메뉴 건너뛰기




Volumn 23, Issue 4, 2009, Pages 367-386

Therapeutic opportunities of small interfering RNA

Author keywords

Cancer; Cardiovascular diseases; CNS disorders; Delivery; SiRNA

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA; NUCLEASE; SHORT HAIRPIN RNA; SINGLE STRANDED RNA; SMALL INTERFERING RNA;

EID: 68749087654     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2009.00694.x     Document Type: Review
Times cited : (12)

References (178)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 391 806 811. (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 0032410928 scopus 로고    scopus 로고
    • Double stranded RNA induced mRNA degradation in Trypanosoma brucei
    • Ngo H., Tschudi C., Gull K., Ullu E. Double stranded RNA induced mRNA degradation in Trypanosoma brucei. Proc. Natl Acad. Sci. USA (1998) 95 14687 14692.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 14687-14692
    • Ngo, H.1    Tschudi, C.2    Gull, K.3    Ullu, E.4
  • 3
    • 0032443021 scopus 로고    scopus 로고
    • Use of dsRNA mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
    • Kennerdell J.R., Carthew R.W. Use of dsRNA mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell (1998) 95 1017 1026.
    • (1998) Cell , vol.95 , pp. 1017-1026
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 4
    • 0033608994 scopus 로고    scopus 로고
    • Double stranded RNA specifically disrupts gene expression during planarian regeneration
    • Sanchez A.A., Newmark P.A. Double stranded RNA specifically disrupts gene expression during planarian regeneration. Proc. Natl Acad. Sci. USA (1999) 96 5049 5054.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5049-5054
    • Sanchez, A.A.1    Newmark, P.A.2
  • 5
    • 0038071491 scopus 로고    scopus 로고
    • A simple ''soaking method'' for RNA interference in planarian Dugesia japonica
    • Oril H., Mochii M., Watnabe K. A simple ''soaking method'' for RNA interference in planarian Dugesia japonica. Dev. Genes. Evol. (2003) 213 138 141.
    • (2003) Dev. Genes. Evol. , vol.213 , pp. 138-141
    • Oril, H.1    Mochii, M.2    Watnabe, K.3
  • 6
    • 0033214763 scopus 로고    scopus 로고
    • Silencing of developmental genes in Hydra
    • Lohmann J.U., Endl I., Bosch T.C. Silencing of developmental genes in Hydra. Dev. Biol. (1999) 1 211 214.
    • (1999) Dev. Biol. , vol.1 , pp. 211-214
    • Lohmann, J.U.1    Endl, I.2    Bosch, T.C.3
  • 7
    • 0037227689 scopus 로고    scopus 로고
    • Exploring plant genomes by RNA-induced gene silencing
    • Waterhouse P.M., Helliwell C.A. Exploring plant genomes by RNA-induced gene silencing. Nat. Rev. Genet. (2003) 4 29 38.
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 29-38
    • Waterhouse, P.M.1    Helliwell, C.A.2
  • 8
    • 0033575910 scopus 로고    scopus 로고
    • Double stranded RNA induces specific developmental defects in zebrafish embryo
    • Wargelius A., Ellingsen S., Fjose A. Double stranded RNA induces specific developmental defects in zebrafish embryo. Biochem. Biophys. Res. Commun. (1999) 263 156 161.
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 156-161
    • Wargelius, A.1    Ellingsen, S.2    Fjose, A.3
  • 9
    • 0033789992 scopus 로고    scopus 로고
    • Specific interference with gene function by double-stranded RNA in early mouse development
    • Wianny F., Zernicka G.M. Specific interference with gene function by double-stranded RNA in early mouse development. Nat. Cell Biol. (2000) 2 70 75.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 70-75
    • Wianny, F.1    Zernicka, G.M.2
  • 10
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic siRNAs in adult mice
    • Sorensen D.R., Leirdal M., Siod M. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J. Mol. Biol. (2003) 327 761 766.
    • (2003) J. Mol. Biol. , vol.327 , pp. 761-766
    • Sorensen, D.R.1    Leirdal, M.2    Siod, M.3
  • 11
    • 0037377201 scopus 로고    scopus 로고
    • Transgenic RNAi in mouse oocytes: A simple and fast approach to study gene function
    • Stein P., Svoboda P., Schultz R.M. Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function. Dev. Biol. (2003) 256 187 193.
    • (2003) Dev. Biol. , vol.256 , pp. 187-193
    • Stein, P.1    Svoboda, P.2    Schultz, R.M.3
  • 12
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • McManus M.T., Sharp P.A. Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet. (2002) 3 737 747.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 737-747
    • McManus, M.T.1    Sharp, P.A.2
  • 13
    • 0037213559 scopus 로고    scopus 로고
    • Mammalian RNAi for the masses
    • Shi Y. Mammalian RNAi for the masses. Trends Genet. (2003) 19 9 12.
    • (2003) Trends Genet. , vol.19 , pp. 9-12
    • Shi, Y.1
  • 14
    • 0141706705 scopus 로고    scopus 로고
    • SiRNA agents inhibit oncogene expression and attenuate human tumor cell growth
    • Yin J.Q., Gao J., Shao R., Tian W.N., Wang J., Wan Y. siRNA agents inhibit oncogene expression and attenuate human tumor cell growth. J. Exp. Ther. Oncol. (2003) 3 194 204.
    • (2003) J. Exp. Ther. Oncol. , vol.3 , pp. 194-204
    • Yin, J.Q.1    Gao, J.2    Shao, R.3    Tian, W.N.4    Wang, J.5    Wan, Y.6
  • 15
    • 3242677639 scopus 로고    scopus 로고
    • SiRNAs: Applications in functional genomics and potential as therapeutics
    • Drosett Y., Tuschl T. siRNAs: applications in functional genomics and potential as therapeutics. Nat. Rev. Drug. Discov. (2004) 3 318 329.
    • (2004) Nat. Rev. Drug. Discov. , vol.3 , pp. 318-329
    • Drosett, Y.1    Tuschl, T.2
  • 16
    • 23944482649 scopus 로고    scopus 로고
    • Challenges and successes in developing new therapies for hepatitis C
    • de Francesco R., Migliaccio G. Challenges and successes in developing new therapies for hepatitis C. Nature (2005) 436 953 960.
    • (2005) Nature , vol.436 , pp. 953-960
    • De Francesco, R.1    Migliaccio, G.2
  • 17
    • 8444233617 scopus 로고    scopus 로고
    • Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer
    • Liu T.G., Yin Q., Shang B.Y. et al. Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer. Cancer Gene Ther. (2004) 11 748 756.
    • (2004) Cancer Gene Ther. , vol.11 , pp. 748-756
    • Liu, T.G.1    Yin, Q.2    Shang, B.Y.3
  • 18
    • 33646190173 scopus 로고    scopus 로고
    • Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs
    • DOI 10.1016/j.jbiotec.2005.12.003, PII S0168165605007571
    • Aigner A. Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. J. Biotechnol. (2006) 124 12 25. (Pubitemid 43816129)
    • (2006) Journal of Biotechnology , vol.124 , Issue.1 , pp. 12-25
    • Aigner, A.1
  • 19
    • 0034724519 scopus 로고    scopus 로고
    • Double-stranded RNA as a template for gene silencing
    • Bass B.L. Double-stranded RNA as a template for gene silencing. Cell (2000) 101 235 238.
    • (2000) Cell , vol.101 , pp. 235-238
    • Bass, B.L.1
  • 20
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals
    • Zamore P., Tuschl T., Sharp P., Bartel D. RNAi: Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals. Cell (2000) 101 25 33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.1    Tuschl, T.2    Sharp, P.3    Bartel, D.4
  • 21
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E., Caudy A.A., Hammond S.M., Hannon G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 409 363 366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 22
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • DOI 10.1101/gad.862301
    • Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. (2001) 15 188 200. (Pubitemid 32107664)
    • (2001) Genes and Development , vol.15 , Issue.2 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 23
    • 0031005267 scopus 로고    scopus 로고
    • Post-transcriptional gene silencing in plants
    • Depicker A., Van Montagu M. Post-transcriptional gene silencing in plants. Curr. Opin. Cell Biol. (1997) 9 373 382.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 373-382
    • Depicker, A.1    Van Montagu, M.2
  • 24
    • 0035798399 scopus 로고    scopus 로고
    • RNAi as random degradation PCR: SiRNA primers convert mRNA into dsRNA that are degraded to generate new siRNAs
    • Lipardi C., Wei Q., Paterrson B.M. RNAi as random degradation PCR: siRNA primers convert mRNA into dsRNA that are degraded to generate new siRNAs. Cell (2001) 107 297 307.
    • (2001) Cell , vol.107 , pp. 297-307
    • Lipardi, C.1    Wei, Q.2    Paterrson, B.M.3
  • 25
    • 0035900651 scopus 로고    scopus 로고
    • On the role of RNA amplification in dsRNA-triggered gene silencing
    • Sijen T., Fleenor J., Simmer F. et al. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell (2001) 107 465 476.
    • (2001) Cell , vol.107 , pp. 465-476
    • Sijen, T.1    Fleenor, J.2    Simmer, F.3
  • 26
    • 0037733977 scopus 로고    scopus 로고
    • Antisense technologies. Improvement through novel chemical modifications
    • Kurreck J. Antisense technologies. Improvement through novel chemical modifications. Eur. J. Biochem. (2003) 270 1628 1644.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 1628-1644
    • Kurreck, J.1
  • 27
    • 0038499722 scopus 로고    scopus 로고
    • Functional tuning of nucleic acids by chemical modifications: Tailored oligonucleotides as drugs, devices, and diagnostics
    • Verma S., Jager S., Thum O., Famulok M. Functional tuning of nucleic acids by chemical modifications: tailored oligonucleotides as drugs, devices, and diagnostics. Chem. Rec. (2003) 3 51 60.
    • (2003) Chem. Rec. , vol.3 , pp. 51-60
    • Verma, S.1    Jager, S.2    Thum, O.3    Famulok, M.4
  • 28
    • 8844262560 scopus 로고    scopus 로고
    • RNA interference and chemically modified small interfering RNAs
    • Manoharan M. RNA interference and chemically modified small interfering RNAs. Curr. Opin. Chem. Biol. (2004) 8 570 579.
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 570-579
    • Manoharan, M.1
  • 30
    • 0038385504 scopus 로고    scopus 로고
    • RNA interference in mammalian cells by chemically-modified RNA
    • Braasch D.A., Jensen S., Liu Y. et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry (2003) 42 7967 7975.
    • (2003) Biochemistry , vol.42 , pp. 7967-7975
    • Braasch, D.A.1    Jensen, S.2    Liu, Y.3
  • 31
    • 0038606999 scopus 로고    scopus 로고
    • Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
    • Czauderna F., Fechtner M., Dames S. et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res. (2003) 31 2705 2716.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2705-2716
    • Czauderna, F.1    Fechtner, M.2    Dames, S.3
  • 32
    • 24344500241 scopus 로고    scopus 로고
    • Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
    • Harborth J., Elbashir S.M., Vandenburgh K. et al. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev. (2003) 13 83 105.
    • (2003) Antisense Nucleic Acid Drug Dev. , vol.13 , pp. 83-105
    • Harborth, J.1    Elbashir, S.M.2    Vandenburgh, K.3
  • 34
    • 21244497878 scopus 로고    scopus 로고
    • Positional effect of chemical modifications on short interference RNA activity in mammalian cells
    • Prakash T.P., Allerson C.R., Dande P. et al. Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J. Med. Chem. (2005) 48 4247 4253.
    • (2005) J. Med. Chem. , vol.48 , pp. 4247-4253
    • Prakash, T.P.1    Allerson, C.R.2    Dande, P.3
  • 35
    • 20444410838 scopus 로고    scopus 로고
    • RNA interference induced by siRNAs modified with 4′- thioribonucleosides in cultured mammalian cells
    • Hoshika S., Minakawa N., Kamiya H., Harashima H., Matsuda A. RNA interference induced by siRNAs modified with 4′- thioribonucleosides in cultured mammalian cells. FEBS Lett. (2005) 579 3115 3118.
    • (2005) FEBS Lett. , vol.579 , pp. 3115-3118
    • Hoshika, S.1    Minakawa, N.2    Kamiya, H.3    Harashima, H.4    Matsuda, A.5
  • 36
    • 25844481481 scopus 로고    scopus 로고
    • Biomembrane-permeable and ribonuclease resistant siRNA with enhanced activity
    • Liao H., Wang J.H. Biomembrane-permeable and ribonuclease resistant siRNA with enhanced activity. Oligonucleotides (2005) 15 196 205.
    • (2005) Oligonucleotides , vol.15 , pp. 196-205
    • Liao, H.1    Wang, J.H.2
  • 37
    • 0842346326 scopus 로고    scopus 로고
    • Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
    • Muratovska A., Eccles M.R. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett. (2004) 558 63 68.
    • (2004) FEBS Lett. , vol.558 , pp. 63-68
    • Muratovska, A.1    Eccles, M.R.2
  • 38
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J., Akinc A., Bramlage B. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature (2004) 432 173 178.
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3
  • 39
    • 23244435548 scopus 로고    scopus 로고
    • State-of the- art modified RNAi compounds for therapeutics
    • Carstea E.D., Hough S., Wiederholt K., Welch P.J. State-of the- art modified RNAi compounds for therapeutics. IDrugs (2005) 8 642 647.
    • (2005) IDrugs , vol.8 , pp. 642-647
    • Carstea, E.D.1    Hough, S.2    Wiederholt, K.3    Welch, P.J.4
  • 40
    • 32944454941 scopus 로고    scopus 로고
    • Design of non-inflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge A.D., Bola G., Lee A.C.H., MacLachlan I. Design of non-inflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. (2006) 13 494 505.
    • (2006) Mol. Ther. , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.H.3    MacLachlan, I.4
  • 42
    • 33645155231 scopus 로고    scopus 로고
    • Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs
    • de Jonge J., Holtrop M., Wilschut J., Huckriede A. Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs. Gene Ther. (2006) 13 400 411.
    • (2006) Gene Ther. , vol.13 , pp. 400-411
    • De Jonge, J.1    Holtrop, M.2    Wilschut, J.3    Huckriede, A.4
  • 43
    • 14144255291 scopus 로고    scopus 로고
    • Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs
    • Uprichard S.L., Boyd B., Althage A., Chisari F.V. Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. Proc. Natl. Acad. Sci. U S A (2005) 102 773 778.
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 773-778
    • Uprichard, S.L.1    Boyd, B.2    Althage, A.3    Chisari, F.V.4
  • 44
    • 3042853830 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo
    • Uchida H., Tanaka T., Sasaki K. et al. Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol. Ther. (2004) 10 162 171.
    • (2004) Mol. Ther. , vol.10 , pp. 162-171
    • Uchida, H.1    Tanaka, T.2    Sasaki, K.3
  • 45
    • 19944429120 scopus 로고    scopus 로고
    • Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo
    • Dittgen T., Nimmerjahn A., Komai S. et al. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc. Natl. Acad. Sci. USA (2004) 101 18206 18211.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 18206-18211
    • Dittgen, T.1    Nimmerjahn, A.2    Komai, S.3
  • 46
    • 15244363671 scopus 로고    scopus 로고
    • Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA
    • Godfrey A., Anderson J., Papanastasiou A., Takeuchi Y., Bosho C. Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA. Blood (2005) 105 2510 2518.
    • (2005) Blood , vol.105 , pp. 2510-2518
    • Godfrey, A.1    Anderson, J.2    Papanastasiou, A.3    Takeuchi, Y.4    Bosho, C.5
  • 47
    • 20244381261 scopus 로고    scopus 로고
    • Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
    • Ralph G.S., Radcliffe P.A., Day D.M. et al. Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat. Med. (2005) 11 429 433.
    • (2005) Nat. Med. , vol.11 , pp. 429-433
    • Ralph, G.S.1    Radcliffe, P.A.2    Day, D.M.3
  • 48
    • 17644383664 scopus 로고    scopus 로고
    • Lentiviral mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
    • Raoul C., Abbas-Terki T., Bensadoun J.C. et al. Lentiviral mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat. Med. (2005) 11 423 428.
    • (2005) Nat. Med. , vol.11 , pp. 423-428
    • Raoul, C.1    Abbas-Terki, T.2    Bensadoun, J.C.3
  • 49
    • 23744505924 scopus 로고    scopus 로고
    • Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo
    • Bot I., Guo J., Van Eck M. et al. Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo. Blood (2005) 106 1147 1153.
    • (2005) Blood , vol.106 , pp. 1147-1153
    • Bot, I.1    Guo, J.2    Van Eck, M.3
  • 50
    • 13844254500 scopus 로고    scopus 로고
    • Viral vectors for cancer gene therapy: Viral dissemination and tumor targeting
    • Jia W., Zhou Q. Viral vectors for cancer gene therapy: viral dissemination and tumor targeting. Curr. Gene. Thera. (2005) 5 133 142.
    • (2005) Curr. Gene. Thera. , vol.5 , pp. 133-142
    • Jia, W.1    Zhou, Q.2
  • 51
    • 13844251902 scopus 로고    scopus 로고
    • Helper-dependent adenoviral vectors for gene therapy
    • Palmer D.J., Ng P. Helper-dependent adenoviral vectors for gene therapy. Hum. Gene Ther. (2005) 16 1 16.
    • (2005) Hum. Gene Ther. , vol.16 , pp. 1-16
    • Palmer, D.J.1    Ng, P.2
  • 52
    • 15944391296 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Novel gene therapy approaches for AIDS
    • Wolkowicz R., Nolan G.P. Gene therapy progress and prospects: novel gene therapy approaches for AIDS. Gene Ther. (2005) 12 467 476.
    • (2005) Gene Ther. , vol.12 , pp. 467-476
    • Wolkowicz, R.1    Nolan, G.P.2
  • 53
    • 13844254514 scopus 로고    scopus 로고
    • Retroviral gene therapy: Safety issues and possible solutions
    • Yi Y., Hahm S.H., Lee K.H. Retroviral gene therapy: safety issues and possible solutions. Curr. Gene Ther. (2005) 5 25 35.
    • (2005) Curr. Gene Ther. , vol.5 , pp. 25-35
    • Yi, Y.1    Hahm, S.H.2    Lee, K.H.3
  • 54
    • 29744449337 scopus 로고    scopus 로고
    • Soluble receptor mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor
    • Wurdinger T., Verheije M.H., Broen K. et al. Soluble receptor mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor. J. Virol. (2005) 79 15314 15322.
    • (2005) J. Virol. , vol.79 , pp. 15314-15322
    • Wurdinger, T.1    Verheije, M.H.2    Broen, K.3
  • 55
    • 33746781077 scopus 로고    scopus 로고
    • Imaging chemically modified adenovirus for targeting tumors expressing integrin {alpha}v{beta}3 in living mice with mutant herpes simplex virus type 1 thymidine Kinase PET reporter gene
    • Xiong Z., Cheng Z., Zhang X. et al. Imaging chemically modified adenovirus for targeting tumors expressing integrin {alpha}v{beta}3 in living mice with mutant herpes simplex virus type 1 thymidine Kinase PET reporter gene. J. Nucl. Med. (2006) 47 130 139.
    • (2006) J. Nucl. Med. , vol.47 , pp. 130-139
    • Xiong, Z.1    Cheng, Z.2    Zhang, X.3
  • 56
    • 0035525955 scopus 로고    scopus 로고
    • Safety considerations in vector development
    • Kappes J.C., Wu X. Safety considerations in vector development. Somat. Cell Mol. Genet. (2001) 26 175 191.
    • (2001) Somat. Cell Mol. Genet. , vol.26 , pp. 175-191
    • Kappes, J.C.1    Wu, X.2
  • 57
    • 0009963512 scopus 로고    scopus 로고
    • Safety of adeno-associated virus gene therapy vectors: A current evaluation
    • Monahan P.E., Jooss K., Sands M.S. Safety of adeno-associated virus gene therapy vectors: a current evaluation. Expert Opin. Drug Saf 2002) 1 79 91.
    • (2002) Expert Opin. Drug Saf , vol.1 , pp. 79-91
    • Monahan, P.E.1    Jooss, K.2    Sands, M.S.3
  • 58
    • 24944512987 scopus 로고    scopus 로고
    • Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29motor pRNA
    • Guo S., Tschammer N., Mohammed S., Guo P. Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29motor pRNA. Hum. Gene Ther. (2005) 16 1097 1109.
    • (2005) Hum. Gene Ther. , vol.16 , pp. 1097-1109
    • Guo, S.1    Tschammer, N.2    Mohammed, S.3    Guo, P.4
  • 59
    • 33645519567 scopus 로고    scopus 로고
    • An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons
    • Luo M.C., Zhang D.Q., Ma S.W. et al. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Mol. Pain (2005) 1 29 36.
    • (2005) Mol. Pain , vol.1 , pp. 29-36
    • Luo, M.C.1    Zhang, D.Q.2    Ma, S.W.3
  • 60
    • 22644439250 scopus 로고    scopus 로고
    • Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer
    • Pal A., Ahmad A., Khan S. et al. Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Int. J. Onc. (2005) 26 1087 1091.
    • (2005) Int. J. Onc. , vol.26 , pp. 1087-1091
    • Pal, A.1    Ahmad, A.2    Khan, S.3
  • 61
    • 24644504130 scopus 로고    scopus 로고
    • Toxicogenomics of cationic lipid based vectors for gene therapy: Impact of microarray technology
    • Omidi Y., Barar J., Akhtar S. Toxicogenomics of cationic lipid based vectors for gene therapy: impact of microarray technology. Curr. Drug Deliv. (2005) 2 429 441.
    • (2005) Curr. Drug Deliv. , vol.2 , pp. 429-441
    • Omidi, Y.1    Barar, J.2    Akhtar, S.3
  • 62
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
    • Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol. (2005) 348 1079 1090.
    • (2005) J. Mol. Biol. , vol.348 , pp. 1079-1090
    • Sioud, M.1
  • 63
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein B., Werth S., Abuharbeid S., Czubayko F., Aigner A. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther. (2005) 12 461 466.
    • (2005) Gene Ther. , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 64
    • 3242733298 scopus 로고    scopus 로고
    • Atelocollagen mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
    • Minakuchi Y., Takeshita F., Kosaka N. et al. Atelocollagen mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res. (2004) 32 e109.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 109
    • Minakuchi, Y.1    Takeshita, F.2    Kosaka, N.3
  • 65
    • 2442668068 scopus 로고    scopus 로고
    • A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
    • Takei Y., Kadomatsu K., Yuzawa Y., Matsuo S., Muramatsu T. A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res. (2004) 64 3365 3370.
    • (2004) Cancer Res. , vol.64 , pp. 3365-3370
    • Takei, Y.1    Kadomatsu, K.2    Yuzawa, Y.3    Matsuo, S.4    Muramatsu, T.5
  • 66
    • 24744464786 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
    • Takeshita F., Minakuchi Y., Nagahara S. et al. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc. Natl. Acad. Sci. U S A (2005) 102 12177 12182.
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 12177-12182
    • Takeshita, F.1    Minakuchi, Y.2    Nagahara, S.3
  • 67
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E., Zhu P., Lee S.K. et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature Biotech. (2005) 23 709 717.
    • (2005) Nature Biotech. , vol.23 , pp. 709-717
    • Song, E.1    Zhu, P.2    Lee, S.K.3
  • 68
    • 30744457637 scopus 로고    scopus 로고
    • Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery
    • Pirollo K.F., Zon G., Rait A. et al. Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery. Hum. Gene Ther. (2006) 17 117 124.
    • (2006) Hum. Gene Ther. , vol.17 , pp. 117-124
    • Pirollo, K.F.1    Zon, G.2    Rait, A.3
  • 69
    • 14544298301 scopus 로고    scopus 로고
    • Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
    • Schifielers R.M., Ansari A., Xu J. et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. (2004) 32 e149.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 149
    • Schifielers, R.M.1    Ansari, A.2    Xu, J.3
  • 70
    • 9644275599 scopus 로고    scopus 로고
    • Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis
    • Kim B., Tang Q., Biswas P.S. et al. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am. J. Pathol. (2004) 165 2177 2185.
    • (2004) Am. J. Pathol. , vol.165 , pp. 2177-2185
    • Kim, B.1    Tang, Q.2    Biswas, P.S.3
  • 71
    • 0026323462 scopus 로고
    • Left ventricular hypertrophy as a risk factor: The Framingham experience
    • Kannel W.B. Left ventricular hypertrophy as a risk factor: the Framingham experience. J. Hypertens. (1991) 9 (Suppl) S3.
    • (1991) J. Hypertens. , vol.9 , Issue.SUPPL. , pp. 3
    • Kannel, W.B.1
  • 72
    • 0034595316 scopus 로고    scopus 로고
    • Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men. the Suita Study
    • Higachi J., Baba S., Katsuya T. et al. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men. The Suita Study. Circulation (2000) 101 2060 2065.
    • (2000) Circulation , vol.101 , pp. 2060-2065
    • Higachi, J.1    Baba, S.2    Katsuya, T.3
  • 73
    • 0034685168 scopus 로고    scopus 로고
    • Angiotensin II receptor antagonists
    • Burnier M., Brunner H.R. Angiotensin II receptor antagonists. Lancet (2000) 355 637 645.
    • (2000) Lancet , vol.355 , pp. 637-645
    • Burnier, M.1    Brunner, H.R.2
  • 74
    • 0038801208 scopus 로고    scopus 로고
    • Gene-targeting studies of the renin-angiotensin system: Mechanisms of hypertension and cardiovascular disease
    • Gurley S.B., Le T.H., Coffman T.M. Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. Cold Spring Harb. Symp. Quant. Biol. (2002) 67 451 457.
    • (2002) Cold Spring Harb. Symp. Quant. Biol. , vol.67 , pp. 451-457
    • Gurley, S.B.1    Le, T.H.2    Coffman, T.M.3
  • 75
    • 11244279685 scopus 로고    scopus 로고
    • Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference
    • Vazquez J., Correa de Adjounian M.F., Sumners C. et al. Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference. Hypertension (2005) 45 115 119.
    • (2005) Hypertension , vol.45 , pp. 115-119
    • Vazquez, J.1    Correa De Adjounian, M.F.2    Sumners, C.3
  • 76
    • 29144528140 scopus 로고    scopus 로고
    • Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NF-kappaB and AP-1 in vascular smooth muscle cells
    • Chen Y., Currie R.W. Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NF-kappaB and AP-1 in vascular smooth muscle cells. Cardiovasc. Res. (2006) 69 66 75.
    • (2006) Cardiovasc. Res. , vol.69 , pp. 66-75
    • Chen, Y.1    Currie, R.W.2
  • 78
    • 18044396920 scopus 로고    scopus 로고
    • Contractile properties of the cultured vascular smooth muscle cells. the crucial role played by RhoA in the regulation of contractility
    • Bi D., Nishimura J., Niiro N., Hirano K., Kanaide H. Contractile properties of the cultured vascular smooth muscle cells. The crucial role played by RhoA in the regulation of contractility. Circ. Res. (2005) 96 890 897.
    • (2005) Circ. Res. , vol.96 , pp. 890-897
    • Bi, D.1    Nishimura, J.2    Niiro, N.3    Hirano, K.4    Kanaide, H.5
  • 79
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hansson S.M., Bernstein E., Beach D., Hannon G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 404 293 296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hansson, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 80
    • 33644683065 scopus 로고    scopus 로고
    • Adiponectin inhibits endothelial synthesis of interleukin-8
    • Kobashi C., Urakaze M., Kishida M. et al. Adiponectin inhibits endothelial synthesis of interleukin-8. Circ. Res. (2005) 97 1245 1252.
    • (2005) Circ. Res. , vol.97 , pp. 1245-1252
    • Kobashi, C.1    Urakaze, M.2    Kishida, M.3
  • 81
    • 0034746311 scopus 로고    scopus 로고
    • NF-kappa B: Pivotal mediator or innocent bystander in atherogenesis?
    • Collins T., Cybulsky M.I. NF-kappa B: pivotal mediator or innocent bystander in atherogenesis? J. Clin. Invest. (2001) 107 255 264.
    • (2001) J. Clin. Invest. , vol.107 , pp. 255-264
    • Collins, T.1    Cybulsky, M.I.2
  • 82
    • 1842715005 scopus 로고    scopus 로고
    • Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappaB)
    • Dwarakanath R.S., Sahar S., Reddy M.A., Castanotto D., Rossi J.J., Natarajan R. Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappaB). J. Mol. Cell. Cardiol. (2004) 36 585 595.
    • (2004) J. Mol. Cell. Cardiol. , vol.36 , pp. 585-595
    • Dwarakanath, R.S.1    Sahar, S.2    Reddy, M.A.3    Castanotto, D.4    Rossi, J.J.5    Natarajan, R.6
  • 83
    • 0033053063 scopus 로고    scopus 로고
    • Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture
    • Bennett M.R. Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture. Cardiovasc. Res. (1999) 41 361 368.
    • (1999) Cardiovasc. Res. , vol.41 , pp. 361-368
    • Bennett, M.R.1
  • 84
    • 3543146709 scopus 로고    scopus 로고
    • C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells
    • Blaschke F., Bruemmer D., Yin F. et al. C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells. Circulation (2004) 110 579 587.
    • (2004) Circulation , vol.110 , pp. 579-587
    • Blaschke, F.1    Bruemmer, D.2    Yin, F.3
  • 85
    • 0037016707 scopus 로고    scopus 로고
    • The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
    • Martins L.M., Iaccarino I., Tenev T. et al. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. (2002) 277 439 444.
    • (2002) J. Biol. Chem. , vol.277 , pp. 439-444
    • Martins, L.M.1    Iaccarino, I.2    Tenev, T.3
  • 87
    • 23044499489 scopus 로고    scopus 로고
    • Detection of cardiac signaling in the injured and hypertrophied heart
    • Si X., Rahmarni M., Yuan J., Lou H. Detection of cardiac signaling in the injured and hypertrophied heart. Methods Mol. Med. (2005) 112 291 303.
    • (2005) Methods Mol. Med. , vol.112 , pp. 291-303
    • Si, X.1    Rahmarni, M.2    Yuan, J.3    Lou, H.4
  • 88
    • 22544488420 scopus 로고    scopus 로고
    • Estrogen inhibits cardiomyocyte hypertrophy in vitro: Antagonism of calcineurin- related hypertrophy through induction of MCIP1
    • Pedram A., Razandi M., Aitkenhead M., Levin E.R. Estrogen inhibits cardiomyocyte hypertrophy in vitro: Antagonism of calcineurin- related hypertrophy through induction of MCIP1. J. Biol. Chem. (2005) 280 26339 26348.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26339-26348
    • Pedram, A.1    Razandi, M.2    Aitkenhead, M.3    Levin, E.R.4
  • 89
    • 0029797631 scopus 로고    scopus 로고
    • Viral myocarditis: Balance between viral infection and immune response
    • Liu P., Martino T., Opavsky M.A., Penninger J. Viral myocarditis: balance between viral infection and immune response. Can. J. Cardiol. (1996) 12 935 943.
    • (1996) Can. J. Cardiol. , vol.12 , pp. 935-943
    • Liu, P.1    Martino, T.2    Opavsky, M.A.3    Penninger, J.4
  • 90
    • 0033515431 scopus 로고    scopus 로고
    • Viral myocarditis identification of five differentially expressed genes in coxsackievirus B3-infected mouse heart
    • Yang D., Yu J., Luo Z. et al. Viral myocarditis identification of five differentially expressed genes in coxsackievirus B3-infected mouse heart. Circ. Res. (1999) 84 704 712.
    • (1999) Circ. Res. , vol.84 , pp. 704-712
    • Yang, D.1    Yu, J.2    Luo, Z.3
  • 92
    • 13444303918 scopus 로고    scopus 로고
    • Inhibition of coxsackie virus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand
    • Yuan J., Cheung P.K., Zhang H.M., Chau D., Yang D. Inhibition of coxsackie virus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand. J. Virol. (2005) 79 2151 2159.
    • (2005) J. Virol. , vol.79 , pp. 2151-2159
    • Yuan, J.1    Cheung, P.K.2    Zhang, H.M.3    Chau, D.4    Yang, D.5
  • 93
    • 0035916903 scopus 로고    scopus 로고
    • Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure
    • Hobai I.A., O'Rourke B. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation (2001) 103 1577 1584.
    • (2001) Circulation , vol.103 , pp. 1577-1584
    • Hobai, I.A.1    O'Rourke, B.2
  • 95
    • 0036895043 scopus 로고    scopus 로고
    • Survival in Duchenne muscular dystrophy: Improvements in life expectancy since 1967 and the impact of home nocturnal ventilation
    • Eagle M., Baudouin S.V., Chandler C., Giddings D.R., Bullock R., Bushby K. Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation. Neuromuscul. Disord. (2002) 12 926 929.
    • (2002) Neuromuscul. Disord. , vol.12 , pp. 926-929
    • Eagle, M.1    Baudouin, S.V.2    Chandler, C.3    Giddings, D.R.4    Bullock, R.5    Bushby, K.6
  • 96
    • 0037055258 scopus 로고    scopus 로고
    • Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans
    • Grisoni K., Martin E., Gieseler K., Mariol M.C., Segalat L. Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans. Gene (2002) 294 77 86.
    • (2002) Gene , vol.294 , pp. 77-86
    • Grisoni, K.1    Martin, E.2    Gieseler, K.3    Mariol, M.C.4    Segalat, L.5
  • 97
    • 0035975968 scopus 로고    scopus 로고
    • Muscular degeneration in the absence of dystrophin is a calcium-dependent process
    • Mariol M.C., Segalat L. Muscular degeneration in the absence of dystrophin is a calcium-dependent process. Curr. Biol. (2001) 11 1691 1694.
    • (2001) Curr. Biol. , vol.11 , pp. 1691-1694
    • Mariol, M.C.1    Segalat, L.2
  • 99
    • 0036500323 scopus 로고    scopus 로고
    • The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans
    • Gruenbaum Y., Lee K.K., Liu J., Cohen M., Wilson K.L. The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans. J. Cell Sci. (2002) 115 (Pt 5 923 929.
    • (2002) J. Cell Sci. , vol.115 , Issue.PART 5 , pp. 923-929
    • Gruenbaum, Y.1    Lee, K.K.2    Liu, J.3    Cohen, M.4    Wilson, K.L.5
  • 100
    • 0037446880 scopus 로고    scopus 로고
    • MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans
    • Liu J., Lee K.K., Segura-Totten M., Neufeld E., Wilson K.L., Gruenbaum Y. MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA (2003) 100 4598 4603.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4598-4603
    • Liu, J.1    Lee, K.K.2    Segura-Totten, M.3    Neufeld, E.4    Wilson, K.L.5    Gruenbaum, Y.6
  • 101
    • 0032718045 scopus 로고    scopus 로고
    • The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability
    • Miguel-Aliaga I., Culetto E., Walker D.S., Baylis H.A., Sattelle D.B., Davies K.E. The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability. Hum. Mol. Genet. (1999) 8 2133 2143.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 2133-2143
    • Miguel-Aliaga, I.1    Culetto, E.2    Walker, D.S.3    Baylis, H.A.4    Sattelle, D.B.5    Davies, K.E.6
  • 102
    • 0038039295 scopus 로고    scopus 로고
    • Neuromuscular defects in a Drosophila survival motor neuron gene mutant
    • Chan Y.B., Miguel-Aliaga I., Franks C. et al. Neuromuscular defects in a Drosophila survival motor neuron gene mutant. Hum. Mol. Genet. (2003) 12 1367 1376.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1367-1376
    • Chan, Y.B.1    Miguel-Aliaga, I.2    Franks, C.3
  • 103
    • 0041731808 scopus 로고    scopus 로고
    • Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells
    • Ilangovan R., Marshall W.L., Hua Y., Zhou J. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J. Biol. Chem. (2003) 278 30993 30999.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30993-30999
    • Ilangovan, R.1    Marshall, W.L.2    Hua, Y.3    Zhou, J.4
  • 104
    • 0037405291 scopus 로고    scopus 로고
    • Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model
    • Link C.D., Taft A., Kapulkin V. et al. Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol. Aging (2003) 24 397 413.
    • (2003) Neurobiol. Aging , vol.24 , pp. 397-413
    • Link, C.D.1    Taft, A.2    Kapulkin, V.3
  • 106
    • 2142645114 scopus 로고    scopus 로고
    • Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila
    • Greeve I., Kretzschmar D., Tschape J.A. et al. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J. Neurosci. (2004) 24 3899 3906.
    • (2004) J. Neurosci. , vol.24 , pp. 3899-3906
    • Greeve, I.1    Kretzschmar, D.2    Tschape, J.A.3
  • 107
    • 2342473791 scopus 로고    scopus 로고
    • Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: A potential model for Alzheimer's disease
    • Iijima K., Liu H.P., Chiang A.S., Hearn S.A., Konsolaki M., Zhong Y. Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc. Natl. Acad. Sci. U S A (2004) 101 6623 6628.
    • (2004) Proc. Natl. Acad. Sci. U S A , vol.101 , pp. 6623-6628
    • Iijima, K.1    Liu, H.P.2    Chiang, A.S.3    Hearn, S.A.4    Konsolaki, M.5    Zhong, Y.6
  • 108
    • 0037147220 scopus 로고    scopus 로고
    • The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals
    • Takasugi N., Takahashi Y., Morohashi Y., Tomita T., Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J. Biol. Chem. (2002) 277 50198 50205.
    • (2002) J. Biol. Chem. , vol.277 , pp. 50198-50205
    • Takasugi, N.1    Takahashi, Y.2    Morohashi, Y.3    Tomita, T.4    Iwatsubo, T.5
  • 109
    • 18444417998 scopus 로고    scopus 로고
    • Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of beta APP and presenilin protein accumulation
    • Francis R., McGrath G., Zhang J. et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of beta APP and presenilin protein accumulation. Dev. Cell. (2002) 3 85 97.
    • (2002) Dev. Cell. , vol.3 , pp. 85-97
    • Francis, R.1    McGrath, G.2    Zhang, J.3
  • 110
    • 0037474447 scopus 로고    scopus 로고
    • Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
    • Asai M., Hattori C., Szabo B. et al. Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem. Biophys. Res. Commun. (2003) 301 231 235.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 231-235
    • Asai, M.1    Hattori, C.2    Szabo, B.3
  • 111
    • 0345826094 scopus 로고    scopus 로고
    • BACE1 suppression by RNA interference in primary cortical neurons
    • Kao S.C., Krichevsky A.M., Kosik K.S., Tsai L.H. BACE1 suppression by RNA interference in primary cortical neurons. J. Biol. Chem. (2004) 279 1942 1949.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1942-1949
    • Kao, S.C.1    Krichevsky, A.M.2    Kosik, K.S.3    Tsai, L.H.4
  • 112
    • 0021028244 scopus 로고
    • A polymorphic DNA marker genetically linked to Huntington's disease
    • Gusella J.F., Wexler N.S., Conneally P.M. et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature (1983) 306 234 238.
    • (1983) Nature , vol.306 , pp. 234-238
    • Gusella, J.F.1    Wexler, N.S.2    Conneally, P.M.3
  • 113
    • 2342598416 scopus 로고    scopus 로고
    • Experimental therapeutics in transgenic mouse models of Huntington's disease
    • Beal M.F., Ferrante R.J. Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat. Rev. Neurosci. (2004) 5 373 384.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 373-384
    • Beal, M.F.1    Ferrante, R.J.2
  • 114
    • 0034640011 scopus 로고    scopus 로고
    • Fourteen and counting: Unraveling trinucleotide repeat diseases
    • Cummings C.J., Zoghbi H.Y. Fourteen and counting: unraveling trinucleotide repeat diseases. Hum. Mol. Genet. (2000) 9 909 916.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 909-916
    • Cummings, C.J.1    Zoghbi, H.Y.2
  • 115
    • 0034043493 scopus 로고    scopus 로고
    • Triplet repeat expansion in neuromuscular disease
    • Lieberman A.P., Fischbeck K.H. Triplet repeat expansion in neuromuscular disease. Muscle Nerve (2000) 23 843 850.
    • (2000) Muscle Nerve , vol.23 , pp. 843-850
    • Lieberman, A.P.1    Fischbeck, K.H.2
  • 116
    • 2342652188 scopus 로고    scopus 로고
    • Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
    • Nollen E.A., Garcia S.M., van Haaften G. et al. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. U S A (2004) 101 6403 6408.
    • (2004) Proc. Natl. Acad. Sci. U S A , vol.101 , pp. 6403-6408
    • Nollen, E.A.1    Garcia, S.M.2    Van Haaften, G.3
  • 117
    • 0037081772 scopus 로고    scopus 로고
    • Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference
    • Caplen N.J., Taylor J.P., Statham V.S., Tanaka F., Fire A., Morgan R.A. Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference. Hum. Mol. Genet. (2002) 11 175 184.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 175-184
    • Caplen, N.J.1    Taylor, J.P.2    Statham, V.S.3    Tanaka, F.4    Fire, A.5    Morgan, R.A.6
  • 118
    • 0037468831 scopus 로고    scopus 로고
    • Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    • Yang Y., Nishimura I., Imai Y., Takahashi R., Lu B. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron (2003) 37 911 924.
    • (2003) Neuron , vol.37 , pp. 911-924
    • Yang, Y.1    Nishimura, I.2    Imai, Y.3    Takahashi, R.4    Lu, B.5
  • 119
    • 0346216853 scopus 로고    scopus 로고
    • Local gene knockdown in the brain using viral-mediated RNA interference
    • Hommel J.D., Sears R.M., Georgescu D., Simmons D.L., DiLeone R.J. Local gene knockdown in the brain using viral-mediated RNA interference. Nat. Med. (2003) 9 1539 1544.
    • (2003) Nat. Med. , vol.9 , pp. 1539-1544
    • Hommel, J.D.1    Sears, R.M.2    Georgescu, D.3    Simmons, D.L.4    Dileone, R.J.5
  • 120
    • 0038132996 scopus 로고    scopus 로고
    • Allele-specific silencing of dominant disease genes
    • Miller V.M., Xia H., Marrs G.L. et al. Allele-specific silencing of dominant disease genes. Proc. Natl Acad. Sci. USA (2003) 100 7195 7200.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7195-7200
    • Miller, V.M.1    Xia, H.2    Marrs, G.L.3
  • 121
    • 0035125109 scopus 로고    scopus 로고
    • Ancestral origins of the Machado-Joseph disease mutation: A worldwide haplotype study
    • Gaspar C., Lopes-Cendes I., Hayes S. et al. Ancestral origins of the Machado-Joseph disease mutation: a worldwide haplotype study. Am. J. Hum. Genet. (2001) 68 523 528.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 523-528
    • Gaspar, C.1    Lopes-Cendes, I.2    Hayes, S.3
  • 122
    • 0038137215 scopus 로고    scopus 로고
    • Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor
    • Hemmings-Mieszczak M., Dorn G., Natt F.J., Hall J., Wishart W.L. Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor. Nucleic Acids Res. (2003) 31 2117 2126.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2117-2126
    • Hemmings-Mieszczak, M.1    Dorn, G.2    Natt, F.J.3    Hall, J.4    Wishart, W.L.5
  • 124
    • 0042933866 scopus 로고    scopus 로고
    • A novel function of Goá: Mediation of extracellular signal-regulated kinase activation by opioid receptors in neural cells
    • Zhang W.B., Zhang Z., Ni Y.X., Wu Y.L., Pei G. A novel function of Goá: Mediation of extracellular signal-regulated kinase activation by opioid receptors in neural cells. J. Neurochem. (2003) 86 1213 1222.
    • (2003) J. Neurochem. , vol.86 , pp. 1213-1222
    • Zhang, W.B.1    Zhang, Z.2    Ni, Y.X.3    Wu, Y.L.4    Pei, G.5
  • 125
    • 0038578021 scopus 로고    scopus 로고
    • Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA
    • Grünweller A., Wyszko E., Bieber B., Jahnel R., Erdmann V.A., Kurreck J. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. (2003) 31 3185 3193.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 3185-3193
    • Grünweller, A.1    Wyszko, E.2    Bieber, B.3    Jahnel, R.4    Erdmann, V.A.5    Kurreck, J.6
  • 127
    • 1042274886 scopus 로고    scopus 로고
    • Neurochemical and behavioral studies on ethanol and nicotine interactions
    • Larsson A., Engel J.A. Neurochemical and behavioral studies on ethanol and nicotine interactions. Neurosci. Biobehav. Rev. (2004) 27 713 720.
    • (2004) Neurosci. Biobehav. Rev. , vol.27 , pp. 713-720
    • Larsson, A.1    Engel, J.A.2
  • 128
    • 0038641709 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: Adult RNA interference and pharmacological evidence
    • Dzitoyeva S., Dimitrijevic N., Manev H. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc. Natl. Acad. Sci. USA (2003) 100 5485 5490.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5485-5490
    • Dzitoyeva, S.1    Dimitrijevic, N.2    Manev, H.3
  • 130
    • 0034554823 scopus 로고    scopus 로고
    • Long-term nicotine adaptation in Caenorhabditis elegans involves PKC-dependent changes in nicotinic receptor abundance
    • Waggoner L.E., Dickinson K.A., Poole D.S., Tabuse Y., Miwa J., Schafer W.R. Long-term nicotine adaptation in Caenorhabditis elegans involves PKC-dependent changes in nicotinic receptor abundance. J. Neurosci. (2000) 20 8802 8811.
    • (2000) J. Neurosci. , vol.20 , pp. 8802-8811
    • Waggoner, L.E.1    Dickinson, K.A.2    Poole, D.S.3    Tabuse, Y.4    Miwa, J.5    Schafer, W.R.6
  • 131
    • 0642307773 scopus 로고    scopus 로고
    • RNA interference: Gene silencing in the fast lane
    • Kittler R., Buchholz F. RNA interference: gene silencing in the fast lane. Semin. Cancer Biol. (2003) 13 259 265.
    • (2003) Semin. Cancer Biol. , vol.13 , pp. 259-265
    • Kittler, R.1    Buchholz, F.2
  • 132
    • 0141613693 scopus 로고    scopus 로고
    • SiRNA-mediated antitumorigenesis for drug target validation and therapeutics
    • Lu P.Y., Xie F.Y., Woodle M.C. siRNA-mediated antitumorigenesis for drug target validation and therapeutics. Curr. Opin. Mol. Ther. (2003) 5 225 234.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 225-234
    • Lu, P.Y.1    Xie, F.Y.2    Woodle, M.C.3
  • 133
    • 0242317385 scopus 로고    scopus 로고
    • Small RNA: Can RNA interference be exploited for therapy?
    • Wall N.R., Shi Y. Small RNA: can RNA interference be exploited for therapy? Lancet (2003) 362 1401 1403.
    • (2003) Lancet , vol.362 , pp. 1401-1403
    • Wall, N.R.1    Shi, Y.2
  • 134
    • 9144268607 scopus 로고    scopus 로고
    • Proapoptotic therapy with oblimersen (bcl-2 antisense oligonucleotide) - Review of preclinical and clinical results
    • Buchele T. Proapoptotic therapy with oblimersen (bcl-2 antisense oligonucleotide) - review of preclinical and clinical results. Onkologie (2003) 26 (Suppl. 7) 60 69.
    • (2003) Onkologie , vol.26 , Issue.SUPPL. 7 , pp. 60-69
    • Buchele, T.1
  • 135
    • 0037158901 scopus 로고    scopus 로고
    • Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)
    • Wilda M., Fuchs U., Wossmann W., Borkhardt A. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene (2002) 21 5716 5724.
    • (2002) Oncogene , vol.21 , pp. 5716-5724
    • Wilda, M.1    Fuchs, U.2    Wossmann, W.3    Borkhardt, A.4
  • 136
    • 0037441756 scopus 로고    scopus 로고
    • Specific inhibition of bcr-abl gene expression by small interfering RNA
    • Scherr M., Battmer K., Winkler T., Heidenreich O., Ganser A., Eder M. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood (2003) 101 1566 1569.
    • (2003) Blood , vol.101 , pp. 1566-1569
    • Scherr, M.1    Battmer, K.2    Winkler, T.3    Heidenreich, O.4    Ganser, A.5    Eder, M.6
  • 137
    • 0038047685 scopus 로고    scopus 로고
    • AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells
    • Heidenreich C., Krauter J., Riehle H. et al. AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells. Blood (2003) 101 3157 3163.
    • (2003) Blood , vol.101 , pp. 3157-3163
    • Heidenreich, C.1    Krauter, J.2    Riehle, H.3
  • 139
    • 0037329372 scopus 로고    scopus 로고
    • RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines
    • Cioca D.P., Aoki Y., Kiyosawa K. RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines. Cancer Gene Ther. (2003) 10 125 133.
    • (2003) Cancer Gene Ther. , vol.10 , pp. 125-133
    • Cioca, D.P.1    Aoki, Y.2    Kiyosawa, K.3
  • 140
    • 0344321886 scopus 로고    scopus 로고
    • Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL induced apoptosis
    • Siegmund D., Hadwiger P., Pfizenmaier K., Vornlocher H.P., Wajant H. Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL induced apoptosis. Mol. Med. (2002) 8 725 732.
    • (2002) Mol. Med. , vol.8 , pp. 725-732
    • Siegmund, D.1    Hadwiger, P.2    Pfizenmaier, K.3    Vornlocher, H.P.4    Wajant, H.5
  • 141
    • 0037020234 scopus 로고    scopus 로고
    • Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. the potential role of MCL1 as a fortilin chaperone
    • Zhang D., Li F., Weidner D., Mnjoyan Z.H., Fujise K. Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone. J. Biol. Chem. (2002) 277 37430 37438.
    • (2002) J. Biol. Chem. , vol.277 , pp. 37430-37438
    • Zhang, D.1    Li, F.2    Weidner, D.3    Mnjoyan, Z.H.4    Fujise, K.5
  • 142
    • 0036911338 scopus 로고    scopus 로고
    • Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells
    • Nagashima K., Endo A., Ogita H. et al. Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol. Biol. Cell (2002) 13 4231 4242.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 4231-4242
    • Nagashima, K.1    Endo, A.2    Ogita, H.3
  • 143
    • 0037144437 scopus 로고    scopus 로고
    • A novel myc target gene, mina53, that is involved in cell proliferation
    • Tsuneoka M., Koda Y., Soejima M., Teye K., Kimura H. A novel myc target gene, mina53, that is involved in cell proliferation. J. Biol. Chem. (2002) 277 35450 35459.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35450-35459
    • Tsuneoka, M.1    Koda, Y.2    Soejima, M.3    Teye, K.4    Kimura, H.5
  • 144
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 296 550 553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 145
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp T.R., Bernards R., Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 2 243 247.
    • (2002) Cancer Cell , vol.2 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 146
    • 0037866466 scopus 로고    scopus 로고
    • The PML gene is not involved in the regulation of MHC class i expression in human cell lines
    • Bruno S., Ghiotto F., Fais F. et al. The PML gene is not involved in the regulation of MHC class I expression in human cell lines. Blood (2003) 101 3514 3519.
    • (2003) Blood , vol.101 , pp. 3514-3519
    • Bruno, S.1    Ghiotto, F.2    Fais, F.3
  • 147
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive humancervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M., Milner J. Selective silencing of viral gene expression in HPV-positive humancervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene (2002) 21 6041 6048.
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 148
    • 0037112508 scopus 로고    scopus 로고
    • Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation
    • Peng Y., Zhang Q., Nagasawa H., Okayasu R., Liber H.L., Bedford J.S. Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res. (2002) 62 6400 6404.
    • (2002) Cancer Res. , vol.62 , pp. 6400-6404
    • Peng, Y.1    Zhang, Q.2    Nagasawa, H.3    Okayasu, R.4    Liber, H.L.5    Bedford, J.S.6
  • 149
    • 0036529825 scopus 로고    scopus 로고
    • Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia
    • Crans-Vargas H.N., Landaw E.M., Bhatia S., Sandusky G., Moore T.B., Sakamoto K.M. Expression of cyclic adenosine monophosphate response-element binding protein in acute leukemia. Blood (2002) 99 2617 2619.
    • (2002) Blood , vol.99 , pp. 2617-2619
    • Crans-Vargas, H.N.1    Landaw, E.M.2    Bhatia, S.3    Sandusky, G.4    Moore, T.B.5    Sakamoto, K.M.6
  • 150
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • Hannon G.J., Rossi J.J. Unlocking the potential of the human genome with RNA interference. Nature (2004) 431 371 378.
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 151
    • 0037173610 scopus 로고    scopus 로고
    • Modulation of HIV-1 replication by RNA interference
    • Jacque J.M., Triques K., Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature (2002) 418 435 438.
    • (2002) Nature , vol.418 , pp. 435-438
    • Jacque, J.M.1    Triques, K.2    Stevenson, M.3
  • 152
    • 0036256430 scopus 로고    scopus 로고
    • Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells
    • Lee N.S., Dohjima T., Bauer G. et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat. Biotechnol. (2002) 20 500 505.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 500-505
    • Lee, N.S.1    Dohjima, T.2    Bauer, G.3
  • 153
    • 0036066508 scopus 로고    scopus 로고
    • SiRNA-directed inhibition of HIV-1 infection
    • Novina C.D., Murray M.F., Dykxhoorn D.M. et al. siRNA-directed inhibition of HIV-1 infection. Nat. Med. (2002) 8 681 686.
    • (2002) Nat. Med. , vol.8 , pp. 681-686
    • Novina, C.D.1    Murray, M.F.2    Dykxhoorn, D.M.3
  • 154
    • 0142124143 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 escape from RNA interference
    • Boden D., Pusch O., Lee F., Tucker L., Ramratnam B. Human immunodeficiency virus type-1 escape from RNA interference. J. Virol. (2003) 77 11531 11535.
    • (2003) J. Virol. , vol.77 , pp. 11531-11535
    • Boden, D.1    Pusch, O.2    Lee, F.3    Tucker, L.4    Ramratnam, B.5
  • 155
    • 0021720872 scopus 로고
    • T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
    • Klatzmann D., Champagne E., Chamaret S. et al. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature (1984) 312 767 768.
    • (1984) Nature , vol.312 , pp. 767-768
    • Klatzmann, D.1    Champagne, E.2    Chamaret, S.3
  • 156
    • 0023028190 scopus 로고
    • The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
    • Maddon P.J., Dalgleish A.G., McDougal J.S., Clapham P.R., Weiss R.A., Axel R. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 47 333 348.
    • (1986) Cell , vol.47 , pp. 333-348
    • Maddon, P.J.1    Dalgleish, A.G.2    McDougal, J.S.3    Clapham, P.R.4    Weiss, R.A.5    Axel, R.6
  • 157
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R., Paxton W.A., Choe S. et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell (1996) 86 367 377.
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 158
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M., Libert F., Doranz B.J. et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature (1996) 382 722 725.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 159
    • 0037422583 scopus 로고    scopus 로고
    • Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
    • Qin X.F., An D.S., Chen I.S., Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc. Natl Acad. Sci. USA (2003) 100 183 188.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 183-188
    • Qin, X.F.1    An, D.S.2    Chen, I.S.3    Baltimore, D.4
  • 160
    • 0036891843 scopus 로고    scopus 로고
    • RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication
    • Surabhi R.M., Gaynor R.B. RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication. J. Virol. (2002) 76 12963 12973.
    • (2002) J. Virol. , vol.76 , pp. 12963-12973
    • Surabhi, R.M.1    Gaynor, R.B.2
  • 161
    • 0036840946 scopus 로고    scopus 로고
    • RNA interference: A promising approach to antiviral therapy?
    • Silva J.M., Hammond S.M., Hannon G.J. RNA interference: a promising approach to antiviral therapy? Trends Mol. Med. (2002) 8 505 508.
    • (2002) Trends Mol. Med. , vol.8 , pp. 505-508
    • Silva, J.M.1    Hammond, S.M.2    Hannon, G.J.3
  • 162
    • 0034254448 scopus 로고    scopus 로고
    • Molecular strategies for overcoming antibiotic resistance in bacteria
    • Tan Y.T., Tillett D.J., McKay I.A. Molecular strategies for overcoming antibiotic resistance in bacteria. Mol. Med. Today (2000) 6 309 314.
    • (2000) Mol. Med. Today , vol.6 , pp. 309-314
    • Tan, Y.T.1    Tillett, D.J.2    McKay, I.A.3
  • 163
    • 0036673672 scopus 로고    scopus 로고
    • Biological terrorism: Understanding the threat, preparation and medical response
    • Franz D.R., Zajtchuk R. Biological terrorism: understanding the threat, preparation and medical response. Dis. Monit. (2002) 48 493 564.
    • (2002) Dis. Monit. , vol.48 , pp. 493-564
    • Franz, D.R.1    Zajtchuk, R.2
  • 164
    • 0036963990 scopus 로고    scopus 로고
    • Rotavirus gene silencing by small interfering RNAs
    • Dector M.A., Romero P., López S., Arias C.F. Rotavirus gene silencing by small interfering RNAs. EMBO Rep. (2002) 3 1175 1180.
    • (2002) EMBO Rep. , vol.3 , pp. 1175-1180
    • Dector, M.A.1    Romero, P.2    López, S.3    Arias, C.F.4
  • 165
    • 0037418322 scopus 로고    scopus 로고
    • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
    • Ge Q., McManus M.T., Nguyen T. et al. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc. Natl Acad. Sci. USA (2003) 100 2718 2723.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2718-2723
    • Ge, Q.1    McManus, M.T.2    Nguyen, T.3
  • 166
    • 0036049784 scopus 로고    scopus 로고
    • Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum
    • Malhotra P., Dasaradhi P.V., Kumar A. et al. Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum. Mol. Microbiol. (2002) 45 1245 1254.
    • (2002) Mol. Microbiol. , vol.45 , pp. 1245-1254
    • Malhotra, P.1    Dasaradhi, P.V.2    Kumar, A.3
  • 167
  • 170
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight K.J., Kolykhalov A.A., Rice C.M. Efficient initiation of HCV RNA replication in cell culture. Science (2000) 290 1972 1974.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 171
    • 0035148546 scopus 로고    scopus 로고
    • Characterization of cell lines carrying self-replicating hepatitis C virus RNAs
    • DOI 10.1128/JVI.75.3.1252-1264.2001
    • Pietschmann T., Lohmann V., Rutter G., Kurpanek K., Bartenschlager R. Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. J. Virol. (2001) 75 1252 1264. (Pubitemid 32094684)
    • (2001) Journal of Virology , vol.75 , Issue.3 , pp. 1252-1264
    • Pietschmann, T.1    Lohmann, V.2    Rutter, G.3    Kurpanek, K.4    Bartenschlager, R.5
  • 172
    • 0036190918 scopus 로고    scopus 로고
    • Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells
    • Ikeda M., Yi M., Li K., Lemon S.M. Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. J. Virol. (2002) 76 2997 3006.
    • (2002) J. Virol. , vol.76 , pp. 2997-3006
    • Ikeda, M.1    Yi, M.2    Li, K.3    Lemon, S.M.4
  • 173
    • 0344321890 scopus 로고    scopus 로고
    • RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells
    • Wilson J.A., Jayasena S., Khvorova A. et al. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells. Proc. Natl Acad. Sci. USA (2003) 100 2783 2788.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2783-2788
    • Wilson, J.A.1    Jayasena, S.2    Khvorova, A.3
  • 174
    • 0037422607 scopus 로고    scopus 로고
    • Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
    • Randall G., Grakoui A., Rice C.M. Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc. Natl Acad. Sci. USA (2003) 100 235 240.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 235-240
    • Randall, G.1    Grakoui, A.2    Rice, C.M.3
  • 175
    • 0038610713 scopus 로고    scopus 로고
    • Caspase 8 small interfering RNA prevents acute liver failure in mice
    • Zender L., Hutker S., Liedtke C. et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc. Natl Acad. Sci. USA (2003) 100 7797 7802.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7797-7802
    • Zender, L.1    Hutker, S.2    Liedtke, C.3
  • 176
    • 21144435142 scopus 로고    scopus 로고
    • Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
    • Chalupsky K., Cai H. Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA (2005) 102 9056 9061.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 9056-9061
    • Chalupsky, K.1    Cai, H.2
  • 177
    • 4644302005 scopus 로고    scopus 로고
    • Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure
    • Li Y., Takemura G., Kosai K. et al. Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure. Circ. Res. (2004) 95 627 636.
    • (2004) Circ. Res. , vol.95 , pp. 627-636
    • Li, Y.1    Takemura, G.2    Kosai, K.3
  • 178
    • 6944238701 scopus 로고    scopus 로고
    • Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury
    • Hamar P., Song E., Kokeny G., Chen A., Ouyang N., Lieberman J. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc. Natl Acad. Sci. USA (2004) 101 14883 14888.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14883-14888
    • Hamar, P.1    Song, E.2    Kokeny, G.3    Chen, A.4    Ouyang, N.5    Lieberman, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.