Eur Respir J 25 5 (2005) 896-901
53. Li A.M., Chan D., Wong E., et al. The effects of obesity on pulmonary function. Arch Dis Child 88 4 (2003) 361-363
54. Zavorsky G.S., Kim do J., Sylvestre J.L., et al. Alveolar-membrane diffusing capacity improves in the morbidly obese after bariatric surgery. Obes Surg 18 3 (2008) 256-263
55. Gilbert R., Sipple J.H., and Auchincloss Jr. J.H. Respiratory control and work of breathing in obese subjects. J Appl Phys 16 (1961) 21-26
56. Mokhlesi B., and Tulaimat A. Recent advances in obesity hypoventilation syndrome. Chest 132 4 (2007) 1322-1336
57. Shore S.A., and Johnston R.A. Obesity and asthma. Pharmacol Ther 110 1 (2006) 83-102
58. Ding D.J., Martin J.G., and Macklem P.T. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Phys 62 3 (1987) 1324-1330
59. Seow C.Y. Myosin filament assembly in an ever-changing myofilament lattice of smooth muscle. Am J Physiol, Cell Physiol 289 6 (2005) C1363-C1368
60. Fredberg J.J. Airway smooth muscle in asthma: flirting with disaster. Eur Respir J 12 6 (1998) 1252-1256
61. Shore S.A., Schwartzman I.N., Mellema M.S., et al. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 115 1 (2005) 103-109
62. Shore S.A., Terry R.D., Flynt L., et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118 2 (2006) 389-395
63. Sood A., Camargo Jr. C.A., and Ford E.S. Association between leptin and asthma in adults. Thorax 61 4 (2006) 300-305
64. Sood A., Cui X., Qualls C., et al. Association between asthma and serum adiponectin concentration in women. Thorax 63 10 (2008) 877-882
65. Zavala D.C., and Printen K.J. Basal and exercise tests on morbidly obese patients before and after gastric bypass. Surgery 95 2 (1984) 221-229
66. Hansen J.E., Sue D.Y., and Wasserman K. Predicted values for clinical exercise testing. Am Rev Respir Dis 129 2 Pt 2 (1984) S49-S55
67. Buskirk E., and Taylor H.L. Maximal oxygen intake and its relation to body composition, with special reference to chronic physical activity and obesity. J Appl Phys 11 1 (1957) 72-78
68. Wasserman K., and Whipp B.J. Exercise physiology in health and disease. Am Rev Respir Dis 112 2 (1975) 219-249
69. Wasserman K., Hansen J.E., Sue D.Y., et al. Principles of exercise testing and interpretation. 4th edition (2005), Lippincott Williams & Wilkins, Philadelphia
70. DeLorey D.S., Wyrick B.L., and Babb T.G. Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men. Int J Obes (Lond) 29 9 (2005) 1039-1047
71. Sakamoto S., Ishikawa K., Senda S., et al. The effect of obesity on ventilatory response and anaerobic threshold during exercise. J Med Syst 17 3-4 (1993) 227-231
72. Ross R.M. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 167 2 (2003) 211-277
73. Zarich S.W., Kowalchuk G.J., McGuire M.P., et al. Left ventricular filling abnormalities in asymptomatic morbid obesity. Am J Cardiol 68 4 (1991) 377-381