Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.

Protein science : a publication of the Protein Society

Volumn 18, Issue 5, 2009, Pages 1107-1114

  Afshar, Sepideh ^a   Sawaya, Michael R ^a   Morrison, Sherie L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUOROADENINE; 2' DEOXY 2' FLUOROADENOSINE; 2'-FLUORO-2'-DEOXYADENOSINE; 2-FLUOROADENINE; ADENINE; ANTINEOPLASTIC AGENT; DEOXYADENOSINE DERIVATIVE; DRUG DERIVATIVE; PRODRUG; PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETIC ENGINEERING; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ADENINE; ANTINEOPLASTIC AGENTS; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; DEOXYADENOSINES; GENETIC ENGINEERING; HUMANS; MODELS, MOLECULAR; MUTATION; PRODRUGS; PROTEIN BINDING; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; SUBSTRATE SPECIFICITY;

EID: 68849093170     PISSN: None     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.91     Document Type: Article

References (0)