Drug-induced brugada syndrome

Europace

Volumn 11, Issue 8, 2009, Pages 989-994

  Yap, Yee Guan ^a   Behr, Elijah R ^b   Camm, A John ^b  

^a Prince Court Medical Centre ^*  (Malaysia)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Drug induced Brugada syndrome; Sudden cardiac death

Indexed keywords

AJMALINE; AMITRIPTYLINE; ANTIHISTAMINIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUPIVACAINE; CALCIUM CHANNEL BLOCKING AGENT; CLOMIPRAMINE; COCAINE; DESIPRAMINE; DILTIAZEM; DIMENHYDRINATE; DIPHENHYDRAMINE; FLECAINIDE; FLUOXETINE; ISOSORBIDE 5 NITRATE; LIDOCAINE; LITHIUM; LITHIUM CHLORIDE; MAPROTILINE; MEXILETINE; NITRATE; NORTRIPTYLINE; PHENOTHIAZINE; PROCAINAMIDE; PROPOFOL; TRICYCLIC ANTIDEPRESSANT AGENT; TRIFLUOPERAZINE; VERAPAMIL;

ATRIOVENTRICULAR BLOCK; BIPOLAR DISORDER; BRUGADA SYNDROME; CLINICAL FEATURE; DEPRESSION; DISEASE COURSE; DRUG MECHANISM; DRUG MEGADOSE; ECG ABNORMALITY; HEART ARREST; HEART ARRHYTHMIA; HEART ATRIUM FLUTTER; HEART DEATH; HEART LEFT ANTERIOR BUNDLE BRANCH BLOCK; HEART RIGHT BUNDLE BRANCH BLOCK; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; NONHUMAN; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; QT PROLONGATION; REVIEW; SIDE EFFECT; SINUS NODE DYSFUNCTION; ST SEGMENT ELEVATION; SUDDEN DEATH; TORSADE DES POINTES; UNSPECIFIED SIDE EFFECT;

ANTI-ARRHYTHMIA AGENTS; BRUGADA SYNDROME; CARDIOTONIC AGENTS; HEART CONDUCTION SYSTEM; HUMANS;

EID: 68649098060     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eup114     Document Type: Review

References (71)

1. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association Brugada Syndrome: report of the second consensus conference. Circulation 2005;111:659-70.
2. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol 1992;20:1391-6.
3. Antzelevitch C, Brugada P, Brugada J, Brugada R, Nademanee K, Towbin J. The Brugada Syndrome. Armonk, NY: Futura Publishing Company, Inc; 1999. p1-99.
4. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada P, Potenza D et al. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature 1998;392:293-6.
5. Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 2007;115:442-9.
6. London B, Michalec M, Mehdi H, Zhu X, Kerchner L, Sanyal S et al. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Nap current and causes inherited arrhythmias. Circulation 2007;116:2260-8.
7. Koopmann TT, Beekman L, Alders M, Meregalli PG, Mannens MMAN, Moorman AFM et al. Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort. Heart Rhythm 2007;4:752-5.
8. Di Diego JM, Cordeiro JM, Goodrow RJ, Fish JM, Zygmunt AC, Pérez GJ et al. Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation 2002;106:2004-11.
9. Priori SG, Napolitano C, Giordano U, Collisani G, Memmi M. Brugada syndrome and sudden cardiac death in children. Lancet 2000;355:808-9.
10. Rolf S, Bruns HJ, Wichter T, Kirchhof P, Ribbing M, Wasmer K et al. The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol. Eur Heart J 2003;24:1104-12.
11. Fish JM, Antzelevitch C. Role of sodium and calcium channel block in unmasking the Brugada syndrome. Heart Rhythm 2004;1:210-7.
12. Akhtar M, Goldschlager NF. Brugada electrocardiographic pattern due to tricyclic antidepressant overdose. J Electrocardiol 2006;39:336-9.
13. Brugada R, Brugada J, Antzelevitch C, Kirsch GE, Potenza D, Towbin JA et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation 2000;101:510-5.
14. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 1996;27:1061-70.
15. Fujiki A, Usui M, Nagasawa H, Mizumaki K, Hayashi H, Inoue H. ST segment elevation in the right precordial leads induced with class Ic antiarrhythmic drugs: insight into the mechanism of Brugada syndrome. J Cardiovasc Electrophysiol 1999;10:214-8.
16. Hermida JS, Jandaud S, Lemoine JL, Rodriguez-Lafrasse C, Delonca J, Bertrand C et al. Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population. Am J Cardiol 2004;94:230-3.
17. Chow BJ, Gollob M, Birnie D. Brugada syndrome precipitated by a tricyclic anti-depressant. Heart 2005;91:651.
18. Yasuda M, Nakazato Y, Yamashita H, Sekita G, Kawano Y, Mineda Y et al. ST segment elevation in the right precordial leads following administration of class Ic antiarrhythmic drugs. Heart 2001;85:E3.
19. Morita H, Takenaka-Morita S, Fukushima-Kusano K, Kobayashi M, Nagase S, Kakishita M et al. Risk stratification for asymptomatic patients with Brugada syndrome. Circ J 2003;67:312-6.
20. Takagi M, Doi A, Takeuchi K, Yoshikawa J. Pilsicanide-induced marked T wave alternans and ventricular fibrillation in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 2002;13:837.
21. Chinushi M, Washizuka T, Okumura H, Aizawa Y. Intravenous administration of class I antiarrhythmic drugs induced T wave alternans in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 2001;12:493-5.
22. Aksay E, Okan T, Yanturali S. Brugada syndrome, manifested by propafenone induced ST segment elevation. Emerg Med J 2005;22:748-50.
23. Caenepeel A, Geelen P, Peytchev P, de Zutter M, Brugada P. Cibenzoline induced Brugada ECG pattern. Europace 2005;7:537-9.
24. Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N et al. Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2000;11: 1320-9.
25. Wolpert C, Echternach C, Veltmann C, Antzelevitch C, Thomas GP, Spehl S et al. Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome. Heart Rhythm 2005;2:254-60.
26. Pinar Bermúdez E, García-Alberola A, Martínez Sánchez J, Sánchez Muñoz JJ, Valdés Chávarri M. Spontaneous sustained monomorphic ventricular tachycardia after administration of ajmaline in a patient with Brugada syndrome. Pacing Clin Electrophysiol 2000;23:407-9.
27. Ray WA, Meredith S, Thapa PB, Hall K, Murray KT. Cyclic antidepressants and the risk of sudden cardiac death. Clin Pharmacol Ther 2004;75:234.
28. Yap YG, Camm AJ. Risk of torsades de pointes with non-cardiac drugs. Br Med J 2000;320:1158-9.
29. Rouleau F, Asfar P, Boulet S, Dube L, Dupuis JM, Alquier P et al. Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome. J Cardiovasc Electrophysiol 2001;12:61-5.
30. Bolognesi R, Tsialtas D, Vasini P, Conti M, Manca C. Abnormal ventricular repo-larization mimicking myocardial infarction after heterocyclic antidepressant overdose. Am J Cardiol 1997;79:242-5.
31. Tada H, Sticherling C, Oral H, Morady F. Brugada syndrome mimicked by tricyclic antidepressant overdose. J Cardiovasc Electrophysiol 2001;12:275.
32. Bigwood B, Galler D, Amir N, Smith W. Brugada syndrome following tricyclic antidepressant overdose. Anaesth Intensive Care 2005;33:266-70.
33. Goldgran-Toledano D, Sideris G, Kevorkian JP. Overdose of cyclic antidepressants and the Brugada syndrome. N Engl J Med 2002;346:1591-2.
34. Brahmi N, Thabet H, Kouraichi N, Driss I, Amamou M. Brugada syndrome and other cardiovascular abnormalities related to tricyclic antidepressants and related drugs intoxication. Arch Mal Coeur Vaiss 2007;100:28-33.
35. Bebarta VS, Waksman JC. Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate. Clin Toxicol (Phila) 2007;45:186-8.
36. Bebarta VS, Phillips S, Eberhardt A, Calihan KJ, Waksman JC, Heard K. Incidence of Brugada electrocardiographic pattern and outcomes of these patients after intentional tricyclic antidepressant ingestion. Am J Cardiol 2007;100: 656-60.
37. Bril A, Rochette L, Bertrand JP, Gautier P. Electrophysiological effects of some anti-depressant drugs on canine Purkinje fibers. Cardiovasc Res 1987;21: 783-9.
38. Barber M, Starmer C, Grant A. Blockade of cardiac sodium channels by amitripty-line and diphenylhydantoin. Evidence for two use-dependent binding sites. Circ Res 1991;69:677-93.
39. Casis O, Sanchez-Chapula A. Mechanism of block of cardiac transient outward K1 current (Ito) by anti-depressant drugs. J Cardiovasc Pharmacol 1998;32:527-34.
40. Endo G, Hori T, Tanimukai S, Aihara H, Aonuma K, Asada T. A case of Brugada syndrome with convulsive seizure during antidepressant administration: relation of antidepressant agents and arrhythmia leading to sudden death. Seishin Shinkeigaku Zasshi 2006;108:792-800.
41. Babaliaros VC, Hurst JW. Tricyclic antidepressants and the Brugada syndrome: an example of Brugada waves appearing after the administration of desipramine. Clin Cardiol 2002;25:395-8.
42. Chow BJW, Gollob M, Birnie D. Brugada syndrome precipitated by a tricyclic anti-depressant. Heart 2005;91:651.
43. Pacher P, Magyar J, Scigligeti P, Banyasz T, Pankucsi C, Korom Z et al. Electrophy-siologial effects of fluoxetine in mammalian cardiac tissues. Naunyn Schmiedebergs Arch Pharmacol 2000;361:67-73.
44. Arita M, Surawicz B. Electrophysiologic effects of phenothiazine on canine cardiac fibers. J Pharmacol Exp Ther 1973;184:619-30.
45. Ogata N, Narahashi T. Blockade of sodium channel by psychotropic drugs in single guinea-pig cardiac myocytes. Br J Pharmacol 1989;97:905- 13.
46. Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SHL. QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet 2000;355:1048-52.
47. Mitchell JE, Mackenzie TB. Cardiac effects of lithium therapy in man: a review. J Clin Psychiatry 1982;43:47-51.
48. Mateer JR, Clark MR. Lithium toxicity with rarely reported ECG manifestations. Ann Emerg Med 1982;11:208-11.
49. Darbar D, Yang T, Churchwell K, Wilde AA, Roden DM. Unmasking of Brugada syndrome by lithium. Circulation 2005;112:1527-31.
50. Pastor A, Núñez A, Cantale C, Cosío FG. Asymptomatic Brugada syndrome case unmasked during dimenhydrinate infusion.J Cardiovasc Electrophysiol 2001;12:1192-4.
51. López-Barbeito B, Lluis M, Delgado V, Jiménez S, Díaz-Infante E, Nogué-Xarau S et al. Diphenhydramine overdose and Brugada sign. Pacing Clin Electrophysiol 2005; 28:730-2.
52. Bauman JL, Grawe JJ, Winecoff AP, Hariman RJ. Cocaine-related sudden cardiac death: a hypothesis correlating basic science and clinical observations. J Clin Pharmacol 1994;34:902-11.
53. Littmann L, Monroe MH, Svenson RH. Brugada-type electrocardiographic pattern induced by cocaine. Mayo Clic Proc 2000;75:845-9.
54. Ortega-Carnicer J, Bertos-Polo J, Gutiérrez-Tirado C. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J Electrocardiol 2001;34:345-9.
55. Grigorov V, Goldberg L, Foccard JP. Cardiovascular complications of acute cocaine poisoning: a clinical case report. Cardiovasc J S Afr 2004;15: 139-42.
56. Bebarta VS, Summers S. Brugada electrocardiographic pattern induced by cocaine toxicity. Ann Emerg Med 2007;49:827-9.
57. Daga B, Miñano A, de la Puerta I, Pelegrín J, Rodrigo G, Ferreira I. Electrocardiographic findings typical of Brugada syndrome unmasked by cocaine consumption. Rev Esp Cardiol 2005;58:1355-7.
58. Parker RB, Perry GY, Horan LG, Flowers NC. Comparative effects of sodium bicarbonate and sodium chloride on reversing cocaine-induced changes in the electrocardiogram. J Cardiovasc Pharmacol 1999;34:864-9.
59. Wilson LD, Shelat C. Electrophysiologic and hemodynamic effects of sodium bicarbonate in a canine model of severe cocaine intoxication. J Toxicol Clin Toxicol 2003;41:777-88.
60. Kolecki PF, Curry SC. Poisoning by sodium channel blocking agents. Crit Care Clin 1997;13:829-48.
61. Xiao YF, Ke Q, Wang SY, Yang Y, Chen Y, Wang GK et al. Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels. Eur J Pharmacol 2004;485:31-41.
62. Vernooy K, Sicouri S, Dumaine R, Hong K, Oliva A, Burashnikov E et al. Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome. Heart Rhythm 2006;3: 1079-81.
63. Phillips N, Priestley M, Denniss AR, Uther JB. Brugada-type electrocardiographic pattern induced by epidural bupivacaine. Anesth Analg 2003;97:264-7.
64. Moller RA, Covino BG. Cardiac electrophysiologic effects of lidocaine and bupi-vacaine. Anesth Analg 1988;67:107-14.
65. Shimizu W. Acquired forms of Brugada syndrome. In: Antzelevitch C (ed). The Brugada Syndrome: From Bench to Bedside, Chapter 14. UK: Blackwell Futura; 2004. p166-77.
66. Cannon ML, Glazier SS, Bauman LA. Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. J Neurosurg 2001;95: 1053-6.
67. Stelow EB, Johari VP, Smith SA, Crosson JT, Apple FS. Propofol-associated rhab-domyolysis with cardiac involvement in adults: chemical and anatomic findings. Clin Chem 2000;46:577-81.
68. Vernooy K, Delhaas T, Cremer OL, Di Diego JM, Oliva A, Timmermans C et al. Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. Heart Rhythm 2006;3:131-7.
69. Junttila MJ, Gonzalez M, Lizotte E, Benito B, Vernooy K, Sarkozy A et al. Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation 2008;117:1890-3.
70. Brugada J, Brugada R, Antzelevitch C, Towbin J, Nademanee K, Brugada P. Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. Circulation 2002;105:73-8.
71. Antzelevitch C. The Brugada syndrome: ionic basis and arrhythmia mechanisms. J Cardiovasc Electrophysiol 2001;12:268-72.