Glycinergic projection neurons of the cerebellum

Journal of Neuroscience

Volumn 29, Issue 32, 2009, Pages 10104-10110

  Bagnall, Martha W ^a,b   Zingg, Brian ^b   Sakatos, Alexandra ^b   Moghadam, Setareh H ^b   Zeilhofer, Hanns Ulrich ^d,e   Du Lac, Sascha ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE RECEPTOR; GLYCINE TRANSPORTER; GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CEREBELLUM; CEREBELLUM NUCLEUS; CONTROLLED STUDY; FASTIGIAL NUCLEUS; MOUSE; NERVE FIBER; NERVE PROJECTION; NEUROTRANSMISSION; NONHUMAN; PREMOTOR CORTEX; PRIORITY JOURNAL; PURKINJE CELL;

ACTION POTENTIALS; ANIMALS; BRAIN STEM; CELL SIZE; CEREBELLAR NUCLEI; ELECTRIC STIMULATION; FUNCTIONAL LATERALITY; GLUTAMIC ACID; GLYCEROL; GREEN FLUORESCENT PROTEINS; MICE; MICE, TRANSGENIC; NEURAL PATHWAYS; NEURONS; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; SYNAPSES;

EID: 68849108926     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2087-09.2009     Document Type: Article

References (54)

1. Aizenman CD, Huang EJ, Manis PB, Linden DJ (2000) Use-dependent changes in synaptic strength at the Purkinje cell to deep nuclear synapse. Prog Brain Res 124:257-273.
2. Aizenman CD, Huang EJ, Linden DJ (2003) Morphological correlates of intrinsic electrical excitability in neurons of the deep cerebellar nuclei. J Neurophysiol 89:1738-1747.
3. Angaut P, Bowsher D (1970) Ascending projections of the medial cerebellar (fastigial) nucleus: an experimental study in the cat. Brain Res 24:49-68.
4. Asanuma C, Thach WT, Jones EG (1983) Brainstem and spinal projections of the deep cerebellar nuclei in the monkey, with observations on the brainstem projections of the dorsal column nuclei. Brain Res 286:299-322.
5. Bagnall MW, Stevens RJ, du Lac S (2007) Transgenic mouse lines subdivide medial vestibular nucleus neurons into discrete, neurochemically distinct populations. J Neurosci 27:2318-2330.
6. Batini C (1990) Cerebellar localization and colocalization of GABA and calcium binding protein-D28K. Arch Ital Biol 128:127-149.
7. Batini C, Compoint C, Buisseret-Delmas C, Daniel H, Guegan M (1992) Cerebellar nuclei and the nucleocortical projections in the rat: retrograde tracing coupled to GABA and glutamate immunohistochemistry. J Comp Neurol 315:74-84.
8. Batton RR 3rd, Jayaraman A, Ruggiero D, Carpenter MB (1977) Fastigial efferent projections in the monkey: an autoradiographic study. J Comp Neurol 174:281-305.
9. Bäurle J, Grüsser-Cornehls U (1997) Differential number of glycine- and GABA-immunopositive neurons and terminals in the deep cerebellar nuclei of normal and Purkinje cell degeneration mutant mice. J Comp Neurol 382:443-458.
10. Büttner U, Fuchs AF, Markert-Schwab G, Buckmaster P (1991) Fastigial nucleus activity in the alert monkey during slow eye and head movements. J Neurophysiol 65:1360-1371.
11. Chan-Palay V (1977) Cerebellar dentate nucleus: organization, cytology and transmitters. Berlin: Springer.
12. Chen S, Hillman DE (1993) Colocalization of neurotransmitters in the deep cerebellar nuclei. J Neurocytol 22:81-91.
13. Chung SH, Marzban H, Hawkes R (2009) Compartmentalization of the cerebellar nuclei of the mouse. Neuroscience 161:123-138.
14. De Zeeuw CI, Berrebi AS (1995) Postsynaptic targets of Purkinje cell terminals in the cerebellar and vestibular nuclei of the rat. Eur J Neurosci 7:2322-2333.
15. de Zeeuw CI, Holstege JC, Ruigrok TJ, Voogd J (1989) Ultrastructural study of the GABAergic, cerebellar, and mesodiencephalic innervation of the cat medial accessory olive: anterograde tracing combined with immunocytochemistry. J Comp Neurol 284:12-35.
16. 2+ conductances define and encode the bimodal firing pattern of vestibulocerebellar unipolar brush cells. J Neurosci 27:3823-3838.
17. Dugué GP, Dumoulin A, Triller A, Dieudonné S (2005) Target-dependent use of coreleased inhibitory transmitters at central synapses. J Neurosci 25:6490-6498.
18. Fredette BJ, Mugnaini E (1991) The GABAergic cerebello-olivary projection in the rat. Anat Embryol 184:225-243.
19. Gorodnov VL, Fanardjian VV (1987) Functional properties of the cerebellorubral synapses in the cat. Brain Res 410:340-342.
20. Heckroth JA (1994) Quantitative morphological analysis of the cerebellar nuclei in normal and lurcher mutant mice. I. Morphology and cell number. J Comp Neurol 343:173-182.
21. Homma Y, Nonaka S, Matsuyama K, Mori S (1995) Fastigiofugal projection to the brainstem nuclei in the cat: an anterograde PHA-L tracing study. Neurosci Res 23:89-102.
22. Ito M (1984) The cerebellum and neural control. New York: Raven.
23. Ito M, Nisimaru N, Yamamoto M (1977) Specific patterns of neuronal connexions involved in the control of the rabbit's vestibulo-ocular reflexes by the cerebellar flocculus. J Physiol 265:833-854.
24. Jahnsen H (1986) Electrophysiological characteristics of neurones in the guinea-pig deep cerebellar nuclei in vitro. J Physiol 372:129-147.
25. Jiang MC, Alheid GF, Nunzi MG, Houk JC (2002) Cerebellar input to magnocellular neurons in the red nucleus of the mouse: synaptic analysis in horizontal brain slices incorporating cerebello-rubral pathways. Neuroscience 110:105-121.
26. Kandel ER, Schwartz JH, Jessell TM (1991) Principles of neural science, Ed 3. Norwalk, CT: Appleton and Lange.
27. Kim SG, Uǧurbil K, Strick PL (1994) Activation of a cerebellar output nucleus during cognitive processing. Science 265:949-951.
28. Kurzan R, Straube A, Büttner U (1993) The effect of muscimol microinjections into the fastigial nucleus on the optokinetic response and the vestibulo-ocular reflex in the alert monkey. Exp Brain Res 94:252-260.
29. Leclerc N, Schwarting GA, Herrup K, Hawkes R, Yamamoto M (1992) Compartmentation in mammalian cerebellum: zebrin II and P-path antibodies define three classes of sagittally organized bands of Purkinje cells. Proc Natl Acad Sci U S A 89:5006-5010.
30. Matsushita M, Hosoya Y (1978) The location of spinal projection neurons in the cerebellar nuclei (cerebellospinal tract neurons) of the cat. A study with the horseradish peroxidase technique. Brain Res 142:237-248.
31. Miller DM, Cotter LA, Gandhi NJ, Schor RH, Huff NO, Raj SG, Shulman JA, Yates BJ (2008) Responses of rostral fastigial nucleus neurons of conscious cats to rotations in vertical planes. Neuroscience 155:317-325.
32. Noda H, Sugita S, Ikeda Y (1990) Afferent and efferent connections of the oculomotor region of the fastigial nucleus in the macaque monkey. J Comp Neurol 302:330-348.
33. Ohyama T, Nores WL, Medina JF, Riusech FA, Mauk MD (2006) Learning-induced plasticity in deep cerebellar nucleus. J Neurosci 26:12656-12663.
34. Pélisson D, Goffart L, Guillaume A (1998) Contribution of the rostral fastigial nucleus to the control of orienting gaze shifts in the headunrestrained cat. J Neurophysiol 80:1180-1196.
35. Pugh JR, Raman IM (2006) Potentiation of mossy fiber EPSCs in the cerebellar nuclei by NMDA receptor activation followed by postinhibitory rebound current. Neuron 51:113-123.
36. Schwarz C, Schmitz Y (1997) Projection from the cerebellar lateral nucleus to precerebellar nuclei in the mossy fiber pathway is glutamatergic: a study combining anterograde tracing with immunogold labeling in the rat. J Comp Neurol 381:320-334.
37. Sekirnjak C, Vissel B, Bollinger J, Faulstich M, du Lac S (2003) Purkinje cell synapses target physiologically unique brainstem neurons. J Neurosci 23:6392-6398.
38. Spencer RF, Wenthold RJ, Baker R (1989) Evidence for glycine as an inhibitory neurotransmitter of vestibular, reticular, and prepositus hypoglossi neurons that project to the cat abducens nucleus. J Neurosci 9:2718-2736.
39. Spencer RM, Zelaznik HN, Diedrichsen J, Ivry RB (2003) Disrupted timing of discontinuous but not continuous movements by cerebellar lesions. Science 300:1437-1439.
40. Squire LR, Bloom FE, Spitzer NC, du Lac S, Ghosh A, Berg D (2008) Fundamental neuroscience. San Diego: Academic.
41. Sugihara I, Shinoda Y (2007) Molecular, topographic, and functional organization of the cerebellar nuclei: analysis by three-dimensional mapping of the olivonuclear projection and aldolase C labeling. J Neurosci 27:9696-9710.
42. Sugimoto T, Mizuno N, Itoh K (1981) An autoradiographic study on the terminal distribution of cerebellothalamic fibers in the cat. Brain Res 215:29-47.
43. Tanaka I, Ezure K (2004) Overall distribution of GLYT2 mRNA-containing versus GAD67 mRNA-containing neurons and colocalization of both mRNAs in midbrain, pons, and cerebellum in rats. Neurosci Res 49:165-178.
44. Telgkamp P, Raman IM (2002) Depression of inhibitory synaptic transmission between Purkinje cells and neurons of the cerebellar nuclei. J Neurosci 22:8447-8457.
45. Telgkamp P, Padgett DE, Ledoux VA, Woolley CS, Raman IM (2004) Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sites. Neuron 41:113-126.
46. Teune TM, van der Burg J, de Zeeuw CI, Voogd J, Ruigrok TJ (1998) Single Purkinje cell can innervate multiple classes of projection neurons in the cerebellar nuclei of the rat: a light microscopic and ultrastructural tripletracer study in the rat. J Comp Neurol 392:164-178.
47. Teune TM, van der Burg J, van der Moer J, Voogd J, Ruigrok TJ (2000) Topography of cerebellar nuclear projections to the brain stem in the rat. Prog Brain Res 124:141-172.
48. Thach WT, Goodkin HP, Keating JG (1992) The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 15:403-442.
49. Thompson RF, Steinmetz JE (2009) The role of the cerebellum in classical conditioning of discrete behavioral responses. Neuroscience. Advance online publication. Retrieved July 1, 2009. doi:10.1016/j.neuroscience.2009.01.041.
50. Uusisaari M, Knöpfel T (2008) GABAergic synaptic communication in the GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Neuroscience 156:537-549.
51. Uusisaari M, Obata K, Knöpfel T (2007) Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei. J Neurophysiol 97:901-911.
52. Verveer C, Hawkins RK, Ruigrok TJ, De Zeeuw CI (1997) Ultrastructural study of the GABAergic and cerebellar input to the nucleus reticularis tegmenti pontis. Brain Res 766:289-296.
53. Wadiche JI, Jahr CE (2005) Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity. Nat Neurosci 8:1329-1334.
54. Zeilhofer HU, Studler B, Arabadzisz D, Schweizer C, Ahmadi S, Layh B, Bösl MR, Fritschy JM (2005) Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice. J Comp Neurol 482:123-141.