Effect of neutralization of rat interleukin 6 bioactivity on inducible nitric oxide synthase up-regulation and cerebral ischemic damage

Neurological Research

Volumn 31, Issue 7, 2009, Pages 714-720

  Tuna, Metin ^a   Yilmaz, Derviş M ^a   Erman, Tahsin ^a   Arslan, Ali ^a   Özgür, Hülya ^a   Polat, Sait ^a  

^a CUKUROVA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Cerebral ischemia; Inducible nitric oxide synthase; Interleukin 6; Rat

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PROTEIN STRUCTURE; RAT; UPREGULATION;

ANIMALS; ANTIBODIES; BRAIN; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERLEUKIN-6; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NITRIC OXIDE SYNTHASE TYPE II; RANDOM ALLOCATION; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; UP-REGULATION;

EID: 68849113688     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X380892     Document Type: Article

References (30)

1. Wang X, Yue TL, Young PR, et al. Expression of interleukin-6, cfos, and zif268 mRNA in rat ischemic cortex. J Cereb Blood Flow Metab 1995; 15: 166-171
2. Benveniste EN. Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action. Am J Physiol 1992; 263: 1-16
3. Gaetani P, Tartara F, Pignatti P, et al. Cisternal cerebrospinal fluid levels of cytokines after subarachnoid hemorrhage. Neurol Res 1998; 20: 337-342 (Pubitemid 28247128)
4. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6: 3051-3064
5. Berata M, Berata J, Georgoff I, et al. Methylxanthines and calciummobilizing agents inhibit expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells. Exp Cell Res 1994; 212: 230-242 (Pubitemid 24216697)
6. Dawson V, Brahmbhatt HP, Mong JA, et al. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 1994; 33: 1425-1430 (Pubitemid 24353737)
7. Iadecola C, Zhang F, Xu S, et al. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 1995; 15: 378-384
8. Samdani AF, Dawson TM, Dawson VL. Nitric oxide synthase in models of focal ischemia. Stroke 1997; 28: 1283-1288 (Pubitemid 27248908)
9. Forster C, Clark HB, Ross ME, et al. Inducible nitric oxide synthase expression in human cerebral infarcts. Acta Neuropathol (Berl) 1999; 97: 215-220 (Pubitemid 29137269)
10. Zhu DY, Deng Q, Yao HH, et al. Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice. Life Sci 2002; 13: 1985-1996 (Pubitemid 34908005)
11. Tamura A, Graham DI, McCulloch J, et al. Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1981; 1: 53-60
12. Menzies SA, Hoff JT, Betz L. Middle cerebral artery occlusion in rats. A neurological and pathological evaluation of a reproducible model. Neurosurgery 1992; 31: 100-107
13. Clark WM, Rinker LG, Lessov NS, et al. Time course of interleukin- 6 expression in experimental central nervous system ischemia. Neurol Res 1999; 21: 287-292
14. Hill JK, Gunion-Rinker L, Kulhanek D, et al. Temporal modulation of cytokine expression following focal cerebral ischemia in mice. Brain Res 1999; 820: 45-54 (Pubitemid 29225477)
15. Milloning G. Advantages of a phosphate buffer for 0504 solutions and fixation. J Appl Phys 1961; 32: 1637
16. Nathan C, Xie Q-W. Nitric oxide synthases: Roles, tolls, and controls. Cell 1994; 78: 915-918 (Pubitemid 24292319)
17. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 1997; 20: 132-139 (Pubitemid 27086729)
18. Chao CC, Hu S, Molitor TW, et al. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 1992; 149: 2341-2741
19. Minc-Golomb D, Tsarfaty I, Schwartz JP. Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine. Br J Pharmacol 1994; 112: 720-722 (Pubitemid 24199072)
20. Murphy S, Simmons ML, Agullo L, et al. Synthesis of nitric oxide in central nervous system glial cells. Trends Neurosci 1993; 16: 323-328
21. Block F, Peters M, Nolden-Koch M. Expression of interleukin-6 in the ischemic penumbra. Neuroreport 2000; 11: 963-967
22. Gijbels K, Brocke S, Abrams JS, et al. Administration of neutralizing antibodies to interleukin-6 (interleukin-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of interleukin-6 bioactivity in central nervous system and circulation. Mol Med 1995; 1: 795-805 (Pubitemid 3013088)
23. Sharma HS, Olsson Y, Nyberg F. Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma. Prog Brain Res 1995; 104: 401-416
24. Widenka DC, Medele RJ, Stummer W, et al. Inducible nitric oxide synthase: A possible key factor in the pathogenesis of chronic vasospasm after experimental subarachnoid hemorrhage. J Neurosurg 1999; 90: 1098-1104 (Pubitemid 29241179)
25. Sayama T, Suzuki S, Masashi F. Expression of inducible nitric oxide synthase in rats following subarachnoid hemorrhage. Neurol Res 1998; 20: 79-84 (Pubitemid 28051662)
26. Wada K, Chatzipanteli K, Kraydieh S, et al. Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats. Neurosurgery 1998; 43: 1427-1436 (Pubitemid 28545874)
27. Gahm C, Holmin S, Mathiesen T. Temporal profiles and cellular sources of three nitric oxide synthase isoforms in the brain after experimental contusion. Neurosurgery 2000; 46: 169-177 (Pubitemid 30030277)
28. Iadecola C, Zhang F, Xu X. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 1995; 268: R286-R292
29. Zhang J, Benveniste H, Klitzman B, et al. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995; 26: 298-304
30. Dawson TM, Dawson VL, Snyder SH. Molecular mechanisms of nitric oxide actions in the brain. Ann NY Acad Sci 1994; 738: 76-85