FTIR spectroscopic analysis of sputum: Preliminary findings on a potential novel diagnostic marker for COPD

Therapeutic Advances in Respiratory Disease

Volumn 2, Issue 1, 2008, Pages 23-31

  Whiteman, S C ^a   Yang, Y ^a   Jones, J M ^b   Spiteri, M A ^a  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

Author keywords

biomarkers; COPD; FTIR spectroscopy; spectral profiles; sputum analysis

Indexed keywords

AMIDE; AMINOPHYLLINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; GLYCOGEN; IPRATROPIUM BROMIDE;

ABSORPTION SPECTROSCOPY; ADULT; AGED; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; FEMALE; HUMAN; INFRARED SPECTROSCOPY; MALE; PATIENT MONITORING; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; REVIEW; SENSITIVITY ANALYSIS; SPUTUM ANALYSIS; VOLUNTEER;

AGED; AMIDES; BIOLOGICAL MARKERS; FEMALE; GLYCOGEN; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REPRODUCIBILITY OF RESULTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPUTUM;

EID: 68749093263     PISSN: 17534658     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753465807087972     Document Type: Article

References (25)

1. Celli, B.R. and MacNee, W. (2004) Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper. Eur Respir J 23: 932–946.
2. Choo, L.P., Jackson, M., Halliday, W.C., Mantsch, H.H. (1993) Infrared spectroscopic characterisation of multiple sclerosis plaques in the human central nervous system. Biochim Biophys Acta 1182: 333–337.
3. Chung, K.F. (2005) Inflammatory mediators in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 4(6): 619–625.
4. Donaldson, G.C. and Wedzicha, J.A. (2006) COPD Exacerbations-1. Epidemiology. Thorax 61: 164–168.
5. Donohue, J.F. (2006) Ageing, smoking and oxidative stress. Thorax 61: 461–462. Editorial
6. Ellis, D.I. and Goodacre, R. (2006) Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy. Analyst 131: 875–885.
7. Girod, S., Zahm, J.M., Plotkowski, C., Beck,G., Puchelle, E. (1992) Role of the physiochemical properties of mucus in the protection of the respiratory epithelium. Eur Respir J 5: 477–487.
8. Hill, A.T., Campbell, E.J., Hill, S.L., Bayley, D.L., Stockley, R.A. (2000) Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. Am J Med 109: 288–295.
9. Holz, O. (2005) Catching breath: monitoring airway inflammation using exhaled breath condensate. Eur Respir J 26: 371–372.
10. Jackson, M., Sowa, M.G., Mantsch, H.H. (1997) Infrared spectroscopy: a new frontier in medicine. Biophysical Chemistry 68: 109–125.
11. Kharitonov, S. and Barnes, P.J. (2006) Exhaled biomarkers. Chest 130: 1541–1546.
12. Kleiner, O., Ramesh, J., Huleihel, M., Cohen, B., Kantarovich, K., Levi, C. et al. (2002) A comparative study of gallstones from children and adults using FTIR spectroscopy and fluorescence microscopy. BMC Gastroenterology 2(1): 3, (Published online 2002 February 11. doi: 10.1186/1471-230x-2-3).
13. Lofdahl, J.M., Wahlstrom, J., Skold, C.M. (2006) Differential inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. Clin Exp Immunol 145: 428–437.
14. Maestrelli, P., Richeldi, L., Moretti, M., Fabbri, L.M. (2001) Analysis of sputum in COPD. Thorax 56: 420–422.
15. Montuschi, P. (2007) Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications. Ther Adv Respir Med 1: 5–23.
16. Mordechai, J., Ramesh, J., Huleihel, M., Cohen, Z., Kleiner, O., Talyshinsky, M. et al. (2004) Studies on acute human infections using FTIR microspectrscopy and cluster analysis. Biopolymers 73: 494–502.
17. Nadel, J.A. (2000) Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies. Chest 117: 386–389.
18. Parr, D.G., White, A.J., Bayley, D.L., Guest, P.J., Stockley, R.A. (2006) Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study. Respiratory Research 7: 136. doi:10.1186/1465-9921-7-136.
19. Pauwels, R.A., Buist, A.S., Calverley, P.M.A., Jenkins, C.R., Hurd, S.S. (2001) Global strategy for the diagnostic management and prevention of chronic obstructive pulmonary disease. NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med 163: 1256–1276.
20. Saetta, M., Turato, G., Maestrelli, P., Mapp, C.E., Fabbri, L.M. (2001) Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163: 1304–1309.
21. Tetley, T.D. (2005) Inflammatory cells and chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 4(6): 607–618.
22. Thomas, R.A., Green, R.H., Brightling, C.E., Birring, A.A., Parker, D., Wardlaw, A.J. et al. (2004) The influence of age on induced sputum differential cell counts in normal subjects. Chest 126: 1811–1814.
23. Uemura, T., Nishida, K., Sakakida, M., Ichinose, K., Shimoda, S., Sichiri, M. (1999) Non-invasive blood glucose measurement by Fourier transform infrared spectroscopic analysis through the mucous membrane of the lip: application of a chalcogenide optical fiber system. Front Med Biol Eng 9: 137–153.
24. World Health Organisation 1998. Life in the 21st Century: A vision for all. In World Health Report, Geneva.
25. Wouters, E.F. (2003) Economic analysis of the confronting COPD survey: an overview of results. Respir Med 97: S3–14.