Construction of a quantitative structure-permeability relationship (QSPR) for the transdermal delivery of NSAIDs

Journal of Controlled Release

Volumn 138, Issue 3, 2009, Pages 260-267

  Liou, Yi Bo ^a   Ho, Hsiu O ^a   Yang, Chun Jen ^a   Lin, Ying Ku ^a   Sheu, Ming Thau ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b Clinical Research Center   (Taiwan)

Author keywords

Biological parameters; NSAID; Quantitative structure permeability relationship (QSPR); Solubility parameter; Transdermal permeability

Indexed keywords

BIOLOGICAL PARAMETERS; NSAID; QUANTITATIVE STRUCTURE-PERMEABILITY RELATIONSHIP (QSPR); SOLUBILITY PARAMETER; TRANSDERMAL PERMEABILITY;

CONTROLLED DRUG DELIVERY; DIELECTRIC PROPERTIES; HYDROPHILICITY; SKIN; SOLUBILITY; SULFUR COMPOUNDS; TERNARY SYSTEMS; WATER CONTENT;

CAPILLARITY;

ACETYLSALICYLIC ACID; DICLOFENAC; DIFLUNISAL; FLUFENAMIC ACID; IBUPROFEN; INDOMETACIN; KETOPROFEN; NABUMETONE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; TENOXICAM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG PENETRATION; DRUG SOLUBILITY; ELASTICITY; HYDRATION; HYDROPHILICITY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEBUM; SKIN PENETRATION; SKIN PERMEABILITY; SKIN WATER LOSS;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; MALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; PERMEABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN; SOLUBILITY;

EID: 68749108031     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.05.024     Document Type: Article

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