Expression analysis of early response-related genes in rat liver epithelial cells exposed to thioacetamide in vitro

Journal of Veterinary Medical Science

Volumn 71, Issue 6, 2009, Pages 719-727

  Yeom, Hye Jung ^a   Park, Joon Suk ^b   Oh, Moon Ju ^a   Paul, Saswati ^a   Kim, Joo Kyoung ^a   Kim, Seung Jun ^a   Lee, Yong Soon ^b   Kang, Kyung Sun ^b   Hwang, Seung Yong ^a  

^a GenoCheck Co Ltd   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Cytotoxicity; Gene expression; Microarray; Thioacetamide; Toxicogenomics

Indexed keywords

THIOACETAMIDE;

ANIMAL; ARTICLE; CELL LINE; CELL SURVIVAL; CLUSTER ANALYSIS; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; EPITHELIUM CELL; FISCHER 344 RAT; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; MALE; METHODOLOGY; PHYSIOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; CELL SURVIVAL; CLUSTER ANALYSIS; EPITHELIAL CELLS; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIOACETAMIDE;

RATTUS;

EID: 68849086063     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.71.719     Document Type: Article

References (36)

1. Ballal, N.R., Goldknopf, I.L., Goldberg, D.A. and Busch, H. 1974. The dynamic state of liver nucleolar proteins as reflected by their changes during administration of thioacetamide. Life Sci. 14: 1835-1845.
2. Barker, E.A. and Smuckler, E.A. 1972. Altered microsome function during acute thioacetamide poisoning. Mol. Pharmacol. 8: 318-326.
3. Bulera, S.J., Eddy, S.M., Ferguson, E., Jatkoe, T.A., Reindel, J.F., Bleavins, M.R. and De La Iglesia, F.A. 2001. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology 33: 1239-1258.
4. Cascorbi, I. 2006. Genetic basis of toxic reactions to drugs and chemicals. Toxicol. Lett. 162: 16-28.
5. Chakrabartty, P.K. and Schneider, W.C. 1978. Increased activity of rat liver messenger RNA and of albumin messenger RNA modulated by thioacetamide. Cancer Res. 38: 2043-2047.
6. Corton, J.C., Anderson, S.P., Stauber, A.J., Janszen, D.B., Kimbell, J.S. and Cononlly, R.B. 1999. Entering Era of Toxicogenomics with DNA Microarrays. Activities 19: 1-8.
7. Cunningham, M.L., Bogdanffy, M.S., Zacharewski, T.R. and Hines, R.N. 2003. Workshop overview: use of genomic data in risk assessment. Toxicol. Sci. 73: 209-215.
8. Dumble, M. L., Croager, E. J., Yeoh, G. C., and Quail, E. A. 2002. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 23:435-445.
9. Fielden, M.R. and Kolaja, K.L. 2006. The state-of-the-art in predictive toxicogenomics. Curr. Opin. Drug. Discov. Devel. 9: 84-91.
10. Goodsaid, F.M. 2003. Genomic biomarkers of toxicity. Curr. Opin. Drug. Discov. Devel. 6: 41-49.
11. Gore, M.A., Morshedi, M.M. and Reidhaar-Olson, J.F. 2000. Gene expression changes associated with cytotoxicity identified using cDNA arrays. Funct. Integr. Genomics. 1: 114-126.
12. Hay, B.A., Huh, J.R. and Guo, M. 2004. The genetics of cell death: approaches, insights and opportunities in drosophila. Nat. Rev. Genet. 5: 911-922.
13. Heo, J., Thapar, R. and Campbell, S.L. 2005 Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors. Biochemistry 44: 6573-65
14. Irwin, R.D., Boorman, G.A., Cunningham, M.L., Heinloth, A.N., Malarkey, D.E. and Paules, R.S. 2004. Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data. Toxicol. Pathol. 32: 72-83.
15. Jeong, J.S., Kim, I.H., Lee, H.J. and Choi, Y.C. 1998. Nucleolus contains signal molecules that constitute membrane-nucleolus linked pathway. Exp. Mol. Med. 30: 205-213.
16. Jung, J.W., Park, J.S., Hwang, J.W., Kang, K.S., Lee, Y.S., Song, B.S., Lee, G.J., Yeo, C.D., Kang, J.S., Lee, W.S., Jeon, K.S., Um, C.H., Kim, Y.S., Oh, M.J., Youn, J.P., Li, P., Park, J.E. and Hwang, S.Y. 2004. Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray. J. Vet. Med. Sci. 66: 1329-1333.
17. Kim, J.H., Kim, S.J., Yeon, J.P., Yeom, H.J., Jung, J.W., Oh, M.J., Park, J.S., Kang, K.S. and Hwang, S.Y. 2006. Whole genomic expression analysis of rat liver epithelial cells in response to phenytoin. Mol. Cell. Toxicol. 2: 120-125.
18. Kim, S.J., Oh, M.J., Park, H.W., Kim, J.S., Paul, S., Ha, J.M., Kim, Y.J., Kim, Y.J., Ryu, J.C., Lee, C.W., Kim, H.M., Choi, K.H. and Hwang, S.Y. 2008. Gene expression profiles of nonylphenol as representative EDCs in normal human kidney HK- 2 cells. BioChip J. 2: 135-140.
19. Lee, K., Burgoon, L.D., Lamb, L., Dere, E., Zacharewski, T.R., Hogenesch, J.B. and LaPres, J.J. 2006. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chem. Res. Toxicol. 19: 1284-1293.
20. Lu, S.C., Huang, Z.Z., Yang, H. and Tsukamoto, H. 1999. Effect of thioacetamide on the hepatic expression of gammaglutamylcysteine synthetase subunits in the Rat. Toxicol. Appl. Pharmacol. 159: 161-168.
21. Maggioli, J., Hoover, A. and Weng, L. 2006. Toxicogenomic analysis methods for predictive toxicology. J. Pharmacol. Tox icol. Methods. 53: 31-37.
22. Marchant, G.E. 2002. Toxicogenomics and toxic torts. Trends. Biotechnol. 20: 329-332.
23. Mattes, W.B., Pettit, S.D., Sansone, S.A., Bushel, P.R. and Waters, M.D. 2004. Database development in toxicogenomics: issues and efforts. Environ. Health. Perspect. 112: 495-505.
24. Merrill, C.L., Ni, H., Yoon, L.W., Tirmenstein, M.A., Narayanan, P., Benavides, G.R., Easton, M.J., Creech, D.R., Hu, C.X., McFarland, D.C., Hahn, L.M., Thomas, H.C. and Morgan, K.T. 2002. Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically. Toxicol. Sci. 68: 93-101.
25. Minami, K., Saito, T., Narahara, M., Tomita, H., Kato, H., Sugiyama, H., Katoh, M., Nakajima, M. and Yokoi, T. 2005. Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats. Toxicol. Sci. 87: 296-305.
26. Minami, K., Maniratanachote, R., Katoh, M., Nakajima, M. and Yokoi, T. 2006. Simultaneous measurement of gene expression for hepatotoxicity in thioacetamide-administered rats by DNA microarrays. Mutat. Res. 603: 64-73.
27. Moggs, J.G., Tinwell, H., Spurway, T., Chang, H.S., Pate, I., Lim, F.L., Moore, D.J., Soames, A., Stuckey, R., Currie, R., Zhu, T., Kimber, I., Ashby, J. and Orphanides, G. 2004. Phenotypic anchoring of gene expression changes during estrogeninduced uterine growth. Environ. Health Perspect. 112: 1589-1606.
28. Moorthy, B. 2000. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 294: 313-322.
29. Paules, R. 2003. Phenotypic anchoring: linking cause and effect. Environ. Health Perspect. 111: 338-339.
30. Shafritz, D. A. and Dabeva, M. D. 2002. Liver stem cells and model systems for liver repopulation. J. Hepatol. 36: 552-564.
31. Spira, B. and Raw, I. 2000. The effect of thioacetamide on the activity and expression of cytosolic rat liver glutathione-Stransferase. Mol. Cell. Biochem. 211: 103-110.
32. Steele, W.J. and Busch, H. 1966. Increased content of high molecular weight RNA fractions in nuclei and nucleoli of livers of thioacetamide-treated rats. Biochim. Biophys. Acta 119: 501-509.
33. Thomas, L.R., Henson, A., Reed, J.C., Salsbury, F.R. and Thorburn, A. 2004. Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. J. Biol. Chem. 279: 32780-32785.
34. Tsao, M.S., Smith, J.D., Nelson, K.G. and Grisham, J.W. 1984. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp. Cell Res. 154: 38-52.
35. Yang, Y., Abel, S.J., Ciurlionis, R. and Waring, J.F. 2006. Development of a toxicogenomics in vitro assay for the efficient characterization of compounds. Pharmacogenomics. 7: 177-186.
36. Zaragoza, A., Andres, D., Sarrion, D. and Cascales, M. 2000. Potentiation of thioacetamide hepatotoxicity by Phenobarbital pretreatment in rats. Inducibility of FAD monooxygenase system and age effect. Chem. Biol. Interact. 124: 87-101.