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Volumn 11, Issue 4, 2009, Pages 375-382

Cellular therapies in acute lymphoblastic leukemia

Author keywords

Acute lymphoblastic leukemia; Adoptive cell therapy; Chimeric antigen receptor; Donor lymphocyte infusion; Hematopoietic stem cell transplantation; Immunotherapy

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 68649111623     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (72)
  • 1
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui CH, Evans WE: Treatment of acute lymphoblastic leukemia. N Engl J Med (2006) 354(2):166-178.
    • (2006) N Engl J Med , vol.354 , Issue.2 , pp. 166-178
    • Pui, C.H.1    Evans, W.E.2
  • 2
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • Pui CH, Robison LL, Look AT: Acute lymphoblastic leukaemia. Lancet (2008) 371 (9617):1030-1043.
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 1030-1043
    • Pui, C.H.1    Robison, L.L.2    Look, A.T.3
  • 4
    • 33644798329 scopus 로고    scopus 로고
    • Childhood acute lymphoblastic leukaemia and relapse
    • Gaynon PS: Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol (2005) 131(5):579-587.
    • (2005) Br J Haematol , vol.131 , Issue.5 , pp. 579-587
    • Gaynon, P.S.1
  • 6
    • 0033011097 scopus 로고    scopus 로고
    • The graft-versus-leukemia effects of allogeneic cell therapy
    • Porter DL, Antin JH: The graft-versus-leukemia effects of allogeneic cell therapy. Annu Rev Med (1999) 50:369-386.
    • (1999) Annu Rev Med , vol.50 , pp. 369-386
    • Porter, D.L.1    Antin, J.H.2
  • 7
    • 50549087555 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for adults with ALL
    • Larson R: Allogeneic hematopoietic cell transplantation for adults with ALL. Bone Marrow Transplant (2008) 42 (Suppl 1) :S18-S24.
    • (2008) Bone Marrow Transplant , vol.42 , Issue.SUPPL. 1
    • Larson, R.1
  • 9
    • 0033636586 scopus 로고    scopus 로고
    • Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87
    • Thiebaut A, Vernant JP, Degos L, Huguet FR, Reiffers J, Sebban C, Lepage E, Thomas X, Fière D: Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. Hematol Oncol Clin North Am (2000) 14(6):1353-1366.
    • (2000) Hematol Oncol Clin North Am , vol.14 , Issue.6 , pp. 1353-1366
    • Thiebaut, A.1    Vernant, J.P.2    Degos, L.3    Huguet, F.R.4    Reiffers, J.5    Sebban, C.6    Lepage, E.7    Thomas, X.8    Fière, D.9
  • 11
    • 33745185595 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: A metaanalysis
    • Yanada M, Matsuo K, Suzuki T, Naoe T: Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: A metaanalysis. Cancer (2006) 106(12):2657-2663.
    • (2006) Cancer , vol.106 , Issue.12 , pp. 2657-2663
    • Yanada, M.1    Matsuo, K.2    Suzuki, T.3    Naoe, T.4
  • 12
    • 85117737981 scopus 로고    scopus 로고
    • Goldstone AH, Richards SM, Lazarus HM, Tallman MS, Buck G, Fielding AK, Burnett AK, Chopra R, Wiernik PH, Foroni L, Paietta E et al: In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: Final results of the International ALL Trial (MRC UKALL XII/ECOG E2993). Blood (2008) 111(4):1827-1833.
    • Goldstone AH, Richards SM, Lazarus HM, Tallman MS, Buck G, Fielding AK, Burnett AK, Chopra R, Wiernik PH, Foroni L, Paietta E et al: In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: Final results of the International ALL Trial (MRC UKALL XII/ECOG E2993). Blood (2008) 111(4):1827-1833.
  • 13
    • 68649104153 scopus 로고    scopus 로고
    • Challenges the standard-of-care in patients with ALL with respect to allo-HSCT, demonstrating improved outcomes in patients with standard, but not high-risk, ALL
    • Challenges the standard-of-care in patients with ALL with respect to allo-HSCT, demonstrating improved outcomes in patients with standard, but not high-risk, ALL.
  • 14
    • 27144543159 scopus 로고    scopus 로고
    • Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as postremission treatment for adult patients with high-risk acute lymphoblastic leukemia. Results of the PETHEMA ALL-93 trial
    • Ribera JM, Oriol A, Bethencourt C, Parody R, Hernández-Rivas JM, Moreno MJ, del Potro E, Torm M, Rivas C, Besalduch J, Sanz MA et al: Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as postremission treatment for adult patients with high-risk acute lymphoblastic leukemia. Results of the PETHEMA ALL-93 trial. Haematologica (2005) 90(10):1346-1356.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1346-1356
    • Ribera, J.M.1    Oriol, A.2    Bethencourt, C.3    Parody, R.4    Hernández-Rivas, J.M.5    Moreno, M.J.6    del Potro, E.7    Torm, M.8    Rivas, C.9    Besalduch, J.10    Sanz, M.A.11
  • 15
    • 68649084366 scopus 로고    scopus 로고
    • Similar to reference [12], this study contradicts the standard-of-care for patients with high-risk ALL, challenging the notion that high-risk patients have an improved outcome following allo-HSCT.
    • Similar to reference [12], this study contradicts the standard-of-care for patients with high-risk ALL, challenging the notion that high-risk patients have an improved outcome following allo-HSCT.
  • 16
    • 34547642358 scopus 로고    scopus 로고
    • Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: Favorable outcome with BMT at first remission and HLA-matched unrelated donor
    • Chim CS, Lie AK, Liang R, Au WY, Kwong YL: Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: Favorable outcome with BMT at first remission and HLA-matched unrelated donor. Bone Marrow Transplant (2007) 40(4):339-347.
    • (2007) Bone Marrow Transplant , vol.40 , Issue.4 , pp. 339-347
    • Chim, C.S.1    Lie, A.K.2    Liang, R.3    Au, W.Y.4    Kwong, Y.L.5
  • 18
    • 4344682975 scopus 로고    scopus 로고
    • Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: No difference in related compared with unrelated transplant in first complete remission
    • Kiehl MG, Kraut L, Schwerdtfeger R, Hertenstein B, Remberger M, Kroeger N, Stelljes M, Bornhaeuser M, Martin H, Scheid C, Ganser A et al: Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: No difference in related compared with unrelated transplant in first complete remission. J Clin Oncol (2004) 22(14):2816-2825.
    • (2004) J Clin Oncol , vol.22 , Issue.14 , pp. 2816-2825
    • Kiehl, M.G.1    Kraut, L.2    Schwerdtfeger, R.3    Hertenstein, B.4    Remberger, M.5    Kroeger, N.6    Stelljes, M.7    Bornhaeuser, M.8    Martin, H.9    Scheid, C.10    Ganser, A.11
  • 22
    • 8544279030 scopus 로고    scopus 로고
    • Singleinstitute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies
    • Takahashi S, Iseki T, Ooi J, Tomonari A, Takasugi K, Shimohakamada Y, Yamada T, Uchimaru K, Tojo A, Shirafuji N, Kodo H et al: Singleinstitute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood (2004) 104(12):3813-3820.
    • (2004) Blood , vol.104 , Issue.12 , pp. 3813-3820
    • Takahashi, S.1    Iseki, T.2    Ooi, J.3    Tomonari, A.4    Takasugi, K.5    Shimohakamada, Y.6    Yamada, T.7    Uchimaru, K.8    Tojo, A.9    Shirafuji, N.10    Kodo, H.11
  • 23
    • 56649103742 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: Impact of donor source on survival
    • Kumar P, Defor TE, Brunstein C, Barker JN, Wagner JE, Weisdorf DJ, Burns LJ: Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: Impact of donor source on survival. Biol Blood Marrow Transplant (2008) 14(12):1394-1400.
    • (2008) Biol Blood Marrow Transplant , vol.14 , Issue.12 , pp. 1394-1400
    • Kumar, P.1    Defor, T.E.2    Brunstein, C.3    Barker, J.N.4    Wagner, J.E.5    Weisdorf, D.J.6    Burns, L.J.7
  • 24
    • 61849109215 scopus 로고    scopus 로고
    • Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia
    • Atsuta Y, Suzuki R, Nagamura-Inoue T, Taniguchi S, Takahashi S, Kai S, Sakamaki H, Kouzai Y, Kasai M, Fukuda T, Azuma H et al: Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. Blood (2009) 113(8):1631-1638.
    • (2009) Blood , vol.113 , Issue.8 , pp. 1631-1638
    • Atsuta, Y.1    Suzuki, R.2    Nagamura-Inoue, T.3    Taniguchi, S.4    Takahashi, S.5    Kai, S.6    Sakamaki, H.7    Kouzai, Y.8    Kasai, M.9    Fukuda, T.10    Azuma, H.11
  • 25
    • 64049089054 scopus 로고    scopus 로고
    • Prolonged survival in adults with acute lymphoblastic leukemia after reduced-intensity conditioning with cord blood or sibling donor transplantation
    • Bachanova V, Verneris MR, DeFor T, Brunstein CG, Weisdorf DJ: Prolonged survival in adults with acute lymphoblastic leukemia after reduced-intensity conditioning with cord blood or sibling donor transplantation. Blood (2009) 113(13):2902-2905.
    • (2009) Blood , vol.113 , Issue.13 , pp. 2902-2905
    • Bachanova, V.1    Verneris, M.R.2    DeFor, T.3    Brunstein, C.G.4    Weisdorf, D.J.5
  • 26
    • 40749099814 scopus 로고    scopus 로고
    • Haploidentical haematopoietic stem cell transplantation for acute leukaemia in adults: Experience in Europe and the United States
    • Aversa F: Haploidentical haematopoietic stem cell transplantation for acute leukaemia in adults: Experience in Europe and the United States. Bone Marrow Transplant (2008) 41(5):473-481.
    • (2008) Bone Marrow Transplant , vol.41 , Issue.5 , pp. 473-481
    • Aversa, F.1
  • 27
    • 68649121047 scopus 로고    scopus 로고
    • An outstanding review of the development of haploidentical donor allo-HSCT into a feasible alternative approach for patients lacking suitably matched HSCT donors
    • An outstanding review of the development of haploidentical donor allo-HSCT into a feasible alternative approach for patients lacking suitably matched HSCT donors.
  • 28
    • 0028125191 scopus 로고
    • Successful engraftment of T-cell-depleted haploidentical 'three-loci' incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum
    • Aversa F, Tabilio A, Terenzi A, Velardi A, Falzetti F, Giannoni C, Iacucci R, Zei T, Martelli MP, Gambelunghe C et al: Successful engraftment of T-cell-depleted haploidentical 'three-loci' incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood (1994) 84(11):3948-3955.
    • (1994) Blood , vol.84 , Issue.11 , pp. 3948-3955
    • Aversa, F.1    Tabilio, A.2    Terenzi, A.3    Velardi, A.4    Falzetti, F.5    Giannoni, C.6    Iacucci, R.7    Zei, T.8    Martelli, M.P.9    Gambelunghe, C.10
  • 31
    • 55749091291 scopus 로고    scopus 로고
    • A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: A risk factor analysis of outcomes for patients in remission at transplantation
    • Ciceri F, Labopin M, Aversa F, Rowe JM, Bunjes D, Lewalle P, Nagler A, Di Bartolomeo P, Lacerda JF, Lupo Stanghellini MT, Polge E et al: A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: A risk factor analysis of outcomes for patients in remission at transplantation. Blood (2008) 112(9):3574- 3581.
    • (2008) Blood , vol.112 , Issue.9 , pp. 3574-3581
    • Ciceri, F.1    Labopin, M.2    Aversa, F.3    Rowe, J.M.4    Bunjes, D.5    Lewalle, P.6    Nagler, A.7    Di Bartolomeo, P.8    Lacerda, J.F.9    Lupo Stanghellini, M.T.10    Polge, E.11
  • 33
    • 57649126380 scopus 로고    scopus 로고
    • Treatment of adult acute lymphoblastic leukemia
    • Gökbuget N, Hoelzer D: Treatment of adult acute lymphoblastic leukemia. Semin Hematol (2009) 46(1):64-75.
    • (2009) Semin Hematol , vol.46 , Issue.1 , pp. 64-75
    • Gökbuget, N.1    Hoelzer, D.2
  • 35
    • 1542267219 scopus 로고    scopus 로고
    • Graft-versus-leukemia reactions in allogeneic chimeras
    • Kolb HJ, Schmid C, Barrett AJ, Schendel DJ: Graft-versus-leukemia reactions in allogeneic chimeras. Blood (2004) 103(3):767-776.
    • (2004) Blood , vol.103 , Issue.3 , pp. 767-776
    • Kolb, H.J.1    Schmid, C.2    Barrett, A.J.3    Schendel, D.J.4
  • 36
    • 40749121702 scopus 로고    scopus 로고
    • Donor leukocyte infusions for the treatment of relapsed acute leukemia after allogeneic stem cell transplantation
    • Loren AW, Porter DL: Donor leukocyte infusions for the treatment of relapsed acute leukemia after allogeneic stem cell transplantation. Bone Marrow Transplant (2008) 41(5):483-493.
    • (2008) Bone Marrow Transplant , vol.41 , Issue.5 , pp. 483-493
    • Loren, A.W.1    Porter, D.L.2
  • 37
    • 22744448681 scopus 로고    scopus 로고
    • Treatment of relapsed acute lymphoblastic leukemia after allogeneic bone marrow transplantation with chemotherapy followed by G-CSF-primed donor leukocyte infusion: A prospective study
    • Choi SJ, Lee JH, Lee JH, Kim S, Lee YS, Seol M, Ryu SG, Lee JS, Kim WK, Jang S, Park CJ et al: Treatment of relapsed acute lymphoblastic leukemia after allogeneic bone marrow transplantation with chemotherapy followed by G-CSF-primed donor leukocyte infusion: A prospective study. Bone Marrow Transplant (2005) 36(2):163-169.
    • (2005) Bone Marrow Transplant , vol.36 , Issue.2 , pp. 163-169
    • Choi, S.J.1    Lee, J.H.2    Lee, J.H.3    Kim, S.4    Lee, Y.S.5    Seol, M.6    Ryu, S.G.7    Lee, J.S.8    Kim, W.K.9    Jang, S.10    Park, C.J.11
  • 39
    • 0031887050 scopus 로고    scopus 로고
    • Donor leukocyte infusion as salvage therapy in an adult with relapsed acute lymphoblastic leukemia after allogeneic bone marrow transplantation
    • Chang CS, Lin SF, Liu TC, Huang SM, Chen TP: Donor leukocyte infusion as salvage therapy in an adult with relapsed acute lymphoblastic leukemia after allogeneic bone marrow transplantation. J Formos Med Assoc (1998) 97(1):55-58.
    • (1998) J Formos Med Assoc , vol.97 , Issue.1 , pp. 55-58
    • Chang, C.S.1    Lin, S.F.2    Liu, T.C.3    Huang, S.M.4    Chen, T.P.5
  • 40
    • 4844231048 scopus 로고    scopus 로고
    • Successful treatment of hematological and extramedullary relapse of MLL-positive acute lymphoblastic leukemia after bone marrow transplantation using donor leukocyte infusion
    • Patriarca F, Sperotto A, Skert C, Damiani D, Prosdocimo S, Fanin R: Successful treatment of hematological and extramedullary relapse of MLL-positive acute lymphoblastic leukemia after bone marrow transplantation using donor leukocyte infusion. Ann Hematol (2004) 83(10):667-669.
    • (2004) Ann Hematol , vol.83 , Issue.10 , pp. 667-669
    • Patriarca, F.1    Sperotto, A.2    Skert, C.3    Damiani, D.4    Prosdocimo, S.5    Fanin, R.6
  • 41
    • 0031059857 scopus 로고    scopus 로고
    • Successful prevention of hematological relapse for a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic bone marrow transplantation by donor leukocyte infusion
    • Yazaki M, Andoh M, Ito T, Ohno T, Wada Y: Successful prevention of hematological relapse for a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic bone marrow transplantation by donor leukocyte infusion. Bone Marrow Transplant (1997) 19(4):393-394.
    • (1997) Bone Marrow Transplant , vol.19 , Issue.4 , pp. 393-394
    • Yazaki, M.1    Andoh, M.2    Ito, T.3    Ohno, T.4    Wada, Y.5
  • 45
    • 34548857324 scopus 로고    scopus 로고
    • Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia
    • Rezvani K, Yong AS, Savani BN, Mielke S, Keyvanfar K, Gostick E, Price DA, Douek DC, Barrett AJ: Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. Blood (2007) 110(6):1924-1932.
    • (2007) Blood , vol.110 , Issue.6 , pp. 1924-1932
    • Rezvani, K.1    Yong, A.S.2    Savani, B.N.3    Mielke, S.4    Keyvanfar, K.5    Gostick, E.6    Price, D.A.7    Douek, D.C.8    Barrett, A.J.9
  • 46
    • 4544245023 scopus 로고    scopus 로고
    • Novel approaches to immunotherapy for B-cell malignancies
    • Brentjens RJ: Novel approaches to immunotherapy for B-cell malignancies. Curr Oncol Rep (2004) 6(5):339-347.
    • (2004) Curr Oncol Rep , vol.6 , Issue.5 , pp. 339-347
    • Brentjens, R.J.1
  • 47
    • 65249101637 scopus 로고    scopus 로고
    • The promise and potential pitfalls of chimeric antigen receptors
    • Sadelain M, Brentjens R, Rivière I: The promise and potential pitfalls of chimeric antigen receptors. Curr Opin Immunol (2009) 21(2):215-223.
    • (2009) Curr Opin Immunol , vol.21 , Issue.2 , pp. 215-223
    • Sadelain, M.1    Brentjens, R.2    Rivière, I.3
  • 48
    • 68649124933 scopus 로고    scopus 로고
    • An updated review on the status of adoptive T-cell therapy for the treatment of cancer using CAR-engineered T-cells
    • An updated review on the status of adoptive T-cell therapy for the treatment of cancer using CAR-engineered T-cells.
  • 49
    • 0037264471 scopus 로고    scopus 로고
    • Targeting tumours with genetically enhanced T lymphocytes
    • Sadelain M, Rivière I, Brentjens R: Targeting tumours with genetically enhanced T lymphocytes. Nat Rev Cancer (2003) 3(1):35-45.
    • (2003) Nat Rev Cancer , vol.3 , Issue.1 , pp. 35-45
    • Sadelain, M.1    Rivière, I.2    Brentjens, R.3
  • 51
    • 68649123731 scopus 로고    scopus 로고
    • First reported study demonstrating in vivo efficacy of CD19-targeted CAR+ T-cells.
    • First reported study demonstrating in vivo efficacy of CD19-targeted CAR+ T-cells.
  • 56
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai C, Mihara K, Andreansky M, Nicholson IC, Pui CH, Geiger TL, Campana D: Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia (2004) 18(4):676-684.
    • (2004) Leukemia , vol.18 , Issue.4 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3    Nicholson, I.C.4    Pui, C.H.5    Geiger, T.L.6    Campana, D.7
  • 57
    • 33845294816 scopus 로고    scopus 로고
    • CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
    • Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, Smith DD, Forman SJ, Jensen MC, Cooper LJ: CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res (2006) 66(22):10995-11004.
    • (2006) Cancer Res , vol.66 , Issue.22 , pp. 10995-11004
    • Kowolik, C.M.1    Topp, M.S.2    Gonzalez, S.3    Pfeiffer, T.4    Olivares, S.5    Gonzalez, N.6    Smith, D.D.7    Forman, S.J.8    Jensen, M.C.9    Cooper, L.J.10
  • 58
    • 33750061330 scopus 로고    scopus 로고
    • Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    • Loskog A, Giandomenico V, Rossig C, Pule M, Dotti G, Brenner MK: Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia (2006) 20(10):1819-1828.
    • (2006) Leukemia , vol.20 , Issue.10 , pp. 1819-1828
    • Loskog, A.1    Giandomenico, V.2    Rossig, C.3    Pule, M.4    Dotti, G.5    Brenner, M.K.6
  • 59
    • 0037085804 scopus 로고    scopus 로고
    • Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy
    • Rossig C, Bollard CM, Nuchtern JG, Rooney CM, Brenner MK: Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy. Blood (2002) 99(6):2009-2016.
    • (2002) Blood , vol.99 , Issue.6 , pp. 2009-2016
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3    Rooney, C.M.4    Brenner, M.K.5
  • 62
    • 68649103407 scopus 로고    scopus 로고
    • Monoculture-derived T lymphocytes providing multiple virus specificity and anti-leukemia activity for recipients of hematopoietic stem cells or umbilical cord blood transplants
    • Abs
    • Savoldo B, Mickllethwaite K, Cooper L, Shpall EJ, Rooney CM, Heslop HE, Brenner MK, Bollard CM, Dotti G: Monoculture-derived T lymphocytes providing multiple virus specificity and anti-leukemia activity for recipients of hematopoietic stem cells or umbilical cord blood transplants. Blood (2008) 112:Abs 3909.
    • (2008) Blood , vol.112 , pp. 3909
    • Savoldo, B.1    Mickllethwaite, K.2    Cooper, L.3    Shpall, E.J.4    Rooney, C.M.5    Heslop, H.E.6    Brenner, M.K.7    Bollard, C.M.8    Dotti, G.9
  • 65
    • 68649094843 scopus 로고    scopus 로고
    • First report demonstrating the clinical application of KIR-mismatch in allo-HSCT outcomes in acute leukemias, demonstrating the potential of adoptive transfer of KIR-mismatched NK cells as an alternative therapeutic approach for relapsed leukemias
    • First report demonstrating the clinical application of KIR-mismatch in allo-HSCT outcomes in acute leukemias, demonstrating the potential of adoptive transfer of KIR-mismatched NK cells as an alternative therapeutic approach for relapsed leukemias.
  • 68
  • 69
    • 68049132603 scopus 로고    scopus 로고
    • Clinical-grade ex vivo - expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells
    • Berg M, Lundqvist A, McCoy P Jr, Samsel L, Fan Y, Tawab A, Childs R: Clinical-grade ex vivo - expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells. Cytotherapy (2009) 11(3):341-355.
    • (2009) Cytotherapy , vol.11 , Issue.3 , pp. 341-355
    • Berg, M.1    Lundqvist, A.2    McCoy Jr, P.3    Samsel, L.4    Fan, Y.5    Tawab, A.6    Childs, R.7
  • 71
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • Imai C, Iwamoto S, Campana D: Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood (2005) 106(1):376-383.
    • (2005) Blood , vol.106 , Issue.1 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 72
    • 68649111077 scopus 로고    scopus 로고
    • Preclinical studies demonstrating the efficacy and feasibility of CAR-modified NK cells to target and lyse otherwise NK cell-refractory ALL tumor cell lines, providing the rationale for a pending clinical trial using genetically modified NK cells targeted to CD19 in patients with ALL; the first such trial of its kind
    • Preclinical studies demonstrating the efficacy and feasibility of CAR-modified NK cells to target and lyse otherwise NK cell-refractory ALL tumor cell lines, providing the rationale for a pending clinical trial using genetically modified NK cells targeted to CD19 in patients with ALL; the first such trial of its kind.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.