Fluconazole use as an important risk factor in the emergence of fluconazole-resistant Candida glabrata fungemia

Archives of Internal Medicine

Volumn 169, Issue 15, 2009, Pages 1444-1445

  Tumbarello, Mario ^b   Posteraro, Brunella ^a   Trecarichi, Enrico M ^b   Sanguinetti, Maurizio ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CEFEPIME; CEPHALOSPORIN; FLUCONAZOLE; LINEZOLID; METRONIDAZOLE;

ALLELE; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; CANDIDA GLABRATA; CANDIDIASIS; FUNGEMIA; FUNGUS ISOLATION; GENE EXPRESSION; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR;

ANTIFUNGAL AGENTS; CANDIDA GLABRATA; DRUG RESISTANCE, FUNGAL; FLUCONAZOLE; FUNGEMIA; HUMANS; RISK FACTORS; SURVIVAL RATE;

EID: 68849097500     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2009.243     Document Type: Letter

References (5)

1. Lee I, Fishman NO, Zaoutis TE, et al. Risk factors for fluconazole-resistant Candida glabrata bloodstream infections. Arch Intern Med. 2009;169(4):379-383.
2. Tumbarello M, Sanguinetti M, Trecarichi EM, et al. Fungaemia caused by Candida glabrata with reduced susceptibility to fluconazole due to altered gene expression: risk factors, antifungal treatment and outcome. J Antimicrob Chemother. 2008;62(6):1379-1385.
3. Vermitsky JP, Earhart KD, Smith WL, Homayouni R, Edlind TD, Rogers PD. Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies. Mol Microbiol. 2006;61(3):704-722.
4. Torelli R, Posteraro B, Ferrari S, et al. The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata. Mol Microbiol. 2008;68(1):186-201.
5. Ferrari S, Ischer F, Calabrese D, et al. Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence. PLoS Pathog. 2009;5(1):e1000268.