Nutrient dyshomeostasis in congestive heart failure

American Journal of the Medical Sciences

Volumn 338, Issue 1, 2009, Pages 28-33

  Kamalov, German ^a   Holewinski, Joshua P ^b   Bhattacharya, Syamal K ^a   Ahokas, Robert A ^a   Sun, Yao ^a   Gerling, Ivan C ^a   Weber, Karl T ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF MEMPHIS   (United States)

Author keywords

African Americans; Aldosteronism; Calcium; Magnesium; Zinc

Indexed keywords

ALDOSTERONE; AMLODIPINE; ANGIOTENSIN II; BIOLOGICAL MARKER; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CYANOCOBALAMIN; FUROSEMIDE; MAGNESIUM; MELANIN; PARATHYROID HORMONE; RENIN; SELENIUM; SODIUM CHLORIDE; SOMATOMEDIN; SPIRONOLACTONE; THIAMINE; ZINC; ZINC SULFATE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIOXIDANT;

AFRICAN AMERICAN; ANTIOXIDANT ACTIVITY; APOPTOSIS; BONE DENSITY; BONE STRENGTH; CACHEXIA; CALCIUM CELL LEVEL; CALCIUM EXCRETION; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CARDIOMYOPATHY; CENTRAL VENOUS PRESSURE; CONFERENCE PAPER; CONGESTIVE CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; DIET SUPPLEMENTATION; FECES; HORMONAL REGULATION; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; HYPOALBUMINEMIA; HYPOCALCEMIA; HYPOKALEMIA; HYPOMAGNESEMIA; INFERIOR CAVA VEIN; LACTOSE INTOLERANCE; LIVER CONGESTION; LYMPHOCYTOPENIA; MAGNESIUM EXCRETION; MUSCLE ATROPHY; NONHUMAN; NUTRITIONAL DEFICIENCY; OSTEOLYSIS; OXIDATIVE STRESS; PARATHYROID HORMONE BLOOD LEVEL; PLASMA RENIN ACTIVITY; PROTEIN DEGRADATION; SECONDARY HYPERPARATHYROIDISM; SELENIUM DEFICIENCY; SKELETAL MUSCLE; SODIUM INTAKE; SUN EXPOSURE; SYSTOLIC DYSFUNCTION; TRICUSPID VALVE REGURGITATION; URINARY EXCRETION; VITAMIN D DEFICIENCY; ZINC DEFICIENCY; ANIMAL; HEART FAILURE; HOMEOSTASIS; METABOLISM; NUTRITIONAL DISORDER; PATHOPHYSIOLOGY; REVIEW;

AFRICAN AMERICANS; ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; HEART FAILURE; HOMEOSTASIS; HUMANS; NEUROTRANSMITTER AGENTS; NUTRITION DISORDERS; OXIDATIVE STRESS;

EID: 68849089322     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3181aaee63     Document Type: Conference Paper

References (45)

1. Bhattacharya SK, Ahokas RA, Carbone LD, et al. Macro-and micronutrients in African-Americans with heart failure. Heart Fail Rev 2006;11:45-55.
2. Strassburg S, Anker SD. Metabolic and immunologic derangements in cardiac cachexia: Where to from here? Heart Fail Rev 2006;11:57-64.
3. von Haehling S, Doehner W, Anker SD. Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure. Cardiovasc Res 2007;73:298-309.
4. Weber KT, Weglicki WB, Simpson RU. Macro-and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium. Cardiovasc Res 2009;81:500-508
5. Song YH, Li Y, Du J, et al. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest 2005;115:451-458
6. Brilla CG, Pick R, Tan LB, et al. Remodeling of the rat right and left ventricle in experimental hypertension. Circ Res 1990;67:1355-1364
7. Weber KT. From inflammation to fibrosis: A stiff stretch of highway. Hypertension 2004;43:716-719
8. Gerling IC, Sun Y, Ahokas RA, et al. Aldosteronism: An immunostimulatory state precedes the proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol 2003;285:H813-H821.
9. Chhokar VS, Sun Y, Bhattacharya SK, et al. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation 2005;111:871-878
10. Chhokar VS, Sun Y, Bhattacharya SK, et al. Loss of bone minerals and strength in rats with aldosteronism. Am J Physiol Heart Circ Physiol 2004;287:H2023-H2026.
11. Law PH, Sun Y, Bhattacharya SK, et al. Diuretics and bone loss in rats with aldosteronism. J Am Coll Cardiol 2005;46:142-146
12. Thomas M, Vidal A, Bhattacharya SK, et al. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. Am J Physiol Heart Circ Physiol 2007;293:H2361-H2366.
13. Selektor Y, Parker RB, Sun Y, et al. Tissue 65zinc translocation in a rat model of chronic aldosteronism. J Cardiovasc Pharmacol 2008;51: 359-364
14. Massry SG, Smogorzewski M. Mechanisms through which parathyroid hormone mediates its deleterious effects on organ function in uremia. Semin Nephrol 1994;14:219-231
15. Ahokas RA, Warrington KJ, Gerling IC, et al. Aldosteronism and peripheral blood mononuclear cell activation. A neuroendocrine-immune interface. Circ Res 2003;93:e124-e135.
16. Ahokas RA, Sun Y, Bhattacharya SK, et al. Aldosteronism and a proinflammatory vascular phenotype. Role of Mg2-, Ca2- and H2O2 in peripheral blood mononuclear cells. Circulation 2005;111:51-57
17. Gandhi MS, Deshmukh PA, Kamalov G, et al. Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol 2008;52:245-252
18. Kamalov G, Deshmukh PA, Baburyan NY, et al. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol 2009;53:414-423
19. Goodwin KD, Ahokas RA, Bhattacharya SK, et al. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. Am J Med Sci 2006;332:73-78
20. Vidal A, Sun Y, Bhattacharya SK, et al. Calcium paradox of aldosteronism and the role of the parathyroid glands. Am J Physiol Heart Circ Physiol 2006;290:H286-H294.
21. Selektor Y, Ahokas RA, Bhattacharya SK, et al. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. Am J Med Sci 2008;335:105-110
22. Sun Y, Zhang J, Lu L, et al. Aldosterone-induced inflammation in the rat heart. Role of oxidative stress. Am J Pathol 2002;161:1773-1781
23. Cai L. Diabetic cardiomyopathy and its prevention by metallothionein: Experimental evidence, possible mechanisms and clinical implications. Curr Med Chem 2007;14:2193-2203
24. Wang J, Song Y, Elsherif L, et al. Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation 2006;113:544-554
25. Nickerson PA. A low dose of a calcium antagonist (nitrendipine) ameliorates cardiac and renal lesions induced by DOC in the rat. Exp Mol Pathol 1984;41:309-320
26. Alsafwah S, LaGuardia SP, Nelson MD, et al. Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure. Am J Med Sci 2008;335:292-297
27. Lee AH, Mull RL, Keenan GF, et al. Osteoporosis and bone morbidity in cardiac transplant recipients. Am J Med 1994;96:35-41.
28. Shane E, Mancini D, Aaronson K, et al. Bone mass, vitamin D deficiency, and hyperparathyroidism in congestive heart failure. Am J Med 1997;103:197-207.
29. Kerschan-Schindl K, Strametz-Juranek J, Heinze G, et al. Pathogenesis of bone loss in heart transplant candidates and recipients. J Heart Lung Transplant 2003;22:843-850
30. Frost RJ, Sonne C, Wehr U, et al. Effects of calcium supplementation on bone loss and fractures in congestive heart failure. Eur J Endocrinol 2007;156:309-314
31. Kenny AM, Boxer R, Walsh S, et al. Femoral bone mineral density in patients with heart failure. Osteoporos Int 2006;17:1420-1427
32. Abou-Raya S, Abou-Raya A. Osteoporosis and congestive heart failure (CHF) in the elderly patient: Double disease burden. Arch Gerontol Geriatr. In press.
33. van Diepen S, Majumdar SR, Bakal JA, et al. Heart failure is a risk factor for orthopedic fracture: A population-based analysis of 16,294 patients. Circulation 2008;118:1946-1952
34. Carbone LD, Cross JD, Raza SH, et al. Fracture risk in men with congestive heart failure. Risk reduction with spironolactone. J Am Coll Cardiol 2008;52:135-138
35. Raza SH, Law P, Farooqui N, et al. Atraumatic fractures in heart failure. Am J Med Sci 2009;338:45-47
36. Arroyo M, LaGuardia SP, Bhattacharya SK, et al. Micronutrients in African-Americans with decompensated and compensated heart failure. Transl Res 2006;148:301-308
37. Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev 2006;11:19-24.
38. Ali S, Shahbaz AU, Nelson MD, et al. Reduced relative lymphocyte count in African-Americans with decompensated heart failure. Am J Med Sci 2009;337:156-160
39. Battin DL, Ali S, Whitted AD, et al. A protein-losing enteropathy in patients with decompensated, biventricular failure having hypoalbuminemia [abstr]. J Investig Med 2009;57:372.
40. Niebauer J, Volk HD, Kemp M, et al. Endotoxin and immune activation in chronic heart failure: A prospective cohort study. Lancet 1999;353:1838-1842
41. Zafarullah H, Shahbaz AU, Alturkmani R, et al. Elevated serum cobalamin in patients with decompensated biventricular failure. Am J Med Sci 2008;336:383-388
42. Seligmann H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: A pilot study. Am J Med 1991;91:151-155
43. Shimon I, Almog S, Vered Z, et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med 1995;98:485-490
44. Zenuk C, Healey J, Donnelly J, et al. Thiamine deficiency in congestive heart failure patients receiving long term furosemide therapy. Can J Clin Pharmacol 2003;10:184-188
45. Witte KK, Clark AL, Cleland JG. Chronic heart failure and micronutrients. J Am Coll Cardiol 2001;37:1765-1774