Evaluation of a new lead for acetylcholinesterase inhibition

Medicinal Chemistry Research

Volumn 18, Issue 3, 2009, Pages 231-241

  Khorana, Nantaka ^a   Markmee, Sutthatip ^a   Ingkaninan, Kornkanok ^a   Ruchirawat, Somsak ^b   Kitbunnadaj, Ruengwit ^a   Pullagurla, Manik Reddy ^c  

^a NARESUAN UNIVERSITY   (Thailand)

^b CHULABHORN RESEARCH INSTITUTE   (Thailand)

^c Biophore Pharmaceuticals Pvt Ltd   (India)

Author keywords

Acetylcholinesterase inhibitor; Butyrylcholinesterase inhibitor; Isoquinoline analogs; Synthesis

Indexed keywords

1 (3,4 DIMETHOXYBENZYL) 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE; 1 (3,4 DIMETHOXYBENZYL) 6,7 DIMETHOXYISOQUINOLINE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIHYDROISOQUINOLINE DERIVATIVE; ISOQUINOLINE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 68849119601     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-008-9122-3     Document Type: Article

References (17)

1. SO Bachurin 2003 Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease Med Res Rev 23 48 88 10.1002/med.10026 (Pubitemid 36024908)
2. R Cocabelos A Nordberg J Caamano A Franco-Maside L Fernandez-Novoa MJ Gomez 1994 Molecular strategies for the first generation of antidementia drugs (I) Tacrine and related compounds Drugs Today (Barc) 30 259 337
3. S Darvesh D Hopkins 2003 Neurobiology of butyrylcholinesterase Nat Rev Neurosci 4 131 138 10.1038/nrn1035 (Pubitemid 37271383)
4. LG Ellman KD Courtney V Andres MR Featherstone 1961 A new and rapid colorimetric determination of acetylcholinesterase activity Biochem Pharmacol 7 88 95 10.1016/0006-2952(61)90145-9
5. A Graulich J Scuvée-Moreau L Alleva C Lamy O Waroux V Seutin 2006 Synthesis and radioligand binding studies of methoxylated 1, 2, 3, 4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2 + -activated K + channels J Med Chem 49 7208 7214 10.1021/jm0607395 (Pubitemid 44886006)
6. NH Greig T Utsuki QS Yu X Zhu 2001 A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase Curr Med Res Opin 17 159 165 10.1185/03007990152673800 (Pubitemid 34003119)
7. K Ingkaninan P Phengpa S Yuenyongsawad N Khorana 2006 Acetylcholinesterase inhibitors from Stephania venosa tuber J Pharm Pharmacol 58 695 700 10.1211/jpp.58.5.0015
8. K Ingkaninan P Temkitthawon K Chuenchom T Yuyaem W Thongnoi 2003 Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies J Ethnopharmacol 89 261 264 10.1016/j.jep.2003.08.008 (Pubitemid 37378200)
9. NTD Johnson N Bosanquet 2000 The epidermic of Alzheimer's disease Pharmacoeconomics 18 215 223 10.2165/00019053-200018030-00002
10. P Kasa Z Rakonczay K Gulya 1997 The cholinergic system in Alzheimer's disease Prog Neurobiol 52 511 535 10.1016/S0301-0082(97)00028-2 (Pubitemid 27405078)
11. S Markmee S Ruchirawat V Prachyawarakorn 2006 Isoquinoline derivatives as potential acetylcholinesterase inhibitors Bioorg Med Chem Lett 16 2170 2172 10.1016/j.bmcl.2006.01.067 (Pubitemid 43351072)
12. NH Martin CW Jefford 1982 Synthesis and photooxygenation of some substituted 1-benzyl-3,4-dihydroisoquinolines. Mechanism of enamine photooxygenation HeIv Chim Acta 65 762 774 10.1002/hlca.19820650314
13. T Ogino T Yamaguchi T Sato H Sasaki K Sugama M Okada 1997 Studies on inhibitory activity against acetylcholinesterase of new bisbenzylisoquinoline alkaloid and its related compounds Heterocycles 45 2253 2260
14. A Padwa S Beall TM Heidelbaugh B Liu SM Sheehan 2000 A one-pot bicycloannulation method for the synthesis of tetrahydroisoquinoline systems J Org Chem 65 2684 2695 10.1021/jo991742h (Pubitemid 30249691)
15. Pappano AJ (1998) Cholinoceptor-activating & cholinesterase- inhibiting drugs. In: Katzung BG (ed) Basic clinical pharmacology, 7th edn. New York, McGraw-Hill, pp 90-104
16. DL Price 1986 New perspectives on Alzheimer's disease Neurosciences 9 489 512 10.1016/0166-2236(86)90156-6 (Pubitemid 17205684)
17. J Ulrichová D Walterová V Preininger J Slavík J Lenfeld M Cushman 1983 Isolation, chemistry and biology of alkaloids from plants of the Papaveraceae. Inhibition of acetylcholinesterase activity by some isoquinoline alkaloids Planta Med 48 111 115 10.1055/s-2007-969901