Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: A single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea

Clinical Therapeutics

Volumn 31, Issue 6, 2009, Pages 1234-1243

  Kim, Bo Hyung ^a   Yi, SoJeong ^a   Kim, JaeWoo ^a   Lim, Kyoung Soo ^a   Kim, Kyu pyo ^a   Lee, BongYong ^b   Shin, Sang Goo ^a   Jang, In Jin ^a   Yu, Kyung Sang ^a  

^a Seoul National University College of Medicine   (South Korea)

^b SK Chemicals   (South Korea)

Author keywords

alcohol; hemodynamic; mirodenafil; PDE 5 inhibitors; pharmacokinetics

Indexed keywords

ALCOHOL; MIRODENAFIL; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DRUG ABSORPTION; DRUG ALCOHOL INTERACTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG MONITORING; DRUG SAFETY; DRUG TOLERABILITY; ELECTROCARDIOGRAPHY; EROSION; HEMODYNAMICS; HICCUP; HUMAN; HUMAN EXPERIMENT; KOREA; LIP DISEASE; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NORMAL HUMAN; NOSE CONGESTION; OPEN STUDY; OUTCOME ASSESSMENT; PULSE RATE; RANDOMIZED CONTROLLED TRIAL; RHINORRHEA; SINGLE DRUG DOSE; SYSTOLIC BLOOD PRESSURE; TIME TO MAXIMUM PLASMA CONCENTRATION; VITAL SIGN; VOLUNTEER;

ADULT; AREA UNDER CURVE; BLOOD PRESSURE; CROSS-OVER STUDIES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; ETHANOL; HEMODYNAMICS; HUMANS; KOREA; MALE; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINONES; SULFONAMIDES; TIME FACTORS; YOUNG ADULT;

EID: 68649115304     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2009.06.008     Document Type: Article

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