Enhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes

European Heart Journal

Volumn 30, Issue 15, 2009, Pages 1844-1852

  Yunoki, Kei ^a   Naruko, Takahiko ^a   Komatsu, Ryushi ^a   Ehara, Shoichi ^b   Shirai, Nobuyuki ^b   Sugioka, Kenichi ^b   Nakagawa, Masashi ^b   Kitabayashi, Chizuko ^b   Ikura, Yoshihiro ^b   Itoh, Akira ^a   Kusano, Kengo ^c   Ohe, Tohru ^c   Haze, Kazuo ^a   Becker, Anton E ^d   Ueda, Makiko ^b  

^a OSAKA CITY GENERAL HOSPITAL   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Angina; Atherosclerosis; Coronary disease; Lipoproteins

Indexed keywords

4 HYDROXYNONENAL; CD163 ANTIGEN; CD31 ANTIGEN; GLYCOPHORIN A; HEMOGLOBIN;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; ATHERECTOMY; ATHEROSCLEROTIC PLAQUE; BLEEDING; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STABLE ANGINA PECTORIS; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; AGED; ALDEHYDES; ANGINA PECTORIS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CROSS-LINKING REAGENTS; FEMALE; GENE EXPRESSION; HEMORRHAGE; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MIDDLE AGED; RECEPTORS, CELL SURFACE; RECEPTORS, SCAVENGER;

EID: 68749116503     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp257     Document Type: Article

References (36)

1. Maseri A, Fuster V. Is there a vulnerable plaque? Circulation 2003; 107:2068-2071.
2. van der Wai AC, Becker AE, van der Loos CM, Das PK Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circutotion 1994; 89:36-44.
3. Farb A, Burke AP, Tang AL, Liang TY, Mannan P, Smialek J, Virmani R. Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation 1996; 93:1354-1363.
4. Hosono M, de Boer OJ, van der Wai AC, van der Loos CM, Teeling P, Piek JJ, Ueda M, Becker AE. Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction. Atherosclerosis 2003; 168:73-80.
5. Ehara S, Ueda M, Naruko T, Haze K, Itoh A, Otsuka M, Komatsu R, Matsuo T, Itabe H, Takano T, Tsukamoto Y, Yoshiyama M, Takeuchi K, Yoshikawa J, Becker AE. Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation 2001; 103:1955-1960.
6. Yamashita H, Ehara S, Yoshiyama M, Naruko T, Haze K, Shirai N, Sugama Y, Ikura Y, Ohsawa M, Itabe H, Kataoka T, Kobayashi Y, Becker AE, Yoshikawa J, Ueda M. Elevated plasma levels of oxidized low-density lipoprotein relate to the presence of angiographically detected complex and thrombotic coronary artery lesion morphology in patients with unstable angina. Circ J 2007; 71: 681-687.
7. Naruko T, Ueda M, Haze K, van der Wal AC, van der Loos CM, Itoh A, Komatsu R, Ikura Y, Ogami M, Shimada Y, Ehara S, Yoshiyama M, Takeuchi K, Yoshikawa J, Becker AE. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002; 106:2894-2900.
8. Kayo S, Ohsawa M, Ehara S, Naruko T, Ikura Y, Hai E, Yoshimi N, Shirai N, Tsukamoto Y, Itabe H, Higuchi K, Arakawa T, Ueda M. Oxidized low density lipoprotein levels circulating in plasma and deposited in the tissues: comparison between helicobacter pylori-associated gastritis and acute myocardial infarction. Am Heart J 2004; 148:818-825.
9. Pasterkamp G, Virmani R. The erythrocyte: a new player in atheromatous core formation. Heart 2002; 88:115-116.
10. Kolodgie FD, Gold HK, Burke AP, Fowler DR, Kruth HS, Weber DK, Farb A, Guerrero LJ, Hayase M, Kutys R, Narula J, Finn AV, Virmani R. Intraplaque hemorrhage and progression of coronary atheroma. N Eng J Med 2003; 349:2316-2325.
11. Kolodgie FD, Virmani R, Burke AP, Farb A, Weber DK, Kutys R, Finn AV, Gold HK Pathologic assessment of the vulnerable human coronary plaque. Heart 2004; 90:1385-1391.
12. Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, Tulenko TN, Wrenn SP, Narula J. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 2005; 25:2054-2061.
13. Takaya N, Yuan C, Chu B, Saam T, Polissar NL, Jarvik GP, Isaac C, McDonough J, Natiello C, Small R, Ferguson MS, Hatsukami TS. Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation 2005; 111:2768-2775.
14. Feng Z, Hu W. Tang MS. Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci USA 2004; 101:8598-8602.
15. Graversen JH, Madsen M. Moestrup SK. CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int J Biochem Cell Biol 2002; 34: 309-314.
16. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK Identification of the haemoglobin scavenger receptor. Nature 2001; 409:198-201.
17. Schaer DJ, Boretti FS, Schoedon G, Schaffner A. Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel antiinflammatory action of glucocorticoids. Br J Haematol 2002; 119:239-243.
18. Schaer CA, Schoedon G, Imhof A, Kurrer MO, Schaer DJ. Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin. Circ Res 2006; 99:943-950.
19. Van den Heuvel MM, Tensen CP, van As JH, Van den Berg TK, Fluitsma DM, Dijkstra CD, Döpp EA, Droste A, Van Gaalen FA, Sorg C, Högger P, Beelen RH. Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation. J Leukoc Biol 1999; 66:858-866.
20. Miyamoto S, Ueda M, Ikemoto M, Naruko T, Itoh A, Tamaki S, Nohara R, Terasaki F, Sasayama S, Fujita M. Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina. Heart 2008; 94:1002-1007.
21. Braunwald E. Unstable angina. A classification. Circulation 1989; 80:410-414.
22. Ambrose JA, Winters SL, Stern A, Eng A, Teichholz LE, Gorlin R, Fuster V. Angiographic morphology and the pathogenesis of unstable angina pectoris. J Am Coll Cardiol 1985; 5:609-616.
23. Van der Loos CM, Becker AE, van den Oord JJ. Practical suggestions for successful immunoenzyme double-staining experiments. Histochem J 1993; 25:1-13.
24. Moreno PR, Purushothaman KR, Fuster V, Echeverri D, Truszczynska H, Sharma SK, Badimon JJ, O'Connor WN. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation 2004; 110:2032-2038.
25. Moreno PR, Purushothaman KR, Sirol M, Levy AP, Fuster V. Neovascularization in' human atherosclerosis. Circulation 2006; 113:2245-2252.
26. Kolodgie FD, Narula J, Yuan C, Burke AP, Finn AV, Virmani R. Elimination of neoangiogenesis for plaque stabilization: is there a role for local drug therapy? J Am Coll Cardiol 2007; 49:2093-2101.
27. Kockx MM, Cromheeke KM, Knaapen MWM, Bosmans JM, De Meyer GRY, Herman AG, Bult H. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol 2003; 23:440-446.
28. Sambrano GR, Parthasarathy S, Steinberg D. Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein. Proc Natl Acad Sci USA 1994; 91:3265-3269.
29. Yuan XM, Brunk UT, Olsson AG. Effects of iron- and hemoglobin-loaded human monocyte-derived macrophages on oxidation and uptake of LDL Arteriosder Thromb Vasc Biol 1995; 15:1345-1351.
30. Coffey MD, Cole RA, Colles SM, Chisolm GM. In vitro cell injury by oxidized low density lipoprotein involves lipid hydro peroxide-induced formation of alkoxyl, lipid, and peroxyl radicals. J Clin Invest 1995; 96:1866-1873.
31. Yuan XM, Anders WL, Olsson AG, Brunk UT. Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis. Atherosclerosis 1996; 124:61-73.
32. De Martin R, Hoeth M, Hofer-Warbinek R, Schmid JA. The transcription factor; NF-kappa B and the regulation of vascular cell function. Arteriosder Thromb Vosc Biol 2000; 20:e83-e88.
33. Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW, Balla G. Pro-oxidant and cytotoxic effects of circulating heme. Blood 2002; 100: 879-887.
34. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. J Am Med Assoc 2005; 293:1653-1662.
35. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash Al, Schaffner A. CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood 2006; 107: 373-380.
36. Fernandez AZ, López F, Tablante A, Romano E, Hurt-Camejo E, Camejo G, Apitz-Castro R. Intravascular hemolysis increases atherogenicity of diet-induced hypercholesterolemia in rabbits in spite of heme oxygenase-1 gene and protein induction. Atherosderosis 2001; 158:103-111.