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Volumn 10, Issue 8, 2009, Pages 787-794

The relevance of the polymicrobial nature of airway infection in the acute and chronic management of patients with cystic fibrosis

Author keywords

Antibacterial; Cystic fbrosis; Microbial community; Microbiome; Oropharyngeal flora; Pathogen; Polymicrobial; Pseudomonas aeroginosa; Pulmonary exacerbation; Streptococcus milleri group

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ARIKACE; AZITHROMYCIN; AZTREONAM LYSINATE; BAYQ 3939; CIPROFLOXACIN; COLISTIN; FOSFOMYCIN PLUS TOBRAMYCIN; GS 9310 11; LEVOFLOXACIN; LIPOSOMAL AMIKACIN; MACROLIDE; MP 376; PLACEBO; TMB 100; TOBRAMYCIN; UNCLASSIFIED DRUG;

EID: 68649125562     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (49)

References (62)
  • 1
    • 34248682574 scopus 로고    scopus 로고
    • Cystic fibrosis: A polymicrobial infectious disease
    • Sibley CD, Rabin H, Surette MG: Cystic fibrosis: A polymicrobial infectious disease. Future Microbiol (2006) 1(1):53-61.
    • (2006) Future Microbiol , vol.1 , Issue.1 , pp. 53-61
    • Sibley, C.D.1    Rabin, H.2    Surette, M.G.3
  • 2
    • 0026058195 scopus 로고
    • Microbiology of airway disease in patients with cystic fibrosis
    • Gilligan PH: Microbiology of airway disease in patients with cystic fibrosis. Clin Microbiol Rev (1991) 4(1):35-51.
    • (1991) Clin Microbiol Rev , vol.4 , Issue.1 , pp. 35-51
    • Gilligan, P.H.1
  • 3
    • 68649127406 scopus 로고    scopus 로고
    • Recent advances in the microbiology of respiratory tract infection in cystic fibrosis
    • Foweraker J: Recent advances in the microbiology of respiratory tract infection in cystic fibrosis. Br Med Bull (2009) 89(1):93-110.
    • (2009) Br Med Bull , vol.89 , Issue.1 , pp. 93-110
    • Foweraker, J.1
  • 4
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • Gibson RL, Burns JL, Ramsey BW: Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med (2003) 168(8):918-951.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.8 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Ramsey, B.W.3
  • 5
    • 0020658444 scopus 로고
    • Clinical and bacteriological responses to three antibiotic regimens for acute exacerbations of cystic fibrosis: Ticarcillin-tobramycin, azlocillin-tobramycin, and azlocillin-placebo
    • McLaughlin FJ, Matthews WJ Jr, Strieder DJ, Sullivan B, Taneja A, Murphy P, Goldmann DA: Clinical and bacteriological responses to three antibiotic regimens for acute exacerbations of cystic fibrosis: Ticarcillin-tobramycin, azlocillin-tobramycin, and azlocillin-placebo. J Infect Dis (1983) 147(3):559-567.
    • (1983) J Infect Dis , vol.147 , Issue.3 , pp. 559-567
    • McLaughlin, F.J.1    Matthews Jr, W.J.2    Strieder, D.J.3    Sullivan, B.4    Taneja, A.5    Murphy, P.6    Goldmann, D.A.7
  • 6
    • 0037541096 scopus 로고    scopus 로고
    • Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration: Lack of association in cystic fibrosis
    • Smith AL, Fiel SB, Mayer-Hamblett N, Ramsey B, Burns JL: Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration: Lack of association in cystic fibrosis. Chest (2003) 123(5):1495-1502.
    • (2003) Chest , vol.123 , Issue.5 , pp. 1495-1502
    • Smith, A.L.1    Fiel, S.B.2    Mayer-Hamblett, N.3    Ramsey, B.4    Burns, J.L.5
  • 7
    • 2442526705 scopus 로고    scopus 로고
    • Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis
    • Moskowitz SM, Foster JM, Emerson J, Burns JL: Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis. J Clin Microbiol (2004) 42(5):1915-1922.
    • (2004) J Clin Microbiol , vol.42 , Issue.5 , pp. 1915-1922
    • Moskowitz, S.M.1    Foster, J.M.2    Emerson, J.3    Burns, J.L.4
  • 8
    • 27744591507 scopus 로고    scopus 로고
    • Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection
    • Moskowitz SM, Foster JM, Emerson JC, Gibson RL, Burns JL: Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection. J Antimicrob Chemother (2005) 56(5):879-886.
    • (2005) J Antimicrob Chemother , vol.56 , Issue.5 , pp. 879-886
    • Moskowitz, S.M.1    Foster, J.M.2    Emerson, J.C.3    Gibson, R.L.4    Burns, J.L.5
  • 9
    • 0034518939 scopus 로고    scopus 로고
    • Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with multiresistant strains of Pseudomonas aeruginosa
    • Lang BJ, Aaron SD, Ferris W, Hebert PC, MacDonald NE: Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with multiresistant strains of Pseudomonas aeruginosa. Am J Respir Crit Care Med (2000) 162(6):2241-2245.
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.6 , pp. 2241-2245
    • Lang, B.J.1    Aaron, S.D.2    Ferris, W.3    Hebert, P.C.4    MacDonald, N.E.5
  • 10
    • 68649127146 scopus 로고    scopus 로고
    • Biofilm susceptibility testing: Does it have a role in CF microbiology?
    • Moskowitz S: Biofilm susceptibility testing: Does it have a role in CF microbiology? Pediatr Pulmonol (2008) 43 (S31): 159-160.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 159-160
    • Moskowitz, S.1
  • 11
    • 23444457294 scopus 로고    scopus 로고
    • Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: A randomised, double-blind, controlled clinical trial
    • Aaron SD, Vandemheen KL, Ferris W, Fergusson D, Tullis E, Haase D, Berthiaume Y, Brown N, Wilcox P, Yozghatlian V, Bye P et al: Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: A randomised, double-blind, controlled clinical trial. Lancet (2005) 366 (9484):463-471.
    • (2005) Lancet , vol.366 , Issue.9484 , pp. 463-471
    • Aaron, S.D.1    Vandemheen, K.L.2    Ferris, W.3    Fergusson, D.4    Tullis, E.5    Haase, D.6    Berthiaume, Y.7    Brown, N.8    Wilcox, P.9    Yozghatlian, V.10    Bye, P.11
  • 12
    • 21244451543 scopus 로고    scopus 로고
    • Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing
    • Foweraker JE, Laughton CR, Brown DF, Bilton D: Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing. J Antimicrob Chemother (2005) 55(6):921-927.
    • (2005) J Antimicrob Chemother , vol.55 , Issue.6 , pp. 921-927
    • Foweraker, J.E.1    Laughton, C.R.2    Brown, D.F.3    Bilton, D.4
  • 13
    • 68649118909 scopus 로고    scopus 로고
    • Reliability of antibiotic susceptibility testing in CF and relationship to clinical outcomes
    • Foweraker JE: Reliability of antibiotic susceptibility testing in CF and relationship to clinical outcomes. Pediatr Pulmonol (2008) 43 (S31) :160-161.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 160-161
    • Foweraker, J.E.1
  • 14
    • 0346887122 scopus 로고    scopus 로고
    • Duan K, Dammel C, Stein J, Rabin H, Surette MG: Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication. Mol Microbiol (2003) 50(5):1477- 1491. • Provided the first evidence for the relevance of the role of OF in CF.
    • Duan K, Dammel C, Stein J, Rabin H, Surette MG: Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication. Mol Microbiol (2003) 50(5):1477- 1491. • Provided the first evidence for the relevance of the role of OF in CF.
  • 15
    • 55449135547 scopus 로고    scopus 로고
    • Sibley CD, Duan K, Fischer C, Parkins MD, Storey DG, Rabin HR, Surette MG: Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections. PLoS Pathog (2008) 4(10):e1000184. • The first demonstration that the OF in CF sputum are represented by a large proportion of potentially pathogenic isolates and organisms that can synergistically enhance the virulence of the principal pathogen in CF, P aeruginosa.
    • Sibley CD, Duan K, Fischer C, Parkins MD, Storey DG, Rabin HR, Surette MG: Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections. PLoS Pathog (2008) 4(10):e1000184. • The first demonstration that the OF in CF sputum are represented by a large proportion of potentially pathogenic isolates and organisms that can synergistically enhance the virulence of the principal pathogen in CF, P aeruginosa.
  • 16
    • 54449089545 scopus 로고    scopus 로고
    • Sibley CD, Parkins MD, Rabin HR, Duan K, Norgaard JC, Surette MG: A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients. Proc Natl Acad Sci USA (2008) 105(39):15070-15075. •• Provided the first evidence that categorizing airway disease in CF as polymicrobial can have a clinical impact. This study demonstrated that the airway microbiome in CF can foster unrecognized pathogens, and specifically targeting such organisms can result in positive clinical outcomes.
    • Sibley CD, Parkins MD, Rabin HR, Duan K, Norgaard JC, Surette MG: A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients. Proc Natl Acad Sci USA (2008) 105(39):15070-15075. •• Provided the first evidence that categorizing airway disease in CF as polymicrobial can have a clinical impact. This study demonstrated that the airway microbiome in CF can foster unrecognized pathogens, and specifically targeting such organisms can result in positive clinical outcomes.
  • 17
    • 0041424873 scopus 로고    scopus 로고
    • Molecular typing of the bacterial flora in sputum of cystic fibrosis patients
    • Kolak M, Karpati F, Monstein HJ, Jonasson J: Molecular typing of the bacterial flora in sputum of cystic fibrosis patients. Int J Med Microbiol (2003) 293(4):309-317.
    • (2003) Int J Med Microbiol , vol.293 , Issue.4 , pp. 309-317
    • Kolak, M.1    Karpati, F.2    Monstein, H.J.3    Jonasson, J.4
  • 18
    • 0043025364 scopus 로고    scopus 로고
    • Rogers GB, Hart CA, Mason JR, Hughes M, Walshaw MJ, Bruce KD: Bacterial diversity in cases of lung infection in cystic fibrosis patients: 16S ribosomal DNA (rDNA) length heterogeneity PCR and 16S rDNA terminal restriction fragment length polymorphism profiling. J Clin Microbiol (2003) 41(8):3548-3558. • The first study to demonstrate that polymicrobial communities characteristically colonize in the airways in CF.
    • Rogers GB, Hart CA, Mason JR, Hughes M, Walshaw MJ, Bruce KD: Bacterial diversity in cases of lung infection in cystic fibrosis patients: 16S ribosomal DNA (rDNA) length heterogeneity PCR and 16S rDNA terminal restriction fragment length polymorphism profiling. J Clin Microbiol (2003) 41(8):3548-3558. • The first study to demonstrate that polymicrobial communities characteristically colonize in the airways in CF.
  • 19
    • 8644256676 scopus 로고    scopus 로고
    • Characterization of bacterial community diversity in cystic fibrosis lung infections by use of 16S ribosomal DNA terminal restriction fragment length polymorphism profiling
    • Rogers GB, Carroll MP, Serisier DJ, Hockey PM, Jones G, Bruce KD: Characterization of bacterial community diversity in cystic fibrosis lung infections by use of 16S ribosomal DNA terminal restriction fragment length polymorphism profiling. J Clin Microbiol (2004) 42(11):5176- 5183.
    • (2004) J Clin Microbiol , vol.42 , Issue.11 , pp. 5176-5183
    • Rogers, G.B.1    Carroll, M.P.2    Serisier, D.J.3    Hockey, P.M.4    Jones, G.5    Bruce, K.D.6
  • 20
    • 33746255217 scopus 로고    scopus 로고
    • Use of 16S rRNA gene profiling by terminal restriction fragment length polymorphism analysis to compare bacterial communities in sputum and mouthwash samples from patients with cystic fibrosis
    • Rogers GB, Carroll MP, Serisier DJ, Hockey PM, Jones G, Kehagia V, Connett GJ, Bruce KD: Use of 16S rRNA gene profiling by terminal restriction fragment length polymorphism analysis to compare bacterial communities in sputum and mouthwash samples from patients with cystic fibrosis. J Clin Microbiol (2006) 44(7):2601-2604.
    • (2006) J Clin Microbiol , vol.44 , Issue.7 , pp. 2601-2604
    • Rogers, G.B.1    Carroll, M.P.2    Serisier, D.J.3    Hockey, P.M.4    Jones, G.5    Kehagia, V.6    Connett, G.J.7    Bruce, K.D.8
  • 21
    • 0022481020 scopus 로고
    • Conformity of bacterial growth in sputum and contamination free endobronchial samples in patients with cystic fibrosis
    • Gilljam H, Malmborg AS, Strandvik B: Conformity of bacterial growth in sputum and contamination free endobronchial samples in patients with cystic fibrosis. Thorax (1986) 41(8): 641-646.
    • (1986) Thorax , vol.41 , Issue.8 , pp. 641-646
    • Gilljam, H.1    Malmborg, A.S.2    Strandvik, B.3
  • 22
    • 0021325047 scopus 로고
    • Cultures of thoracotomy specimens confirm usefulness of sputum cultures in cystic fibrosis
    • Thomassen MJ, Klinger JD, Badger SJ, van Heeckeren DW, Stern RC: Cultures of thoracotomy specimens confirm usefulness of sputum cultures in cystic fibrosis. J Pediatr (1984) 104(3):352-356.
    • (1984) J Pediatr , vol.104 , Issue.3 , pp. 352-356
    • Thomassen, M.J.1    Klinger, J.D.2    Badger, S.J.3    van Heeckeren, D.W.4    Stern, R.C.5
  • 23
    • 38049129070 scopus 로고    scopus 로고
    • Harris JK, De Groote MA, Sagel SD, Zemanick ET, Kapsner R, Penvari C, Kaess H, Deterding RR, Accurso FJ, Pace NR: Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc Natl Acad Sci USA (2007) 104(51):20529-20533. •• The largest culture-independent study to define the microbial constituents of human airways. Provided a comprehensive perspective on the complexity of the airway microbiome in CF.
    • Harris JK, De Groote MA, Sagel SD, Zemanick ET, Kapsner R, Penvari C, Kaess H, Deterding RR, Accurso FJ, Pace NR: Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc Natl Acad Sci USA (2007) 104(51):20529-20533. •• The largest culture-independent study to define the microbial constituents of human airways. Provided a comprehensive perspective on the complexity of the airway microbiome in CF.
  • 24
    • 42949105490 scopus 로고    scopus 로고
    • Tunney MM, Field TR, Moriarty TF, Patrick S, Doering G, Muhlebach MS, Wolfgang MC, Boucher R, Gilpin DF, McDowell A, Elborn JS: Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am J Respir Crit Care Med (2008) 177(9):995-1001. • Discusses the possibilities and necessity of exploring alternatives to the traditional practices for CF microbiology to improve the understanding of the microbial composition of the airways in CF.
    • Tunney MM, Field TR, Moriarty TF, Patrick S, Doering G, Muhlebach MS, Wolfgang MC, Boucher R, Gilpin DF, McDowell A, Elborn JS: Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am J Respir Crit Care Med (2008) 177(9):995-1001. • Discusses the possibilities and necessity of exploring alternatives to the traditional practices for CF microbiology to improve the understanding of the microbial composition of the airways in CF.
  • 25
    • 65949091603 scopus 로고    scopus 로고
    • Worlitzsch D, Rintelen C, Bohm K, Wollschlager B, Merkel N, Borneff-Lipp M, Doring G: Antibiotic-resistant obligate anaerobes during exacerbations of cystic brosis patients. Clin Microbiol Infect (2009) 15(5):454-46f0.
    • Worlitzsch D, Rintelen C, Bohm K, Wollschlager B, Merkel N, Borneff-Lipp M, Doring G: Antibiotic-resistant obligate anaerobes during exacerbations of cystic brosis patients. Clin Microbiol Infect (2009) 15(5):454-46f0.
  • 26
    • 0020672729 scopus 로고
    • Transtracheal aspiration in pulmonary infection in children with cystic fibrosis
    • Brook I, Fink R: Transtracheal aspiration in pulmonary infection in children with cystic fibrosis. Eur J Respir Dis (1983) 64(1):51-57.
    • (1983) Eur J Respir Dis , vol.64 , Issue.1 , pp. 51-57
    • Brook, I.1    Fink, R.2
  • 27
    • 0025359917 scopus 로고
    • The incidence of anaerobes in the sputum of patients with cystic fibrosis
    • Jewes LA, Spencer RC: The incidence of anaerobes in the sputum of patients with cystic fibrosis. J Med Microbiol (1990) 31(4):271-274.
    • (1990) J Med Microbiol , vol.31 , Issue.4 , pp. 271-274
    • Jewes, L.A.1    Spencer, R.C.2
  • 28
    • 33845594506 scopus 로고    scopus 로고
    • Appleman MD Ed, American Society of Microbiology, Washington DC, USA
    • Appleman MD (Ed): Cumitech 43: Cystic Fibrosis Microbiology. American Society of Microbiology, Washington DC, USA (2006).
    • (2006) Cumitech 43: Cystic Fibrosis Microbiology
  • 29
    • 0032696604 scopus 로고    scopus 로고
    • Pathogenicity of microbes associated with cystic fibrosis
    • Hutchison ML, Govan JR: Pathogenicity of microbes associated with cystic fibrosis. Microbes Infect (1999) 1(12):1005-1014.
    • (1999) Microbes Infect , vol.1 , Issue.12 , pp. 1005-1014
    • Hutchison, M.L.1    Govan, J.R.2
  • 30
    • 0036225688 scopus 로고    scopus 로고
    • Lung infections associated with cystic fibrosis
    • Lyczak JB, Cannon CL, Pier GB: Lung infections associated with cystic fibrosis. Clin Microbiol Rev (2002) 15(2):194-222.
    • (2002) Clin Microbiol Rev , vol.15 , Issue.2 , pp. 194-222
    • Lyczak, J.B.1    Cannon, C.L.2    Pier, G.B.3
  • 32
    • 43249098872 scopus 로고    scopus 로고
    • The Streptococcus milleri group - an unrecognized cause of disease in cystic fibrosis: A case series and literature review
    • Parkins MD, Sibley CD, Surette MG, Rabin HR: The Streptococcus milleri group - an unrecognized cause of disease in cystic fibrosis: A case series and literature review. Pediatr Pulmonol (2008) 43(5):490-497.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.5 , pp. 490-497
    • Parkins, M.D.1    Sibley, C.D.2    Surette, M.G.3    Rabin, H.R.4
  • 33
    • 0033024532 scopus 로고    scopus 로고
    • Acute bronchopulmonary infection due to Streptococcus milleri in a child with cystic fibrosis
    • Cade A, Denton M, Brownlee KG, Todd N, Conway SP: Acute bronchopulmonary infection due to Streptococcus milleri in a child with cystic fibrosis. Arch Dis Child (1999) 80(3):278-279.
    • (1999) Arch Dis Child , vol.80 , Issue.3 , pp. 278-279
    • Cade, A.1    Denton, M.2    Brownlee, K.G.3    Todd, N.4    Conway, S.P.5
  • 34
    • 32544448208 scopus 로고    scopus 로고
    • 1 in young adults with cystic fibrosis
    • 1 in young adults with cystic fibrosis. Thorax (2006) 61(2): 155-157.
    • (2006) Thorax , vol.61 , Issue.2 , pp. 155-157
    • Que, C.1    Cullinan, P.2    Geddes, D.3
  • 35
    • 62549149444 scopus 로고    scopus 로고
    • Variable antibiotic susceptibility in populations of Pseudomonas aeruginosa infecting patients with bronchiectasis
    • Gillham MI, Sundaram S, Laughton CR, Haworth CS, Bilton D, Foweraker JE: Variable antibiotic susceptibility in populations of Pseudomonas aeruginosa infecting patients with bronchiectasis. J Antimicrob Chemother (2009) 63(4):728-732.
    • (2009) J Antimicrob Chemother , vol.63 , Issue.4 , pp. 728-732
    • Gillham, M.I.1    Sundaram, S.2    Laughton, C.R.3    Haworth, C.S.4    Bilton, D.5    Foweraker, J.E.6
  • 37
    • 0037190575 scopus 로고    scopus 로고
    • Long term azithromycin in children with cystic fibrosis: A randomised, placebo-controlled crossover trial
    • Equi A, Balfour-Lynn IM, Bush A, Rosenthal M: Long term azithromycin in children with cystic fibrosis: A randomised, placebo-controlled crossover trial. Lancet (2002) 360 (9338): 978-984.
    • (2002) Lancet , vol.360 , Issue.9338 , pp. 978-984
    • Equi, A.1    Balfour-Lynn, I.M.2    Bush, A.3    Rosenthal, M.4
  • 39
    • 0036185807 scopus 로고    scopus 로고
    • Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised trial
    • Wolter J, Seeney S, Bell S, Bowler S, Masel P, McCormack J: Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised trial. Thorax (2002) 57(3):212-216.
    • (2002) Thorax , vol.57 , Issue.3 , pp. 212-216
    • Wolter, J.1    Seeney, S.2    Bell, S.3    Bowler, S.4    Masel, P.5    McCormack, J.6
  • 40
    • 33749984264 scopus 로고    scopus 로고
    • Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial
    • Demonstrated that the beneficial effect of chronic azithromycin therapy can occur independently of P aeruginosa colonization, •
    • Clement A, Tamalet A, Leroux E, Ravilly S, Fauroux B, Jais JP: Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial. Thorax (2006) 61(10):895-902. • Demonstrated that the beneficial effect of chronic azithromycin therapy can occur independently of P aeruginosa colonization.
    • (2006) Thorax , vol.61 , Issue.10 , pp. 895-902
    • Clement, A.1    Tamalet, A.2    Leroux, E.3    Ravilly, S.4    Fauroux, B.5    Jais, J.P.6
  • 45
    • 1042265016 scopus 로고    scopus 로고
    • Effects of subinhibitory concentrations of macrolide antibiotics on Pseudomonas aeruginosa
    • Wozniak DJ, Keyser R: Effects of subinhibitory concentrations of macrolide antibiotics on Pseudomonas aeruginosa. Chest (2004) 125 (2 Suppl) :62S-69S.
    • (2004) Chest , vol.125 , Issue.2 SUPPL.
    • Wozniak, D.J.1    Keyser, R.2
  • 46
    • 0029096003 scopus 로고
    • Effect on Pseudomonas aeruginosa alginate expression of direct plating and culture of fresh cystic fibrosis sputum on to Pseudomonas isolation agar containing subinhibitory concentrations of roxithromycin and rifampicin
    • Dupont MJ, Lapointe JR: Effect on Pseudomonas aeruginosa alginate expression of direct plating and culture of fresh cystic fibrosis sputum on to Pseudomonas isolation agar containing subinhibitory concentrations of roxithromycin and rifampicin. J Antimicrob Chemother (1995) 36(1):231-236.
    • (1995) J Antimicrob Chemother , vol.36 , Issue.1 , pp. 231-236
    • Dupont, M.J.1    Lapointe, J.R.2
  • 47
  • 48
    • 0030928478 scopus 로고    scopus 로고
    • Yamasaki T, Ichimiya T, Hirai K, Hiramatsu K, Nasu M: Effect of antimicrobial agents on the piliation of Pseudomonas aeruginosa and adherence to mouse tracheal epithelium. J Chemother (1997) 9(1):32-37.
    • Yamasaki T, Ichimiya T, Hirai K, Hiramatsu K, Nasu M: Effect of antimicrobial agents on the piliation of Pseudomonas aeruginosa and adherence to mouse tracheal epithelium. J Chemother (1997) 9(1):32-37.
  • 49
    • 0029842787 scopus 로고    scopus 로고
    • Direct evidence for antipseudomonal activity of macrolides: Exposuredependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin
    • Tateda K, Ishii Y, Matsumoto T, Furuya N, Nagashima M, Matsunaga T, Ohno A, Miyazaki S, Yamaguchi K: Direct evidence for antipseudomonal activity of macrolides: Exposuredependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. Antimicrob Agents Chemother (1996) 40(10):2271-2275.
    • (1996) Antimicrob Agents Chemother , vol.40 , Issue.10 , pp. 2271-2275
    • Tateda, K.1    Ishii, Y.2    Matsumoto, T.3    Furuya, N.4    Nagashima, M.5    Matsunaga, T.6    Ohno, A.7    Miyazaki, S.8    Yamaguchi, K.9
  • 50
    • 30344437587 scopus 로고    scopus 로고
    • Macrolide resistance mechanisms and in vitro susceptibility patterns of viridans group streptococci isolated from blood cultures
    • Ergin A, Ercis S, Hascelik G: Macrolide resistance mechanisms and in vitro susceptibility patterns of viridans group streptococci isolated from blood cultures. J Antimicrobhemother (2006) 57(1):139-141.
    • (2006) J Antimicrobhemother , vol.57 , Issue.1 , pp. 139-141
    • Ergin, A.1    Ercis, S.2    Hascelik, G.3
  • 51
    • 0036094575 scopus 로고    scopus 로고
    • Gordon KA, Beach ML, Biedenbach DJ, Jones RN, Rhomberg PR, Mutnick AH: Antimicrobial susceptibility patterns of β-hemolytic and viridans group streptococci: Report from the SENTRY Antimicrobial Surveillance Program (1997-2000). Diagn Microbiol Infect Dis (2002) 43(2):157-162.
    • Gordon KA, Beach ML, Biedenbach DJ, Jones RN, Rhomberg PR, Mutnick AH: Antimicrobial susceptibility patterns of β-hemolytic and viridans group streptococci: Report from the SENTRY Antimicrobial Surveillance Program (1997-2000). Diagn Microbiol Infect Dis (2002) 43(2):157-162.
  • 52
    • 33845975311 scopus 로고    scopus 로고
    • Maintenance azithromycin treatment in pediatric patients with cystic fibrosis: Long-term outcomes related to macrolide resistance and pulmonary function
    • Tramper-Stranders GA, Wolfs TF, Fleer A, Kimpen JL, van der Ent CK: Maintenance azithromycin treatment in pediatric patients with cystic fibrosis: Long-term outcomes related to macrolide resistance and pulmonary function. Pediatr Infect Dis J (2007) 26(1):8-12.
    • (2007) Pediatr Infect Dis J , vol.26 , Issue.1 , pp. 8-12
    • Tramper-Stranders, G.A.1    Wolfs, T.F.2    Fleer, A.3    Kimpen, J.L.4    van der Ent, C.K.5
  • 56
    • 38349058630 scopus 로고    scopus 로고
    • A phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection
    • Retsch-Bogart GZ, Burns JL, Otto KL, Liou TG, McCoy K, Oermann C, Gibson RL: A phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection. Pediatr Pulmonol (2008) 43(1):47-58.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.1 , pp. 47-58
    • Retsch-Bogart, G.Z.1    Burns, J.L.2    Otto, K.L.3    Liou, T.G.4    McCoy, K.5    Oermann, C.6    Gibson, R.L.7
  • 57
    • 68649110997 scopus 로고    scopus 로고
    • A randomized placebo-controlled study of nebulized liposomal amikacin (Arikace™) in the treatment of cystic brosis patients with chronic Pseudomonas aeruginosa lung infection
    • Dupont LJM, Fustik S, Mazurek H, Solyom E, Feketeova A, Csiszer E, Okusanya OO, Larsen EK, Gupta R: A randomized placebo-controlled study of nebulized liposomal amikacin (Arikace™) in the treatment of cystic brosis patients with chronic Pseudomonas aeruginosa lung infection. Pediatr Pulmonol (2008) 43 (S31) :301-302.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 301-302
    • Dupont, L.J.M.1    Fustik, S.2    Mazurek, H.3    Solyom, E.4    Feketeova, A.5    Csiszer, E.6    Okusanya, O.O.7    Larsen, E.K.8    Gupta, R.9
  • 58
    • 66949134436 scopus 로고    scopus 로고
    • A phase 1 open label trial to assess the safety and tolerability of fosfomycin/tobramycin for inhalation (fti) in subjects with cystic fibrosis (cf) or bronchiectasis (be)
    • Wilson J, Moorehead L, Montgomery B: A phase 1 open label trial to assess the safety and tolerability of fosfomycin/tobramycin for inhalation (fti) in subjects with cystic fibrosis (cf) or bronchiectasis (be). Pediatr Pulmonol (2008) 43 (S31): 320-321.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 320-321
    • Wilson, J.1    Moorehead, L.2    Montgomery, B.3
  • 59
    • 68649104076 scopus 로고    scopus 로고
    • GS-9310/11 mechanism of action: Enhanced inhibition of protein synthesis
    • MacLeod D, Velayudhan J, Kenney T, Therrien J, Baker W: GS-9310/11 mechanism of action: Enhanced inhibition of protein synthesis. Pediatr Pulmonol (2008) 43 (S31) :325.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 325
    • MacLeod, D.1    Velayudhan, J.2    Kenney, T.3    Therrien, J.4    Baker, W.5
  • 60
    • 34247193128 scopus 로고    scopus 로고
    • Novel tobramycin inhalation powder in cystic fibrosis subjects: Pharmacokinetics and safety
    • Geller DE, Konstan MW, Smith J, Noonberg SB, Conrad C: Novel tobramycin inhalation powder in cystic fibrosis subjects: Pharmacokinetics and safety. Pediatr Pulmonol (2007) 42(4):307-313.
    • (2007) Pediatr Pulmonol , vol.42 , Issue.4 , pp. 307-313
    • Geller, D.E.1    Konstan, M.W.2    Smith, J.3    Noonberg, S.B.4    Conrad, C.5
  • 61
    • 84877094120 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of inhaled dry powder ciprofloxacin after single and multiple inhalations in patients with cystic fibrosis
    • Stass HL, Nagelschmitz J, Staab D: Safety and pharmacokinetics of inhaled dry powder ciprofloxacin after single and multiple inhalations in patients with cystic fibrosis. Pediatr Pulmonol (2008) 43 (S31) :301-302.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 301-302
    • Stass, H.L.1    Nagelschmitz, J.2    Staab, D.3
  • 62
    • 66949121984 scopus 로고    scopus 로고
    • A phase 1 safety, tolerability and pharmacokinetic (PK) study of MP-376 (levofloxacin solution for inhalation) in stable cystic fibrosis (CF) patients
    • Geller P, Schwab R, Fornos P, Conrad DJ, Morgan E, Griffith D, Lomovskaya O, Loutit J, Dudley M: A phase 1 safety, tolerability and pharmacokinetic (PK) study of MP-376 (levofloxacin solution for inhalation) in stable cystic fibrosis (CF) patients. Pediatr Pulmonol (2008) 43 (S31):315.
    • (2008) Pediatr Pulmonol , vol.43 , Issue.S31 , pp. 315
    • Geller, P.1    Schwab, R.2    Fornos, P.3    Conrad, D.J.4    Morgan, E.5    Griffith, D.6    Lomovskaya, O.7    Loutit, J.8    Dudley, M.9


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