Thromboelastography to direct the administration of recombinant activated factor VII in a child with traumatic injury requiring massive transfusion

Pediatric Critical Care Medicine

Volumn 10, Issue 2, 2009, Pages

  Nylund, Cade M ^a   Borgman, Matthew A ^a   Holcomb, John B ^c   Jenkins, Donald ^b   Spinella, Philip C ^a  

^a Medical Center   (United States)

^b BROOKE ARMY MEDICAL CENTER   (United States)

^c US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

Children; Coagulopathy; Recombinant activated factor VII; Thromboelastography; Trauma

Indexed keywords

FRESH FROZEN PLASMA; RECOMBINANT BLOOD CLOTTING FACTOR 7A; SODIUM CHLORIDE; BLOOD CLOTTING FACTOR 7A; RECOMBINANT PROTEIN;

ARTERY INJURY; ARTICLE; ARTIFICIAL EMBOLISM; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; CASE REPORT; CHILD; COIL EMBOLIZATION; COMPUTER ASSISTED TOMOGRAPHY; CRYOPRECIPITATE; CRYSTALLOID; ECHOGRAPHY; FIBRINOLYSIS; HEMORRHAGIC SHOCK; HEPATIC ARTERY; HUMAN; INJURY SEVERITY; INTERNATIONAL NORMALIZED RATIO; LABORATORY TEST; LAPAROTOMY; LIVER INJURY; MALE; PLASMA TRANSFUSION; PRESCHOOL CHILD; PRIORITY JOURNAL; RESUSCITATION; SPLEEN INJURY; SURVIVAL; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOELASTOGRAPHY; VITAL SIGN; INJURY;

BLOOD TRANSFUSION; CHILD, PRESCHOOL; FACTOR VIIA; HUMANS; MALE; RECOMBINANT PROTEINS; THROMBELASTOGRAPHY; WOUNDS AND INJURIES;

EID: 68849090586     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31819bb939     Document Type: Article

References (34)

1. Sauaia A, Moore FA, Moore EE, et al: Epidemiology of trauma deaths: A reassessment. J Trauma 1995; 38:185-193
2. Krug EG, Sharma GK, Lozano R: The global burden of injuries. Am J Public Health 2000; 90:523-526
3. Brohi K, Singh J, Heron M, et al: Acute traumatic coagulopathy. J Trauma 2003; 54: 1127-1130
4. Como JJ, Dutton RP, Scalea TM, et al: Blood transfusion rates in the care of acute trauma. Transfusion 2004; 44:809-813
5. McMullin NR, Holcomb JB, Sondeen J: Hemostatic Resuscitation. In: Yearbook of Intensive Care and Emergency Medicine. Vincent J, (Ed). New York, Springer, 2006, pp 265-278
6. Stewart RM, Myers JG, Dent DL, et al: Seven hundred fifty-three consecutive deaths in a level I trauma center: The argument for injury prevention. J Trauma 2003; 54:66-70; discussion 70-161
7. Deleted in proof
8. Borgman MA, Spinella PC, Perkins JG, et al: The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007; 63:805-813
9. Spinella PC, Perkins JG, McLaughlin DF, et al: The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma 2008; 64:286-293; discussion 293-1284
10. Shore-Lesserson L, Manspeizer HE, DePerio M, et al: Thromboelastography- guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999; 88:312-319
11. Srinivasa V, Gilbertson LI, Bhavani-Shankar K: Thromboelastography: Where is it and where is it heading? Int Anesthesiol Clin 2001; 39:35-49
12. Kaufmann CR, Dwyer KM, Crews JD, et al: Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma 1997; 42:716-720; discussion 720-1712
13. Goodman AM, Pollack MM, Patel KM, et al: Pediatric red blood cell transfusions increase resource use. J Pediatr 2003; 142:123-127
14. Kneyber MC, Hersi MI, Twisk JW, et al: Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med 2007; 33:1414-1422
15. Trowbridge CC, Stammers AH, Ciccarelli N, et al: Dose titration of recombinant factor VIIa using thromboelastograph monitoring in a child with hemophilia and high titer inhibitors to factor VIII: A case report and brief review. J Extra Cor-por Technol 2006; 38:254-259
16. Martinowitz U, Michaelson M: Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: A report by the Israeli Multidisciplinary rFVIIa Task Force. J Thromb Haemost 2005; 3:640-648
17. Sorensen B, Ingerslev J: Tailoring haemostatic treatment to patient requirements-An update on monitoring haemostatic response using thrombelastography. Haemophilia 2005; 11(Suppl 1):1-6
18. Salooja N, Perry DJ: Thrombelastography. Blood Coagul Fibrinolysis 2001; 12:327-337
19. Attar S, Boyd D, Layne E, et al: Alterations in coagulation and fibrinolytic mechanisms in acute trauma. J Trauma 1969; 9:939-965
20. Sorensen B, Ingerslev J: Thromboelastogra-phy and recombinant factor VIIa-hemophilia and beyond. Semin Hematol 2004; 41(Suppl 1):140-144
21. Schreiber MA: Coagulopathy in the trauma patient. Curr Opin Crit Care 2005; 11:590-597
22. Hendriks HG, Meijer K, de Wolf JT, et al: Effects of recombinant activated factor VII on coagulation measured by thromboelastogra-phy in liver transplantation. Blood Coagul Fibrinolysis 2002; 13:309-313
23. Avidan MS, Da Fonseca J, Parmar K, et al: The effects of aprotinin on thromboelastog-raphy with three different activators. Anesthesiology 2001; 95:1169-1174
24. Miller BE, Tosone SR, Guzzetta NA, et al: Fibrinogen in children undergoing cardiac surgery: Is it effective? Anesth Analg 2004; 99:1341-1346; table of contents
25. Jamnicki M, Zollinger A, Seifert B, et al: Compromised blood coagulation: An in vitro comparison of hydroxyethyl starch 130/0.4 and hydroxyethyl starch 200/0.5 using thrombelastography. Anesth Analg 1998; 87:989-993
26. Nielsen VG, Lyerly RT III, Gurley WQ: The effect of dilution on plasma coagulation kinetics determined by thrombelastography is dependent on antithrombin activity and mode of activation. Anesth Analg 2004; 99: 1587-1592, table of contents
27. Cotton BA, Guy JS, Morris JA Jr, et al: The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock 2006; 26:115-121
28. Levi M, van der Poll T: Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 2005; 15:254-259
29. Hoffman M: A cell-based model of coagulation and the role of factor VIIa. Blood Rev 2003; 17(Suppl 1):S1-S5
30. Boffard KD, Riou B, Warren B, et al: Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: Two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma 2005; 59: 8-15; discussion 15-18
31. Yamakage M, Tsujiguchi N, Kohro S, et al: The usefulness of celite-activated throm-boelastography for evaluation of fibrinolysis. Can J Anaesth 1998; 45:993-996
32. Fries D, Haas T, Salchner V, et al: [Management of coagulation after multiple trauma]. Anaesthesist 2005; 54:137-144
33. Napolitano LM, Corwin HL: Efficacy of red blood cell transfusion in the critically ill. Crit Care Clin 2004; 20:255-268
34. Spinella PC, Perkins JG, Grathwohl KW, et al: Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital. Crit Care Med 2007; 35:2576-2581