MeCP2 function in the basolateral amygdala in Rett syndrome

Journal of Neuroscience

Volumn 29, Issue 32, 2009, Pages 9941-9942

  Wu, Synphen H ^a,b   Camarena, Vladimir ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE DEACETYLASE; HISTONE H3; HISTONE H4; METHYL CPG BINDING PROTEIN 2; TRANSCRIPTION FACTOR SIN3A;

ACETYLATION; AMYGDALOID NUCLEUS; ANXIETY; FOREBRAIN; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; LOXP SITE; MICROARRAY ANALYSIS; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN FUNCTION; RETT SYNDROME; SOCIAL INTERACTION; TRANSCRIPTION REGULATION; X CHROMOSOME;

ACETYLATION; AMYGDALA; ANIMALS; ANXIETY; ENZYME INHIBITORS; FEAR; GENE EXPRESSION REGULATION; HISTONES; HYDROXAMIC ACIDS; LEARNING; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURONS; PHENOTYPE; RETT SYNDROME; SOCIAL BEHAVIOR;

EID: 68849106530     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2540-09.2009     Document Type: Note

References (7)

1. Adachi M, Autry AE, Covington HE 3rd, Monteggia LM (2009) MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome. J Neurosci 29:4218-4227.
2. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG binding protein 2. Nat Genet 23:185-188.
3. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320:1224-1229.
4. Chen RZ, Akbarian S, Tudor M, Jaenisch R (2001) Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27:327-331.
5. Gemelli T, Berton O, Nelson ED, Perrotti LI, Jaenisch R, Monteggia LM (2006) Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biol Psychiatry 59:468-476.
6. Guy J, Hendrich B, Holmes M, Martin JE, Bird A (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27:322-326.
7. Hagberg B, Aicardi J, Dias K, Ramos O (1983) A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann Neurol 14:471-479.