A study of the mechanism and inhibitory effect of aspirin on U251 cells in vitro

Chinese Pharmacological Bulletin

Volumn 25, Issue 6, 2009, Pages 805-808

  Wu, Wei Lun ^a   Liang, Zhong Qin ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Aspirin; Cell apoptosis; U251 cell line

Indexed keywords

ACETYLSALICYLIC ACID; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 68849115518     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Gu Q, Wang J D, Xia H H, et al. Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer [J]. Carcinogenesis, 2005,26(3):541-546 (Pubitemid 41214142)
2. Dikshit P, Chatterjee M, Goswami A, et al. Aspirin induces apoptosis through the inhibition of proteasome function[J]. J Biol Chem, 2006,281(39):22928-22935 (Pubitemid 44507066)
3. Li M, Lotan R, Levin B, et al. Aspirin induction of apoptosis in esophageal cancer: a potential for chemoprevention[J]. Cancer Epidem Biomar, 2000,9:545-549
4. Zhou X M, Wong B C Y, Fan X M, et al. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through upregulation of bax and bak[J]. Carcinogenesis, 2001,22(9):1393-1397
5. Kulp S K, Yang Y T, Hung C C, et al. 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells[J]. Cancer Res, 2004,64:1444-1451
6. Ren X D, LU Y Q, Ye K H, et al. The anti-tumor molecular mechanism s of non-steroid anti-inflammatory drugs [J]. Chin Pharmacol Bull, 2005,21(5):527-531
7. Arango H A, Icely S, Roberts W S, et al. Aspirin effects on endometrial cancer cell growth[J]. Obstet Gynecol, 2001,97(3):4237. (Pubitemid 32184705)
8. Din F V, Stark L A, Dunlop M G. Aspirin-induced nuclear translocation of NFkB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency[J]. Brit J Cancer, 2005,92:1137-1143
9. Borthwick G M,Johnson A S. Partington M, et al. Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a cox-independent mechanism[J]. FASEB J, 2006,20:2009-2016 (Pubitemid 44953901)
10. Wang H, Lei Z Y, Chen H, et al. Antitumor activity of PB2LY and itsmechanism in vitro [J]. Chin Pharmacol Bull, 2008,24(9):1208-1212
11. Kaifu K, Kiyomoto H, Hitomi H, et al. Insulin attenuates apoptosis induced by high glucose via the PD-kinase/Akt pathway in rat peritoneal mesothelial cells[J]. Nephrol Dial Transpl, 2009,24(3):809-815
12. Goel A, Chang D K, Ricciardiello L, et al. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells [J]. Clin Cancer Res, 2003,9(1):383-390 (Pubitemid 36109756)
13. Chen F, Arseven O K, Cryns V L. Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis[J]. J Biol Chem, 2004,279(26):27542-27548 (Pubitemid 38812595)
14. Leung A M, Redlak M J, Miller T A. Aspirin-induced mucosal cell death in human gastric cells : role of a caspase-independent mechanism[J]. Dig Dis Sci, 2009,54(1):28-35.
15. Redlak M J, Power J J, Miller T A. Aspirin-induced apoptosis in human gastric cancer epithelial cells : relationship with protein kinase C signaling[J]. Dig Dis Sci, 2007,52(3):810-816