Solid phase pegylation of hemoglobin

Artificial Cells, Blood Substitutes, and Biotechnology

Volumn 37, Issue 4, 2009, Pages 147-155

  Suo, Xiaoyan ^a   Zheng, Chunyang ^a   Yu, Pengzhan ^a   Lu, Xiuling ^a   Ma, Guanghui ^a   Su, Zhiguo ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

Author keywords

Hemoglobin; Polyethylene glycol; Red blood cell substitute; Solid phase

Indexed keywords

BOVINE HEMOGLOBIN; CONVENTIONAL METHODS; ION EXCHANGE CHROMATOGRAPHY; LIQUID PHASE; MOBILE PHASE; PEGYLATED HEMOGLOBINS; PEGYLATION; RED BLOOD CELL; RED BLOOD CELL SUBSTITUTE; SDS-PAGE; SOLID MEDIUM; SOLID PHASE;

ADSORPTION; BLOOD; CELL MEMBRANES; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DIFFUSERS (OPTICAL); HEMOGLOBIN; HEMOGLOBIN OXYGEN SATURATION; ION CHROMATOGRAPHY; ION EXCHANGE; LIQUIDS; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYETHYLENE OXIDES; THERMOPLASTICS;

POLYETHYLENE GLYCOLS;

HEMOGLOBIN; MACROGOL;

ADSORPTION CHROMATOGRAPHY; ARTICLE; CHEMICAL STRUCTURE; CONJUGATION; ELUTION; ERYTHROCYTE; FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; LIGHT SCATTERING; POLYACRYLAMIDE GEL ELECTROPHORESIS; SOLID;

ADSORPTION; ANIMALS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEMOGLOBINS; INDICATORS AND REAGENTS; LASERS; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; SCATTERING, RADIATION;

BOVINAE;

EID: 68849121480     PISSN: 10731199     EISSN: 15324184     Source Type: Journal    
DOI: 10.1080/10731190903041188     Document Type: Article

References (21)

1. Abuchowski, A., Es, T.V. et al. (1977). Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J. Biol. Chem 252:3578-3581.
2. Basu, A., Yang, K. et al. (2006). Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-pegylation. Bioconjug Chem 17:618-630.
3. Chang, T.M.S. (1999). Future prospects for artificial blood. Trends in Boitechnology. Tibtech 17(2): 181:61-67.
4. Chang, T.M.S. (2000). Red blood cell substitutes. Best Pract Res Clin Haematol 13:651-668.
5. Fronticelli, C., Bucci, E., Orth, C. (1984). Solvent regulation of oxygen affinity in hemoglobin. J. Biol. Chem 259:10841-10844.
6. Gong, X.W., Wei, D.Z. et al. (2006). Lowry method for the determination of pegylated proteins: the error, it reason, and a method for eliminating it. Anal Biochem 354:157-158.
7. Gundersen, S., Palmer, A.F. (2007). Conjugation of methoxypolyethylene glycol to the surface of bovine red blood cells. Biotechnology and Bioengineering 96(6): 1199-1210.
8. Hai, T.T., Pereira, D.E. et al. (2000). Surface modification of diaspirin cross-linked hemoglobin (DCLHb) with chondroitin-4-sulfate derivatives, part 1. Bioconjug Chem 11: 705-713.
9. Harris, J.M., Zalipsky, S. (1997). Poly (etylene glycol) Chemistry and Biological Applications, American Chemical Society, Washington, DC.
10. Harris, J.M., Chess, R.B. (2003). Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2:214-21.
11. Hu, T., Su, Z.G. (2003). A solid phase adsorption method for preparation of bovine serum albumin bovine hemoglobin conjugate. Journal of Biotechnology 100:267-275.
12. Israelachvili, J. (1997). The different faces of poly (ethylene glycol). Proc Natl Acad Sci USA 94:8378-8379.
13. Kozlowski, A., Harris, J.M. (2001). Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C. J. Control. Release 72:217-224.
14. Kroeger, K.S., Kundrot, C.E. (1997). Structures of a hemoglobin-based blood substitute: insights into the function of allosteric proteins. Structure 5(2):227-237.
15. Laemmli, U.K. (1970). Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature 227(259):680-685.
16. Lee, B. K., Lee, E. K. et al. (2007). Solid-phase pegylation of recombinant interferon α-2a for site-specific modification: process performance, characterization, and in vitro bioactivity. Bioconjugate Chem 18:1728-1734.
17. Lu, X.L., Zhao, D.X., Su, Z.G. (2004). Purification of hemoglobin by ion exchange chromatography in flow-through mode with PEG as an escort institute of process engineering. Artificial Cell, Blood Substitutes, and Biotechnology 32(2):209-227.
18. Monkarsh, S.P., Spence, et al. (1997). Isolation of positional isomers of monopoly (ethylene glycol)ylated inter-feron-2a and the determination of their biochemical and biological characteristics. In Harris, J.M., Zalipsky, S., Poly(ethyleneglycol) ACS Symposium Series, American Chemical Society, Washington, DC., 207-216.
19. Planas, M., Cros, E. et al. (2002). Solid-phase synthesis of new peptide-arene hybrids from N-TCP amino acids. Tetrahedron Letters 43:4431-4434.
20. Winslow, R.M. (1992). Hemoglobin-based Red Cell Substitutes, John Hopkins University Press, Baltimore, MD, p 58.
21. Zalipsky, S., Seltzar, R., Menon-Rudolph, S. (1992). Evaluation of a new reagent for covalent attachment of polyethylene glycol to proteins. Biotechnol Appl Biochem 15:100-114.