Prothrombin Complex Concentrate and Fatal Thrombosis: Poor Evidence to Implicate a Relatively Safe Drug

Annals of Emergency Medicine

Volumn 54, Issue 3, 2009, Pages 481-482

  Sarode, Ravindra ^a   Matevosyan, Karén ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ACTIVATED PROTHROMBIN COMPLEX; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9 COMPLEX; DESMOPRESSIN; DIPYRIDAMOLE; GRIFOLS; PROTHROMBIN; PROTHROMBIN COMPLEX; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; WARFARIN;

BLEEDING; DRUG SAFETY; ELECTRIC ACTIVITY; ELECTROCARDIOGRAPHY; HEMOPHILIA B; HUMAN; INTERNATIONAL NORMALIZED RATIO; LETTER; LONG TERM CARE; MORTALITY; PERICARDIOCENTESIS; PRIORITY JOURNAL; THROMBOSIS;

BLOOD COAGULATION; BLOOD COAGULATION FACTORS; CHEMISTRY, PHARMACEUTICAL; COAGULANTS; DEAMINO ARGININE VASOPRESSIN; DRUG INTERACTIONS; EVIDENCE-BASED MEDICINE; HUMANS; THROMBOSIS;

EID: 68649118140     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2009.07.004     Document Type: Letter

References (3)

1. Warren O., and Simon B. Massive, fatal, intracardiac thrombosis associated with prothrombin complex concentrate. Ann Emerg Med 53 (2009) 758-761
2. Sarode R., Rawal A., Lee R., et al. Poor correlation of supratherapeutic international normalized ratio and vitamin k-dependent procoagulant factor levels during Warfarin therapy. Br J Haematol 132 (2006) 604-607
3. Holland L, Warkentin TE, Refaai M, et al. Suboptimal Effect of a Three Factor Prothrombin Complex Concentrate (Profilnine-SD) in Correcting Supratherapeutic INR due to Warfarin Overdose. Transfusion. Epub PMID: 19210325.